Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Protective effects of Ginsan against Cyclophosphamide-induced immunosuppression in mice

  • Shim, Ji-Young (Laboratory of Immunology, Korea Institute of Radiological and Medical Sciences, KAERI) ;
  • Ahn, Ji-Yeon (Laboratory of Immunology, Korea Institute of Radiological and Medical Sciences, KAER) ;
  • Han, Young-Soo (Laboratory of Immunology, Korea Institute of Radiological and Medical Sciences, KAER) ;
  • Jung, In-Sung (Laboratory of Immunology, Korea Institute of Radiological and Medical Sciences, KAER) ;
  • Yun, Yeon-Sook (Laboratory of Immunology, Korea Institute of Radiological and Medical Sciences, KAER) ;
  • Song, Jie-Young (Laboratory of Immunology, Korea Institute of Radiological and Medical Sciences, KAERI)
  • Published : 2003.04.01
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Abstract

The immunomodulator Ginsan has been found previously by us to stimulate the secretion of high levels of IL -1. IL -6 and TNF-alpha in irradiated mice. These cytokines are known to induce proliferation and differentiation of hematopoietic progenitor cells from the spleen and bone marrow and to protect mice from DNA-damaging agents. The present studies were evaluated as a cytoprotective agent against toxicity of the alkylating drugs. (omitted)

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