• Proceedings of the PSK Conference
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• 2001.04a
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• pp.166.2-167
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• 2001

• Proceedings of the PSK Conference
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• 2002.04a
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• pp.151.3-152
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• 2002

• Proceedings of the PSK Conference
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• 2002.04a
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• pp.152.1-152.1
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• 2002

• Proceedings of the Ginseng society Conference
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• 1988.08a
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• pp.157-157
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• 1988

• Allergy, Asthma & Immunology Research
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• v.10 no.6
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• pp.571-574
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• 2018

• IMMUNE NETWORK
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• v.12 no.6
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• pp.253-260
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• 2012

${\alpha}$-Mangostin is a xanthon derivative contained in the fruit hull of mangosteen (Garcinia mangostana L.), and the administration of ${\alpha}$-Mangostin inhibited the growth of transplanted colon cancer, Her/CT26 cells which expressed Her-2/neu as tumor antigen. Although ${\alpha}$-Mangostin was reported to have inhibitory activity against sarco/endoplasmic reticulum $Ca^{2+}$ ATPase like thapsigargin, it showed different activity for autophagy regulation. In the current study, we found that ${\alpha}$-Mangostin induced autophagy activation in mouse intestinal epithelial cells, as GFP-LC3 transgenic mice were orally administered with 20 mg/kg of ${\alpha}$-Mangostin daily for three days. However, the activation of autophagy by ${\alpha}$-Mangostin did not significantly increase OVA-specific T cell proliferation. As we assessed ER stress by using XBP-1 reporter system and phosphorylation of $eIF2{\alpha}$, thapsigargin-induced ER stress was significantly reduced by ${\alpha}$-Mangostin. However, coadministration of thapsigargin with ${\alpha}$-Mangostin completely blocked the antitumor activity of ${\alpha}$-Mangostin, suggesting ER stress with autophagy blockade accelerated tumor growth in mouse colon cancer model. Thus the antitumor activity of ${\alpha}$-Mangostin can be ascribable to the autophagy activation rather than ER stress induction.

• Biomolecules & Therapeutics
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• v.27 no.3
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• pp.311-317
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• 2019

Mast cells are the most prominent effector cells of Type 1 hypersensitivity immune responses. CYC116 [4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin-4-yl)phenyl] pyrimidin-2-amine] is under development to be used as an anti-cancer drug, but the inhibitory effects of CYC116 on the activation of mast cells and related allergy diseases have not reported as of yet. In this study, we demonstrated, for the first time, that CYC116 inhibited the degranulation of mast cells by antigen stimulation ($IC_{50}$, ${\sim}1.42{\mu}M$). CYC116 also inhibited the secretion of pro-inflammatory cytokines including TNF-${\alpha}$ ($IC_{50}$, ${\sim}1.10{\mu}M$), and IL-6 ($IC_{50}$, ${\sim}1.24{\mu}M$). CYC116 inhibited the mast cell-mediated allergic responses, passive cutaneous anaphylaxis (ED50, ~22.5 mg/kg), and passive systemic anaphylaxis in a dose-dependent manner in laboratory experiments performed on mice. Specifically, CYC116 inhibited the activity of Fyn in mast cells and inhibited the activation of Syk and Syk-dependent signaling proteins including LAT, $PLC{\gamma}$, Akt, and MAP kinases. Our results suggest that CYC116 could be used as an alternative therapeutic medication for mast cell-mediated allergic disorders, such as atopic dermatitis and allergic rhinitis.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.208.2-209
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• 2003

Ginsan. a new polysaccharide isolated from Panax ginseng, has been previously reported as a good immunomodulator. In this study, we investigated the protective effect of Ginsan against a lethal sepsis induced by Staphylococcus aureus infection. The survival rate of mice treated with Ginsan 24 h prior to S. aureus infection was 80％ whereas PBS-treated mice showed 20％ of survival in the same infection. (omitted)

• Proceedings of the Zoological Society Korea Conference
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• 2001.10a
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• pp.264.2-265
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• 2001

No Abstract, See Full Text

• Proceedings of the Korean Society of Life Science Conference
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• 2006.09a
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• pp.104.1-104.1
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• 2006