• 대한수의학회지
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• 제48권3호
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• pp.305-310
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• 2008

A 10-year-old female Yorkshire terrier with the clinical signs of nasal swelling, epistaxis and nasal discharge was presented to the Veterinary Teaching Hospital in the Cheju National University. Abnormal nasal mass was detected in physical examination and radiographic findings. After surgical excision, the sample of nasal mass was referred to Pathology Department of Veterinary Medicine. Grossly, the mass was soft, friable, and $2.5{\times}4cm$ cm in size. Histopathologically, the mass was composed of mediumsized non-keratinizing columnar to polyhedral cells arranged in anastomosing ribbon and large nest. It has complex in-folding of thick epithelial layers separated by fibrovascular septa. Tumor cells showed characteristic palisading arrangement of columnar cells, and perpendicularly distributed to the basement membrane. The cells had pale basophilic cytoplasm, oval nucleus and one or more nucleoli, and indistinct cellular border. Many tumor cell emboli were presented in lymphatics. Immunohistochemistry revealed that tumor cells were cytokeratin (CK) 19 and CK clone MNF116 positive and but CK7 and CK high molecular weight negative. Based on the gross, histopathologic, and immunohistochemical findings, the mass was diagnosed as transitional carcinoma in nasal cavity. In our best knowledge, this is the first report of transitional carcinoma originated from transitional zone of canine nasal cavity in Korea.

• Clinical and Experimental Pediatrics
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• 제48권2호
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• pp.228-231
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• 2005

저자들은 재태기간 36주 6일로 출생한 환아가 대천문 팽대와 활동량 감소를 보여 시행했던 방사선과적 검사에서 발견된 천막 상부에 위치한 종양에 대해 일차적으로 교모세포종으로 진단하였다가 치료 중 재발된 종양에 대해 이차 수술 후 조직검사소견과 면역조직화학검사로 비정형 기형/횡문근양 종양으로 진단한 매우 드믄 악성 뇌종양 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 한국동물위생학회지
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• 제41권1호
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• pp.41-45
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• 2018

An 11 year-old male Korean short-haired cat was presented to local animal hospital due to weight loss, vomiting, and intestinal hypomotility. After the cat was euthanized by poor clinical outcomes, necropsy was performed at Animal and Plant Quarantine Agency. At necropsy, the stomach was enlarged and had some nearly complete pellet food and the yellow mucous contents. The lumen of the middle and lower parts of the jejunum became narrow. Histopathologically, medium-sized lymphoid cells with hyperchromatic nuclei enclosed by scant cytoplasm were diffusely proliferated from mucosa to serosa of the small intestine. These findings were mainly observed in the jejunum and slightly in the duodenum and ileum. The monomorphous lymphocytes were 1 to 1.5 times larger than red blood cells and had few mitotic figures. Metastasis of the tumor cells to other organs was not observed. In the result of immunohistochemical analysis for identifying the origin of tumor cells, CD3 was expressed, but $CD79{\alpha}$ was not detected in the infiltrated cells. This case was diagnosed as T cell intestinal lymphoma in a Korean short-haired cat based on the clinical signs, gross findings, histopathology, and immunohistochemistry.

• 한국동물위생학회지
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• 제31권1호
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• pp.57-70
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• 2008

The purpose of this study was to investigate the protective effects of the modified live vaccines against canine Bordetella bronchiseptica (Bb) and canine parainfluenza virus (CPIV) in puppies by nasal administration. A total of 24 puppies were classified as 3 groups consisting of 8, and each one was divided into two subgroups; vaccinated (n=4) and unvaccinated (n=4). Group I, group II and group III were challenged with Bb, CPIV, and Bb+CPIV, respectively. In group I vaccinated puppies (n=4) were experimentally challenged with Bb 2 weeks after vaccination and unvaccinated puppies (n=4) were experimentally challenged with Bb alone. The same methods of the above were applied for group II and group III. We carried out several studies including serum tests, isolation, and histopathological examination. The vaccinated puppies showed higher antibody titers than unvaccinated puppies and the titer sustained during the experimental period. In the isolation test, recovery period was shorter in the vaccinated subgroup than in the other. In clinical signs, the unvaccinated puppies showed the typical signs of tracheobronchitis (coughing, nasal and occular discharge), but another subgroup showed delayed incidence and mild clinical signs. The typical gross lesions and histopathological findings were observed in the unvaccinated puppies. In immunohistochemical findings, the vaccinated puppies showed little intensive in reaction for CPIV antigen than the other. It could be concluded that intranasal vaccination of modified live Bb and CPIV vaccine to puppies is effective to prevent canine infectious tracheobronchitis.

• 치과방사선
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• 제29권2호
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• pp.549-559
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• 1999

Leiomyosarcoma is extremely rare in the oral cavity and especially in the mandible. At first. the case of this report was diagnosed as odontogenic fibroma but after approximately 3.5 years. it was diagnosed as leiomyosarcoma. Conventional radiograph of the first time showed an ill-defined radiolucent lesion in the mandible. After local recurrence. CT images showed a large irregular soft tissue mass with some necrotic areas. These findings were not specific for leiomyosarcoma, but they suggested that this lesion was a recurrent soft tissue sarcoma. Histopathological examinations using H & E staining, immunohistochemical staining and Masson's trichrome staining confirmed this case as leiomyosarcoma. Deciding its malignancy or benignancy, defining the tumor extent and its relationship to the surrounding anatomic structures, and evaluating the distant metastasis are more important roles of radiographic examination than finding out the name of disease.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제16권4호
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• pp.273-278
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• 2013

We present a case of a 7-year-old boy who had cholestasis after trimethoprim-sulfamethoxazole combination therapy. Liver biopsy was performed 36 days after the onset of jaundice because of no evidence of improving cholestasis. Liver histology revealed portal inflammation, bile plug, and biliary stasis around the central vein with the loss of the interlobular bile ducts. Immunohistochemical stains for cytokeratin 7 and 19 were negative. These findings were consistent with those of vanishing bile duct syndrome (VBDS). Chlestasis was progressively improved with dose increment of urosodeoxycholic acid from conventional to high dose. This is the first case report of trimethoprime-sulfamethoxazole associated VBDS in Korean children. The case suggests that differential diagnosis of VBDS should be considered in case of progressive cholestatic hepatitis with elevation of alkaline phosphatase and gamma-glutamyl transpeptidase after or during taking medicine to treat nonhepatobiliary diseases illness.

• 대한세포병리학회지
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• 제7권2호
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• pp.207-212
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• 1996

Angiosarcoma of the bone is rare with an incidence of 0.13%. It may be solitary or multiple. Its cytologic findings by FNA have rarely been reported. We report a case of angiosarcoma of the rib in a 66 year-old man. FNA revealed single or clusters of round to oval shaped cells in a hemorrhagic and myxoid background. The large central nuclei had irregular nuclear membrane, chromatin clumping and prominent nucleoli. The cytoplasm was scanty with an eosinophilic distinct cytoplasmic border. Erythrophagocytosis by malignant cells was also found. Histopathologic examination confirmed the diagnosis of angiosarcoma revealing irregular and complex anastomosing vascular channels lined by malignant round tumor cells, protruding into the lumen. Immunohistochemical staining revealed diffuse strong positive reaction to factor VIII-related antigen and CD31.

• 대한세포병리학회지
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• 제11권1호
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• pp.35-39
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• 2000

Since inflammatory myofibroblastic turner was initially recognized in the lung, this tumor has been described in other extrapulmonary sites. In spite of relatively uniform histologic findings in various organs, a rarity in extrapulmonary sites and highly vascular characteristics frequently lead to a misdiagnosis in preoperative radiology and fine needle aspiration cytology. We present a case of inflammatory myofibroblastic tumor occurring in the mesentery of a 4-month-old girl. Fine needle aspiration cytology smear disclosed characteristic spindle cells intermixed with prominent mature plasma cells and lymphocytes. According to the immunohistochemical staining, we recognized that the intervening spindle cells are myofibroblasts which have reactivity for the both actin and vimentin.

• 한국임상수의학회지
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• 제28권4호
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• pp.460-465
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• 2011

A 15-year-old, castrated male shih-tzu dog was referred to Veterinary Medical Teaching Hospital of Gyeongsang National University due to dyspnea, anorexia, depression of 1 week's duration. On thoracic radiography, triangular shaped soft tissue opacity mass presented in the left cranial lung lobe region. On computed tomography, there was a $3.8{\times}2.5$ cm mass in the left thoracic cavity, which was lobulated and adhered to ventral pleural surface. Histopathologically, the neoplastic cell population consisted of a lot of lymphocytes and a few of Hassal's corpuscles. The immunohistochemistry, lymphocytes were diffusely positive for CD3 and focal positive $CD79{\alpha}$. Based on gross, histologic, and immunohistochemical findings, the neoplasm was diagnosed a lymphocyte predominant thymoma.

• Journal of Chest Surgery
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• 제35권8호
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• pp.634-637
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• 2002

흉선 유암종 또는 흉선의 신경내분비 종양은 매우 드문 질환이며 재발이나 전이가 많아 예후가 좋지 못하다. 43세 남자 환자로 우측 흉부의 통증과 불편감으로 내원하였다. 단순 흉부 촬영상 우측 전종격동에 $7{\times}8$cm 크기의 종양을 발견하였으며 추가검사 후 수술적 절제를 시행하였다. 절제된 종괴는 조직학적, 면역조직화학적, 전자현미경적 소견상 흉선 낭종을 동반한 흉선의 비정형 유암종으로 진단 되었다. 수술 후 재발이나 전이 소견 없이 3개월째 외래 관찰중이다. 저자들은 흉선 낭종을 동반한 비정형 흉선유암종 1례를 치험하였기에 문헌고찰과 함께 보고하는 바이다.