• IMMUNE NETWORK
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• 제20권1호
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• pp.9.1-9.21
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• 2020

Immune checkpoint inhibitors (ICIs) have been changing the paradigm of cancer treatment. However, immune-related adverse effects (irAEs) have also increased with the exponential increase in the use of ICIs. ICIs can break up the immunologic homeostasis and reduce T-cell tolerance. Therefore, inhibition of immune checkpoint can lead to the activation of autoreactive T-cells, resulting in various irAEs similar to autoimmune diseases. Gastrointestinal toxicity, endocrine toxicity, and dermatologic toxicity are common side effects. Neurotoxicity, cardiotoxicity, and pulmonary toxicity are relatively rare but can be fatal. ICI-related gastrointestinal toxicity, dermatologic toxicity, and hypophysitis are more common with anti- CTLA-4 agents. ICI-related pulmonary toxicity, thyroid dysfunction, and myasthenia gravis are more common with PD-1/PD-L1 inhibitors. Treatment with systemic steroids is the principal strategy against irAEs. The use of immune-modulatory agents should be considered in case of no response to the steroid therapy. Treatment under the supervision of multidisciplinary specialists is also essential, because the symptoms and treatments of irAEs could involve many organs. Thus, this review focuses on the mechanism, clinical presentation, incidence, and treatment of various irAEs.

• 전자공학회논문지CI
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• 제42권5호
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• pp.59-68
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• 2005

본 논문에서는 하드웨어 오류 검출을 위하여 공생 진화(symbiotic evolution)에 기반을 둔 새로운 immunotronic 알고리즘을 제안한다. 면역학(immunology)과 전자공학(Electronics)을 결합한 immunotronic 시스템에서 가장 중요한 점은 포용 조건 (tolerance condition)을 생성하는 방식이다. 여기서 포용 조건 생성은 생체 면역 시스템에서의 항체 생성을 의미한다. 본 논문에서는 생체 면역 시스템에서 매우 중요한 개념인 항체의 다양성 원리(principle of antibody diversity)를 포용 조건 생성에 적용한 후 공생 진화를 통하여 이를 구현한다. 공생 진화는 기존의 유전자 알고리즘(standard genetic algorithm, SGA)에 비해서 더욱 더 생체 면역 시스템이 항체를 생성하는 방식과 유사하며 이러한 방식은 이전의 immunotronic 방식에 비해서 더 향상된 비자기 검출 율을 보여 준다. 이렇게 제안된 알고리즘을 FSM(Finite State Machine)의 가장 전형적인 예인 십진 카운터와 MCNC benchmark FSM에 적용한 후 컴퓨터 모의 실험을 통해 그 성능을 확인한다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권3호
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• pp.735-748
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• 2014

The fault-tolerance routing problem is one of the most important issues in the application of the Internet of Things, and has been attracting growing research interests. In order to maintain the communication paths from source sensors to the macronodes, we present a hybrid routing scheme and model, in which alternate paths are created once the previous routing is broken. Then, we propose an improved efficient and intelligent fault-tolerance algorithm (IEIFTA) to provide the fast routing recovery and reconstruct the network topology for path failure in the Internet of Things. In the IEIFTA, mutation direction of the particle is determined by multi-swarm evolution equation, and its diversity is improved by the immune mechanism, which can improve the ability of global search and improve the converging rate of the algorithm. The simulation results indicate that the IEIFTA-based fault-tolerance algorithm outperforms the EARQ algorithm and the SPSOA algorithm due to its ability of fast routing recovery mechanism and prolonging the lifetime of the Internet of Things.

• International Journal of Fuzzy Logic and Intelligent Systems
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• 제4권1호
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• pp.7-11
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• 2004

This paper proposes a new immunotronic approach for the fault detection in hardware. The suggested method is, inspired by biology and its implementation is based on genetic algorithm. Tolerance conditions in the immunotronic system for fault detection correspond to the antibodies in the biological immune system. A novel algorithm of generating tolerance conditions is suggested based on the principle of the antibody diversity and GA optimization is employed to select mature tolerance conditions in immunotronic fault detection system. The suggested method is applied to the fault detection for MCNC benchmark FSMs (finite state machines) and its effectiveness is demonstrated by the computer simulation.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권4호
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• pp.1178-1191
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• 2014

The fault-tolerance routing problem is one of the most important issues in the application of the Internet of Things, and has been attracting growing research interests. In order to maintain the communication paths from source sensors to the macronodes, we present a hybrid routing scheme and model, in which alternate paths are created once the previous routing is broken. Then, we propose an improved efficient and intelligent fault-tolerance algorithm (IEIFTA) to provide the fast routing recovery and reconstruct the network topology for path failure in the Internet of Things. In the IEIFTA, mutation direction of the particle is determined by multi-swarm evolution equation, and its diversity is improved by the immune mechanism, which can improve the ability of global search and improve the converging rate of the algorithm. The simulation results indicate that the IEIFTA-based fault-tolerance algorithm outperforms the EARQ algorithm and the SPSOA algorithm due to its ability of fast routing recovery mechanism and prolonging the lifetime of the Internet of Things.

• 대한두경부종양학회지
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• 제33권1호
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• pp.1-5
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• 2017

두경부 편평상피세포암은 전세계적으로 6번째로 흔하며 예후가 불량한 암종이다. 면역 감시는 두경부암의 발생과 진행을 억제하는 중요한 기전으로 알려져 있다. 두경부암세포는 면역 감시를 T세포의 관용을 유도하거나 체크포인트를 통한 T세포 기능을 억제하는 등의 방법으로 회피할 수 있다. 한편 진행성 두경부암 임상연구에서 체크포인트 억제제는 명확한 항종양효과를 입증하였다. 이처럼 면역항암제가 중요한 암치료 방법으로 떠오르는 이때에 본 종설은 두경부암의 면회회피 기전 및 임상적용근거에 대한 최근 지식을 정리하였다.

• IMMUNE NETWORK
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• 제14권4호
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• pp.182-186
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• 2014

Lymphatic vessels are routes for leukocyte migration and fluid drainage. In addition to their passive roles in migration of leukocytes, increasing evidence indicates their active roles in immune regulation. Tissue inflammation rapidly induces lymphatic endothelial cell proliferation and chemokine production, thereby resulting in lymphangiogenesis. Furthermore, lymphatic endothelial cells induce T cell tolerance through various mechanisms. In this review, we focus on the current knowledge on how inflammatory cytokines affect lymphangiogenesis and the roles of lymphatic vessels in modulating immune responses.

• 대한의생명과학회지
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• 제23권3호
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• pp.175-184
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• 2017

Cholera toxin (CT) is an ADP-ribosylating bacterial exotoxin that has been used as an adjuvant in animal studies of oral immunization. The mechanisms of mucosal immunogenicity and adjuvanticity of CT remain to be established. In this study, we investigated the role of indoleamine 2,3-dioxygenase (IDO), which participates in the induction of immune tolerance, in CT-mediated breakdown of oral tolerance. When IDO-deficient ($IDO^{-/-}$) mice and their littermates were given oral ovalbumin, significant changes in antibody responses, footpad swelling and $CD4^+$ T cell proliferation were not observed in $IDO^{-/-}$ mice. Feeding of CT decreased IDO expression in mesenteric lymph nodes (MLN) and Peyer's patch (PP). CT-induced downregulation of IDO expression was reversed by inhibitors of nuclear factor-kappa B (NF-${\kappa}B$), pyrrolidine dithiocarbamate and p50 small interfering RNA. IDO expression was downregulated by the NF-${\kappa}B$ inducers lipopolysaccharide and tumor necrosis factor-${\alpha}$. CT dampened IDO activity and mRNA expression in dendritic cells from MLN and PP. These data indicate that CT disrupts oral tolerance by activating NF-${\kappa}B$, which in turn downregulates IDO expression. This study betters the understanding of the molecular mechanism underlying CT-mediated abrogation of oral tolerance.

• 한국항공우주학회지
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• 제31권3호
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• pp.95-100
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• 2003

위성에서 사용되는 전자장비는 고신뢰성을 요구하고 있으며 예비부품을 보유함으로써 어느 정도의 심각한 결함에도 면역(Immune)되도록 설계되어야 한다. 통신위성은 통상 15년의 임무기간을 가지고 있으므로 위성에서 사용되는 전장 부품은 결함에 대한 분석이 수행되어야 한다. 본 논문은 명령 처리기의 결함 허용 설계와 그에 따른 신뢰도 예측값들은 무궁화 위성3호 자료와 다목적 위성 1호 자료를 참고하였다. 결함 허용 설계에는 많은 Trade-off연구가 필요하나 특히 결함 시나리오에 가장 적합한 결함 허용 방식을 선정하는 것이 중요하다고 할 수 있다.

• 한국축산식품학회지
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• 제36권1호
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• pp.14-18
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• 2016

Oral administration of soluble antigen can induce peripheral tolerance to the antigen. This study was conducted to evaluate whether gamma-irradiated ovalbumin (OVA) can induce oral tolerance. To investigate this, we administrated intact or irradiated OVA to mice, induced allergic response using intact OVA and alum, then compared humoral and cellular immune responses. Mice treated with gammairradiated OVA had less OVA-specific IgE compared with those who were administered intact OVA. There was no difference in levels of OVA-specific IgG+A+M, IgG1, and IgG2a. Splenocytes of mice administered irradiated OVA showed similar OVA-specific T cell proliferation and secretion of IFN-γ and IL-4. However, there was an increase in IL-2 and a decrease of IL-6 secretion in mice treated with irradiated OVA. These results indicate that gamma-irradiated OVA have similar effects to intact OVA on antigen tolerance.