• 대한상한금궤의학회지
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• v.12 no.1
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• pp.101-112
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• 2020

Objective: This study aimed to report the effect of Baekhogainsam-tang on brain fog. Methods: A 59-year-old female patient complained of brain fog and waking up frequently during the night. Based on the Shanghanlun disease pattern identification diagnostic system, the patient was treated with Baekhogainsam-tang. The result was evaluated using the score. Results: After administration of Baekhogainsam-tang for 45 days, the MFI score decreased from 89 to 40. The average number of instances of waking up during the night decreased from 3 to 1.5. Conclusions: Some cases of brain fog can be treated by Baekhogainsam-tang.

• 대한상한금궤의학회지
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• v.13 no.1
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• pp.99-110
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• 2021

Objective: This study aimed to report the effect of Oryeong-san on Menière's disease. Methods : A 48-year-old female complained of Menière's disease and daily frequent headache. Based on the Shanghanlun disease pattern identification diagnostic system, the patient was treated with Oryeong-san. The result was evaluated by the Dizziness Handicap Inventory (DHI) and a numerical rating score. Results : After administration of Oryeong-san for 46 days, the DHI score decreased from 42 to 4. The average number of dizzy spells decreased from 6 to 0. Conclusions : Some cases of Menière's disease can be treated by Oryeong-san.

• The Journal of Korean Medicine
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• v.45 no.1
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• pp.225-232
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• 2024

Objectives: The purpose of this case study was to report the effect of Chuna therapy include Space Spinal Conduction Exercise and Manipulation Treatment for Functional dyspepsia patients. Methods: A 32-years-old male patients with functional dyspepsia visited the clinic ten times from March 17th 2023 to April 22th 2023. To assess the treatment outcomes, we used the Standard tool for pattern identification of Functional dyspepsia and Nepean Dyspepsia Index-Korean version (NDI-K) symptom score. Result: After treatment, Standard tool for pattern identification of Functional dyspepsia and Nepean Dyspepsia Index-Korean version (NDI-K) score decreased. Conclusion: Chuna therapy include Space Spinal Conduction Exercise and Manipulation Treatment was effective in the treatment of patient with Functional dyspepsia.

• Journal of Korean Medicine Rehabilitation
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• v.29 no.3
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• pp.113-128
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• 2019

Objectives To evaluate the pattern identification tool for knee osteoarthritis and to investigate the relationship between pattern identification tool and knee ROM (range of motion), VAS (visual analog scale) and WOMAC (Western Ontario & McMaster Universities osteoarthritis index). Methods We studied 50 patients who are diagnosed as degenerative osteoarthritis. With one patient dropping out, total of 49 patient went through pattern identification tool. Re-test of the pattern identification tool was implemented after about a week. The reliability was analyzed by calculating ICC (intraclass correlation coefficient). Also, reliability of each pattern identification score was calculated along with influence factor and correlation between knee ROM, VAS and WOMAC. Results Reliability of the pattern identification tool was evaluated as 'poor agreement beyond chance' with ICC value of 0.396. Reliablility of each pattern identification score was calculated and four out of five were measured 'good' with one 'moderate' reliability. Two of inter-item consistency were 'good', two were 'acceptable' and one was 'questionable'. Correlation between each pattern identification and knee ROM showed 'clear negative linear relationship' with two patterns. VAS showed 'clear positivie linear relationship' with all five patterns. WOMAC showed 'positivie linear relationship' with all five patterns. Conclusions According to the results, pattern identification tool for knee osteoarthritis seems to have meaningful relationship with other agnedas. Also, further research is needed to develop the tool.

• The Journal of Internal Korean Medicine
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• v.41 no.6
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• pp.1052-1065
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• 2020

Objectives: To evaluate the reliability of a pattern identification tool for benign prostatic hyperplasia and to examine the relationship between pattern identification tool readings and IPSS and uroflowmetry. Methods: We analyzed 56 patients diagnosed with benign prostatic hyperplasia from December 27th, 2017 to December 26th, 2018 by two different Korean medical doctors and followed with a pattern identification tool and by IPSS and uroflowmetry. One week later, the patients were retested to analyze the reliability of the pattern identification tool, determined with the intraclass correlation coefficient (ICC) using the test-retest method. The correlation between IPSS and uroflowmetry was analyzed with the Pearson coefficient. Result: The reliability of the pattern identification tool for benign prostatic hyperplasia was evaluated as "poor agreement beyond chance" (ICC=0.349). The reliability of each pattern identification score was evaluated as "good" for Yang Deficiency of Kidney, Yin Deficiency of Kidney, Deficiency of Middle Qi, and Dampness-heat of Lower Energizer. The internal consistency was evaluated as "good" for Yang Deficiency of Kidney, Yin Deficiency of Kidney, and Dampness-heat of Lower Energizer, and as "excellent" for Deficiency of Middle Qi. The correlation between pattern identification and IPSS was evaluated as a "moderate positive correlation" for all pattern identifications. The average flow rate and maximum flow rate using uroflowmetry was evaluated with "moderate negative correlation" for Yang Deficiency of Kidney and Dampness-heat of Lower Energizer. Conclusion: The reliability of a pattern identification tool for benign prostatic hyperplasia was evaluated as "poor agreement beyond chance." Further research is needed.

• The Journal of Korean Obstetrics and Gynecology
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• v.32 no.3
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• pp.174-191
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• 2019

Objectives: This study was aimed to analyze clinical characteristics and menstrual pattern of female patients who have cold hypersensitivity on hands and feet. Methods: This study was performed from May, 2018 to April, 2019. We checked the patients' hand and feet's temperature and those who diagnosed with cold hypersensitivity filled in survey. Data were collected from 27 participants and we divided data into 2 group; Dysmenorrhea group and Non-dysmenorrhea group. Results: Throughout the study, we found out differences between 2 groups in age, height, weight, VAS score of cold hypersensitivity on hands and feet, menstrual pattern, upper and lower extremity temperature difference, pattern identification, VAS of menstrual pain, and pattern of leukorrhea. Conclusions: By analyzing of study, Dysmenorrhea group's VAS score of cold hypersensitivity on hands and feet was $6.67{\pm}1.73$, Non-dysmenorrhea group's VAS score of cold hypersensitivity on hands and feet was $7.78{\pm}1.72$ (p-value 0.015). This shows that the degree of hypersensitivity on hands and feet is not necessarily proportional to the degree of menstrual pain.

• 대한상한금궤의학회지
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• v.14 no.1
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• pp.81-93
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• 2022

Objective : This study reports on the case of a patient with irritable bowel syndrome (IBS) diagnosed by the Shanghanlun disease pattern identification diagnostic system (DPIDS). We tried to verify the therapeutic effects of Soseunggi-tang (SSGT) administration and pathological character. Methods : The patient was administered SSGT for 31 days. We observed the progression of symptoms, patient compliance, and the presence of side effects. The progression of IBS was evaluated based the on Gastrointestinal Symptom Rating Scale (GSRS). Abdominal pain, flatus, visual findings, and patient statements were also assessed. Results : According to the DPIDS, the patient was diagnosed with Yangmingbing (陽明病). As a result, his GSRS score dropped from 15 to 5, the visual analog scale (VAS) score for abdominal pain lowered from 9 to 4, and the VAS score for flatus decreased from 8 to 4. The stool type changed from diarrhea to a loose stool form. Conclusions : SSGT showed therapeutic effects on the patient diagnosed with IBS and Yangmingbing.

• Journal of Microbiology
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• v.33 no.2
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• pp.95-102
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• 1995

A probability identification matrix of acidophilic Streptomyces was constructed. The phenetic data of the strains were derived from numerical classification described by Seong et al. The minimum number of diagnostic characters was determined using computer programs for calculation of different separation indices. The resulting matrix consisted of 25 clusters versus 53 characters. Theoretical evaluation of this matrix was achieved by estimating the chuster overlap and the identification scores for the Hypothetical Median Organisms (HMO) and for the representatives of each cluster. Cluster overlap was found to be relatively small. Identification scores for the HMO and the randomly selected representatives of each cluster were satisfactory. The matrix was assessed practically by applying the matrix to the identification of unknown isolates. Of the unknown isolates, 71.9% were clearly identified to one of eight clusters. The numerical classification data was also used to design a selective isolation medium for antibiotic-producing organisms. Four chemical substances including 2 antibiotics were determined by the DLACHAR program as diagnostic for the isolation of target organisms which have antimicrobial activity against Micrococcus luteus. It was possible to detect the increased rate of selective isolation on the synthesized medium. Theresults show that the numerical phenetic data can be applied to a variety of purposes, such as construction of identification matrix and selective isolation medium for acidophilic antinomycetes.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.3
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• pp.142-148
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• 2020

The purpose of this study was to evaluate the validity of Deficiency and Excess Pattern Identification Questionnaire. The number of subjects enrolled in this study was 431. Pearson Correlation Coefficient analysis were conducted to reveal the correlation among Deficiency and Excess Pattern Identification Questionnaire, Grip Strength and Quality of life. ROC-curve analysis were used to suggest optimal cut off value. Cohen Kappa also used to analyze for diagnostic validity. The significant p-value was < .05. The Deficiency questionnaire had positive correlation with the score of the expert and negative correlation with Grip Strength and Quality of life (p<.001). The Excess questionnaire had positive correlation with the score of the expert and negative correlation with Quality of life (p<.001). The optimal cut off value was 56.5 to separate deficiency and non deficiency and 47.5 to separate excess and non-excess. Furthermore, AUC was .900 and .851 accordingly. Cohen Kappa value between deficiency questionnaire and the expert was .640. Cohen Kappa value between excess questionnaire and the expert was .513. This study reveals that Deficiency and Excess Pattern Identification Questionnaire is valid. However, further study considering of gender, age, and health condition and so on, is needed.

• KIPS Transactions on Software and Data Engineering
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• v.10 no.12
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• pp.547-554
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• 2021

Cancer patients can have different kinds of cancer driver genes, and identification of these patient-specific cancer driver genes is an important step in the development of personalized cancer treatment and drug development. Several bioinformatic methods have been proposed for this purpose, but there is room for improvement in terms of accuracy. In this paper, we propose NPD (Network based Patient-specific Driver gene identification) for identifying patient-specific cancer driver genes. NPD consists of three steps, constructing a patient-specific gene network, applying the modified PageRank algorithm to assign scores to genes, and identifying cancer driver genes through a score comparison method. We applied NPD on six cancer types of TCGA data, and found that NPD showed generally higher F1 score compared to existing patient-specific cancer driver gene identification methods.