• Title/Summary/Keyword: i.m. injection

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Histological Changes of the Ovary and the Uterus of Guinea pigs Administerd Radioiodine (방사성옥소(131I)가 Guinea pig의 난소조직과 자궁조직에 미치는 영향)

  • Lee, Heung Shik;Lee, Kang Wook;Shin, Kwang Soon
    • Korean Journal of Veterinary Research
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    • v.13 no.1
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    • pp.1-4
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    • 1973
  • This experiment was performed in order to investigate the effect of radioiodine upon the uterus and the ovary of guinea pigs. The animals were injected single dose of 4. 5 mCi of radioiodine per kg of body weight. They were sacrificed on various time intervals; 1, 7, 14, 28, 42 and 56 days after the injection. The results were as follows: 1. In the ovary, the follicle cells and the ova were degenerated with lapse of time after the injection. 2. In the uterus, hyperplasia of the lamina propria of the endometrium and atrophy of the myometrium were observed in accordance with time after the injection.

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Breakup Characteristics of Liquid Sheets Formed by Impinging Jets in High Pressure Environments (고압분위기에서 충돌제트로 형성되는 액막의 분열특성)

  • Jung, Ki-Hoon;Khil, Tea-Ock;Lim, Byoung-Jik;Yoon, Young-Bin
    • Journal of ILASS-Korea
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    • v.9 no.4
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    • pp.1-8
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    • 2004
  • Breakup characteristics of liquid sheets formed by the impingement of two water jets, such as a breakup length and a breakup wavelength of sheet, were investigated as increasing the injection velocity up to 30m/s and the ambient gas pressure up to 4.0MPa. While round edged orifices formed a laminar sheet which has no waves on the sheet when the injection velocity is low, sharp edged orifices formed a turbulent sheet which has impact waves irrespective of the injection velocity. Thus we compared the differences of breakup characteristics between them. The results showed that the aerodynamic force significantly affects the breakup of laminar sheet when the gas based Weber number is higher than unity, It was also found that the turbulent sheets have three breakup regimes, i.e. expansion regime, wave breakup regime and catastrophic breakup regime according to the gas based Weber number.

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Breakup Characteristics of Laminar and Turbulent Liquid Sheets Formed by Impinging Jets in High Pressure Environments

  • Jung, K.;Khil, T.;Lim, B.;Yoon, Y.
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • 2004.03a
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    • pp.173-179
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    • 2004
  • Breakup characteristics of liquid sheets formed by the impingement of two water jets, such as a breakup length and a breakup wavelength of sheet, were investigated as increasing the injection velocity up to 30m/s and the ambient gas pressure up to 4.0㎫. While round edged orifices formed a laminar sheet which has no waves on the sheet when the injection velocity is low, sharp edged orifices formed a turbulent sheet which has impact waves irrespective of the injection velocity. Thus we compared the differences of breakup characteristics between them. The results showed that the aerodynamic force significantly affects the breakup of laminar sheet when the gas based Weber number is higher than unity. It was also found that the turbulent sheets have three breakup regimes, i.e. expansion regime, wave breakup regime and catastrophic breakup regime according to the gas based Weber number.

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A Comparative Pharmacokinetic and Biodistributional Study of $^{131}I$ OIH and $^{99m}Tc-MAG_3$ ($^{131}I$ OIH와 $^{99m}Tc-MAG_3$의 약물동력학 및 체내 분포에 관한 비교 연구)

  • Jeong, Jae-Min;Yeom, Mi-Kyoung;Kim, Mun-Hye;Park, Kyung-Ho;Song, Sae-Heum;Lee, Bum-Woo;Lee, Dong-Soo;Chung, June-Key;Lee, Myung-Chul;Cho, Bo-Youn;Koh, Chang-Soon
    • The Korean Journal of Nuclear Medicine
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    • v.24 no.1
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    • pp.74-79
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    • 1990
  • $^{99m}Tc-MAG_3$ was synthesized, and biodistribution and blood clearance rate were compared with those of $^{131}I-OIH$ in mice and rats respectively. Finally renal image was obtained from a normal male volunteer before and after prescription of probenecid. The results obtained were as follows: 1) The uptake of $^{99m}Tc-MAG_3$ by kindey was higher than that of $^{131}I-OIH$ in mice 10 mins after injection (n=6, p<0.05), but slightly lower uptakes were found in all organs (kindney, blood, stomach, intestinge and liver) 2 hrs after injection. 2) For $^{99m}Tc-MAG_3$ $4\frac{1}{2}\;\alpha=2.4{\pm}0.0\;min,\;t\frac{1}{2}\;\beta=44.3{\pm}7.4\;min$, and blood clearance=$3.4{\pm}0.5ml/min$, and for $^{131}I-OIH\;t\frac{1}{2}\;\alpha=1.8{\pm}0.2\;min,\;\beta=69.1{\pm}9.5\;min$, and blood clearance=$1.3{\pm}0.1\;min$ were found in rats. 3) From the renogram of normal male volunteer, we could find that tmax=130 sec and $t\frac{1}{2}=430\;sec$ before probenecid prescription, and $tmax=150\sim170$ sec and $t\frac{1}{2}=810\sim1,170$ sec after probenecid prescriprion. From these results we concluded that $^{99m}Tc-MAG_3$ can be used instead of $^{131}I-OIH$ for obtaining renal image.

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A PARAMETRIC SENSITIVITY STUDY OF GDI SPRAY CHARACTERISTICS USING A 3-D TRANSIENT MODEL

  • Comer, M.A.;Bowen, P.J.;Sapsford, S.M.;Kwon, S.I.
    • International Journal of Automotive Technology
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    • v.5 no.3
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    • pp.145-153
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    • 2004
  • Potential fuel economy improvements and environmental legislation have renewed interest in Gasoline Direct Injection (GDI) engines. Computational models of fuel injection and mixing processes pre-ignition are being developed for engine optimisation. These highly transient thermofluid models require verification against temporally and spatially resolved data-sets. The authors have previously established the capability of PDA to provide suitable temporally and spatially resolved spray characteristics such as mean droplet size, velocity components and qualitative mass distribution. This paper utilises this data-set to assess the predictive capability of a numerical model for GDI spray prediction. After a brief description of the two-phase model and discretisation sensitivity, the influence of initial spray conditions is discussed. A minimum of 5 initial global spray characteristics are required to model the downstream spray characteristics adequately under isothermal, atmospheric conditions. Verification of predicted transient spray characteristics such as the hollow-cone, cone collapse, head vortex, stratification and penetration are discussed, and further improvements to modelling GDI sprays proposed.

Studies on the Ultrasound-guided Transvaginal Retrieval of Oocytes in Korean Native, Hanwoo Heifers I. Characteristics of Hanwoo Ovary during the Estrous Cycle (한우에 있어서 초음파기기를 이용한 생체내 난자 채취에 관한 연구 I. 발정주기중 난소의 특성 변화)

  • 박성재;양보석;임기순;성환후;장원경;조성근;박충생
    • Korean Journal of Animal Reproduction
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    • v.24 no.1
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    • pp.77-82
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    • 2000
  • This study was conducted to establish the methods of ultrasound-guided transvaginal retrieval of oocytes (ovum pick-up) in Korean native, Hanwoo Heifers. To obtain the basic data about Hanwoo, the size of ovaries in luteal and follicular phases were measured and the number of follicles in ovaries during the estrus cycle was counted by using ultrasound. And to determine the effective anesthetic to Hanwoo, various mixture of anesthetic compounds, Rompun(equation omitted), lidocaine, Monzal(equation omitted), and Domosedan(equation omitted), were treated. The size of Hanwoo ovaries were not significant differently between luteal and follicular phases. The number of medium and small follicles were peak on day 3 and 12 of the estrous cycle, and this result suggested that Hanwoo has 2 follicular growth waves per estrus cycle. The most effective anesthetic method was intramuscular injection of a.3m! Rompun(equation omitted), epidural injection of 5$m\ell$ lidocaine and sprayed cervix by 2$m\ell$ lidocaine.

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An Experiment Study on Combustion Characteristics of the Spud Type Gas Burner (스퍼드형 가스버너의 연소특성에 관한 실험적 연구)

  • Yang, G.M.;Chon, M.H.;Seon, C.Y.;Chang, I.G.;Jang, G.H.
    • Proceedings of the KSME Conference
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    • 2000.11b
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    • pp.668-673
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    • 2000
  • Spud angle( ${\alpha}$ ) and fuel injection angle ( ${\beta}$ ) have strong influence on spud type gas burner combustion. A wide range of flame stability is shown at ${\alpha}=60^{\circ}$, but at ${\alpha}=30^{\circ}$ is narrow. Optimum condition of flame stability swirl angle( ${\gamma}$ ) is $40^{\circ}$. At condition of ${\alpha}=30^{\circ}$ flame shape is relatively narrow and long, on the other hand, at ${\alpha}=60^{\circ}$ flame is wide and short. Regardless of spud angle, maximum flame temperature shows in the range of Z=200mm and R=0mm. Flame temperature, on the whole, is high at ${\alpha}=45^{\circ}$. At ${\alpha}=45^{\circ}$, NOx emission is higher than other conditions that may be concerned with flame temperature. At ${\beta}=60^{\circ}$ and ${\gamma}=40^{\circ}$, NOx emission is reduced due to fuel injection angle.

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Antipruritic Effect of DA-5018m A Capsaicin Derivative, in Mice

  • Kim, Dong-Hwan;Ahn, Byoung-Ok;Kim, Soon-Hoe;Kim, Won-Bae
    • Archives of Pharmacal Research
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    • v.22 no.6
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    • pp.549-553
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    • 1999
  • The antipruritic effect of DA-5018m a capsaicin derivative, was examined in mice. Male ICR mice were topically pretreated with Zostrix-HP (0.075% capsaicin cream), 0.1%, 0.3% DA-5018 cream or cream base (control) twice daily for 4 days. One hour after the last application, itch was induced either by compound 48/80 ($50{\mu}g$, s.c.) or leukotriene B4 (0.03 nmol, i.d.) injection into the rostral back of the animals, and the number of scratches made by the animals at the injection site was counted for 60 min post-injection. DA-5018 cream (both 0.1 and 0.3%) significantly inhibited compound 48/80-induced scratching when compared with the cream base control (p<0.01), which Zostrix-HP showed minimal inhibition of the scratching behavior. In leukotriene B4-induced itch model, Zostrix-HP and 0.3% DA-5018 cram significantly inhibited the scratching during the first 10-min period (p<0.01). The results suggest that DA-5018 cream can be used as an antipruritic agent and warrant clinical evaluation.

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A Study on Effective Application of $Methylenediphosphonate-^{99m}Tc$ ($Methylenediphosphonate-^{99m}Tc$의 효과적 이용에 관한 연구)

  • Kim, Jae-Rok;Awh, Ok-Doo;Park, Kyung-Bae;Koo, Hyeon-Sook
    • The Korean Journal of Nuclear Medicine
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    • v.16 no.1
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    • pp.55-61
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    • 1982
  • Biodistribution studies has been carried out to elucidate the cause of poor bone imagings often encountered in using $methylenediphosphonate(MDP)-^{99m}Tc$ and to establish effective conditions in using the popular bone imaging agent. After 150 minutes from the I.V. injection of $MDP-^{99m}Tc$ to mice, the radioactivities accumulated at bone(B), liver(L), and stomach(S) were counted. The radiochemical purity (RCP), the volume, the radioactivity concentration and the amount of radioactivity of $MDP-^{99m}Tc$ were controlled. Data were expressed either in %cpm/g organ or % cpm/organ. The organ distribution ratios(B/L and B/S) were correlated with the RCP, the volume of injection, the radioactivity concentration etc. Results indicated that the RCP plays a major role in biodistributions. High radioactivity concentration and injection of a small amount is recommended. Negligible effect was observed with the amount of radioactivity. It has been confirmed that the up-to-date methods of RCP determinations cannot sensitively detect the sharply affecting trace impurities. A particular biodistribution pattern of crossed B/L and B/S lines was observed in case of using $MDP-^{99m}Tc$ of low RCP. In such a case, rather a higher dosage would be effective for improving the contrast between bone and liver.

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Marginal Zinc Deficiency Affects Biochemical and Physiological Parameters in Beef Heifer Calves

  • Engle, T.E.;Nockels, C.F.;Hossner, K.L.;Kimberling, C.V.;Toombs, R.E.;Yemm, R.S.;Weaber, D.L.;Johnson, A.B.
    • Asian-Australasian Journal of Animal Sciences
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    • v.10 no.5
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    • pp.471-477
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    • 1997
  • A study detennined whether certain biochemical and physiological variables were altered during marginal Zn deficiency. Ten weaned crossbred Hereford Angus heifer calves, weighing $163{\pm}2kg$, were utilized. Five calves were fed a Zn - deficient (- Zn) brome-alfalfa hay diet containing 17 mg Zn/kg diet DM, and five calves were fed a Zn-adequate (+Zn) diet with 23 mg Zn/kg diet DM from $ZnSO_4$ added to the - Zn diet (total diet, 40 mg Zn/kg diet DM), for 32 d. At 21 d the - Zn calves had a reduction (p < .05) in feed efficiency. By 25 d, plasma Zn and alkaline phosphatase concentrations were reduced (p < .05) in the - Zn calves. Blood urea nitrogen, glucose, insulin, IGF-I, Cu plasma concentration and Zn and Cu concentrations of red blood cell (RBC) and liver were not altered (p > .05) by the - Zn diet through 25 d. In response to a single i. m. injection of dexamethasone (20 mg) on d 25, calves fed the two dietary Zn amounts showed no changes (p > .05) in plasma or RBC Zn and Cu concentrations, serum IGF-I, insulin, and glucose when measured at 6, 12, 24, 48, 72, and 96 h after injection. In response to an intradermal injection of phytohemagglutinin on d 30, cell mediated immune (CMI) response was reduced (p < .05) in the - Zn calves. These observations indicate that during a marginal Zn deficiency in calves, there was a decrease in feed efficiency, plasma Zn, serum alkaline phosphatase, and CMI response.