• Title/Summary/Keyword: i.m. injection

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Experimental Investigation on the Enhancement of Gas Hydrate Formation for tile Solid Transportation of Natural Gas (천연가스 고체화 수송을 위한 가스 하이드레이트 생성촉진에 대한 실험적 연구)

  • Kim Nam-Jin
    • New & Renewable Energy
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    • v.2 no.2 s.6
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    • pp.94-101
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    • 2006
  • [ $1m^3$ ] solid hydrate contains up to $200m^3$ of natural gas, depending on pressure and temperature. Such large volume of natural gas hydrate can be utilized to store and transport large quantity of natural gas in a stable condition. So, in the present investigation, experiments carried out for the formation of natural gas hydrate governed by pressure, temperature, and gas compositions, etc.. The results show that the equilibrium pressure of structure II natural gas hydrate) is approximately 65% lower and the solubility is approximately three times higher than structure I methane hydrate). Also, the subcooling conditions of the structure I and II must be above 9K and 11K in order to form hydrate rapidly regardless of gas components, but the pressure increase is more advantageous than the temperature decrease in order to increase the gas consumption. And utilizing nozzles for spraying water in the form of droplets into the natural gas dramatically reduces the hydrate formation time and increases its solubility at the same time.

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Quantitative Analysis of Hyangsayukgunja-Tang Using an Ultra-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry (LC-MS/MS를 이용한 향사육군자탕의 주요성분의 함량분석)

  • Seo, Chang-Seob;Shin, Hyeun-Kyoo
    • Korean Journal of Pharmacognosy
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    • v.46 no.4
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    • pp.352-364
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    • 2015
  • The aim of this study was to quantitatively analyze for quality assessment of eighteen marker compounds, including homogentisic acid, 3,4-dihydroxybenzaldehyde, spinosin, liquiritin, hesperidin, ginsenoside Rg1, liquiritigenin, ginsenoside Rb1, glycyrrhizin, 6-gingerol, atractylenolide III, honokiol, costunolide, dehydrocostuslactone, atractylenolide II, nootkatone, magnolol, and atractylenolide I, in Hyangsayukgunja-tang using an ultra-performance liquid chromatography-electrospray ionization-mass spectrometer. The column for separation of eighteen marker components were used a UPLC BEH $C_{18}$ analytical column ($2.1{\times}100mm$, $1.7{\mu}$) and kept at $45^{\circ}C$ by gradient elution with 0.1% (v/v) formic acid in water and acetonitrile as mobile phase. The flow rate and injection volume were 0.3 mL/min and $2.0{\mu}l$, respectively. The correlation coefficient of all marker compounds was ${\geq}0.9914$, which means good linearity, within the test ranges. The limits of detection and quantification values of the all analytes were in the ranges 0.04-1.11 and 0.13-3.33 ng/mL, respectively. As a result, five compounds, homogentisic acid, 3,4-dihydroxybenzaldehyde, spinosin, liquiritigenin, and atractylenolide I, in this sample were not detected and the amounts of the 13 compounds except for the 5 compounds were $8.10-6736.37{\mu}g/g$ in Hyangsayukgunja-tang extract.

Development of An Onion Peeler (I) - Air Injection Type Peeling Equipment - (양파박피기 개발 (I) - 공기분사식 박피장치 -)

  • 민영봉;김성태;강동현;최선웅;유준현
    • Proceedings of the Korean Society for Agricultural Machinery Conference
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    • 2002.02a
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    • pp.323-328
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    • 2002
  • 양파의 껍질에 칼금을 내고 꼭지와 뿌리를 절단한 후 회전하는 두 개의 롤러 위에 양파를 낙하시켜 구르게 하면서 그 위에 고압공기를 분사시켜 양파의 외각 껍질을 제거하는 공기분사식 박피장치의 최적 작동조건을 구명하기 위하여 수행한 시험결과를 요약하면 다음과 같다. 1, 박피장치에 고압공기를 분사하지 않았을 때, 롤러의 원주속도가 빠를수록, 양파의 무게가 가벼울수록 구름소요시간은 줄어들었고 직경방향 구름율이 가장 높았는데, 직경방향 구름소요시간이 가장 짧게 나타나는 주롤러의 원주속도는 2.4 m/s이었다. 2. 주롤러의 원주속도 2.4 m/s일 때 양파의 무게, 분사공기압 및 칼금수가 증가할수록 박피율은 증가하였으며, 박피율이 가장 높은 조건은 칼금수 4개, 분사공기압 3.5 kg/$cm^2$이상이었다. 3. 박피소요시간은 칼금수가 많을수록, 분사공기압이 높을수록 짧아지는 것으로 나타났고, 칼금수를 4개로 하고 분사공기압을 4.0 kg/$cm^2$이상으로 하면 박피소요시간을 2초 이하로 유지할 수 었다. 4. 양파의 껍질강도는 저장기일과 조건에 따라 다르므로 모든 양파의 박피를 위해서는 분사 공기압을 4.0 kg/$cm^2$이상으로 하고 공기분사시간을 2초에서 5초가지 조절할 수 있는 장치를 부착하는 것이 좋을 것으로 판단된다. 5. 시험에 사용된 양파는 무게는 150~350$\pm$30 g, 직경 60~120 mm의 크기로 우리나라에서 생산되는 양파의 98%에 적용이 가능할 것으로 생각된다.

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Experimental Investigation on the Enhancement of Gas Hydrate Formation for the Solid Transportation of Natural Gas (천연가스 고체화 수송을 위한 가스 하이드레이트 생성촉진에 대한 실험적 연구)

  • Kim, Nam-Jin
    • 한국신재생에너지학회:학술대회논문집
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    • 2006.06a
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    • pp.399-402
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    • 2006
  • [ $1m^3$ ] solid hydrate contains up to $200m^3$ of natural gas, depending on pressure and temperature. Such large volume of natural gas hydrate can be utilized to store and transport large quantity of natural gas in a stable condition. So, in the present investigation, experiments carried out for the formation of natural gas hydrate governed by pressure, temperature, and gas compositions, etc.. The results show that the equilibrium pressure of structure II natural gas hydrate (is approximately 65% lower and the solubility is approximately three times higher than structure I methane hydrate). Also, the subcooling conditions of the structure I and II must be above 9K and 11K in order to form hydrate rapidly regardless of gas components, but the pressure increase is more advantageous than the temperature decrease in order to increase the gas consumption. And utilizing nozzles for spraying water in the form of droplets into the natural gas dramatically reduces the hydrate formation time and increases its solubility at the same time.

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Fabrication of a thermally actuated micro-relay (열구동형 마이크로 릴레이 구조체 제작)

  • Choi, B.Y.;Park, K.H.;Lee, Y.I.;Lee, J.Y.;Lee, J.H.;Yoo, H.J.
    • Proceedings of the KIEE Conference
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    • 1995.11a
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    • pp.606-608
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    • 1995
  • A thermally actuated micro-relay using a mercury-contact has been designed and fabricated. The mercury actuation was achieved by external nitrogen pressure and the mercury-contact was moved by actuation pressure of 110torr in the 100${\mu}m$ wide microchannel. The Injection pressure of mercury was 300torr in the 60${\mu}m$ wide microchannel of the micro relay structure.

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Anti-inflammatory, Analgesic and Antipyretic Activities of Loxoprofen Sodium Given Intramuscularly in Animals

  • Hyun, Jin-Ee;Li, Da-Wei;Lee, Eun-Bang;Jeong, Choon-Sik
    • Archives of Pharmacal Research
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    • v.24 no.6
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    • pp.541-545
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    • 2001
  • The evaluation of the anti-inflammatory analgesic and antipyretic activities of loxoprofen sodium given in intramuscular route was investigated as compared to oral application in rats and mice. The intramuscular $ED_{50}$ values of loxoprofen sodium in carrageenan edema and vascular permeability tests are 1.15 and 7.8 mg/kg, respectively, which represent more potent than in case of oral application. Its therapeutic effects in adjuvant arthritis were shown at 6 mg/kg l.m. and 3mg/kg p.o. Analgesic effect was shown to be more potent as given intramuscularly. Similar potency of antipyretic effects was shown in both administration routes. Considerably weak gastric damages were observed in intramuscular application.

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Serum anti-M$\ddot{u}$llerian hormone is a better predictor of ovarian response than FSH and age in IVF patients with endometriosis

  • Yoo, Ji-Hee;Cha, Sun-Hwa;Park, Chan-Woo;Kim, Jin-Young;Yang, Kwang-Moon;Song, In-Ok;Koong, Mi-Kyoung;Kang, Inn-Soo;Kim, Hye-Ok
    • Clinical and Experimental Reproductive Medicine
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    • v.38 no.4
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    • pp.222-227
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    • 2011
  • Objective: To evaluate the ability of serum anti-M$\ddot{u}$llerian hormone (AMH), FSH, and age to clinically predict ovarian response to controlled ovarian hyperstimulation (COH) in IVF patients with endometriosis. Methods: We evaluated 91 COH cycles, including 43 cycles with endometriosis (group I) and 48 cycles with male factor infertility (group II) from January to December, 2010. Patients were classified into study groups based on their surgical history of endometriosis-group Ia (without surgical history, n=16), group Ib (with a surgical history, n=27). Results: The mean age was not significantly different between group I and group II. However, AMH and FSH were significantly different between group I and group II ($1.9{\pm}1.9$ ng/mL vs. $4.1{\pm}2.9$ ng/mL, $p$ <0.01; $13.1{\pm}7.2$ mIU/mL vs. $8.6{\pm}3.3$ mIU/mL, $p$ <0.01). Furthermore, the number of retrieved oocytes and the number of matured oocytes were significantly lower in group I than in group II. In group II, AMH and FSH as well as age were significant predictors of retrieved oocytes on univariate analysis. Only the serum AMH level was a significant predictor of poor ovarian response in women with endometriosis. Conclusion: Serum AMH may be a better predictor of the ovarian response of COH in patients with endometriosis than basal FSH or age. AMH level can be considered a useful clinical predictor of poor ovarian response in endometriosis patients.

Estimation of Lens Dose of Radioactive Isotopes Using ED3 (ED3를 이용한 방사성동위원소 의약품의 수정체 피폭선량평가)

  • Song, Ha-Jin;Ju, Yong-Jin;Jang, Han;Dong, Kyung-Rae;Kang, Kyeong-Won;Choi, Eun-Jin;Kwak, Jong-Gil;Ryu, Jae-Kwang;Chung, Woon-Kwan
    • Journal of Radiation Industry
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    • v.11 no.1
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    • pp.19-25
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    • 2017
  • It is suggested that the dose limit recommended in the Enforcement Decree of Korea's Nuclear Safety Act should not exceed 150 mSv per year for radiation workers. Recently, however, ICRP 118 report has suggested that the threshold dose of the lens should be reduced to 0.2~0.5 Gy and the mean dose should not exceed 50 mSv per year for an average of 20 mSv over 5 years. Based on these contents, $^{123}I$, $^{99m}Tc$, and $^{18}F-FDG$, which are radioisotope drugs that are used directly by radiation workers in the nuclear medicine department in Korea are expected to receive a large dose of radiation in the lens in distribution and injection jobs to administer them to patients. The ED3 Active Extremity Dosimeter was used to measure the dose of the lens in the nuclear medicine and radiation workers and how much of the dose was received per 1 mCi.

Ictal single-photon emission computed tomography with slow dye injection for determining primary epileptic foci in infantile spasms (영아연축에서 추적자의 느린 점적주사를 이용한 발작기 SPECT)

  • Hur, Yun Jung;Lee, Joon Soo;Kang, Hoon Chul;Park, Hye Jung;Yun, Mi Jin;Kim, Heung Dong
    • Clinical and Experimental Pediatrics
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    • v.52 no.7
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    • pp.804-810
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    • 2009
  • Purpose : We investigated whether ictal single-photon emission computed tomography (SPECT) with prolonged injection of technetium-99m (99mTc) ethyl cysteinate dimer during repeated spasms can localize the epileptogenic foci in children with infantile spasms. Methods : Fourteen children with infantile spasms (11 boys, 3 girls; mean age, $2.2{\pm}1.3$ years) were examined. When a cluster of spasms was detected during video electroencephalography (EEG) monitoring, $^{99m}Tc$ ethyl cysteinate dimer was slowly and continuously injected for 2 minutes to determine the presence of ictal SPECT. For 7 children, the ictal and interictal SPECT images were visually analyzed, while for the remaining 7 children, the SPECT images were analyzed using the subtraction ictal SPECT coregistered to magnetic resonance imaging (MRI) (SISCOM) technique. Subsequently, we analyzed the association between the ictal SPECT findings and those of other diagnostic modalities such as EEG, MRI, and positron emission tomography (PET). Results : Increase in cerebral blood flow on ictal SPECT involved the epileptogenic foci in 10 cases6 cases analyzed by visual assessment and 4 analyzed by the SISCOM technique. The ictal SPECT and video-EEG findings showed moderate agreement (Kappa=0.57; 95% confidence interval, 0.18-0.96). Conclusion : Ictal SPECT with prolonged injection of a tracer could provide supplementary information to localize the epileptogenic foci in infantile spasms.

Ritanserin, a 5HT2/1C Receptor Antagonist, Does Not Block Cocaine-Induced Behavioral Alterations and zif268 mRNA Expression in the Striatum of the Rats

  • Choe, Eun-Sang;Kim, Jong-Yeon
    • The Korean Journal of Physiology and Pharmacology
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    • v.4 no.5
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    • pp.355-359
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    • 2000
  • Cocaine induces immediate early gene expression and behavioral changes by blocking dopamine transporters in the terminals of nigrostriatal neurons in the striatum. The pharmacological role of serotonin 2/1C (5HT2/1C) receptors in cocaine-induced expression of zif268 (NGFI-A, egr1 and Krox-24) mRNA, a member of the zinc finger, was investigated using quantitative in situ hybridization histochemistry in vivo. Behavioral alterations induced by cocaine were also monitored in relation with blockade of the receptors. Systemic injection of ritanserin (1 mg/kg, s.c.), a 5HT2/1C receptor antagonist, did not reverse behavioral alterations and zif268 mRNA gene expression induced by 15 mg/kg cocaine, i.p., in the dorsal and ventral striatum. These data indicate that ritanserin-sensitive 5HT2/1C receptors are not necessary for cocaine-induced behavioral alterations and zif268 mRNA gene expression in the striatum.

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