• YAKHAK HOEJI
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• v.40 no.3
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• pp.251-261
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• 1996

Acanthopanax divaricatus Seem. is a medicinal plant growing widely through out Korea, Japan and China. The plant material of Acanthopanax spp. is used as analgesic , tonic, sedative drug as well as for the treatment of hypertension, rheumatism and diabetes. From the stem barks and root barks of A. divaricatus, diterpenoid compound was isolated and identified as pamaric acid ($C_{20}H_{30}O_2,\;mp\;164^{\circ}C$), lignan compounds were isolated and identified as d-sesamin ($C_{20}H_{18}O_6,\;mp\;123{\sim}124^{\circ}C$), eletheroside E ($C_{34}H_{46}O_{18},\;mp\;257{\sim}259^{\circ}C$), three sterol compounds were identified as ${\beta}$-sitosterol, campesterol, stigmasterol, and six fatty acid compounds were identified as stearic acid, palmitic acid, oleic acid, linolenic acid, arachidonic acid and behenic acid. And also leaves of A. divaricatus, chiisanoside were identified, one of secotriterpenoidal compound(white amorphorous powder crystal, mp $228^{\circ}C$). Anticancer activity and nephrotoxicity were tested by MTT assay. Anticancer effect of chiisanoside was much lower than that of cisplatin.

• Korean Journal of Health Education and Promotion
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• v.26 no.4
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• pp.129-143
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• 2009

Objectives: The purpose of this study is to identify prevalence and related factors of the elderly, who took health examination, with metabolic syndrome. Methods: The health examination and lifestyle survey were performed for 21,512 adults at 60 years of age or older who took health examination in H health promotion center during January-March 2009. Results: The prevalence of metabolic syndrome for the subject was 24.0%. Of the subject with metabolic syndrome, the prevalence of the diseases was obesity 60%, abdominal obesity 78.5%, hypertension 82.6%, dyslipidemia 89.7% and diabetes 51.9%. In comparison of the relationship between metabolic syndrome and other diseases, the male subject with metabolic syndrome were significantly higher in BMI, waist circumference, systolic/diastolic blood pressure, hemoglobin, AST, ALT, $\gamma$-GTP, TG, AC glucose, creatinine than normal male(p<0.001). In comparison of the relationship between metabolic syndrome and lifestyle, more drinking frequency and amount in male and more drinking frequency in female were associated with increased risk of metabolic syndrome(p<0.01). Regardless of exercise intensity, practice of exercise contributed to reduce the risk of metabolic syndrome(p<0.01). Conclusion: In conclusion, TLC program, focused on lifestyle behaviors which is strongly associated with the prevalence of metabolic syndrome, should be developed for the improvement of life quality in the elderly with metabolic syndrome.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.4
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• pp.519-526
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• 2012

Recently, herbal flavonoids have been implicated for anti-cancer therapy. Flavonoids as a commonly known for their anti-oxidant activity, are contained in the herbal medicine as well as root of plants, vegetables, fruits, grains, tea, and wine. Kaempferol, a component of Polygonati rhizoma, a member of the herbal flavonoids, has been studied for anti-hypercholesterol, anti-hypertension and anti-diabetes. It is also known to be effective in anti-cancer therapy for breast, prostate and other type of cancers. However, the anti-cancer therapeutic mechanisms are pooly understood. Here, we investigated the molecular mechanism underlying kaempferol-induced anti-cancer effects using the human liver cancer cell lines, Hep3B, HepG2, and Sk-Hep-1, and human Chang liver cell as a control. As shown by the FACS analysis, measurement of caspase activity, DAPI and trypan blue staining, and DNA fragmentation assay, kaempferol induced apoptosis in the liver cancer cells with the greater potential in Hep3B cells than other liver cancer cells. In addition, we performed microarray analysis to profile the genome-wide mRNA expression regulated by kaempferol. Many of the apoptosis-related genes were significantly induced in kaempferol-treated Hep3B cells, in particular, the genes associated with MAPK cascade. Additionally, kaempferol induced the mRNA expression of genes involved in MKK7-JNK cascade, MKK3-p38 cascade, and caspase signaling pathway, which are all known to trigger apoptosis. Overall, our data suggest that kaempferol has anti-liver cancer effects by inducing apoptosis through the MKK7-JNK cascade, MKK3-p38 cascade, and caspase signaling pathways.

• Journal of radiological science and technology
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• v.26 no.4
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• pp.33-38
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• 2003

The purpose of this study was to examine how lacunar infarction developed and what its characteristics were. As this disease had little noticeable clinical symptoms and is likely to draw less attention than other types of cerebrovascular diseases like panhemispheric infarction, it‘s difficult to make an early diagnosis of it or treat it successfully. The subjects in this study were 196 people who showed no clinical symptoms and took a MRI test. When the MRI test data were analyzed, signal intensity and the part where that disease was detected were primarily taken into account. As a result, it's found that 116 people had no lacunar infarction and 80 people suffered from that disease, including 13 with very mild lacunar infarction, 41 with mild lacunar infarction and 26 with lacunar infarction. However, very mild and mild lacunar infarction could not be viewed as clinically significant cases, and only 26 people, which accounted for 13 percent of the subjects, should be considered to be diagnosed with lacuanr infarction. The most common part where that disease was found was white matter and basal ganglia, regardless of gender. Accordingly, those who are exposed to health hazards such as hypertension or diabetes should take a MRI test to prevent cerebrovascular diseases that might be caused by those illnesses.

• Health Policy and Management
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• v.31 no.3
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• pp.301-311
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• 2021

Background: This study purposed to analyze the relationship between the local extinction index and medical service uses of chronic diseases. The local extinction index is an indicator of the demographic structure and population aging of the region. Methods: The 2014-2018 statistics of National Health Insurance Corporation and Korean Statistical Information Service data were used for the analysis. First, descriptive statistics were used to analyze the general status of research variables. Second, a panel analysis was performed to analyze the relationship between the local extinction index and medical service uses of chronic diseases (hypertension, diabetes mellitus, periodontal disease, arthritis, mental health, epidemic disease, liver disease). Medical service uses were measured by the number of visits/inpatient days and medical charges of seven chronic diseases. Results: Panel analysis results showed that higher local extinction risks (meaning lower local extinction index) had a positive relationship with the number of visits/inpatient days and medical charges of chronic diseases. But the relationships were varied when the seven chronic diseases were analyzed separately. Conclusion: This study showed a significant relationship between the local demographic structure and medical service uses of chronic disease. Analyzing the local demographic structure will be an essential prerequisite step for implementing appropriate regional health care policies.

• Korean Journal of Community Nutrition
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• v.25 no.6
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• pp.512-519
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• 2020

Objectives: A cross-sectional study was conducted to investigate the associations between food groups and hearing loss. Methods: Data of 1,312 individuals were used from the Korea National Health and Nutrition Examination Survey 2013. Hearing loss was determined with a pure tone average (PTA) of greater than 25 dB in either ear. The PTA was measured as the average hearing threshold at speech frequencies of 0.5, 1, 2, and 4 kHz. The dietary intake was examined with a food frequency questionnaire with 112 food items. The food items were classified into 25 food groups. A weighted logistic regression was used to investigate the association. Results: Individuals in the highest tertile of vegetables and nuts food groups were less likely to have hearing loss than those in the lowest tertile [Odds Ratio (OR) = 0.58 (95% Confidence interval (CI) 0.38-0.91), P = 0.019; OR = 0.59 (95% CI 0.39-0.90), P = 0.020, respectively], after adjusting for confounding variables of age, sex, body mass index, drinking, smoking, diabetes, hypertension, and physical activity. Conclusions: In this cross-sectional study, we observed that high intake of vegetables and nuts food groups revealed significant inverse associations with hearing loss, after adjusting for confounding variables among 1,312 participants.

• Korean Journal of Community Nutrition
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• v.28 no.2
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• pp.95-103
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• 2023

Objectives: The budget gap in the health sector of local governments affects the supply of health services, which can cause the health gap. This study classified local governments according to their financial characteristics, such as local financial independence and health budget level. It analyzed the health behaviors and disease prevalence of local residents to examine the effect of local government financial investment on the health of local residents. Methods: To classify types according to the financial characteristics of local governments, financial independence and the health budget data for 17 local governments were collected from the local fiscal yearbook of the Ministry of Public Administration and Security. The prevalence of chronic diseases and healthy behavior was compared using the 16,333 data of adults between the ages of 30 and 65 years among the original data of the National Health and Nutrition Examination Survey (2016-2020). Results: Cluster analysis was used to classify local governments into five clusters according to the health financial capacity type. A comparison of the prevalence of local residents by cluster revealed a similar prevalence of hypertension, diabetes, and hypercholesterolemia. On the other hand, the obesity rate (P < 0.01), high-risk drinking rate (P < 0.01), aerobic physical activity rate (P < 0.001), and healthy eating practice rate (P < 0.001) were significantly different. In addition, an analysis of the odds ratio based on the Seoul area revealed a higher risk of health behavior of non-Seoul residents. Conclusions: It is necessary to review the universal health promotion project budget considering the degree of regional financial vulnerability from the viewpoint of health equity to narrow the health gap among regions.

• Journal of Korean Public Health Nursing
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• v.23 no.2
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• pp.273-284
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• 2009

Purpose: The study examined obesity conditions and related factors in middle aged Korean women who had been diagnosed as obese based body mass index (BMI) or waist circumference (WC) measurement. Presently, BMI alone, WC alone, or BMI + WC were used as obesity measures. Methods: Subjects were 488 women 40~64 years of age living in one city, Korea. Structured questionnaires concerning general characteristics, health behavior practices, and chronic disease history were completed by each subject. Results: The proportions of obesity were 42.4% by BMI, 39.3% by WC, and 51.3% by the combination of both measurements. Chi-square test revealed significant associations of obesity with age, education level, menopausal status, frequency of excessive eating, and history of diabetes mellitus or hypertension. These associations were similar for the three measurement schemes. There was significant positive relationship between BMI and WC, whereas the relationship between BMI and WHR (waist-hip ratio) was not significant. Conclusions: The combination of BMI and WC measurement may be a valid way to evaluate the obesity status in middle-aged women. Developing an obesity management program that includes control of excessive eating, and consideration of menopausal status and history of chronic diseases would be prudent.

• Journal of Korean Academy of Nursing Administration
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• v.12 no.1
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• pp.94-103
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• 2006

Purpose: This study was conducted to evaluate customer satisfaction of general health examination service and to determine how the customer satisfaction affected to revisiting intention, their change of health belief, self-efficacy, and health promoting behavior. Method: Data were collected with questionnaires from 92 customers, who took general health examination at G University Medical Hospital having symptoms of hypertension, diabetes, high blood cholesterol, and obesity. Data were analyzed by the SPSS for windows 10.0 program. Result: Level of customer satisfaction were closely related to one of revisiting intention (r=.791, p=.000). 2) Through multiple regression analysis, factors that affect the customer' revisiting intention were found to be satisfaction in consultation of results (F=126.166, p=.000), examination environment (F=77.490, p=.001), and examination process (F=55.932, p=.024). It could explain 64.4% of customers' revisiting intention. Group displaying higher level of satisfaction showed highly increase in health belief following the examination, and the difference was statistically significant (t=-2.035, p=.045). They also showed a more improved health promoting behavior following the examination, and the difference was statistically significant (t=-2.316, p=.023). Conclusion: Health belief and health promoting behavior was improved following the general health examination. In addition, these changes were more significant in customers who displayed in a higher level of customer satisfaction.

• The Korean Journal of Community Living Science
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• v.25 no.2
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• pp.163-173
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• 2014

This study investigates the dietary risk factors in elderly individuals in rural Korea by focusing on the development of service programs that can improve their health. The sample included 1,000 free-living elderly individuals aged 65 and over in rural Korea. A three-stage stratified random sampling method based on 2010 Korean census data was employed. Data on the dietary status and the need for assistance in meal management were collected through face-to-face interviews. The dietary status was evaluated based on the Nutrition Screening Initiative (NSI) checklist, and the outcomes for three groups classified base on their family type were examined. According to NSI scores, more than 70% of the subjects faced some nutritional risk. The activities most requiring assistance in meal management included preparing meals (18.3%) and purchasing food items (11.7%). More than half of the subjects reported that having meals at community senior centers at least once a week. The results indicate that those subjects from single-individual households were most likely to face some nutritional risk and require, assistance in purchasing food items and preparing meals. In addition, these subjects were least likely to be satisfied with their health and dietary management. To improve the dietary status of elderly individuals in rural Korea, any service programs should facilitate their daily activities by focusing on improving their diet, particularly that of those from low-income, single-individual households.