• The Korea Journal of Herbology
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• v.27 no.3
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• pp.107-112
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• 2012

Objectives : This study was designed to investigate the effects of Tong Xin Lou (TXL) on lipid accumulation in liver tissue in Hypercholesterolemic mice. TXL is new drug, which is one of Cardiotonic Pills. TXL is used for activating the blood flow in the restoration stage of cerebral infarction, and for alleviation of angina pectoris including the symptoms as chest oppressed and stabbing pain. Methods : Hyperlipidemia was induced by providing high fat diet for 6 weeks. Normal group was provided with normal rodent diet. TXL was administered orally in the concentration of 10 mg/day for 2 weeks (TXL group). D/W was administered orally in CTL group for 2 weeks. We observed histopathological changes in liver and heart tissues, and also investigated the effect on body weights, and levels of total cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride in serum. Results : In this study, TXL did not affects weight gain in hypercholesterolemic mice. TXL group showed downward tendency of lipid accumulation compared with CTL group. In addition, oral administration of TXL lowered levels of total cholesterol (P < 0.05) and triglyceride (P < 0.05), which were elevated by induction of hypercholesterolemia. Conclusion : These results suggest that TXL can prevent lipid accumulation in liver tissue through regulation of dyslipidemia.

• The Journal of Korean Medicine
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• v.20 no.4
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• pp.69-81
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• 2000

Etiology and pathogenesis of hyperlipidemia are considered as 'difficiency in origin' of liver, spleen and kidney combined with 'excess in superficiality' of phlegm stagnancy and blood stasis. The prescription of Semyung-Gangji-tang, designed for the treatment of hyperlipidemia and atherosclerosis, consists of herbs effective at treating blood stasis and phlegm stagnancy. It invigorates the liver, kidney and spleen. Its medical nature is not too cold or too hot and it increases human vital energy. The purpose of this study is to examine the currative effects of Semyung-Gangji-tang on hyperlipidemia in rabbits. Twenty-four male NZW rabbits, around 2kg of B.W., were divided into 3 groups. Group I was served as the normal group. Group II was served as the hyperlipidemic control group fed with 1 % cholesterol diet for 8weeks and with normal diet for the next 4weeks. Group III was served as the treatment group, treated the same as the control group and medicated with Semyung-Gangji-tang for the last 4weeks. Blood samples were collected from each of the animals at a, 3, 6, 8, 10, 12 weeks and used for the blood chemical analysis. Animals were sacrificed at 8 and 12weeks and chemical analyses were performed on the collected liver samples. The serum total cholesterol value of treatment group ($938.60{\pm}95.07{\;}mg/dl$) at l2weeks was significantly decreased (P<0.00l) compared with the value of control group ($1375{\pm}37.82{\;}mg/dl$) at 12weeks. The serum LDL-cholesterol value of the treatment group ($838.00{\pm}89.52 mg/dl$) at l2weeks was significantly decreased(p<0.00l) compared with the value of the control group ($1249.60{\pm}37.63{\;}mg/dl$) at l2weeks. These results indicate that Semyung-Gangji-tang has the effects of lowering serum lipid in experimentally induced hyperlipidemic rabbits.