• 대한후두음성언어의학회지
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• 제25권1호
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• pp.20-23
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• 2014

Age-related changes in larynx can have a direct impact on voice quality and general comfort level. Observations of vocal aging have spanned perceptual, acoustic, aerodynamic, physical, electromyographic (EMG) and histological levels. Evidence of differential vocal aging in relation to gender and physical condition has been reported. Perceptual, acoustic, aerodynamic, kinematic, EMG and histological data document age-related changes in laryngeal structure and function with advancing age. These changes contribute to a functional age-related impact of vocal hypofunction or compensatory hyperfunction. This review will focus on the current understanding of the clinical and cellular changes in the larynx that lead to presbyphonia.

• 대한수학회보
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• 제33권4호
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• pp.545-551
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• 1996

It is well known in the theory of distributions and proved in [GS, S] that $$ (i) (Bochner-Schwartz) Every positive definite (tempered) distribution is the Fourier transform of a positive tempered measure \mu. $$ $$ (ii) (Schwartz kernel theorem) Let B(\varphi, \psi) be a bilinear distribution. Then for some u \in D'(R^n \times R^n) B(\varphi, \psi) = u(\varphi(x)\bar{\psi}(y)) for every \varphi, \psi \in C_c^\infty. $$ $$ (iii) A translation invariant positive definite bilinear distribution B(\varphi, \psi) is of the form B(\varphi, \psi) = \smallint \varphi(x)\psi(x) d\mu(x) for every \varphi, \psi \in C_c^\infty (R^n), where \mu is a positive tempered measure.

• The Journal of Korean Physical Therapy
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• 제12권3호
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• pp.361-368
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• 2000

MET is one of the few physical therapy having its own criteria. Mr. Holten approached the Norwegian Health Authority in 1967 to get his MET System recognized as a treatment method of its own. He was granted his approval for his exercise system's specivic criteria connecteed with the treatment method. In MET, the patient exercises himself without manual participation by physiotherapists, however, under continuous supervision.. The apparatus should be designed that functional quality (arthrogenous, circulatory, respiratory, neuromuscular) in question is optimally influenced when the patient carries out exercise in a certain range against a graded resistance. The therapy reassesses the scheme of treatment at least every fifth session and the maximum number of patients being 5 person per hour. The important principles in medical exercise Therapy are stabilization of hyperfunction through the system of autostabilization and mobilization of hypofunction through automobilization. In MET excrcises are adjusted to the patient's reactions. MET equipment is therefore made to meet requirements for treating patients with painful pathological dysfunction in the musculo-skeletal system.

• 대한후두음성언어의학회지
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• 제26권1호
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• pp.21-24
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• 2015

Voice therapy after post-thyroidectomy dysphonia is designed to improve glottal closure without supraglottic hyperfunction by development of abdominal support for breathing and intrinsic muscle strengthening exercises. Regarding voice therapy of unilateral vocal fold paresis/paralysis, several techniques such as head positioning, digital manipulation, pushing and pulling method are used for trial or temporary therapy. And the holistic voice therapy such as LSVT, Accent method, VFE are useful for hypofunctional voice disorders. These may be effective interventions as a temporary improvement until normal voice recovers or may provide the essentials for long-term rehabilitation.

• 대한수학회논문집
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• 제19권4호
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• pp.661-681
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• 2004

We research properties of the space of measurable functions square integrable with weight exp$2\nu $\mid$x$\mid$$, and those of the space of Fourier hyperfunctions. Also we show that the several embedding theorems hold true, and that the Fourier-Lapace operator is an isomorphism of the space of strongly decreasing Fourier hyperfunctions onto the space of analytic functions extended to any strip in $C^n$ which are estimated with the aid of a special exponential function exp($\mu$｜x｜).

• Journal of Korean Neurosurgical Society
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• 제56권3호
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• pp.281-283
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• 2014

McCune-Albright syndrome (MAS) is characterized by a triad of poly/monostotic fibrous dysplasia, caf$\acute{e}$-au-lait macules and hyperfunctioning endocrinopathies including human growth hormone excess. Acromegaly as a manifestation of endocrine hyperfunction with MAS is uncommon. Surgical excision may be challenging due to the associated severe fibrous dysplasia of the skull base. Through the endoscopic procedures, we treated a case of MAS presenting with compressive optic neuropathy due to fibrous dysplasia and acromegaly caused by growth hormone secreting pituitary adenoma. We reviewed the literature on GH excess in MAS to highlight its surgical and medical challenges.

• 생물정신의학
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• 제4권2호
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• pp.246-250
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• 1997

백서모델에 있어서 지연성 운동장애의 예방과 치료에 대한 MK-801의 효과를 알아보기 위해 HD를 장기간 투여받는 백서에 MK-801을 동시투여하여 VCM의 발생빈도를 비교하였고 VCM (+) II군에 MK-801을 투여한후 VCM에 대해 치료효과를 관찰하여 다음과 같은 결과를 얻었다. 1) I군(HD+MK-801)이 II군(HD+PBS)에 비해 11, 12회 측정시 VCM이 유의하게 감소하였다. 2) VCM(+) II군에 MK-801을 0.1mg/kg와 0.3mg/kg로 투여했을 때, 그리고 마지막 용량 투여 14일후의 VCM이 유의하게 감소하였다. 이상의 실험결과는 VCM의 발생기전과 glutamatergic pathway 사이에 관련성이 있다는 것을 제시해주고 아울러 이러한 동물모델의 결과는 인간에게 있어서 지연성 운동장애의 예방 및 그 치료에 있어서 NMDA 수용체 길항제 사용의 유용성을 암시할 수 있다.

• 동의생리병리학회지
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• 제16권5호
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• pp.960-966
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• 2002

Ramulus et Uncus Uncariae (JGD) has sweet in flavour and slightly cold in property, acting on the liver and pericardium channels. This drug was described in a medical classic as having the ability to remove 'heat', check hyperfunction of the liver and relieve dizziness, tremors, and convulsions, and subdue 'endogenous wind'. So this study was estimated to check the anti-neuropathological effect of JGD on the Alzheimer in βAPP overexpression in neuroblastoma cell line and JGD extract was showed significantly anti-alzheimer effects (50 and 100 μg/㎖ of JGD extracts) compared with control group. Ramulus et Uncus Uncariae has anti-alzheimer effects on the βAPP overexpression in neuroblastoma cell line. So we expect that Ramulus et Uncus Uncariae may be used as a drug for neurodegenerative disease, such as stroke, Alzheimer's disease (AD). These results indicate that Ramulus et Uncus Uncariae possess strong inhibitory effect in the nervous system of apoptosis and repair effect against the degeneration of Neuroblastoma cells by βAPP expression.

• 대한후두음성언어의학회지
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• 제30권2호
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• pp.77-81
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• 2019

Dysphagia may result from dysfunction of any of the components involved in the complex neuromuscular interaction of swallowing. Hyperfunction of any of the muscles involved in swallowing is a frequent cause of dysphagia. The cricopharyngeus muscle (CPM) is a key component of the upper esophageal sphincter. Cricopharyngeus muscle dysfunction (CPD) refers to the muscle's failure to appropriately and completely relax or expand during deglutition. A variety of disease processes may cause CPD and accurate diagnosis is paramount for appropriate treatment. In appropriately selected patients, intervention at the CPM may yield significant improvement in dysphagia. Interventions include nonsurgical, pharyngoesophageal segment dilatation, botulinum toxin (BoNT) injection, and criccopharyngeal myotomy. Injections of BoNT in patients with CPD have been reported to result in marked relief of dysphagia. Different techniques for instilling BoNT into the CPM have been described. Awake, in-office CPM BoNT injection with electromyography and/or fluoroscopic or ultrasound guidance is performed transcervically or via flexible endoscopy. Operative CPM BoNT injection involves rigid laryngoscopy and esophagoscopy with direct visualization of the CPM. BoNT should be prepared in low-volume, high-concentration dilutions to minimize the potential for undesired diffusion of the toxin. The effects of BoNT occur within weeks of injection and typically last up to 5 or 6 months.

• 대한후두음성언어의학회지
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• 제10권1호
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• pp.17-23
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• 1999

Vocal hyperfunction is considered to be the most significant characteristic in larynx disorders which is found among many patients presenting hoarseness Primarily as chief complaint. In Pusan National University Hospital, we executed the voice therapy to 28 patients being 17 female and 11 male patients who visited the Voice ＆ Speech Therapy Clinic, due to the voice disorder, and then compared and analysed the voice before and after its therapy using acoustic and aerodynamic test. The obtained results were as follows. In the analysis by the local findings, it was improved to 88% in the patients of vocal nodule, 75% in mutational falsetto, 75% in the functional dysphonia, 75% in the vocal cord palsy, 50% in the vocal polyp and 50% in dysphonia plica ventricularis. For the acoustic analysis, Fo, litter, Shimmer and NHR were measured. In the patients of mutational falsetto, Fo, Jitter and NHR were shown to be improved significantly and in the patients of vocal nodule, Shimmer was shown to be improved significantly. In the patients of vocal polyp, Fo was significantly improved. In the patients of vocal cord palsy in litter and NHH were significantly improved. In the patients of dysphonia plica ventricularis, Shimmer and NHR were significantly improved and the patients of functional dysphonia were more improved in Fo, litter and Shimmer. For the aerodynamic analysis, MPT was measured. In particular, it was shown to be improved significantly in the patients of vocal nodule, improved in the vocal polyp, vocal cord palsy, functional dysphonia patients.