• The Korean Journal of Physiology
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• 제23권2호
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• pp.291-299
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• 1989

Na and Ca effects on contracture were studied in order to estimate Na/Ca exchange ratio in the isolated atrial muscle of the rabbit. All experiments were performed in tris-buffered Tyrode solution which was being aerated with 100% $O_2\;and\;kept\;at\;37^{circ}C$. To load intracellular $Na^+,\;10{-6}M$ ouabain or K-free solution were used. Contractures were induced by brier exposure of atrial muscle to Tyrode solution containing various concentrations of Ca or of Na. The results obtained were as follows: 1 ) Increasing the extracellular Ca concentration, the amplitude of contracture also increased and was maximum at 8 mM Ca-Tyrode solution. 2) The relationship between extracellular Ca concentrations and relative amplitude of the contractures showed hyperbolic pattern. By using Hill plot, the line has the slope of 1 12 which means the number of Ca binding sites of the carrier in the cell membrane. 3) The amplitude of the contracture was maximum in 0 mM Na-Tyrode solution and decreased in dose dependent manner when the Na concentration increased. 4) When the relationship between extracellular Na concentrations and the amplitude of contractures was expressed as dose-response curve, the curve showed sigmoid pattern. The line with the slope of 2.82 was obtained by using Hill plot. 5) From above all the results, it is suggested that exchange ratio of Na and Ca via Na/ca exchange system in the atrial muscle of rabbit could be 3:1 approximately.

• Smart Structures and Systems
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• 제19권2호
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• pp.115-126
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• 2017

In this paper, size dependent bending and free flexural vibration behaviors of functionally graded (FG) nanobeams are investigated using a nonlocal quasi-3D theory in which both shear deformation and thickness stretching effects are introduced. The nonlocal elastic behavior is described by the differential constitutive model of Eringen, which enables the present model to become effective in the analysis and design of nanostructures. The present theory incorporates the length scale parameter (nonlocal parameter) which can capture the small scale effect, and furthermore accounts for both shear deformation and thickness stretching effects by virtue of a hyperbolic variation of all displacements through the thickness without using shear correction factor. The material properties of FG nanobeams are assumed to vary through the thickness according to a power law. The neutral surface position for such FG nanobeams is determined and the present theory based on exact neutral surface position is employed here. The governing equations are derived using the principal of minimum total potential energy. The effects of nonlocal parameter, aspect ratio and various material compositions on the static and dynamic responses of the FG nanobeam are discussed in detail. A detailed numerical study is carried out to examine the effect of material gradient index, the nonlocal parameter, the beam aspect ratio on the global response of the FG nanobeam. These findings are important in mechanical design considerations of devices that use carbon nanotubes.

• 한국지반신소재학회논문집
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• 제14권4호
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• pp.129-137
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• 2015

최근 해상풍력발전 단지 조성은 많은 양의 에너지를 창출할 수 있어 그 기대는 점차적으로 증가하고 있다. 특히 제주도는 풍황이 우수하여 해상풍력발전 시스템 운영을 위한 최적의 대상지이기는 하나, 화산활동에 의해 형성된 지형으로 육지부와 달리 현무암층 사이에 연약층인 화산쇄설물 및 공동이 불규칙하게 발달된 층상구조로 이루어져 있다. 이에 본 연구에서는 프레셔미터 시험으로부터 제주 현무암에 근입된 수평재하말뚝의 p-y 곡선을 유도하기 위하여 프랑스석유협회(IFP, 1983)과 Briaud et al.(1983)의 방법을 이용하였다. 이들의 방법을 이용하여 유도된 p-y 곡선을 LPILE 프로그램에 입력하여 말뚝두부에서 하중-변위 관계를 분석한 후 재하시험으로 측정된 하중-변위 곡선과 비교하였다. 결과, pressuremeter test로부터 제주 현무암에 근입된 수평재하말뚝의 p-y 곡선을 유도할 때 IFP 방법은 매우 합리적인 결과를 도출할 수 있을 것으로 판단된다.

• Geomechanics and Engineering
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• 제4권3호
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• pp.173-190
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• 2012

With recent growing interests in the Performance-Based Seismic Design and Assessment Methodology, more realistic modeling of a structural system is deemed essential in analyzing, designing, and evaluating both newly constructed and existing buildings under seismic events. Consequently, a shallow foundation element becomes an essential constituent in the implementation of this seismic design and assessment methodology. In this paper, a contact interface fiber section element is presented for use in modeling soil-shallow foundation systems. The assumption of a rigid footing on a Winkler-based soil rests simply on the Euler-Bernoulli's hypothesis on sectional kinematics. Fiber section discretization is employed to represent the contact interface sectional response. The hyperbolic function provides an adequate means of representing the stress-deformation behavior of each soil fiber. The element is simple but efficient in representing salient features of the soil-shallow foundation system (sliding, settling, and rocking). Two experimental results from centrifuge-scale and full-scale cyclic loading tests on shallow foundations are used to illustrate the model characteristics and verify the accuracy of the model. Based on this comprehensive model validation, it is observed that the model performs quite satisfactorily. It resembles reasonably well the experimental results in terms of moment, shear, settlement, and rotation demands. The hysteretic behavior of moment-rotation responses and the rotation-settlement feature are also captured well by the model.

• Earthquakes and Structures
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• 제11권6호
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• pp.943-966
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• 2016

Recently, magnetorheological elastomer (MRE) material and its devices have been developed and attracted a good deal of attention for their potentials in vibration control. Among them, a highly adaptive base isolator based on MRE was designed, fabricated and tested for real-time adaptive control of base isolated structures against a suite of earthquakes. To perfectly take advantage of this new device, an accurate and robust model should be built to characterize its nonlinearity and hysteresis for its application in structural control. This paper first proposes a novel hysteresis model, in which a nonlinear hyperbolic sine function spring is used to portray the strain stiffening phenomenon and a Voigt component is incorporated in parallel to describe the solid-material behaviours. Then the fruit fly optimization algorithm (FFOA) is employed for model parameter identification using testing data of shear force, displacement and velocity obtained from different loading conditions. The relationships between model parameters and applied current are also explored to obtain a current-dependent generalized model for the control application. Based on the proposed model of MRE base isolator, a second-order sliding mode controller is designed and applied to the device to provide a real-time feedback control of smart structures. The performance of the proposed technique is evaluated in simulation through utilizing a three-storey benchmark building model under four benchmark earthquake excitations. The results verify the effectiveness of the proposed current-dependent model and corresponding controller for semi-active control of MRE base isolator incorporated smart structures.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2008년도 추계 학술발표회
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• pp.1404-1414
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• 2008

In the mechanistic-empirical trackbed design of railways, the resilient modulus is the key input parameter. This study focused on the resilient modulus prediction model, which is the functions of mean effective principal stress and axial strain, for three types of railroad trackbed materials such as crushed stone, weathered soil, and crushed-rock soil mixture. The model is composed with the maximum Young's modulus and nonlinear values for higher strain in parallel with dynamic shear modulus. The maximum values is modeled by model parameters, $A_E$ and the power of mean effective principal stress, $n_E$. The nonlinear portion is represented by modified hyperbolic model, with the model parameters of reference strain, ${\varepsilon}_r$ and curvature coefficient, a. To assess the performance of the prediction models proposed herein, the elastic response of a test trackbed near PyeongTaek, Korea was evaluated using a 3-D nonlinear elastic computer program (GEOTRACK) and compared with measured elastic vertical displacement during the passages of freight and passenger trains. The material types of sub-ballasts are crushed stone and weathered granite soil, respectively. The calculated vertical displacements within the sub-ballasts are within the order of 0.6mm, and agree well with measured values with the reasonable margin. The prediction models are thus concluded to work properly in the preliminary investigation.

• Structural Engineering and Mechanics
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• 제90권1호
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• pp.83-96
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• 2024

This paper suggests an analytical approach to investigate the free vibration and stability of functionally graded (FG) beams with both perfect and imperfect characteristics using a quasi-3D higher-order shear deformation theory (HSDT) with stretching effect. The study specifically focuses on FG beams resting on variable elastic foundations. In contrast to other shear deformation theories, this particular theory employs only four unknown functions instead of five. Moreover, this theory satisfies the boundary conditions of zero tension on the beam surfaces and facilitates hyperbolic distributions of transverse shear stresses without the necessity of shear correction factors. The elastic medium in consideration assumes the presence of two parameters, specifically Winkler-Pasternak foundations. The Winkler parameter exhibits variable variations in the longitudinal direction, including linear, parabolic, sinusoidal, cosine, exponential, and uniform, while the Pasternak parameter remains constant. The effective material characteristics of the functionally graded (FG) beam are assumed to follow a straightforward power-law distribution along the thickness direction. Additionally, the investigation of porosity includes the consideration of four different types of porosity distribution patterns, allowing for a comprehensive examination of its influence on the behavior of the beam. Using the virtual work principle, equations of motion are derived and solved analytically using Navier's method for simply supported FG beams. The accuracy is verified through comparisons with literature results. Parametric studies explore the impact of different parameters on free vibration and buckling behavior, demonstrating the theory's correctness and simplicity.

• Structural Engineering and Mechanics
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• 제91권1호
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• pp.1-23
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• 2024

This paper formulates a new integral shear deformation shell theory to investigate the free vibration response of carbon nanotube (CNT) reinforced structures with only four independent variables, unlike existing shell theories, which invariably and implicitly induce a host of unknowns. This approach guarantees traction-free boundary conditions without shear correction factors, using a non-polynomial hyperbolic warping function for transverse shear deformation and stress. By introducing undetermined integral terms, it will be possible to derive the motion equations with a low order of differentiation, which can facilitate a closed-form solution in conjunction with Navier's procedure. The mechanical properties of the CNT reinforcements are modeled to vary smoothly and gradually through the thickness coordinate, exhibiting different distribution patterns. A comparison study is performed to prove the efficacy of the formulated shell theory via obtained results from existing literature. Further numerical investigations are current and comprehensive in detailing the effects of CNT distribution patterns, volume fractions, and geometrical configurations on the fundamental frequencies of CNT-reinforced nanocomposite shells present here. The current shell theory is assumed to serve as a potent conceptual framework for designing reinforced structures and assessing their mechanical behavior.

• 대한약리학회지
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• 제31권2호
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• pp.251-259
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• 1995

Pharmacokinetics and pharmacodynamics of metoprolol, a selective beta-l blocker, were examined for 360 minutes after intravenous bolus administration of metoprolol to 6 dogs. Plasma concentration and excreted amount in the urine metoprolol were measured by liquid chromatography with fluorescence detection. PR interval and heart rate were measured by ECG monitoring. Blood pressure was monitored through intraarterial catheter in femoral artery and cardiac output by thermodilution method using Swan-Ganz catheter. To analyze the effect site concentration-response relationship, plasma concentration and pharmacological effects were simultaneously fitted to a two pharmacokinetic compartment linked to pharmacodynamic model with NONLIN program. Results are as follows. 1) The plasma concentration of metoprolol after intrvenous injection decreased biexponentially. The terminal half-life estimated was $1.33{\pm}0.40$ hours and the volume of distribution at steady state (Vdss) and the total body clearance were $1.04{\pm}0.4\;L/kg,\;6.55{\pm}2.21\;L/hr$, respectively. The central compartment volume of distribution and peripheral compartment volume of distribution were $0.35{\pm}0.14L/kg\;and\;0.69{\pm}0.34L/kg$. The renal clearance and intercompartment clearance were $0.53{\pm}0.25\;L/min\;and\;0.35{\pm}0.19\;L/min$. 2) Simulated biophase concentration-response curve shows hyperbolic relationship and the estimated concentration-effect relationship was best explained by Emax model when the prolongation of PR interval and the reduction of the heart rate were used as pharmacodynamic parameters. Emax and EC50 were estimated to be $26.3{\pm}4.7\;msec\;and\;88.8{\pm}82.3\;g/ml$ for PR interval, and $48.7{\pm}18.8\;beats/min\;and\;113.5{\pm}78.7\;ng/ml$ for heart rate, respectively. 3) The changes of cardiac output-effect site concentration relationship was best fitted by a linear model and the slope of the relationship was $0.005{\pm}0.003$. Diastolic blood pressure-effect site concentration relationship was also explained by the linear model and the slope of the relationship was $0.038{\pm}0.034$.

• 한국재난정보학회 논문집
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• 제19권3호
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• pp.572-581
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• 2023

연구목적:이력형 댐퍼에 하중이 작용할 때 편심에 의해서 부재가 면외 방향으로 거동하는 것을 방지하여 응력-변형율 곡선의 불규칙성을 개선하고 감쇠효과의 계산 시 정확성을 기하고자 하는 것이 본 연구의 목적이다. 연구방법:본 연구에서 사용하는 강재 스트립의 제원은 동일하게 하되 각각의 댐퍼를 구성할 스트립의 곡률은 다르게 한다. 곡률이 다른 각각의 강재 스트립을 댐퍼 1개당 3개씩 정삼각형으로 배치하여 곡률이 다른 5개의 댐퍼를 제작한 후 반복하중 실험을 수행하고, 에너지 소산량을 계산하여 댐퍼의 감쇠성능을 측정하였다. 연구결과: 시험 결과, 댐퍼 중에서 초기곡률이 조금이라도 있는 경우는 없는 경우보다 에너지 소산량은 상당히 감소하지만, 곡률의 크기에 따른 에너지 소산량의 변화는 크지 않으며, 곡률의 유무가 중요한 변수로 사료된다. 결론:댐퍼를 적용한 해석적 검토에서 주기는 T=0.3sec에서 T=0.536sec로 약 78.7% 정도 장주기화 되었고, 응답 스펙트럼 가속도는 Sa=0.54g에서 Sa =0.229g로 줄었으므로 댐퍼의 감쇠효과는 충분히 존재한다.