• Parasites, Hosts and Diseases
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• 제57권2호
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• pp.197-200
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• 2019

Cryptosporidium is a common intestinal protozoan that can lead to diarrhea in humans and dogs. The predominant species of infection are C. hominis and C. parvum in humans, and C. canis in dogs. However, C. canis can infect immunocompromised humans. Considering the close contact with humans, dogs have the potential to be reservoirs for human cryptosporidiosis. Breeding kennels are the major supply source of puppies for pet shops. The present study is to determine the molecular prevalence and characteristics of Cryptosporidium spp. found in breeding kennel dogs. A total of 314 fecal samples were collected from young and adult dogs kept in 5 breeding kennels. A polymerase chain reaction targeting the small subunit rRNA gene was employed for the detection of Cryptosporidium spp. To determine the species, the DNA sequences were compared to GenBank data. Overall, 21.0% of the fecal samples were positive for Cryptosporidium spp. infection. Cryptosporidium spp. was detected in all 5 facilities. A sequencing analysis demonstrated that all isolates shared 99-100% similarity with C. canis. The results suggest that Cryptosporidium spp. infection is present at a high-level in breeding kennel dogs. However, because dominant species in this survey was C. canis, the importance of breeding kennel dogs as reservoirs for Cryptosporidium spp. transmission to humans is likely to be low in Japan.

• 한국콘텐츠학회논문지
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• 제20권12호
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• pp.230-240
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• 2020

가상세계 기반 몰입형 가정교사 시스템을 개발하기 위해 상황의 다양성과 사실성을 최대화하기 위한 공간적 측면에서의 시뮬레이션을 개발하고자 한다. 이를 위해서는 가상공간의 모델링과 함께 가상인간들의 지식 및 지능적 사유기능이 필요하다. 먼저 공간의 계층적이고 다면적인 구성과 그에 상응하는 가상인간들의 지식을 모사하기 위한 정보구조가 필요하다. 구체적으로 2.5차원 공간분포표현, 복잡한 공간관계표현, 객체표현, 사건들의 시공간적 표현을 위한 네 개의 구조를 각각 개발한다. 그리고 이와 같이 표현된 지식을 사용하여 공간적인 이동을 하는데 필요한 가상인간의 공간적 사유 기능을 개발한다. 일반적으로 사건은 힘을 매개로 인접하거나 연결된 다른 객체들에게도 연쇄적으로 영향을 미쳐서 다양한 상황들이 펼쳐지며 관련된 가상인간들이 다음 행동을 계획하는 데에 반영된다. 이를 위해 시공간 표현구조 상에 역사적 흐름에 따라 사건들의 전개를 기록한다. 전형적 사건을 구현하여 가상인간의 복잡한 공간속에서의 자주적 행동의 실현가능성을 보여준다.

• 대중서사연구
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• 제25권2호
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• pp.9-32
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• 2019

이 논문은 '감정 기계' 모티프를 설정함으로써, 우리 시대의 포스트 휴먼 현상이 매우 오래된 이야기 속 피조물들과 긴밀하게 연결되어 있으며, 인문학과 기술 문명, 동양과 서양의 문화적 역사적 경계를 넘어서 공유되는 인류의 보편적이면서도 지적인 상상력에 기반하고 있음에 주목했다. 신화 속 이야기에 등장하는 인간을 닮은 피조물들, 기술 문명 시대의 정교한 기계 장치를 통해 공포와 두려움을 불러일으켰던 기계 인간들, 디지털 기술 혁명 속에서 초월적인 형상과 능력을 갖게 된 포스트 휴먼들을 살펴봄으로써, 각각의 시대에 감정기계에 느꼈던 감수성과 인간다움의 조건을 밝히고자 했다. 그 과정에서 인간과 자연, 기계의 경계가 모호함을 이해하고, 인간중심적 인문학의 한계를 넘어, 21세기 포스트휴먼 시대 인간과 자연, 기계의 공존에 대해 음미해 보았다.

• Parasites, Hosts and Diseases
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• 제44권4호
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• pp.271-283
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• 2006

The third-stage larvae (L3) of the parasitic nematode, Anisakis simplex, have been implicated in the induction of hyperimmune allergic reactions in orally infected humans. In this work, we have conducted a review of an investigation into immune reactions occurring in animals experimentally infected with A. simplex L3. The patterns of serum antibody productions if the experimental animals against excretory-secretory products (ESP) of A. simplex L3 contributed to our current knowledge regarding specific humoral immune reactions in humans. In our review, we were able to determine that L3 infection of experimental animals may constitute a good model system for further exploration of immune mechanisms and allergy in anisakiasis of humans.

• Journal of Microbiology and Biotechnology
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• 제19권12호
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• pp.1617-1619
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• 2009

Lactobacillus rhamnosus PL60 was tested for whether it can produce c9,t11- and t10,c12-conjugated linoleic acids (CLAs) in human. After consumption of L. rhamnosus PL60, L. rhamnosus was detected in feces 1 week after the start of intake. Analysis by gas chromatography showed that concentrations of c9,t11- and t10,c12-CLAs in serum had increased and concentrations of serum leptin had significantly decreased. Results showed that L. rhamnosus PL60 can survive in human intestines and produce CLAs in humans. This is the first report that bacteria can produce CLAs in humans.

• Journal of Yeungnam Medical Science
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• 제34권1호
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• pp.1-10
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• 2017

The life history of man is summarized as a birth-aging-disease-death. Man eventually ages and dies. How long can humans live? What is aging? Why do we age? Is aging inevitable? Can we rejuvenate? Recent researches on biological aging suggest that humans might overcome aging and rejuvenate. In this paper, we review the biologic characteristics of aging and the latest results of biological aging research, implicating that aging can be controlled, further treated, and that humans can ultimately be rejuvenated.

• 제어로봇시스템학회논문지
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• 제20권11호
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• pp.1112-1117
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• 2014

Unmanned aerial vehicles (UAVs) are a popular research topic because of a great ripple effect in the future. However, current UAV technologies cannot be applied to manual aerial vehicles without any modification. As an alternative to current UAV technology, humanoid robots are adopted as pilots. If a humanoid robot controls an aerial vehicle autonomously, not only could manual aerial vehicles be utilized as UAVs, but the humanoid robot would also be put into an environment created for humans and conduct some missions suitable for humans. Humanoid robots are also able to handle tools and equipment designed for humans. In order to prove that a humanoid robot can pilot an airplane, an experiment is performed and the results of this experiment are shown in this paper.

• 한국환경성돌연변이발암원학회지
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• 제19권2호
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• pp.95-101
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• 1999

Risk Assessment is an important area in toxicology and the methodology for risk assessment has been developed. Mathematical models used for risk assessment include one-hit multi-hit, two-stage, probit logistic, multistage, and linearized multistage models. For the assessment of exposure dose, environmental monitoring has been applied, but it has limitation to accurately assess exposure level because the levels in the air, water, foods, and soil may vary depending on time of sampling. In addition, humans can be exposed to various sources of exposure and thus it will be impossible to estimate the total level of exposure in humans by environmental monitoring. To eliminate the limitation of environmental monitoring, a direct measurement of toxic materials or modified biomolecules (called biomarkers) associated with the exposure of toxic materials is needed. Here, scientific basis of biomarkers and future direction have been considered for the assessment of carcinogen exposure and cancer risk in humans.

• Archives of Pharmacal Research
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• 제17권4호
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• pp.231-235
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• 1994

Fluorenecarboxaldehyde hydrazone 9FCH)was synthesized as a new fluorescent reagent for the determination of acidity. FCH had no fluorescence in itself, however, it strongly fluoresced under acidic conditions at excitation maximum of 392 nm and emission maximum of 447 nm, respectively. It showed good correlation with pH in the range from pH 0.60 to pH 3.60 in strong acids. As an application, the acidity of gastric juice in rats and humans was determined. In comparision with pH-metry, the acidity measured by the developed method showed generally increased values of about 0.7-1.3 unit and 0.8-1.2 unit in rats and humans, respectively. However, these results had statistically close correlation with those of pH-metry and the correlation coefficients were 0.887 in rats and humans between two methods.

• Archives of Pharmacal Research
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• 제17권5호
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• pp.364-370
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• 1994

A microscopic mass balance approach has been developed to estimate the extent and rate of absorption for camier-mediated comounds. For the case competitive inhibition in the presence of an inhibitor which shares the same camier, the fraction dose absorbed (F) and absorption rate constant ($K_a$) of a drug can be calculated from its concentration profile in the intestinal lumen. Absorption parameters obtained by single-pass perfusion experiments were used in the simultaion of the absorption of some aminopenicilins. Predicted fractions dose absorbed and absorption rate constants of ampicilin and amoxicilin were significantly reduced in the presence of a 6-times higher molar dose of cyclacilin. The drug-drug interactions on the competitive absroption of camier-mediated compounds were determined with regard to F and $K_a$. Predicted decreases in F for some aminopenicilins corrlated well with decrease in the urinary recovery in humans reported in the literature. Predicted decrease in the mean absorption rate constant ($\barK_a$) explain the delays in the time of peak plasma concentration ($T_{max}$) reported in humans.