• BMB Reports
• /
• 제48권1호
• /
• pp.30-35
• /
• 2015

This study was to investigate the role of Fas in the development of Cisplatin-resistant ovarian cancer. On the cellular level, Fas expression was significantly reduced in Cisplatin resistant A2780 (A2780/CP) cells compared with A2780 cells. Fas silence with siRNA would promote tumor cell lines proliferation, facilitate tumor cell cycle transition of G1/S, prevent cell apoptosis, and promote cell migration. Expression of drug resistance gene was negatively correlated to Fas. In nude mice metastasis model of human ovarian carcinoma by subcutaneous transplantation, after Ad-Fas injected intratumorly, we found that upregulation of Fas could inhibit transplantation tumor tissue growth and reduce the expression of drug resistance gene. Our results indicated that upregulation of Fas in epithelial ovarian cancer reversed the development of resistance to Cisplatin. In conclusion, our findings suggested that Fas might act as a promising therapeutic target for improvement of the sensibility to Cisplatin in ovarian cancer.

• 한국정밀공학회지
• /
• 제17권12호
• /
• pp.169-175
• /
• 2000

Stable and comfortable walking supports, which can reduce the body weight load partially, are needed for the recovering patients from neurologic disease and orthopedic procedures. In this paper, the development of a manipulator of rehabilitation robot for the patients with walking disabilities are studied. A force controller using pneumatic actuators is designed and implemented to the human friendly rehabilitation robot considering the safety of patients, reliability of the system, effectiveness of the unloading control and economic maintenance of the system. The mechanism of the unloading manipulator is devised to improve the sensibility for the movement of the patients such as direction and velocity. For the unloading force control, fuzzy control algorithm is adopted to reduce the partial body weight and suppress the unwanted fluctuation of the body weight load to the weak legs due to the unnatural working of the patients with walking disabilities. The effectiveness of the force control is experimentally demonstrated.

• 한국실내디자인학회논문집
• /
• 제24권3호
• /
• pp.79-86
• /
• 2015

Myths and architectural spaces are cultural products symbolizing ideologies and objects respectively. Myth has the structure and the contents of a unique view of the world that reflects thoughts and representations of the nationalities. This study is about 'the spaces of the memory' adapted by the mythic tradition among many aspects of the Japanese tradition. The process of this study is illustrated as follows: At first, it mentions the concept of Gilbert Durand's mythic imaginaries and prototype with the method on how the myth is applied to the architectural spaces in the cultural context. Secondly, It clarifies basic meaning arrangement of the Japanese traditional spaces related to the myth. It shows sourceful 'prototipical system' that lies in the relation between thoughts and representations, regarding the shinto's spaces in terms of mythical imaginaries and Japanness. Thirdly, it ascertains mythical structure represented in the traditional space designs on terms with 'prototype' from symbolic system of the myth. It selects the cases among Japanese contemporary architects's works designed after 1960's, and analyses the meanings. In conclusion, it clarifies that this way can be a suggestion as the space design method combining the human's imaginary property with the time-stratigraphic region, and offering creative ideas for the strategy of the space design brand image that embraces a wide range of culture, ecology, and sensibility.

• 한국실내디자인학회논문집
• /
• 제18권5호
• /
• pp.128-136
• /
• 2009

This study analyzed and defines the property of visual perception throughout the revision of the observation time of the original space and the rotating space. The conclusions of this study are as fellows: First, based on the existing theory and experiment, the study obtained the basis which decides the sector data originating fixation-gaze after staring the specific sector over 300ms time. It will become the turning point hereafter for our research to fix the time in this way. Second, in analyzing the minute data, the study built a revision method of the observation time by analyzing the meanings and the reasons of the revision of the original data. Third, according to the difference of revision quantity, female testee have more increases in the amount of data than male testee from the original screen. On the other hand, the opposite tendency appears from the previous data. This shows there is a difference in the observation properly by sex. Last, we could grasp Information about the property of the observation time throughout eyeball fixations, and the revision and analysis of the 'controlled observation data'. These data can be used in design element arrangement of interior space, hereafter.

• 한국실내디자인학회논문집
• /
• 제38호
• /
• pp.233-240
• /
• 2003

The purpose of this study was to find the coordination trend of the Image of the color and object from the department show-window display locating in the kangnam area. The result of this study were summarized as following: 1) Show window display determinating the first image of department-store marketing service, playing the role of visual marketing provides the valuable impressions with shoppers in the times of sensibility, 2) In contemporary recognition of "Design is namely culture", show window display proceeds on the direction of concrete and practical presentation of merchandise as many customers are pursuing the high graded luxury brands while their life styles change. 3) Main concept is represented by the coordinated fashion goods on the mannequin or the body and the main theme is displayed variously in the circumferential area or on the articles with the abstract and concrete objects of diverse forms of dominant color and accent color conveying the seasonal theme precisely. 4) The compositive element of color Is the decisive factor of the visual sense of space In the coordination-trends of show window display specially representing the seasonal theme or the intentional messages and conduces to the psychological and mental desire in human and the circumstances, 5) Following the color, the compositive element of object presents the concrete image of theme or the abstract and geometrical sense of space besides the visual sense of space and shows the proportionality and the activity in displaying the show window space.dow space.

• 패션비즈니스
• /
• 제20권1호
• /
• pp.115-126
• /
• 2016

Today the Olympics are considered representative of a culture that symbolizes the country's image and cultural specificity, and important colors act as effective means of Olympics marketing. Each color is unique to the natural environment and cultural heritage is one of the languages of each country, region or community and it symbolizes. Hence, the purpose of this study was to examine the color and to view the color image displayed on Olympic uniforms based on the national color sensibility. After analyzing the color image of the Olympic athletes, including six kinds of uniforms and operational personnel, a cool casual/casual image is created more frequently, followed by a modern, gorgeous, dynamic, elegant/chic, dandy/classic image. The uniform color is consistent with the national image and the theme of the Pyeongchang Olympics is to enhance the country's competitiveness by widely promoting the national image of Korea around the world. Furthermore, it is necessary to provide the empirical basis for creating the 2018 Pyeongchang Winter Olympic uniforms.

• 한국지역지리학회지
• /
• 제16권2호
• /
• pp.167-181
• /
• 2010

오늘날 사회는 세계화 다문화로 인해 개인간의 상호 작용이 활발하게 이루어지고 있다. 국제 사회에서 행동의 주체로서 개인의 역할이 커지고 있다. 본 연구는 사회과 세계 지리에서 세계시민교육을 위한 '문화 다양성'교육의 수업 내용을 제시하고자 한다. '문화 다양성' 교육은 세계화 다문화 사회에서 세계시민교육을 위한 대안으로 타당하며 인권, 공정, 다양성, 공생의 가치를 실현해 줄 수 있는 교육이다. 이에 사회과 세계 지리 수업에서 '문화 다양성' 교육의 수업 내용 구성 방안을 제시하였다. 초등 6학년에서의 "세계 여러 지역의 자연과 문화"단원에서 '문화 다양성' 교육의 관점을 추가하여 수업 내용을 재구성하여 제시하였다.

• 대한의용생체공학회:학술대회논문집
• /
• 대한의용생체공학회 1997년도 춘계학술대회
• /
• pp.370-373
• /
• 1997

We are exposed to the various external stimuli input from the environment, which cause emotional changes based on the characteristics of the stimuli. Unfortunately there are no quantitative results on relationship between human sensibility and the characteristics of physiological signals. The objective of this study was to quantify EEG signals evoked by auditory stimulation based on the assumption that the analysis of the variability on the characteristics of the EEG waveform may provide the significant information regarding changes in psychological states of the subject. The experiment was devised with seven experimental conditions, which are control and six different types of auditory stimulation. Six subjects were used to obtain EEGs while introducing auditory stimulation. Wavelet transformation was employed to analyze the EEG signals. The results showed that the reconstructed signals at the decomposition level revealed the different energy value on the EEG signal. Also, general patterns of EEG signals in rest state compare with negative and positive stimulus were found. This study could be extended to establish an algorithm which distinguishes psychophysiological states of the subjects exposed to the auditory stimulation.

• 복식문화연구
• /
• 제13권3호
• /
• pp.391-405
• /
• 2005

This study puts emphasis on showing the change of Stripe Pattern, which has been popular for a long period of time in many societies, with change in time, assessing its value as an art. During medieval period, Strife Pattern had a strong negative meaning as a sign of disgrace or inferiority, or had been used as discrimination against a mental or a sinner, who had been rejected or banished from the society. Through French Revolution, Stripe Pattern has become a symbol of liberty and equality, furthermore, the notion of society as well as countries. This event had positively affected on reevaluating its image, from inferior, negative to significant, artistic. Eventually the variety of aesthetic values of Stripe Pattern led its way to the variation of its functional value expanding its use other than fashion industry. It is anticipated that our fashion industry will flourish in creating new, creative design by understanding design and appreciating their aesthetic values with their applications to human sensibility.

• 대한인간공학회:학술대회논문집
• /
• 대한인간공학회 1987년도 춘계학술대회논문집
• /
• pp.143-148
• /
• 1987

The Design of automotive IP must be designed for improving safety, and for satisfying the consumer's preference and for enlarging the usability of various gauges and information displaydevices. Also, these objects become more important by regarded and will be treated very sensitively for the next-generation vehicle concepts. Therefore, Automotive IP must be designed to adjust these trends, besides accord with car-inner lifestyle. One of these concept's designs is to apply Human Sensibility Ergonomics. This study suggestes the driver-centered design of the IP components that focused on the audio unit and HVAC(Heat and Ventilation Air Conditioner) through cognitive experiment. Primarily, analyzed components of IP in use, then, combined these components (especially, the number and arry of buttons, the position of LCD panel, etc.) nd designed some sample images(prototypes) the same as real size. After the subjects looked at the sam ples at the interval of 0.2/0.4/0.6 seconds, subjects should fill out the given forms from their memory. Then, the optimal prototype of IP was designed in respect to the correctness of cognition. The results will show the basic guideline of optimal design of IP that in the case of aaudio unit, the position of LCD, the array and the number of channel, in the case of HVAC, the position of LCD, TEMP button type and other button types.