• The Journal of Korean Academic Society of Nursing Education
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• v.25 no.2
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• pp.206-215
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• 2019

Purpose: This study was conducted to examine the effects of an intervention program for human tissue donation with nurses, modified from the Korea Foundation for Human Tissue Donation, to promote human tissue donation via nurses' knowledge and attitudes toward human tissue donation, and self-efficacy for teaching tissue donation. Methods: A non-equivalent control group quasi-experimental design was adopted, and data were collected from 82 nurses (41 of each group: experimental and comparison) working at a general hospital in Inchon, South Korea. Results: In a multivariate analysis (MANOVA), the integrative effect on outcome variables from the intervention program was statistically significant (p<.001). Accordingly, an ANOVA was performed to determine which individual outcome variable showed a significant effect with intervention, and it was found that the effects of intervention on all the outcome variables (knowledge and attitude, and self-efficacy for teaching human tissue donation) were significant (p<.001). Conclusion: The results of the study showed that the intervention had positive effects on knowledge and attitudes toward tissue donation, and self-efficacy for teaching tissue donation among nurses. These outcome variables derived from the intervention might be essential for eliciting positive behavior toward human tissue donation.

• Food Science and Biotechnology
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• v.18 no.1
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• pp.103-107
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• 2009

Three traditional Chinese medicines, Agrimonia pilosa Ledeb, Grifola umbellata (pers.) Pilat, and Gambogia, are combined to form a compound extract, AGC. In this study, the in vitro and in vivo inhibitory effects of AGC on human gastric carcinoma MGC-803 cells were demonstrated, and the molecular mechanisms underlying these effects are investigated. Our results indicate that AGC inhibited MGC-803 cell growth in a dose-dependent manner as measured by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, with an $IC_{50}$ of about $6.045{\pm}0.69{\mu}g/mL$. In vivo, AGC inhibited growth of human gastric carcinoma in xenograft tumors in nude mice, and the inhibitory rate reached 55.2% at 300 mg/kg. The pro-apoptotic activity of AGC was attributed to its ability to decrease the expression of Bcl-2 and Pro-caspase3 and increase the expression of Bax. These results demonstrate that AGC can effectively induce programmed cell death and may be a promising anti-tumor drug in human gastric carcinoma.

• The Journal of Korean Academic Society of Nursing Education
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• v.23 no.3
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• pp.309-318
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• 2017

Purpose: This study aimed to verify the relationship between human rights sensitivity, advocacy attitudes, and advocacy interventions for mentally disabled people in psychiatric nurses and nursing students. Methods: This is a descriptive study. Using questionnaires, data were collected from 206 participants who were recruited from one mental health institute, one general hospital, and one university in S city. Data were analyzed by t-test, ANOVA, Pearson's correlation coefficient using SPSS/WIN 22. Results: The mean age was $33.8{\pm}12.89$. The mean scores of human rights sensitivity, advocacy attitudes, and advocacy intervention was $37.7{\pm}18.09$, $53.7{\pm}5.67$, and $47.4{\pm}7.08$, respectively. Human rights sensitivity correlated significantly with advocacy attitudes (r=.25, p=.020) and advocacy intervention (r=.17, p=.015). Also, there was a significant positive correlation between advocacy attitudes and advocacy intervention (r=.44, p<.001). Conclusion: These findings highlight that advocacy attitudes and advocacy interventions for mentally disabled people could be improved by increasing human rights sensitivity. Tailored education programs will be effective in the field of mental health care services to increase human rights sensitivity.

• Food Science and Industry
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• v.51 no.1
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• pp.8-15
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• 2018

Functional food research has been struggling to demonstrate their beneficial effects in human, however, the physiological changes in humans who are in the target for functional food are very subtle and long term. In addition, it is difficult to obtain significant beneficial effect because of the necessity of using relatively healthy subjects. Relatively healthy subjects are homeostatic, and most of the biomarkers maintain a certain level under the "normal" or "resting" state. Moreover, due to wide inter-individual variation, it is difficult to detect significant changes. To address this problem, research has been actively conducted to identify the efficacy of natural products using 'omics' and 'bioinformatics' technology. In this review, we would like to introduce the human intervention studies applied homeostatic challenge model.

• Korean Journal of Acupuncture
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• v.36 no.1
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• pp.19-35
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• 2019

Objectives : The purpose of this study is to review which acupoints and meridians are selected to treat visceral pain in articles published in international journals and to investigate quality of reporting acupuncture intervention according to the STRICTA guidelines. Methods : Electrical and hand search were conducted in PubMed, EMBASE, MEDLINE, and Cochrane Library for acupuncture studies on visceral pain in human and animals. Reporting quality of intervention was evaluated using the revised STRICTA guidelines. Results : We included 51 articles (7 clinical studies and 44 animal studies) in this study. The most frequently adopted meridians and acupoints were Stomach meridian, Spleen meridian, Conception Vessel meridian, and ST36, CV4, SP6, LI4, PC6, SP9, ST25, ST37 in clinical studies. In animal studies, Stomach meridian, Conception Vessel meridian, Pericardium meridian and ST36, ST37, CV12, PC6 were most frequently used. Animal studies showed significantly lower quality of reporting compared to clinical studies. According to the analysis on the effect of year of publication of articles, announcement of STRICTA guidelines did not improve the quality of reporting for studies on visceral pain. Conclusions : These results suggest that both proximal and distal acupoints based on meridian theory were used to study the underlying mechanisms of visceral pain both in human and animal studies. Guidelines of acupuncture intervention reporting for animal study is necessary to improve the quality of evidence, and it will also allow us the integrative understanding of the mechanisms and clinical effects of acupuncture treatment in human and animal.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4859-4864
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• 2013

Background: The purpose of this study was to assess the effectiveness of a recombinant human epidermal growth factor (EGF)-based cream for the prevention of acute radiation dermatitis in breast cancer patients receiving radiotherapy (RT). Materials and Methods: Between December 2012 and April 2013, 40 breast cancer patients who received postoperative RT were prospectively enrolled in this study and randomly assigned to receive human recombinant EGF-based cream (intervention group) or general supportive skin care (control group). The grade of radiation dermatitis and pain score were examined at weekly intervals during RT and 6 weeks after RT completion. Results: All patients completed the planned RT and complied well with instructions for applying the study cream and general supportive skin care. In the intervention group, radiation dermatitis of maximum grade 3, 2, and 1 developed in 3 (15%), 11 (55%), and 6 patients (30%), respectively. In comparison, in the control group, radiation dermatitis of maximum grade 3, 2, and 1 developed in 8 (40%), 10 (50%), and 2 patients (10%), respectively. The intervention group showed lower incidence of grade 3 radiation dermatitis than the control group (p=0.068 in univariate analysis and p=0.035 in multivariate analysis). There was no statistically significant difference in the maximal pain score between the two groups (p=0.934). Conclusions: This single-blind randomized preliminary study showed that recombinant human EGF-based cream can have a beneficial role in preventing or minimizing radiation dermatitis in breast cancer patients. To confirm the results of our study, additional studies with a large sample size are required.

• Korean Journal of Applied Biomechanics
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• v.33 no.2
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• pp.52-61
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• 2023

Objective: This study aimed to investigate the effect of a combined functional intervention program on the pain-related questionnaire, the erector spinae contractile properties, and trunk extensor strength of prime-aged females with non-specific chronic low back pain. Method: 16 (female: 16) prime-aged subjects (age: 60.88 ± 6.09 years, height: 158.16 ± 5.58 cm, weight: 59.05 ± 9.44 kg) participated in this study. Results: Except for Tampa Scale of Kinesiophobia all pain-related questionnaires revealed a significant decrease after the intervention program (p<.001). Tensiomyography of the erector spinae revealed a significant post-intervention program increase in the maximum radial displacement (p<.05) and velocity of contraction (p<.05), however, there wasn't a significant post-intervention program change in the contraction time. Additionally, Trunk extensor strength showed a significant increase post-intervention program (p<.001). Conclusion: Our results indicated that the combined functional intervention program positively changed pain-related questionnaires and reduced erector spinae muscle stiffness, increasing the velocity of erector spinae contraction. Additionally, improved the trunk extensor strength.

• Biomolecules & Therapeutics
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• v.25 no.2
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• pp.194-201
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• 2017

Lysophosphatidylethanolamine (LPE), a lyso-type metabolite of phosphatidylethanolamine, has been reported to be an intercellular signaling molecule. LPE mobilizes intracellular $Ca^{2+}$ through G-protein-coupled receptor (GPCR) in some cells types. However, GPCRs for lysophosphatidic acid (LPA) were not implicated in the LPE-mediated activities in LPA GPCR overexpression systems or in SK-OV3 ovarian cancer cells. In the present study, in human SH-SY5Y neuroblastoma cells, experiments with $LPA_1$ antagonists showed LPE induced intracellular $Ca^{2+}$ increases in an $LPA_1$ GPCR-dependent manner. Furthermore, LPE increased intracellular $Ca^{2+}$ through pertussis-sensitive G proteins, edelfosine-sensitive-phospholipase C, 2-APB-sensitive $IP_3$ receptors, $Ca^{2+}$ release from intracellular $Ca^{2+}$ stores, and subsequent $Ca^{2+}$ influx across plasma membranes, and LPA acted on $LPA_1$ and $LPA_2$ receptors to induce $Ca^{2+}$ response in a 2-APB-sensitive and insensitive manner. These findings suggest novel involvements for LPE and LPA in calcium signaling in human SH-SY5Y neuroblastoma cells.

• Perspectives in Nursing Science
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• v.9 no.2
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• pp.119-126
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• 2012

Purpose: The purpose of this study was to evaluate the effects of mechanical ventilation simulation on the clinical judgment and self-confidence of nursing students. Methods: This study was a quasi-experimental study. From one university, 118 undergraduate nursing students participated in this study. Sixty students were in the intervention group, and fifty-eight students were in the control group. A simulation scenario utilizing a high-fidelity human simulator focusing on nursing care for patients with a mechanical ventilator was developed for this study. Data were collected with a self-report survey method before the intervention, right after intervention, and two weeks later. Results: Students in the intervention group showed significantly higher increases in clinical judgment and self-confidence than those in the control group at the immediate posttest. Moreover, 2 weeks later, the increase in clinical judgment and self-confidence from the pretest among the intervention group was significantly larger than those in the control group. Conclusion: Utilizing simulation education focusing on patients with a mechanical ventilator may contribute to training more competent nurses in the area of critical care nursing. It may also serve to provide a better critical care environment for the safety and health of patients.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.267-274
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• 2016

Background: Cervical cancer is the fourth most common cancer among women worldwide. Studies evaluating the effect of health education on knowledge and perception of cervical cancer have generated conflicting results. Thus, this study aimed to evaluate the effect of educational intervention towards knowledge of HPV vacccination for cervical cancer prevention among pre-university students in Malaysia. Materials and Methods: This was an experimental before and after study performed between October 2014 and March 2015. Five hundred and eighty students were randomly assigned into intervention and control groups. All were required to complete both pre-intervention and post-intervention questionnaires. Those in the intervention group were given an information leaflet to read before answering the post-intervention questionnaire. Results: Almost half (48.3%) of the students had poor knowledge, with a score less than 5, and only 51 (8.8%) exhibited good knowledge, with a score of 11 and above. After educational intervention, the number of students with poor knowledge was reduced to 177 (29.3%) and the number of students who exhibited good knowledge increased to 148 (25.5%). Students from the intervention group demonstrated significant higher total scores in knowledge regarding 'HPV infection and cervical cancer' (p=0.000) and 'HPV vaccination and cervical cancer prevention' (p=0.000) during post-intervention as compared to the control group. Conclusions: Knowledge on HPV infection and vaccination is low among pre-university students. Educational intervention in the form of information leaflets appears effective in creating awareness and improving knowledge.