• 동의생리병리학회지
• /
• 제24권2호
• /
• pp.290-295
• /
• 2010

Gamigunggui-tang (GMGGT) is one of the important prescriptions that has been used in oriental medicine. We investigated the inhibitory effect of an oral administration of hot water extract of GMGGT on the development of atopic dermatitis (AD) by using Balb/c mice. The induction of atopic dermatitis-like lesion was conducted by the removal of the back hairs and topical application of 2,4-Dinitrochlorobenzene (DNCB) on to the back skin repeatedly. GMGGT was orally administered at a different dose (10.0 mg/kg, 50.0 mg/kg). Skin reactions, consisting of increased ear thickness and the presence of ear inflammation, were observed in mice over three weeks. Oral administration of GMGGT significantly suppressed the skin lesions, ear swelling, spleen weight, total serum IgE in a concentration dependent manner, and also inhibited the infiltration of mast cells in the dorsal skin. In the present study, these results suggested that GMGGT extract inhibits inflammatory response atopic dermatitis. Therefore, GMGGT may be effective substances for the management of AD in human.

• 한국미생물·생명공학회지
• /
• 제50권4호
• /
• pp.533-547
• /
• 2022

This study investigated the hair growth effect of Schisandra chinensis extract (TS-SC) and TS-SC fermented by Lactobacillus plantarum (TS-SCLF) on human dermal papilla cells (hDPCs). The production of vascular endothelial growth factor (VEGF), insulin-like growth factor 1 (IGF-1), keratinocyte growth factor/fibroblast growth factor 7 (KGF/FGF-7) and hepatocyte growth factor (HGF), transforming growth factor beta 1 (TGF-β1) were examined. The secretion rates of VEGF and KGF/FGF-7 were high in TS-SC, and the secretion rates of IGF-1 and HGF were high in TS-SCLF. TGF-β1 was inhibited in a concentration-dependent manner in all samples. Gene expression of VEGF, IGF-1, KGF, HGF and alkaline phosphatase, relevant to hair growth, were examined. The data revealed that TS-SC and TS-SCLF successfully promoted hair growth in hDPCs. The IGF-1 gene was expressed in a dose-dependent manner in TS-SCLF. These results indicate that TS-SC and TS-SCLF fermented extract effectively promoted hair growth and gene expression relevant to hair growth in hDPCs. Used in clinical trials the test substance 'CMK-LPF01' showed a statistically significant increase in the number of hairs at 8 weeks, 16 weeks, and 24 weeks compared to before product use, and a change in hair growth, a secondary efficacy evaluation variable. Through additional research in the future, it is expected that "CMK-LPF01" can be developed as a functional material that can help alleviate symptoms of hair loss.

• 인간식물환경학회지
• /
• 제22권6호
• /
• pp.551-561
• /
• 2019

This study was conducted to find out differences in the removal efficiency of particulate matter (PM) depending on the type of plants and the morphological characteristics of leaves. A total of 12 plants were used, with three plants selected for each type of leaves (big leaf, small leaf, compound leaf, needle leaf). We measured the removed amount of PM10 and PM2.5, the structure of the abaxial leaf surface, and the weight of the wax layer of each plant. Plants with the high removal efficiency of PM included Pachira aquatica Aubl., Ardisia crenata, and Dieffenbachia 'Marianne', and plants with the low removal efficiency included Nandina domestica Thunb, Schefflera arboricola, and Quercus dentata. The abaxial leaf surface having a high removal efficiency of PM had many large wrinkles, and the abaxial leaf surface having a medium removal efficiency was flat and smooth. On the other hand, there were many fine hairs on the abaxial leaf surface with a low removal efficiency. According to the plant leaf type, the PM10 removal efficiency of plants with needle leaves was about three times higher than that of other plants. In particular, the wax layer of conifers weighed 6-24 times higher than those of other plants. The stomata of conifers were evenly distributed on the adaxial and abaxial leaf surfaces; however, the stomata of Sciadopitys verticillata appeared in the form of papillae unlike general stomata. Therefore, the removal efficiency of PM varied depending on the macro-, and micro-morphological characteristics of plant leaves such as the structure of the abaxial leaf surface, and the weight of the wax layer. Based on this research, selecting plants that are effective in reducing PM in consideration of the plant type and leaf characteristics will improve indoor air quality and decrease exposure of PM to human body.

• 대한화장품학회지
• /
• 제46권3호
• /
• pp.295-305
• /
• 2020

염색과 같이 산화제를 이용한 미용은 모발의 큐티클 구조를 바꾸거나 단백질 변성 및 지질의 소실을 야기하여 모발을 손상시킨다. 본 연구에서는 모발 손상 변화를 기기 평가를 통해 마찰계수를 측정하고 이것이 소비자들의 손상 인지와 상관성이 있는지 알아보고, 더 나아가 손상 원인을 수분 변화에서 찾아 분석 하였다. 염색, 펌, 탈색 과정을 모발에 반복할 때 마찰계수를 측정한 결과 염색의 경우는 3 회 처리에서 마찰계수 0.60을 기록했는데, 일반인들을 대상으로 동일 모발에 대한 촉감에 의한 손상 인지 조사에서 응답자의 58%가 이 모발에서 처음으로 손상을 인지한다고 답하였다. 탈색의 경우 3 회 처리에서 마찰계수가 0.84 로 크게 변하였는데 응답자의 88%가 손상모로 인지하였다. 지질 소실을 통한 손상에 따른 인지를 알아보기 위하여 모발 표면의 18-methyleicosanoic acid (18-MEA)를 제거해가며 마찰계수를 인위적으로 높인 다양한 모발을 제작하였다. 이 경우 마찰계수가 0.60 인 모발부터 전체 응답자의 68%가 최초로 손상을 인식한다고 답하였다. 기기평가로 확인된 마찰계수와 이와 연관되는 손상 인지가 모발에서 가장 많은 양을 차지하는 수분으로부터 기여되는지 확인하기 위하여 손상모의 수분함량을 측정하였다. 염색 처리 횟수가 증가할수록 모발의 접촉각이 감소하며 모발이 친수성으로 변함을 확인하였는데, 실제로 염색 손상모가 건강한 모발보다 0.42% 더 많은 수분량을 가짐을 유의차 있게 확인하였다. 최종적으로는 손상 모발의 수분량 증가가 마찰계수와 비례하는 점착력 증가를 유도하며 마찰계수가 0.60 이상으로 증가할 때 손상 인지가 됨을 알아보았다.