• English Language & Literature Teaching
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• v.12 no.4
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• pp.235-251
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• 2006

This study aims to analyze what Saul Bellow wants to define "Love" in his recent work, More Die of Heartbreak. As a humanist, Saul Bellow is concerned about materialism in Post-modern age through his works. Today there are so many people that are hurt by the failure of love or experience heartbreak. We need to sense invisible danger all around us. We can find Bellovian love in More Die of Heartbreak. Bellow suggests that there should be "true love" between people, especially between men and women. But Kenneth Trachtenberg and Benn Crader have selfish and materialistic love. Kenneth had only a sensual desire for Treckie who is his daughter's mother. He cannot persuade Treckie to marry him. Benn, a middle-aged widower, peremptorily marries Matilda Layamon who is much younger than he. Unfortunately, the marriage brings him neither peace nor love. Benn recognizes his wrong conception of love through the death of Mrs. Bedell and Villitzer, and breaking off a marriage with Matilda. He decides to go to Antarctica. This is not an escape. This is his determination to save himself. At the North Pole he sets out to recover his gift of vision and redeem his fall from grace. He will desert his materialistic and absurd self. After the expedition, he will experience rebirth as an authentic human being who has acceptable eyes. Kenneth and Benn learn to conceive of love as one of man's strongest inner energies, for it is through love that you can penetrate to the essence of human being. In this study I try to define Bellovian love. In More Die of Heartbreak, love is a spiritual power that may even transfigure man.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.21 no.10
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• pp.1073-1084
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• 2010

In this paper, the bio-heat equation including thermoregulatory functions is solved for an anatomically based human head model comprised of 14 tissues to study the thermal implications of high-power exposure to electromagnetic(EM) fields due to half-wave dipole antenna both at 835 and 1,800 MHz. The dipole antenna is located at the side of the ear and the front of the eyes. The FDTD method has been used for the SAR computation. When solving the BHE, the thermoregulation function and sweating effetecs are included in order to predict more exact temperature increase. It is noted that an approximately proportional relationship between the tissues and the maximum temperature increase and the antenna power is not maintained when the thermoregulation and sweating effects are fully accounted for under high power exposure.

• Journal of Digital Contents Society
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• v.17 no.4
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• pp.219-226
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• 2016

In our general life, what we recognize information with our human eyes and use it is diverse and massive. But even the current technologies improved by artificial intelligence are exorbitantly deficient comparing to human visual processing ability. Nevertheless, many researchers are trying to get information in everyday life, especially concentrate effort on recognizing information consisted of text. In the fields of recognizing text, to extract the text from the general document is used in some information processing fields, but to extract and recognize the text from real image is deficient too much yet. It is because the real images have many properties like color, size, orientation and something in common. In this paper, we applies an adaptive edge enhanced MSER(Maximally Stable Extremal Regions) to extract the text area in those diverse environments and the scene text, and show that the proposed method is a comparatively nice method with experiments.

• Journal of the Korean Institute of Landscape Architecture
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• v.34 no.1 s.114
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• pp.69-80
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• 2006

The purposes of this study are to analyze the meanings of urban spaces which are the background of the Korean films, and to capture the interactions of ordinary culture and urban spaces. By reading urban spaces through films, it is possible to understand the variety of experiences that are hardly captured with direct eyes, specific and vivid urban images, and various events formed by the interactions of spaces and people. The scope of the study is the urban spaces revealed in Korean films portraying cities after the 1960's as their settings, and the total of 18 films was selected with every $4{\sim}5$ films for each time stage. With the selected films, analytical meanings were developed with considering three aspects; 1) phylogenetic meaning that simply reflects social-cultural and historical background, 2) the outer strum meaning that concerns the situation of special background and film scene, and 3) metaphorical and metanymic meaning on films. According to the appearance frequency, spatial backgrounds of film scenes are mainly alleys, main streets, railroad, loft, and riverside. And then the connection between spaces and meaning clusters was grasped, and reflected meanings were derived for every spaces. And the meaning of urban space in films was analyzed based on the meaning of developments and outer stratum. The fundamental characteristics and feelings of people in media such as films are more emphasized than in real world. Urban space is not considered as a simple visible shell, but is recognized as 'a real situation' created by people. The intension of this study was to open the possibility of the various views of urban spaces. The construction of the urban space should be approached from a perspective of creating new places at where the space and human beings interact with considerations of stories of various human lives. I hope new vistas can be opened up for the research subjects and methodologies about the hereafter study of urban spaces through the mutual communications with various adjacent regions including films.

• Parasites, Hosts and Diseases
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• v.57 no.5
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• pp.549-552
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• 2019

This study aimed to determine the prevalence of intestinal helminth parasitic infections and associated risk factors for the human infection among the people of Samarkand, Uzbekistan. Infection status of helminths including Echinococcus granulosus was surveyed in domestic and wild animals from 4 sites in the Samarkand region, Uzbekistan during 2015-2018. Fecal samples of each animal were examined with the formalin-ether sedimentation technique and the recovery of intestinal helminths was performed with naked eyes and a stereomicroscope in total 1,761 animals (1,755 dogs, 1 golden jackal, and 5 Corsac foxes). Total 658 adult worms of E. granulosus were detected in 28 (1.6%) dogs and 1 (100%) golden jackal. More than 6 species of helminths, i.e., Taenia hydatigena, Dipylidium caninum, Diplopylidium nolleri, Mesocestoides lineatus, Toxocara canis, and Trichuris vulpis, were found from 18 (1.0%) dogs. Six (T. hydatigena, Toxascaris leonina, Alaria alata, Uncinaria stenocephala, D. caninum, and M. lineatus) and 2 (D. nolleri and M. lineatus) species of helminths were also detected from 5 Corsac foxes and 1 golden jackal, respectively. Taeniid eggs were found in 2 (20%) out of 10 soil samples. In the present study, it was confirmed that the prevalences of helminths including E. granulosus are not so high in domestic and wild animals. Nevertheless, the awareness on the zoonotic helminth infections should be continuously maintained in Uzbekistan for the prevention of human infection.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.30 no.6
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• pp.1053-1065
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• 2020

With the recent development of hardware performance and artificial intelligence technology, sophisticated fake videos that are difficult to distinguish with the human's eye are increasing. Face synthesis technology using artificial intelligence is called Deepfake, and anyone with a little programming skill and deep learning knowledge can produce sophisticated fake videos using Deepfake. A number of indiscriminate fake videos has been increased significantly, which may lead to problems such as privacy violations, fake news and fraud. Therefore, it is necessary to detect fake video clips that cannot be discriminated by a human eyes. Thus, in this paper, we propose a deep-fake detection model applied with Bidirectional Convolution LSTM and Attention Module. Unlike LSTM, which considers only the forward sequential procedure, the model proposed in this paper uses the reverse order procedure. The Attention Module is used with a Convolutional neural network model to use the characteristics of each frame for extraction. Experiments have shown that the model proposed has 93.5% accuracy and AUC is up to 50% higher than the results of pre-existing studies.

• Biomolecules & Therapeutics
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• v.30 no.3
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• pp.291-297
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• 2022

Dry age-related macular degeneration (AMD) is a type of progressive blindness that is primarily due to dysfunction and the loss of retinal pigment epithelium (RPE). The accumulation of N-retinylidene-N-retinylethanolamine (A2E), a by-product of the visual cycle, causes RPE and photoreceptor degeneration that impairs vision. Genes associated with dry AMD have been identified using a blue light model of A2E accumulation in the retinal pigment epithelium and transcriptomic studies of retinal tissue from patients with AMD. However, dry macular degeneration progresses slowly, and current approaches cannot reveal changes in gene transcription according to stages of AMD progression. Thus, they are limited in terms of identifying genes responsible for pathogenesis. Here, we created a model of long-term exposure to identify temporally-dependent changes in gene expression induced in human retinal pigment epithelial cells (ARPE-19) exposed to blue light and a non-cytotoxic dose of A2E for 120 days. We identified stage-specific genes at 40, 100, and 120 days, respectively. The expression of genes corresponding to epithelial-mesenchymal transition (EMT) during the early stage, glycolysis and angiogenesis during the middle stage, and apoptosis and inflammation pathways during the late stage was significantly altered by A2E and blue light. Changes in the expression of genes at the late stages of the EMT were similar to those found in human eyes with late-stage AMD. Our results provide further insight into the pathogenesis of dry AMD induced by blue light and a novel model in vitro with which relevant genes can be identified in the future.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.2
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• pp.89-94
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• 2014

DA-6034, a eupatilin derivative of flavonoid, has shown potent effects on the protection of gastric mucosa and induced the increases in fluid and glycoprotein secretion in human and rat corneal and conjunctival cells, suggesting that it might be considered as a drug for the treatment of dry eye. However, whether DA-6034 induces $Ca^{2+}$ signaling and its underlying mechanism in epithelial cells are not known. In the present study, we investigated the mechanism for actions of DA-6034 in $Ca^{2+}$ signaling pathways of the epithelial cells (conjunctival and corneal cells) from human donor eyes and mouse salivary gland epithelial cells. DA-6034 activated $Ca^{2+}$-activated $Cl^-$ channels (CaCCs) and increased intracellular calcium concentrations ($[Ca^{2+}]_i$) in primary cultured human conjunctival cells. DA-6034 also increased $[Ca^{2+}]_i$ in mouse salivary gland cells and human corneal epithelial cells. $[Ca^{2+}]_i$ increase of DA-6034 was dependent on the $Ca^{2+}$ entry from extracellular and $Ca^{2+}$ release from internal $Ca^{2+}$ stores. Interestingly, these effects of DA-6034 were related to ryanodine receptors (RyRs) but not phospholipase C/inositol 1,4,5-triphosphate ($IP_3$) pathway and lysosomal $Ca^{2+}$ stores. These results suggest that DA-6034 induces $Ca^{2+}$ signaling via extracellular $Ca^{2+}$ entry and RyRs-sensitive $Ca^{2+}$ release from internal $Ca^{2+}$ stores in epithelial cells.

• Applied Chemistry for Engineering
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• v.30 no.4
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• pp.429-434
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• 2019

A lateral flow immunoassay platform utilizing antibody functionalized water soluble CdSe/ZnS semiconductor quantum dots (QDs) was developed for the analysis of human serum amyloid A-1 (hSAA1) in a buffer solution. hSAA1 was chosen as a target protein because it is regarded as a potential biomarker associated with early diagnosis and prognosis in patients of lung cancer. The immunoassay strip on a nitrocellulose membrane was fabricated by spraying two lines composed of a test line with a monoclonal antibody against hSAA1 (10G1) (anti hSAA1) and a control line of anti-chicken IgY. While the CdSe/ZnS QDs synthesized in an organic phase were transferred to a water phase by ligand exchange using carboxylic acid modified alkane thiol. The QDs was then conjugated to monoclonal antibody against hSAA1 (14F8) [anti hSAA1 (14F8)] and used as a fluorescent detection probe. The sequential lateral flow of hSAA1 in different concentration and QDs-anti hSAA1 (14F8) complex allowed to form the surface sandwich complex of anti hSAA1 (10G1)/hSAA1/QD-anti hSAA1 (14F8), which was then analyzed using fluorescence microscope. A 100 nM concentration of hSAA1 protein can be detected by naked eyes under an optimized lateral flow buffer condition with a sensing time of 5 mins.

• Journal of Pharmacopuncture
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• v.22 no.3
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• pp.166-170
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• 2019

Objectives: Attentional and memory functions are important aspects of neural plasticity that, theoretically, should be amenable to pharmacopuncture treatments. A previous study from our laboratory suggested that quantitative electroencephalographic (qEEG) measurements of theta/beta ratio (TBR), an index of attentional control, may be indicative of academic performance in a first-semester medical school course. The present study expands our prior report by extracting and analyzing data on frontal theta and beta asymmetries. We test the hypothesis that the amount of frontal theta and beta asymmetries (fTA, fBA), are correlated with TBR and academic performance, thereby providing novel targets for pharmacopuncture treatments to improve cognitive performance. Methods: Ten healthy male volunteers were subjected to 5-10 min of qEEG measurements under eyes-closed conditions. The qEEG measurements were performed 3 days before each of first two block examinations in anatomy-physiology, separated by five weeks. Amplitudes of the theta and beta waveforms, expressed in ${\mu}V$, were used to compute TBR, fTA and fBA. Significance of changes in theta and beta EEG wave amplitude was assessed by ANOVA with post-hoc t-testing. Correlations between TBR, fTA, fBA and the raw examination scores were evaluated by Pearson's product-moment coefficients and linear regression analysis. Results: fTA and fBA were found to be negatively correlated with TBR (P<0.03, P<0.05, respectively) and were positively correlated with the second examination score (P<0.03, P=0.1, respectively). Conclusion: Smaller fTA and fBA were associated with lower academic performance in the second of two first-semester medical school anatomy-physiology block examination. Future studies should determine whether these qEEG metrics are useful for monitoring changes associated with the brain's cognitive adaptations to academic challenges, for predicting academic performance and for targeting phamacopuncture treatments to improve cognitive performance.