• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2003년도 제2차 연례학술대회 발표논문집
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• pp.26-51
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• 2003

Large scale protein interaction maps provide a new, global perspective with which to analyse protein function. PSIMAP, the Protein Structural Interactome Map, is a database of all the structurally observed interactions between superfamilies of protein domains with known three-dimensional structure in thePDB. PSIMAP incorporates both functional and evolutionary information into a single network. It makes it possible to age protein domains in terms of taxonomic diversity, interaction and function. One consequence of it is to predict the most important protein domain structure in evolution. We present a global analysis of PSIMAP using several distinct network measures relating to centrality, interactivity, fault-tolerance, and taxonomic diversity. We found the following results: ${\bullet}$ Centrality: we show that the center and barycenter of PSIMAP do not coincide, and that the superfamilies forming the barycenter relate to very general functions, while those constituting the center relate to enzymatic activity. ${\bullet}$ Interactivity: we identify the P-loop and immunoglobulin superfamilies as the most highly interactive. We successfully use connectivity and cluster index, which characterise the connectivity of a superfamily's neighbourhood, to discover superfamilies of complex I and II. This is particularly significant as the structure of complex I is not yet solved. ${\bullet}$ Taxonomic diversity: we found that highly interactive superfamilies are in general taxonomically very diverse and are thus amongst the oldest. This led to the prediction of the oldest and most important protein domain in evolution of lift. ${\bullet}$ Fault-tolerance: we found that the network is very robust as for the majority of superfamilies removal from the network will not break up the network. Overall, we can single out the P-loop containing nucleotide triphosphate hydrolases superfamily as it is the most highly connected and has the highest taxonomic diversity. In addition, this superfamily has the highest interaction rank, is the barycenter of the network (it has the shortest average path to every other superfamily in the network), and is an articulation vertex, whose removal will disconnect the network. More generally, we conclude that the graph-theoretic and taxonomic analysis of PSIMAP is an important step towards the understanding of protein function and could be an important tool for tracing the evolution of life at the molecular level.

• Asian Journal of Business Environment
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• 제9권1호
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• pp.5-12
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• 2019

Purpose - This study aims to explore and describe human resource management (HRM) in Nepalese organizations. Specifically, this study addresses three research questions: (a) what are the key human resource (HR) practices in Nepalese organizations?; (b) what are the major tasks and roles of HR departments in Nepalese organizations?; and (c) how is the status of the HR function expected to change within Nepalese organizations? Research design, data, and methodology - For this purpose, we implemented the Delphi method and developed an informed consensus among selected experts concerning the research questions. Results - The findings illustrate that organizations in Nepal adopt a wide range of HR practices commonly used in Western and developed countries. Simultaneously, some HR practices specific to the Nepalese context are also discovered. The experts' consensus on the future of HRM confirms that the evolution of the HR function to a strategic partner of management is evident in Nepalese organizations. Conclusions - Domestic as well as foreign organizations in Nepal try to create HRM systems that place them on a par with global companies. At the same time, they incorporate cultural features specific to Nepal to compete effectively in local markets. While there are few empirical studies describing HR practices in Nepal, this study contributes to broadening our understanding of the current and future status of HRM in Nepal.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2004년도 추계 종합학술대회 논문집
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• pp.36-42
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• 2004

근대 산업사회에서 현대 지식기반 사회에 이르러 문화에 대한 관심이 증가하고 있다. 중세의 신 중심 사상에서 인간 중심 사상으로의 중심이동은 이제 생명 복제와 같은 과학 기술 발달과 함께 인류가 신의 영역에 점차 가까워지는 단계에 이르게 되었다. 이러한 급진적인 변화의 흐름에서도 인류 문화의 진화는 더디게만 느껴진다. 생명 경시, 종교 전쟁, 환경 파괴, 적자생존의 자본주의 제도 등은 우리가 바라는 인류공영의 발목을 옥죄는 듯하다. 본 논문은 이러한 현대의 문화 개념과 정체성을 되짚어 보고 21세기라는 새로운 시대의 그릇에 담길만한 문화의 개념을 '물'의 특성을 가진 'SeaCricle'이라는 새로운 용어로 재정의해 보고자 한다.

• 한국실내디자인학회논문집
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• 제19권3호
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• pp.234-241
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• 2010

Avoiding the unified productivity that was caused by the mechanical and technical development due to Industrial Revolution in the past, modern design is incessantly evolving in search of new motive, namely, diversity. Further, we live in the age when the propensity that serves public interest and purpose and sometimes shows quite individual character should be considered. As a result, the comprehensive and harmonious trend of emotional design is being highlighted more remarkably. Involving the social background that further respects human dignity, this is closely related to diverse issues such as human right which should be guaranteed and pursued for individual. While the tradition and innovation caused by the encounter of machine and art had confrontation and conflict in the past, the direction has changed to incessant evolution and interaction where paradigm of technical progress and development is newly composed and changed in modern times. The meaning of service in medical area is expanding and developing from the simple treatment to the more comprehensive healing. Medical space will evolve to the healing space that attaches importance to emotional aspect of human dimension which further understands and respects human being in the future.

• Journal of Life Science
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• 제11권2호
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• pp.81-82
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• 2001

The human ribosomal protein 54 genes, RPS4X and RPS4Y are located on the X and Y chromosomes. They have been postulated as candidate for Turner syndrome which was characterized by gonadal dysgenesis, short stature, and various external and internal anomalies. Using the BLAST search program, we identified sixteen RPS4 pseudogenes from the human genome and analyzed them phylogenetically. The RPS4-C12-1, C12-2, and C12-3 pseudogenes from chromosome 12 have been evolved independently during hominid evolution. The RPS4X gene from X chromosome it closely related to the RPS4-C12-2 from chromosome 12 and RPS4-C5 from chromosome 5, whereas the RPS4Y gene is very closely related to RPS4-C16 from chromosome 16. The exact mapping of the RPS4 pseudogene family was peformed, indicating that the RPS4 pseudogene family was mapped on human chromosomes 1, 2, 5, 6, 8, 10, 11, 12, 13, 16, 18, 19 and 20. Taken together, the precise chromosomal localization and phylegenetic relationship of the RPS4 pseudo-genes could be of great use in further study for understanding the Turner syndrome.

• 한국농림기상학회:학술대회논문집
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• 한국농림기상학회 2003년도 춘계 학술발표논문집
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• pp.161-178
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• 2003

Agriculture is probably the most weather-dependent of all human activities. Variations lil climate have been, and continue to be, the principal source of fluctuations in global food production, particularly in the semi-arid tropical countries of the developing world. Throughout history, extremes of heat and cold, droughts and floods, and various forms of violent weather have wreaked havoc on the agricultural systems that depend on for food.(omitted)

• 천문학회지
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• 제45권3호
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• pp.65-69
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• 2012

Physical cosmology tries to understand the Universe at large with its origin and evolution. Observational and experimental situations in cosmology do not allow us to proceed purely based on the empirical means. We examine in which sense our cosmological assumptions in fact have shaped our current cosmological worldview with consequent inevitable limits. Cosmology, as other branches of science and knowledge, is a construct of human imagination reflecting the popular belief system of the era. The question at issue deserves further philosophic discussions. In Whitehead's words, "philosophy, in one of its functions, is the critic of cosmologies". (Whitehead 1925).

• Journal of Contemporary Eastern Asia
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• 제16권2호
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• pp.82-92
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• 2017

The Korean state evolved as a distinct entity in a region of major power convergence and conflict. All states, as human constructions, seek sovereignty and life security of their subjects/citizens, and are rotted in organic society. In the Republic of Korea, constitutional order has provided a framework for political action and a succession of regimes - authoritarianism, military dictatorship, and constitutional democracy. Since 1960 two paradigms have undergone a cycle of growth and decline, and a third, since the 2016 candlelight demonstrations in Gwanghwamun, may be the beginnning of a third generation paradigm - populist constitutionalism.

• 설비공학논문집
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• 제12권6호
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• pp.616-622
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• 2000

This paper concerns the application of smoke and fire spread to road tunnel fire problems. When a road tunnel is on fire. a fire protection system of road tunnel have to offer an adequate escape space to human. Therefore, this study carried out a simulation for predicting a spreading path of smoke and fire. The evolution of the flow field is simulated with the low Reynolds number k-$\varepsilon$ turbulent model and SIMPLE algorithm based on the finite volume method.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 하계학술대회 논문집 G
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• pp.2953-2955
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• 1999

In this paper, the concept of evolvable hardware and evolutionary robotics are introduced and constructing the mobile robot controller without human operator is suggested. The robot controller is evolved to avoid obstacles by genetic learning which determines the weights between sensor inputs and motor outputs. Genetic algorithms which is executed in a computer(PC) searches the best weights by interacting with robot performance under it's environment. The experiment is done by real mobile robot Khepera and a simple GA.