• Journal of Preventive Medicine and Public Health
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• 제51권6호
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• pp.326-328
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• 2018

As over 1000 new cases of HIV/AIDS occur in Korea annually, preventive health programs against HIV/AIDS are urgently needed. Since phylodynamic studies have been suggested as a way to understand how infectious diseases are transmitted and evolve, phylodynamic inferences can be a useful tool for HIV/AIDS research. In particular, phylodynamic models are helpful for dating the origins of an epidemic and estimating its basic reproduction number. Thus, the introduction of phylodynamics would be a highly valuable step towards controlling the HIV/AIDS epidemic in Korea.

• Mass Spectrometry Letters
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• 제13권2호
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• pp.27-34
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• 2022

Atmospheric aerosols have become a major environmental concern because of their adverse effects on human health, air quality, and climate change. Over the last few decades, several mass spectrometry (MS)-based techniques have been developed and applied in the field of atmospheric aerosol research. Particularly, real-time measurement of ambient aerosols using an aerosol mass spectrometer (AMS) has become one of the most powerful tools for aerosol chemistry. This review provides a brief description of AMS and its applications for understanding the physicochemical properties of atmospheric aerosols, as well as its sources and evolution processes.

• 한국콘텐츠학회논문지
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• 제11권1호
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• pp.123-133
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• 2011

현실세계에서의 인간복제에 관련된 생명과학의 급속한 발전은 앞서거니 뒤서거니 영화 속에 투영되며, 멀지 않은 미래에 대한 다양한 인간 군상의 시나리오와 그에 파생되는 화두를 우리에게 던지고 있다. 특히 체세포복제술이 보편화된 이후로 인간복제는 영화 속에서도 보다 새롭고 구체적인 모습으로 그려지고 있는 데, 이 글에서는 그 중에서도 인간복제의 다양한 철학적 문제들에 대한 성찰이 투영된 영화 <블루프린트>를 중심으로 영화 속의 인간복제 모티프의 특성에 대해 고찰해보았다. 이 글은 체세포복제술 개념의 출현과 발전이 철학적 인간학의 문제로 귀결되고, 특히 복제인간의 자기동일성과 비자연성의 문제가 영화 <블루프린트>에서 캐릭터의 욕망과 딜레마로 투영되는 것을 살펴보았다. 또한 원본인간과 복제인간이자, 실제 낳고 기른 친모와 딸이라는 이중적인 관계의 설정과 장르적 특성을 배제한 드라마타이즈는 이 작품이 위와 같은 문제의식에 천착하고 있음을 반증하고 있다고 보았다. 그리고 이에 적절히 부응하는 서사적 평행성을 갖는 플롯 설계와 더불어 다양한 영화적 표현과 기법 들을 통해 일관된 접근 태도와 주제 의식으로 인간복제 모티프의 특성을 효과적으로 강화하고 있음을 고찰하였다.

• Genomics & Informatics
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• 제12권3호
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• pp.105-113
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• 2014

A subset of mammalian genes differ functionally between two alleles due to genomic imprinting, and seven such genes (Peg3, Usp29, APeg3, Zfp264, Zim1, Zim2, Zim3) are localized within the 500-kb genomic interval of the human and mouse genomes, constituting the Peg3 imprinted domain. This Peg3 domain shares several features with the other imprinted domains, including an evolutionarily conserved domain structure, along with transcriptional co-regulation through shared cis regulatory elements, as well as functional roles in controlling fetal growth rates and maternal-caring behaviors. The Peg3 domain also displays some unique features, including YY1-mediated regulation of transcription and imprinting; conversion and adaptation of several protein-coding members as ncRNA genes during evolution; and its close connection to human cancers through the potential tumor suppressor functions of Peg3 and Usp29. In this review, we summarize and discuss these features of the Peg3 domain.

• 한국발생생물학회지:발생과생식
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• 제15권3호
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• pp.187-195
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• 2011

X chromosome inactivation (XCI) is a process that enables mammalian females to ensure the dosage compensation for X-linked genes. Investigating the mechanism of XCI might provide deeper understandings of chromosomal silencing, epigenetic regulation of gene expressions, and even the course of evolution. Studies on mammalian XCI conducted with mice have revealed many fundamental findings on XCI. However, difference of murine and human XCI necessitates the further investigation in human XCI. Recent success in reprogramming of differentiated cells into pluripotent stem cells showed the reversibility of XCI in vitro, X chromosome reactivation (XCR), which provides another tool to study the change in X chromosome status. This review summarizes the current knowledge of XCI during early embryonic development and describes recent achievements in studies of XCI in reprogramming process.

• BMB Reports
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• 제39권5호
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• pp.511-515
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• 2006

Alanine aminotransferase (AAT) is mainly synthesized in the liver, and its level in mammalian serum is elevated after acute phase induction. Here we demonstrated that sheep anti-human AAT antibody cross-reacted with amphioxus humoral fluids as well as human serum; and the concentration of AAT in the humoral fluids in amphioxus increased after the acute challenge with lipopolysaccharide, while the level of total proteins remains unchanged. These suggest the presence of the same acute phase response pattern in amphioxus, as observed in some mammalian species. Immunohistochemically, AAT was localized in the hepatic diverticulum, ovary and testis. It appears that the hepatic diverticulum in amphioxus is functionally homologous to the vertebrate liver in respect of AAT synthesis, supporting the hypothesis that the vertebrate liver evolved from the hepatic diverticulum of an amphioxus-like ancestor during early chordate evolution.

• 한국실내디자인학회논문집
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• 제13권6호
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• pp.48-56
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• 2004

The Affordance, discussed in the theory of ecological perception of environmental psychology, is the concept of perception that deals with inter-relationship between environment and human. It is a theory seeking for gradual evolution, with the change of user experience behavior and the space, by getting feed-backs from the analysis of perception of characteristics of 3-dimensional space and the user as moving entity. Although there has been many attempts to define the Affordance and apply its concept to the architecture, now there's a need to identify the Affordance in the real architectural space, represent Affordance of space and the user inter-relationship in the architecture and apply its design specifically, Thus, the purpose of this study is to present the methodology of applying Affordance in architectural space design by identifying the Affordance of space concept of human experience behavior in the architectural space and analyze its recognition process.

• Animal cells and systems
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• 제12권4호
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• pp.261-267
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• 2008

The human chromosomes 2, 7, 12 and 17 show genomic homology around Hox gene clusters, is taken as evidence that these paralogous gene families might have arisen from a ancestral chromosomal segment through genome duplication events. We have examined protein data from vertebrate and invertebrate genomes to analyze the phylogenetic history of multi-gene families with three or more of their representatives linked to human Hox clusters. Topology comparison based upon statistical significance and information of chromosome location for these genes examined have revealed many of linked genes coduplicated with Hox gene clusters. Most linked genes to Hox clusters share the same evolutionary history and are duplicated in concert with each other. We conclude that gene families linked to Hox clusters may be suggestion of ancient genome duplications.

• Journal of information and communication convergence engineering
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• 제4권1호
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• pp.23-27
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• 2006

The discipline of software performance is very broad; it influences all aspects of the software development lifecycle, including architecture, design, deployment, integration, management, evolution and servicing. Thus, the complexity of software is an important aspect of development and maintenance activities. Much research has been dedicated to defining different software measures that capture what software complexity is. In most cases, the description of complexity is given to humans in forms of numbers. These quantitative measures reflect human-seen complexity with different levels of success. Software complexity growth has been recognized to be beyond human control. In this paper, we have focused our discussion on the increasing software complexity and the issue with the problems being faced in managing this complexity. This increasing complexity in turn affects the software productivity, which is declining with increase in its complexity.

• Genomics & Informatics
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• 제6권3호
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• pp.130-135
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• 2008

The haplotypes of a 200 kb region in the human chromosome X terminal band (q28) were analyzed using the International HapMap Project Phasell data, which had been collected for three analysis panels (YRI, CEU, and CHB＋JPT). When multiple linkage disequilibrium blocks were encountered for a panel, the neighboring haplotypes that had crossover rate of 5% or more in the panel were combined to generate 'haploid' configurations. This resulted in 8, 7, and 5 'haploid' configurations for the panels of YRI, CEU, and CHB＋JPT, respectively. The multiple sequence alignment of these 'haploids' was used for the calculation of allele-sharing distances and the subsequent principal coordinate analysis. Two 'haploids' in CEU and CHB＋JPT were hypothesized as 'parental' in light of the observations that the successive recombinants of these haploids can model two other haploids in CEU and CHB＋JPT, and that their configurations were consistent with those in YRI. This study demonstrates the utility of haplotype phylogeny in understanding population evolution.