• Proceedings of the Korean Society for Bioinformatics Conference
• /
• 2003.10a
• /
• pp.26-51
• /
• 2003

Large scale protein interaction maps provide a new, global perspective with which to analyse protein function. PSIMAP, the Protein Structural Interactome Map, is a database of all the structurally observed interactions between superfamilies of protein domains with known three-dimensional structure in thePDB. PSIMAP incorporates both functional and evolutionary information into a single network. It makes it possible to age protein domains in terms of taxonomic diversity, interaction and function. One consequence of it is to predict the most important protein domain structure in evolution. We present a global analysis of PSIMAP using several distinct network measures relating to centrality, interactivity, fault-tolerance, and taxonomic diversity. We found the following results: ${\bullet}$ Centrality: we show that the center and barycenter of PSIMAP do not coincide, and that the superfamilies forming the barycenter relate to very general functions, while those constituting the center relate to enzymatic activity. ${\bullet}$ Interactivity: we identify the P-loop and immunoglobulin superfamilies as the most highly interactive. We successfully use connectivity and cluster index, which characterise the connectivity of a superfamily's neighbourhood, to discover superfamilies of complex I and II. This is particularly significant as the structure of complex I is not yet solved. ${\bullet}$ Taxonomic diversity: we found that highly interactive superfamilies are in general taxonomically very diverse and are thus amongst the oldest. This led to the prediction of the oldest and most important protein domain in evolution of lift. ${\bullet}$ Fault-tolerance: we found that the network is very robust as for the majority of superfamilies removal from the network will not break up the network. Overall, we can single out the P-loop containing nucleotide triphosphate hydrolases superfamily as it is the most highly connected and has the highest taxonomic diversity. In addition, this superfamily has the highest interaction rank, is the barycenter of the network (it has the shortest average path to every other superfamily in the network), and is an articulation vertex, whose removal will disconnect the network. More generally, we conclude that the graph-theoretic and taxonomic analysis of PSIMAP is an important step towards the understanding of protein function and could be an important tool for tracing the evolution of life at the molecular level.

• Asian Journal of Business Environment
• /
• v.9 no.1
• /
• pp.5-12
• /
• 2019

Purpose - This study aims to explore and describe human resource management (HRM) in Nepalese organizations. Specifically, this study addresses three research questions: (a) what are the key human resource (HR) practices in Nepalese organizations?; (b) what are the major tasks and roles of HR departments in Nepalese organizations?; and (c) how is the status of the HR function expected to change within Nepalese organizations? Research design, data, and methodology - For this purpose, we implemented the Delphi method and developed an informed consensus among selected experts concerning the research questions. Results - The findings illustrate that organizations in Nepal adopt a wide range of HR practices commonly used in Western and developed countries. Simultaneously, some HR practices specific to the Nepalese context are also discovered. The experts' consensus on the future of HRM confirms that the evolution of the HR function to a strategic partner of management is evident in Nepalese organizations. Conclusions - Domestic as well as foreign organizations in Nepal try to create HRM systems that place them on a par with global companies. At the same time, they incorporate cultural features specific to Nepal to compete effectively in local markets. While there are few empirical studies describing HR practices in Nepal, this study contributes to broadening our understanding of the current and future status of HRM in Nepal.

• Proceedings of the Korea Contents Association Conference
• /
• 2004.11a
• /
• pp.36-42
• /
• 2004

People's Interest about culture is increasing to reach in today's knowledge based society on age of modern industrial society. Conversion of human based idea arrived in step that human through scientific technique development such as life reproduction approaches gradually in God's sacred ground. Evolution of human's culture was proceeded slowly in current of such radical change.Life underestimate, religion war, pollution etc. are seeming to keep away human development.This treatise wishes to redefine concept of suitable culture in new terminology of 'SeaCricle' that have characteristic of water at 21C's New Age.

• Korean Institute of Interior Design Journal
• /
• v.19 no.3
• /
• pp.234-241
• /
• 2010

Avoiding the unified productivity that was caused by the mechanical and technical development due to Industrial Revolution in the past, modern design is incessantly evolving in search of new motive, namely, diversity. Further, we live in the age when the propensity that serves public interest and purpose and sometimes shows quite individual character should be considered. As a result, the comprehensive and harmonious trend of emotional design is being highlighted more remarkably. Involving the social background that further respects human dignity, this is closely related to diverse issues such as human right which should be guaranteed and pursued for individual. While the tradition and innovation caused by the encounter of machine and art had confrontation and conflict in the past, the direction has changed to incessant evolution and interaction where paradigm of technical progress and development is newly composed and changed in modern times. The meaning of service in medical area is expanding and developing from the simple treatment to the more comprehensive healing. Medical space will evolve to the healing space that attaches importance to emotional aspect of human dimension which further understands and respects human being in the future.

• Journal of Life Science
• /
• v.11 no.2
• /
• pp.81-82
• /
• 2001

The human ribosomal protein 54 genes, RPS4X and RPS4Y are located on the X and Y chromosomes. They have been postulated as candidate for Turner syndrome which was characterized by gonadal dysgenesis, short stature, and various external and internal anomalies. Using the BLAST search program, we identified sixteen RPS4 pseudogenes from the human genome and analyzed them phylogenetically. The RPS4-C12-1, C12-2, and C12-3 pseudogenes from chromosome 12 have been evolved independently during hominid evolution. The RPS4X gene from X chromosome it closely related to the RPS4-C12-2 from chromosome 12 and RPS4-C5 from chromosome 5, whereas the RPS4Y gene is very closely related to RPS4-C16 from chromosome 16. The exact mapping of the RPS4 pseudogene family was peformed, indicating that the RPS4 pseudogene family was mapped on human chromosomes 1, 2, 5, 6, 8, 10, 11, 12, 13, 16, 18, 19 and 20. Taken together, the precise chromosomal localization and phylegenetic relationship of the RPS4 pseudo-genes could be of great use in further study for understanding the Turner syndrome.

• Proceedings of The Korean Society of Agricultural and Forest Meteorology Conference
• /
• 2003.09a
• /
• pp.161-178
• /
• 2003

Agriculture is probably the most weather-dependent of all human activities. Variations lil climate have been, and continue to be, the principal source of fluctuations in global food production, particularly in the semi-arid tropical countries of the developing world. Throughout history, extremes of heat and cold, droughts and floods, and various forms of violent weather have wreaked havoc on the agricultural systems that depend on for food.(omitted)

• Journal of The Korean Astronomical Society
• /
• v.45 no.3
• /
• pp.65-69
• /
• 2012

Physical cosmology tries to understand the Universe at large with its origin and evolution. Observational and experimental situations in cosmology do not allow us to proceed purely based on the empirical means. We examine in which sense our cosmological assumptions in fact have shaped our current cosmological worldview with consequent inevitable limits. Cosmology, as other branches of science and knowledge, is a construct of human imagination reflecting the popular belief system of the era. The question at issue deserves further philosophic discussions. In Whitehead's words, "philosophy, in one of its functions, is the critic of cosmologies". (Whitehead 1925).

• Journal of Contemporary Eastern Asia
• /
• v.16 no.2
• /
• pp.82-92
• /
• 2017

The Korean state evolved as a distinct entity in a region of major power convergence and conflict. All states, as human constructions, seek sovereignty and life security of their subjects/citizens, and are rotted in organic society. In the Republic of Korea, constitutional order has provided a framework for political action and a succession of regimes - authoritarianism, military dictatorship, and constitutional democracy. Since 1960 two paradigms have undergone a cycle of growth and decline, and a third, since the 2016 candlelight demonstrations in Gwanghwamun, may be the beginnning of a third generation paradigm - populist constitutionalism.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
• /
• v.12 no.6
• /
• pp.616-622
• /
• 2000

This paper concerns the application of smoke and fire spread to road tunnel fire problems. When a road tunnel is on fire. a fire protection system of road tunnel have to offer an adequate escape space to human. Therefore, this study carried out a simulation for predicting a spreading path of smoke and fire. The evolution of the flow field is simulated with the low Reynolds number k-$\varepsilon$ turbulent model and SIMPLE algorithm based on the finite volume method.

• Proceedings of the KIEE Conference
• /
• 1999.07g
• /
• pp.2953-2955
• /
• 1999

In this paper, the concept of evolvable hardware and evolutionary robotics are introduced and constructing the mobile robot controller without human operator is suggested. The robot controller is evolved to avoid obstacles by genetic learning which determines the weights between sensor inputs and motor outputs. Genetic algorithms which is executed in a computer(PC) searches the best weights by interacting with robot performance under it's environment. The experiment is done by real mobile robot Khepera and a simple GA.