• Asian Journal of Innovation and Policy
• /
• v.8 no.2
• /
• pp.180-207
• /
• 2019

This article explores the historical evolutionary process of the biopharmaceutical industry of Korea, and how intentional and unintentional policy interventions have triggered the creation of the industry's system dynamics and paved the way for the generation of a few global leading products, including biosimilar, as well as next-generation therapeutics of gene and cell. The policies cover the simple technology transfer of API synthesis to overcome the endemic parasitic disease, new substance patent adoption and new drug development consortia, human resource development, various national initiatives influenced by the Human Genome Project, and venture promotion schemes. The scope and implementation tools under these policies have been aligned and refined to transform traditional fine chemical-based pharmaceuticals, to stimulate large companies' participation and to create technology-based venture companies in the biopharma business of Korea.

• Korean Institute of Interior Design Journal
• /
• v.22 no.3
• /
• pp.100-107
• /
• 2013

In smart era, concept of User experience has been an important issue both in academic and practical areas in recent years. Interactive space became one of the major design paradigms. For elevating the interactive effect, we need user?centered design methodology which uses the influential factors on the interactivity. As, well developed information technology made a lot of changes to various fields of our society, interactive space with the concept of HCI became a big issue in environmental design field. In this interactive space, various types of informative factors of the given space are sent using sensor and computer networking technology to the main system. So, a user's movement in the space in more than just a movement itself-user's movement now forms a important spatial structure that leads the narrative of the space. in this research, I will come up with the problems that the interactive space has right now, and analyze what the public space must have, and combine them with interactive space by HCI theory. architecture space is not the old space adapting digital technology. In order to take the role as new space paradigm. environment and technology, it has to develop technology continuously and experimental space at the same time. It must have co-evolution of architecture space field and others through organic network. by that, the evolution of space will be in the way that combines space which is responded to human emotion and user centric human friendly.

• Journal of Families and Better Life
• /
• v.24 no.4 s.82
• /
• pp.51-73
• /
• 2006

The purpose of this study is to introduce the evolution of corporate family-friendly policies and programs, a recent business issue throughout the world. In addition, this study suggests implications for a corporate reference guide to work-family policies and programs by providing a comparative analysis of the typical stages of development of U.S. corporate family-friendly policies and programs, and by presenting model initiatives of Korean and American family-friendly companies. Just as technological changes at the time of the Industrial Revolution altered the relationship between workers and their work, more recent technological advances have again transformed this relationship, offering the promise of a society in which work demands a smaller portion of the worker's time and permitting the worker more freedom and control over work conditions. These new work arrangements have the promise of producing a new paradigm for work and family, based on which many industrialized nations have developed family-friendly policies already. Family-friendly policies and programs can be grouped into four discernable stages in the evolution of a corporate work-family agenda. According to these stages, most companies in Korea are in the predevelopment stage or stage 1. Development of scales to assess company family-friendliness is needed to create a family-friendly workplace environment, policies, and programs. It is critical that companies have champions who have the vision to step out in kent, and the determination to ensure that the family-friendly programs are solidly grounded. Companies should develop their work-family initiatives as an integral part of a program for managing diversity focusing on needs of women and minority employees.

• Journal of the Institute of Electronics Engineers of Korea TC
• /
• v.49 no.5
• /
• pp.91-98
• /
• 2012

Since the major cellular data service providers in U.S, Japan as well as in Korea started the LTE (Long Term Evolution) service, there has been more strong need for the methods that can accurately measure the MIMO (Multi Input-Multi Output) OTA (Over The Air) performance of LTE handsets because the performance of the MIMO antenna determines the data throughput in the downlink. In this paper, the hand effect on the MIMO antenna performance is analyzed by numerically and experimentally. The hand effect on the LTE mobile handset is analyzed by measuring the link level performance in the MIMO OTA system.

• Electronics and Telecommunications Trends
• /
• v.14 no.4 s.58
• /
• pp.1-9
• /
• 1999

In this paper, we summarize the lessons learned from the applications of the software reliability engineering to a large-scale software project. The considered software is the software system of the TDX-10 ISDN switching system. The considered software consists of many components, called functional blocks. These functional blocks serve as the unit of coding and test. The software is continuing to be developed by adding new functional blocks. We are mainly concerned with the analysis of the effects of these software components to software reliability and with the analysis of the reliability evolution. We analyze the static characteristics of the software related to software reliability using failure data collected during system test. We also discussed a pattern which represents a local and global growth of the software reliability as version evolves. To find the pattern of software of the TDX-10 ISDN system, we apply the S-shaped model to a collection of failure data sets of each evolutionary version and the Goel-Okumoto (G-O) model to a grouped overall failure data set. We expect this pattern analysis will be helpful to plan and manage necessary human/resources for a new similar software project which is developed under the same developing circumstances by estimating the total software failures with respect to its size and time.

• Genomics & Informatics
• /
• v.6 no.1
• /
• pp.44-49
• /
• 2008

Protein kinase C (PKC) is a family of kinases involved in the transduction of cellular signals that promote lipid hydrolysis. PKC plays a pivotal role in mediating cellular responses to extracellular stimuli involved in proliferation, differentiation and apoptosis. Comparative analysis of the PKC-${\alpha},{\beta},{\varepsilon}$ isozymes of 200 recently sequenced microbial genomes was carried out using variety of bioinformatics tools. Diversity and evolution of PKC was determined by sequence alignment. The ser/thr protein kinases of Streptomyces coelicolor A3 (2), is the only bacteria to show sequence alignment score greater than 30% with all the three PKC isotypes in the sequence alignment. S.coelicolor is the subject of our interest because it is notable for the production of pharmaceutically useful compounds including anti-tumor agents, immunosupressants and over two-thirds of all natural antibiotics currently available. The comparative analysis of three human isotypes of PKC and Serine/threonine protein kinase of S.coelicolor was carried out and possible mechanism of action of PKC was derived. Our analysis indicates that Serine/ threonine protein kinase from S. coelicolor can be a good candidate for potent anti-tumor agent. The presence of three representative isotypes of the PKC super family in this organism helps us to understand the mechanism of PKC from evolutionary perspective.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.10 no.12
• /
• pp.5422-5441
• /
• 2016

Despite the abundant literature in the field, there is still the need to find a time-efficient, highly accurate, easy to deploy and robust localization algorithm for real use. The algorithm only involves minimal human intervention. We propose an enhanced Received Signal Strength Indicator (RSSI) based positioning algorithm for Wi-Fi capable devices, called the Dynamic Weighted Evolution for Location Tracking (DWELT). Due to the multiple phenomena affecting the propagation of radio signals, RSSI measurements show fluctuations that hinder the utilization of straightforward positioning mechanisms from widely known propagation loss models. Instead, DWELT uses data processing of raw RSSI values and applies a weighted posterior-probabilistic evolution for quick convergence of localization and tracking. In this paper, we present the first implementation of DWELT, intended for 1D location (applicable to tunnels or corridors), and the first step towards a more generic implementation. Simulations and experiments show an accuracy of 1m in more than 81% of the cases, and less than 2m in the 95%.

• Journal of the Korean Institute of Intelligent Systems
• /
• v.20 no.4
• /
• pp.522-527
• /
• 2010

In this paper, a new MBHF(Morphology-Based Homomorphic filter) is presented to enhance contrast in mammographic images. The MBH filtering is performed based on the morphological sub-bands, in which an image is morphologically decomposed. The filter is designed to have optimal gain and structuring element in each sub-band through differential evolution. Experimental results show that the proposed method improves the contrast in mammographic images such that an evaluation criterion, WPSNR(Weighted Peak Signal to Noise Ratio) which takes into account human visual system is increased compared with a wavelet-based Homomorphic filter.

• Asian Journal of Innovation and Policy
• /
• v.10 no.3
• /
• pp.355-379
• /
• 2021

This study examined the evolution of S&T Basic Acts in Korea from the Science and Technology Promotion Act (1967) through the Special Act on STI (1997) to the Framework Act on Science and Technology (2001) in the following aspects: 1) comprehensive plans, 2) coordination mechanisms for S&T policies, 3) enforcement of R&D programs and performance diffusion, 4) promotion of human resources, 5) and S&T investment and budgeting. Before the Framework Act on S&T was enacted in 2001, critical issues were found in establishing S&T master plans, promotion of R&D programs, comprehensive coordination mechanisms, and R&D budgeting. The three Basic Acts have expanded the scope of regulation over time to cover the entire cycle of the S&T process. They concern a wide range of issues, including creating a basis for scientific and technological development, S&T promotion, disseminating and commercializing research outcomes, and preventing adverse effects from science and technology. The content of the Basic Acts has evolved in response to changes in the political, economic, and social environment of Korean industry during the past five decades.

• Advances in nano research
• /
• v.12 no.3
• /
• pp.319-336
• /
• 2022

Evaluating the temporal and spatial changes in the ecosystem service value (ESV) of the Sanjiangyuan Nature Reserve is important for understanding the impact of human activities on natural ecosystem and guiding ecosystem restoration and environmental pollution control. In this study, remotely sensed land-cover data and the equivalent factor method were used to analyze the spatiotemporal evolution characteristics of the ESV in Sanjiangyuan Nature Reserve from 1992 to 2015, and regression analysis was employed to determine the factors driving changes in the ESV. The results show that grassland was the main type of ecosystem in the study area, and the transformation of grassland into bare areas was the primary change in land cover. Additionally, the ESV in the study area first decreased and then increased, with an annual growth rate of 0.69%. The ESV mainly increased in the north of the Yellow River's source area, and mainly decreased in the northwest of the Yangtze River's source area. Finally, the gross output value of agriculture, urbanization rate and proportion of secondary industry were found to be the main factors driving the ESV in the study area.