• Title/Summary/Keyword: human damage

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Xylene Induces Oxidative Stress and Mitochondria Damage in Isolated Human Lymphocytes

  • Salimi, Ahmad;Talatappe, Behnaz Shoja;Pourahmad, Jalal
    • Toxicological Research
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    • v.33 no.3
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    • pp.233-238
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    • 2017
  • Xylene is a cyclic hydrocarbon and an environmental pollutant. It is also used in medical technology, paints, dyes, polishes and in many industries as a solvent; therefore, an understanding of the interaction between xylene and human lymphocytes is of significant interest. Biochemical assessment was used to demonstrate that exposure of lymphocytes to xylene induces cytotoxicity (at 6 hr), generates intracellular reactive oxygen species, collapse of mitochondrial membrane potential, lysosomal injury, lipid peroxidation and depletion of glutathione (at 3 hr). The findings show that xylene triggers oxidative stress and organelle damage in lymphocytes. The results of our study suggest that the use of antioxidant, mitochondrial and lysosomal protective agents can be helpful for individuals subject to chronic exposure to xylene.

Investigation for health food intake to prevent damage of the elderly (노인들의 건강식품 피해예방을 위한 사용실태 조사)

  • Kim, Hyo-Chung;Kim, Mee-Ra
    • Korean Journal of Human Ecology
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    • v.15 no.5
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    • pp.849-858
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    • 2006
  • This research aimed to survey problems related to the elderly's purchasing trends and habitual use of health food; it was in order to effectively prevent the monetary and health damage to the elderly of health foods. In February 2006, the data were collected from 271 of the elderly people living in Goyang-si, Kyunggi-Do. The results of the study indicated: first, more than 50% of the respondents had much interest in health foods, and 42.8% of them answered they were taking health foods. Second, about 62% of 116 respondents who were taking health foods were taking one kind of them, for the purpose of maintaining and improving their health condition. Third, the major information regarding health foods was acquired from their family members, relatives and friends, or TV, radio and journals. Lastly, 75% of respondents even did not know whether there was a relief system for damage related to health foods.

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Atypical viscous fracture of human femurs

  • Yosibash, Zohar;Mayo, Romina Plitman;Milgrom, Charles
    • Advances in biomechanics and applications
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    • v.1 no.2
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    • pp.77-83
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    • 2014
  • Creep phenomenon at the scale of bone tissue (small specimens) is known to be present and demonstrated for low strains. Here creep is demonstrated on a pair of fresh-frozen human femurs at the organ level at high strains. Under a constant displacement applied on femur's head, surface strains at the upper neck location increase with time until fracture, that occurs within 7-13 seconds. The monotonic increase in strains provides evidence on damage accumulation in the interior (probably damage to the trabeculae) prior to final fracture, a fact that hints on probable damage of the trabecular bone that occurs prior to the catastrophic fracture of the cortical surface layer.

Development of a structural inspection system with marking damage information at onsite based on an augmented reality technique

  • Junyeon Chung;Kiyoung Kim;Hoon Sohn
    • Smart Structures and Systems
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    • v.31 no.6
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    • pp.573-583
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    • 2023
  • Although unmanned aerial vehicles have been used to overcome the limited accessibility of human-based visual inspection, unresolved issues still remain. Onsite inspectors face difficulty finding previously detected damage locations and tracking their status onsite. For example, an inspector still marks the damage location on a target structure with chalk or drawings while comparing the current status of existing damages to their previous status, as documented onsite. In this study, an augmented-reality-based structural inspection system with onsite damage information marking was developed to enhance the convenience of inspectors. The developed system detects structural damage, creates a holographic marker with damage information on the actual physical damage, and displays the marker onsite via an augmented reality headset. Because inspectors can view a marker with damage information in real time on the display, they can easily identify where the previous damage has occurred and whether the size of the damage is increasing. The performance of the developed system was validated through a field test, demonstrating that the system can enhance convenience by accelerating the inspector's essential tasks such as detecting damages, measuring their size, manually recording their information, and locating previous damages.

Structural damage detection of steel bridge girder using artificial neural networks and finite element models

  • Hakim, S.J.S.;Razak, H. Abdul
    • Steel and Composite Structures
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    • v.14 no.4
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    • pp.367-377
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    • 2013
  • Damage in structures often leads to failure. Thus it is very important to monitor structures for the occurrence of damage. When damage happens in a structure the consequence is a change in its modal parameters such as natural frequencies and mode shapes. Artificial Neural Networks (ANNs) are inspired by human biological neurons and have been applied for damage identification with varied success. Natural frequencies of a structure have a strong effect on damage and are applied as effective input parameters used to train the ANN in this study. The applicability of ANNs as a powerful tool for predicting the severity of damage in a model steel girder bridge is examined in this study. The data required for the ANNs which are in the form of natural frequencies were obtained from numerical modal analysis. By incorporating the training data, ANNs are capable of producing outputs in terms of damage severity using the first five natural frequencies. It has been demonstrated that an ANN trained only with natural frequency data can determine the severity of damage with a 6.8% error. The results shows that ANNs trained with numerically obtained samples have a strong potential for structural damage identification.

DNA Damage of Lymphocytes in Volunteers after 4 hours Use of Mobile Phone (일부 자원자들의 이동전화 4시간 연속 사용 후 림프구 DNA 손상 평가)

  • Ji, Seon-Mi;Oh, Eun-Ha;Sul, Dong-Geun;Choi, Jae-Wook;Park, Hee-Chan;Lee, Eun-Il
    • Journal of Preventive Medicine and Public Health
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    • v.37 no.4
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    • pp.373-380
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    • 2004
  • Objectives : There has been gradually increasing concern about the adverse health effects of electromagnetic radiation originating from cell phones which are widely used in modern life. Cell phone radiation may affect human health by increasing free radicals of human blood cells. This study has been designed to identify DNA damage of blood cells by electromagnetic radiation caused by cell phone use. Methods : This study investigated the health effect of acute exposure to commercially available cell phones on certain parameters such as an indicator of DNA damage for 14 healthy adult volunteers. Each volunteer during the experiment talked over the cell phone with the keypad facing the right side of the face for 4 hours. The single cell gel electrophoresis assay (Comet assay), which is very sensitive in detecting the presence of DNA strand-breaks and alkali-labile damage in individual cells, was used to assess peripheral blood cells (T-cells, B-cells, granulocytes) from volunteers before and after exposure to cell phone radiation. The parameters of Comet assay measured were Olive Tail Moment and Tail DNA %. Results : The Olive Tail Moment of B-cells and granulocytes and Tail DNA % of B-cells and granulocytes were increased by a statistically significant extent after 4-hour use of a cell phone compared with controls. Conclusion : It is concluded that cell phone radiation caused the DNA damage during the 4 hours of experimental condition. Nonetheless, this study suggested that cell phone use may increase DNA damage by electromagnetic radiation and other contributing factors.

A Framework to Estimate GDP Loss due to Extreme Water-related Disaster in Kangwon-do

  • Kang, Sang-Hyeok
    • Journal of the Korean Society of Hazard Mitigation
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    • v.7 no.5
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    • pp.159-166
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    • 2007
  • Large scale flood disasters bring human losses and properties, which lead to the decrease of our productive value and change social environment. Human loss and economic damage are considered to be the same system but they are viewed as separated systems. The total amount of human loss can be represented as the total amount of economic damage estimated in the frame of social system while it will be possible to make mutual changing by clearing the relations between social and economic systems. In this regard, an attempt to estimate economic loss considering per capita Gross Domestic Production (GDP) caused by flood-related mortality was carried out to the typhoon Rusa of 2002 in Kangwon-do. The proposed method tried to capture quantitative factors which are affecting the loss of per capita GDP. The approach has great importance not only to set up governmental policy but also methodological progress in the research due to impact of disaster-related mortality on GDP loss.

Damages, Human Behaviour and Recovery of Urban Residents in the 2005 West off Fukuoka Earthquake

  • Murakami, H.
    • 한국방재학회:학술대회논문집
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    • 2008.02a
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    • pp.13-18
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    • 2008
  • The 2005 west off Fukuoka earthquake with Mjma 7.0 occurred in the vicinity of Fukuoka city with 1.4 million populations, which had been regarded as rather seismically inactive in Japan. The strong motion records by K-net indicated PGV of 64 cm/s in Fukuoka city and some condominium buildings sustained extensive non-structural damages. In this study, we conducted a questionnaire survey for residents of 8 condominium buildings located in the downtown area of Fukuoka city after the earthquake. The results indicate that damaged nonstructural walls and distorted doors disrupted evacuation route for many occupants, and furniture and content damage on upper floors became severer resulting in higher rates of human casualty. Earthquake preparedness for indoor safety was raised after the earthquake, though further safety measures can be advised. In the phase of post-earthquake emergency and restoration period, residents' management organizations play important roles, so that neighborhood activities to promote communication networks are important in urban environment with aging population.

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Determination of nucleosides in human urine by high-performance liquid chromatography with electrospray ionization mass spectrometry(LC/ESI-MS)

  • Lee, Sang-Hee;Jung, Byung-Hwa;Kim, Sun-Yeou;Kim, Ho-Cheol;Chung, Bong-Chul
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.290.1-290.1
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    • 2003
  • Oxidative DNA damage has been associated with many disease. Quantation of DNA adducts is considered to be a useful biomarker of oxidative DNA damage because its formation can also be induced by oxidative stress. Extensive efforts have been taken to identify the analytical methods for minimizing the artifactual formation of oxidative DNA damage. We have done direct analysis of DNA adducts using LC/ESI-MS without urine sample extraction. (omitted)

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