• Biomolecules & Therapeutics
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• v.29 no.3
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• pp.268-272
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• 2021

Novel coronavirus (SARS-CoV-2) has caused more than 100 million confirmed cases of human infectious disease (COVID-19) since December 2019 to paralyze our global community. However, only limited access has been allowed to COVID-19 vaccines and antiviral treatment options. Here, we report the efficacy of the anticancer drug pralatrexate against SARS-CoV-2. In Vero and human lung epithelial Calu-3 cells, pralatrexate reduced viral RNA copies of SARS-CoV-2 without detectable cytotoxicity, and viral replication was successfully inhibited in a dose-dependent manner. In a time-to-addition assay, pralatrexate treatment at almost half a day after infection also exhibited inhibitory effects on the replication of SARS-CoV-2 in Calu-3 cells. Taken together, these results suggest the potential of pralatrexate as a drug repurposing COVID-19 remedy.

• Korean journal of aerospace and environmental medicine
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• v.31 no.1
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• pp.21-23
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• 2021

Purpose: Human papillomavirus (HPV) vaccination schedule is recommended by Strategic Advisory Group of Experts on Immunization of World Health Organization to achieve high efficacy and immunogenicity. However, the patients often cannot keep up their schedule for several reasons. Methods: Monthly numbers of visitors for HPV vaccination between 2019 and 2021 were analyzed to measure the impact of coronavirus disease-19 (COVID-19) outbreak which was the main cause of this delay. Results: In February 2020, the number of foreign patients vaccinated with HPV was dropped suddenly due to COVID-19. Prior to this impact, the average patients per month for HPV vaccination was 160 (95% confidence interval [CI]: 143-176). It was then 30 (95% CI: 20-40). However recent trends show a gradual recovery. Conclusion: If a woman is pregnant after starting the HPV vaccine series, the reminder doses should be delayed until she is no longer pregnant. If this series is interrupted for any length of time, it can be resumed without restarting the series. HPV vaccine series need to be administered with a minimum interval of 14 days before or after administration of COVID-19 vaccines.

• Korean Journal of Veterinary Service
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• v.46 no.4
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• pp.335-338
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• 2023

The COVID-19 pandemic, triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has not only impacted human health on a global scale but also raised concerns about the vulnerability of a wide array of animals that are in close contact with humans. Particularly, the potential for infection and the subsequent immune response in domestic pets such as dogs and cats remain largely unexplored under natural living conditions. In this study, we have undertaken the task of detecting and tracking the presence of antibodies against SARS-CoV-2 in a small cohort of household pets-specifically, two dogs and two cats. Employing techniques such as the indirect ELISA and plaque reduction neutralization tests, we observed that the neutralizing antibodies against SARS-CoV-2 in these animals were maintained for a duration of up to six months following their initial positive test result. This duration mirrors the antibody response documented in human cases of COVID-19, suggesting a comparable post-infection immune response timeline between humans and these domestic animals.

• Nutrition Research and Practice
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• v.15 no.sup1
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• pp.1-21
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• 2021

The coronavirus disease 2019 (COVID-19) pandemic has put focus on the importance of a healthy immune system for recovery from infection and effective response to vaccination. Several nutrients have been under attention because their nutritional statuses showed associations with the incidence or severity of COVID-19 or because they affect several aspects of immune function. Nutritional status, immune function, and viral infection are closely interrelated. Undernutrition impairs immune function, which can lead to increased susceptibility to viral infection, while viral infection itself can result in changes in nutritional status. Here, we review the roles of vitamins A, C, D, and E, and zinc, iron, and selenium in immune function and viral infection and their relevance to COVID-19.

• Journal of the Semiconductor & Display Technology
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• v.21 no.4
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• pp.14-17
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• 2022

Due to the development of IT technology and the on-going Coronavirus disease, non-face-to-face services have been activated. To overcome the inconvenience of non-face-to-face service, service providers have adopted chatbots as a way to feel like a human being. As the increasing chatbot services, chatbot builders have emerged, which can help non-developers to build them. Although its popularity has increased, its performance evaluation has not been conducted on such chatbot builders. In this paper, we implement a prototype chatbot that classifies hospital departments in the medical field using Dialogflow and Rasa, which are popular chatbot builders. By measuring the accuracy of the chatbot's classification of medical subjects, we evaluated the level of accuracy that the most used chatbot builder can have when they are used to build a chatbot service. The simulation results showed that Dialogflow had 87%, 65%, and 60%, and Rasa did 64%, 70%, and 63% in surgery dermatology, and otolaryngology, respectively.

• Korean journal of aerospace and environmental medicine
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• v.31 no.1
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• pp.1-3
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• 2021

In Vol. 31, No. 1, our journal prepared four review articles and two original papers. First, in commemoration of the 30th anniversary of our journal, the first review article described the history, development, and recent efforts for the qualitative improvement of the journal. For aviation workers, dizziness is an important disease that can interfere with their work. So, in the second review, we introduced guidelines that aviation medical examiners should be aware of in evaluating aviation workers who complain of dizziness. In the era of coronavirus disease 19 (COVID-19) pandemic, it is very important for aviation workers to get the vaccination safely and return to their work. So, Kwon introduced the latest updated guidelines for vaccination for aviation workers. In addition, Kim described the relationship between COVID-19 infection and respiratory allergic disease, and appropriate treatment guidelines. Lim investigated the recent trend of human papillomavirus vaccination for foreigners during the COVID-19 period, and investigated its implications. Finally, Ra developed various programs to strengthen students' global competencies and analyzed their satisfaction.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.33 no.3
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• pp.160-165
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• 2022

The coronavirus disease 2019 (COVID-19) pandemic has taken a toll on human lives and health systems worldwide and is still affecting all medical practices years later. In particular, much medical staff had to sacrifice in areas where the medical system was overloaded in the early stages of the outbreak and the resulting shortage of medical resources. In the future, another pandemic disease seems to emerge, which should threaten otolaryngologists inevitably. It is necessary to understand viral aerosolization and practice recommendations for COVID-19. These can guarantee the most effective treatment for the patients during the pandemic and protect the safety of our medical staff and patients.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.11
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• pp.1755-1758
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• 2022

One of the most negative social changes of the last decade is population aging which leads to 19 times more patients with Mild Cognitive Disorder(MCI). It is well established that MCI is the most important state that can prevent dementia with early diagnosis and intervention. However, the social security system for patients with dementia is not working properly due to the coronavirus pandemic and the limited human power. This article proposes a form of workbench and design principles for dementia training programs of extended reality devices. and the findings in this study provide a guide for considering the cognitive and physical and social functions of patients.

• Proceedings of the Korean Society of Computer Information Conference
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• 2021.07a
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• pp.283-284
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• 2021

최근 SARS-CoV-2 백신들의 예방접종이 진행됨에 따라 코로나 19 팬데믹의 종결이 예상되고 있다. 하지만 계속해서 출현 중인 변종 바이러스들은 팬데믹 종결의 위험요소로 남아있다. 본 논문에서는 사전학습된 단백질 BERT와 단백질-단백질 상호작용 모델을 활용한 SARS-CoV-2 스파이크 단백질의 변이 예측 분석 알고리즘을 제안한다. 제안하는 기술은 변이 단백질 서열의 예측과 변이 단백질과 human ACE2 수용체의 친화도에 따른 자연선택으로 이루어진다. 이를 통해 시간이 지나며 나타날 수 있는 변종 바이러스들을 시뮬레이션 할 수 있어 변종 바이러스들의 해결에 기여할 것으로 기대된다.

• The Journal of KAIRB
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• v.2 no.2
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• pp.33-36
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• 2020

In December 2019, coronavirus disease 2019 (COVID-19) was discovered in Wuhan, China. The disease was so severe that as early as 30 January 2020 COVID-19 was declared by WHO as a Public Health Emergency of International Concern. There have been a lot of concerns about conducting COVID-19 clinical researches scientifically and ethically in pandemic. This article is directed at addressing these issues from the perspective of IRB. First of all, the urgency of COVID-19 research requires prompt IRB process through efficient ethics review and oversight system. IRB should determine whether the risks that will be presented to human subjects are justified after assessing possible harm and anticipated benefits. The safety of subjects should not be compromised. Furthermore, informed consent should be voluntarily obtained by sufficient information in consideration of special circumstances during a pandemic.