• Transactions of the Korean Society of Automotive Engineers
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• v.4 no.4
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• pp.97-106
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• 1996

The impact response of the human brain has been determined by three-dimensional finite element modeling. The model includes a layered shell closely representing the cranial bones with the interior contents occupied by an incompressible contimuum to simulate the brain. Flax and tentorium modeled with 4 node membrane element were also incorporated. The computed pressure-time histories at 4 locations within the brain element compared quite favorably with previously published experimental data from cadaver experiments. A parametric study was subsequently conducted to identify the model response when the impact were varied.

• Animal cells and systems
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• v.8
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• pp.18-18
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• 2004

• BMB Reports
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• v.56 no.3
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• pp.172-177
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• 2023

BEST family is a class of Ca²⁺-activated Cl- channels evolutionary well conserved from bacteria to human. The human BEST paralogs (BEST1-BEST4) share significant amino acid sequence homology in the N-terminal region, which forms the transmembrane helicases and contains the direct calcium-binding site, Ca²⁺-clasp. But the cytosolic C-terminal region is less conserved in the paralogs. Interestingly, this domain-specific sequence conservation is also found in the BEST1 orthologs. However, the functional role of the C-terminal region in the BEST channels is still poorly understood. Thus, we aimed to understand the functional role of the C-terminal region in the human and mouse BEST1 channels by using electrophysiological recordings. We found that the calcium-dependent activation of BEST1 channels can be modulated by the C-terminal region. The C-terminal deletion hBEST1 reduced the Ca²⁺-dependent current activation and the hBEST1-mBEST1 chimera showed a significantly reduced calcium sensitivity to hBEST1 in the HEK293 cells. And the C-terminal domain could regulate cellular expression and plasma membrane targeting of BEST1 channels. Our results can provide a basis for understanding the C-terminal roles in the structure-function of BEST family proteins.

• Preventive Nutrition and Food Science
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• v.20 no.4
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• pp.230-237
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• 2015

This study investigated the impact of microalgal oil (MO) on body weight management in C57BL/6J mice. Obesity was induced for 8 weeks and animals were orally supplemented with the following for 8 additional weeks: beef tallow (BT), corn oil, fish oil (FO), microalgal oil (MO), or none, as a high fat diet control group (HD). A normal control group was fed with a normal diet. After completing the experiment, the FO and MO groups showed significant decreases in body weight gain, epididymal fat pad weights, serum triglycerides, and total cholesterol levels compared to the HD and BT groups. A lower mRNA expression level of lipid anabolic gene and higher levels of lipid catabolic genes were observed in both FO and MO groups. Serum insulin and leptin concentrations were lower in the MO group. These results indicated that microalgal oil has an anti-obesity effect that can combat high fat diet-induced obesity in mice.

• International Journal of Stem Cells
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• v.16 no.4
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• pp.385-393
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• 2023

In vertebrates, the entire central nervous system is derived from the neural tube, which is formed through a conserved early developmental morphogenetic process called neurulation. Although the perturbations in neurulation caused by genetic or environmental factors lead to neural tube defects (NTDs), the most common congenital malformation and the precise molecular pathological cascades mediating NTDs are not well understood. Recently, we have developed human spinal cord organoids (hSCOs) that recapitulate some aspects of human neurulation and observed that valproic acid (VPA) could cause neurulation defects in an organoid model. In this study, we identified and verified the significant changes in cell-cell junctional genes/proteins in VPA-treated organoids using transcriptomic and immunostaining analysis. Furthermore, VPA-treated mouse embryos exhibited impaired gene expression and NTD phenotypes, similar to those observed in the hSCO model. Collectively, our data demonstrate that hSCOs provide a valuable biological resource for dissecting the molecular pathways underlying the currently unknown human neurulation process using destructive biological analysis tools.

• Journal of Digital Contents Society
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• v.7 no.1
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• pp.15-23
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• 2006

The hamonious development of human brain has been an indigenous objective of each age. A variety of training programs related to the purpose have turned up at an educational market and a commercial market, as well. I'd like to indicate, however, that these training methods are somewhat prejudiced and have some elements, inherently, which are against the development of human brain for one's whole personality. Therefore, the most desirable brain training program is to induce it to respond to various stimuli, to educate for itself and to generate continuously, to create and strengthen an innumerous synapse among brain cells, so as to form a nero-network. In this study, I have used a brain training program with multimedia which have been produced for a specific purpose. With this method, by measuring directly the effectiveness of human brain development, I have analysed more objectively and more quantitatively.

• Journal of Korean Philosophical Society
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• v.131
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• pp.131-163
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• 2014

This Paper aims to elaborate on the origin of thinking mind. And this is a cooperative project between philosophy and neuroscience and brain science. I have written this paper in admiration for the achievements of twentieth century neuroscience and brain science, and out of desire to assist the subject in future. Much of the history of modern philosophy, from Descartes and Kant forward, consists of failed models of brain. As Edward O. Wilson precisely said, the shortcoming is not the fault of the philosophers, who have doggedly pushed their methods to the limit, but a straightforward consequence of the biological evolution of the brain. Guiding that investigation down pathways that will illuminate brain research is a task of neuroscience and brain science. Investigating logical relations among concepts is a philosophical task. If we are to understand the neural structures and dynamics that make perception, thought, intentional behaviour possible, clarity about these concepts and categories and their relations is essential. Hence our joint venture of philosophy and science. Sure, it is human beings that perceives, not parts of its brain. And it is human beings that who think and reason, not their brain. But the brain and its activities make it possible for human beings-not for it-to perceive and think, to feel emotions, and to form and pursue projects. Thus We try to investigate and reveal the origin of thinking mind as follow: 1) The difference between chimpanzee and human beings 2) brain and mind 3) the origin of thinking 4) the wisdom of nature.

• Proceedings of the KOSOMBE Conference
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• v.1994 no.12
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• pp.3-5
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• 1994

• Food Industry And Nutrition
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• v.4 no.3
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• pp.55-58
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• 1999

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.1745-1748
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• 2005

Near-infrared spectroscopy (NIRS) can be used to monitor brain activation by measuring changes in the concentration of oxy- and deoxy-hemoglobin (Hb) by their different spectra in the near-infrared range. Because NIRS is a noninvasive, highly flexible and portable device, it is very suitable to study brain activation when a human repeatedly performs a manipulative task, and possibly provides useful information to construct human adaptive mechatronics (HAM). There is some evidence that the dorsolateral prefrontal cortex (DLPFC) plays a major role in working memory and it is proposed that the use of working memory decreases as a human develops manipulative skills. In the present study, we investigated the activation of the dorsolateral prefrontal cortex (DLPFC) of the brain in Brodmann's areas 9 and 46 in drawing tasks to examine whether NIRS can measure the changes of DLPFC activation as a human develops manipulative skills. Subjects performed a mirror image drawing task and a square drawing task by ones' left hands. In the mirror image task the subject drew following a star shape based on a mirror image of it, but square drawing did not involve mirror image and was estimated to be simpler. The changes of the concentration of oxy-Hb was higher in the mirror image drawing than the square drawing in most subjects. The changes of oxy-Hb decreased as the subject repeated the drawing task in most subjects. In conclusion, The activation of DLPFC measured by NIRS can reflect the brain activity in the development of manipulative skills.