• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.8
• /
• pp.4553-4557
• /
• 2013

Objective: The purpose of this study was to identify genes related to bladder cancer with samples from normal and disease cases by microarray chip. Methods: After downloading the gene expression profile GSE3167 from Gene Expression Omnibus database which includes 50 bladder samples, comprising 9 normal and 41 disease samples, differentially expressed genes were identified with packages in R language. The selected differentially expressed genes were further analyzed using bioinformatics methods. Firstly, molecular functions, biological processes and cell component analysis were researched by software Gestalt. Then, software String was used to search interaction relationships among differentially expressed genes, and hub genes of the network were selected. Finally, by using plugins of software Cytoscape, Mcode and Bingo, module analysis of hub-genes was performed. Results: A total of 221 genes were identified as differentially expressed by comparing normal and disease bladder samples, and a network as well as the hub gene C1QBP was obtained from the network. The C1QBP module had the closest relationship to production of molecular mediators involved in inflammatory responses. Conclusion: We obtained differentially expressed genes of bladder cancer by microarray, and both PRDX2 and YWHAZ in the module with hub gene C1QBP were most significantly related to production of molecular mediators involved in inflammatory responses. From knowledge of inflammatory responses and cancer, our results showed that, the hub gene and its module could induce inflammation in bladder cancer. These related genes are candidate bio-markers for bladder cancer diagnosis and might be helpful in designing novel therapies.

• Journal of Korean Society of Transportation
• /
• v.29 no.2
• /
• pp.91-100
• /
• 2011

Hub network design for freight transportation is a decision process that determines hub locations together with freight transportation routes among shippers so as to ultimately minimize total logistics cost. This study presents the optimal location of hubs by strict hub network design policy with single allocation, which overcomes the limitation of Kim et al. (2008) that does not allow direct transportation among shippers. The greedy-interchange algorithm is employed for hub location decision process, and EMME/2 is adopted for the route searching process. Application of the processes to the nationwide highway network shows that the best hub locations in order are Seoul metropolitan, GyeongNam, Chung-nam, Jeon-Nam, Gyeong-Buk, Chung-Buk, and the locations are concentrated on the Seoul-Busan corridor. The strict hubnetwork design policy with single allocation increases the transportation distance but decreases the transportation cost by passing through the hubs instead of direct transportation. The reduction in total transportation cost can be achieved as the number of hubs increases, but the amount of the reduction gradually decreases because the cost reduction from the decrease in detour transportation distance between non-hubs and hubs becomes less than the discount reduction from dispersion of inter-hubs transportation volumes.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.19 no.6
• /
• pp.137-146
• /
• 2018

The purpose of this study was to derive and analyze the hub facilities that occupy major positions in the vehicle movement networks of livestock facilities. For this purpose, this study used the KAHIS data provided by Animal and Plant Quarantine Agency. The hub facilities were derived from the degree centrality & betweenness centrality. The analysis results are summarized as follows. First, in a livestock facility's vehicle movement network, there are a small number of hub facilities with very high centrality indicator values compared to other facilities. Second, the hub facilities based on the degree centrality are the feed factory, the milk collecting center, slaughterhouse, slaughterhouse for chicken, and livestock markets. Third, the hub facilities based on the betweenness centrality are the livestock markets, the feed factory, and slaughterhouse. Fourth, hub facilities based on the degree centrality are concentrated in a particular area, but the hub facilities based on betweenness centrality are distributed relatively evenly.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.39 no.2
• /
• pp.103-112
• /
• 2016

As supply chains are globalized, multinational companies are trying to optimize distribution networks using a hub and spoke structure. In this hub and spoke network structure, multinational companies locate regional distribution centers at hub airports, which serve demands in their corresponding regions. Especially when customers put higher priority on the service lead-time, hinterlands of international hub airports become ideal candidate locations for the regional hub distribution centers. By utilizing excellent airport and logistics services from hub airports, regional distribution centers in the hub airports can match supply with demand efficiently. In addition, regional hub distribution centers may increase air cargo volume of each airport, which is helpful in the current extremely competitive airport industry. In this paper, we classified locational preferences into three primary categories including demand, service and risk and applied the analytic hierarchy process methodology to prioritize factors of locational preferences. Primary preference factors include secondary factors. Demand factor contains access to current and prospect markets. Service factor comprises airport and logistics perspectives. Service factor in terms of airport operations includes secondary factors such as airport service and connectivity. Service factor in terms of logistics operations contains infrastructure and logistics operations efficiency. Risk factor consists of country and business risks. We also evaluated competitiveness of Asian hub airports in terms of candidate location for regional hub distribution centers. The candidate hub airports include Singapore, Hong Kong, Shanghai, Narita and Incheon. Based on the analytic hierarchy process analysis, we derived strategic implications for hub airports to attract multinational companies' regional hub distribution centers.

• Proceedings of the Korea Contents Association Conference
• /
• 2008.05a
• /
• pp.842-845
• /
• 2008

The protein interaction network contains a small number of highly connected protein, denoted hub and many destitutely connected proteins. Recently, several studies described that a hub protein is more likely to be essential than a non-hub protein. This phenomenon called as the centrality-lethality rule. This rule is widely credited to exhibit the importance of hub proteins in the complex network and the significance of network architecture as well. To confirm whether the rule is accurate, we investigated all protein interaction DBs of yeast in the public sites such as Uetz, Ito, MIPS, DIP, SGD, and BioGRID. Interestingly, the protein network shows that the rule is correct in lower scale DBs (e.g., Uetz, Ito, and DIP) but is not correct in higher scale DBs (e.g., SGD and BioGRID). We are now analyzing the features of networks obtained from the SGD and BioGRD and comparing those of network from the DIP.

• International Journal of Computer Science & Network Security
• /
• v.21 no.12
• /
• pp.21-28
• /
• 2021

In this paper, a novel data transferring method is introduced that can transmit sensor data without using data bandwidth or an extra-processing cycle in a delay insensitive network. The proposed method uses human devices as Mules, does not disturb the device owner for permission, and saves energy while transferring sensor data to the collection hub in a wireless sensor network. This paper uses IP addressing technique as the data transferring mechanism by embedding the sensor data with the IP address of a Mule. The collection hub uses the ARP sequence method to extract the embedded data from the IP address. The proposed method follows WiFi standard in its every step and ends when data collection is over. Every step of the proposed method is discussed in detail with the help of figures in the paper.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.38 no.9
• /
• pp.652-662
• /
• 2001

A WDM/SCM multiple access protocol suitable for optical double star networks is proposed. A node-grouping scheme is employed in the protocol, which is accomplished by connecting some nodes through passive star sub-hubs forming a group. The resulting multiple groups in a network are then connected through a central passive star hub resulting in a passive double star network. Each group is pre-assigned a WDM channel as its home channel, and SCM channels are used to identify the packet reception at each node. [n the proposed protocol, the average packet delay is remarkably reduced since the frame consists of the number of groups rather than the number of network nodes. Furthermore, additional reduction of the average packet delay is achieved by limiting the propagation paths of control packets to the roundtrip between source nodes and sub-hub using a double star network. It is shown in the performance evaluations using analytic and simulation model that the proposed protocol has the advantages of the higher channel utilization and excellent network throughput and average packet delay characteristic.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
• /
• v.27
• /
• pp.69-95
• /
• 2005

East Asia has played an important role in the economic and social development in the Asian pacific region and in the global arena. In the region the impact of companies centralizing their logistics activities around a few distribution centers has already led some leading ports such as Singapore, Hong Kong to transform and expand their functions and business activities to provide port users with value added logistics services. Other ports in the region also have an important part to play in the total logistics Chain. In these environments, the maritime activities of Jang BoGo, who was the maritime king of the commercial maritime empire in East Asia in the 9th century, give many implications to the international logistics network strategy that Korea has to take in order to become a power of International Logistics. Though the trading and economic environments at that time may be quite different from today, the super-national maritime management pattern that Jang Bo-go, founder of the Northeast Asian maritime trading kingdom devised, gives us many implications in the global trading and economic environments, in the respects of overseas direct investment and international logistics. Accordingly, the paper aims to examine the establishment of hub port in Northeast Asia, modelled after the maritime network management strategy of Jang BoGo.

• Journal of Korean Neurosurgical Society
• /
• v.65 no.5
• /
• pp.697-709
• /
• 2022

Objective : The present study aimed to identify the function of ischemic stroke (IS) patients' peripheral blood and its role in IS, explore the pathogenesis, and provide direction for clinical research progress by comprehensive bioinformatics analysis. Methods : Two datasets, including GSE58294 and GSE22255, were downloaded from Gene Expression Omnibus database. GEO2R was utilized to obtain differentially expressed genes (DEGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs were performed using the database annotation, visualization and integrated discovery database. The protein-protein interaction (PPI) network of DEGs was constructed by search tool of searching interactive gene and visualized by Cytoscape software, and then the Hub gene was identified by degree analysis. The microRNA (miRNA) and miRNA target genes closely related to the onset of stroke were obtained through the miRNA gene regulatory network. Results : In total, 36 DEGs, containing 27 up-regulated and nine down-regulated DEGs, were identified. GO functional analysis showed that these DEGs were involved in regulation of apoptotic process, cytoplasm, protein binding and other biological processes. KEGG enrichment analysis showed that these DEGs mediated signaling pathways, including human T-cell lymphotropic virus (HTLV)-I infection and microRNAs in cancer. The results of PPI network and cytohubba showed that there was a relationship between DEGs, and five hub genes related to stroke were obtained : SOCS3, KRAS, PTGS2, EGR1, and DUSP1. Combined with the visualization of DEG-miRNAs, hsa-mir-16-5p, hsa-mir-181a-5p and hsa-mir-124-3p were predicted to be the key miRNAs in stroke, and three miRNAs were related to hub gene. Conclusion : Thirty-six DEGs, five Hub genes, and three miRNA were obtained from bioinformatics analysis of IS microarray data, which might provide potential targets for diagnosis and treatment of IS.

• Journal of Korean Society of Transportation
• /
• v.27 no.1
• /
• pp.129-141
• /
• 2009

Intermodal freight transportation is defined as the movement of freight from origins to destinations by two or more transportation modes. When implemented in hub networks, it could enhance the efficiency of the networks because consolidated flows are transported by more suitable modes and technologies. In spite of this advantage, the intermodal hub network design problem has received limited attention in the literature partly because of the complex nature of the problem. This paper aims to develop an optimization model for designing intermodal hub networks with sin91e allocation strategy. The model takes into account various cost components of intermodal hub networks including transportation, stationary inventory, and service delay costs. Moreover, using transport frequency variables, it is capable of endogenously determining the transportation economies of scale achieved by consolidation of flows. As such, the model is able to realistically represent the characteristics of intermodal hub networks in practice. Since the model Is a complicated nonlinear integer programming problem, we perform model simplification based on the analytical study of the model, which could facilitate the development of solution algorithms in the future. We expect that this study contributes to the design of intermodal hub networks as well as to the assessment of existing logistics systems.