• Genomics & Informatics
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• v.21 no.3
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• pp.38.1-38.8
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• 2023

Non-small cell lung cancer (NSCLC) is an important cause of cancer-associated deaths worldwide. Therefore, the exact molecular mechanisms of NSCLC are unidentified. The present investigation aims to identify the miRNAs with predictive value in NSCLC. The two datasets were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed miRNAs (DEmiRNA) and mRNAs (DEmRNA) were selected from the normalized data. Next, miRNA-mRNA interactions were determined. Then, co-expression network analysis was completed using the WGCNA package in R software. The co-expression network between DEmiRNAs and DEmRNAs was calculated to prioritize the miRNAs. Next, the enrichment analysis was performed for DEmiRNA and DEmRNA. Finally, the drug-gene interaction network was constructed by importing the gene list to dgidb database. A total of 3,033 differentially expressed genes and 58 DEmiRNA were recognized from two datasets. The co-expression network analysis was utilized to build a gene co- expression network. Next, four modules were selected based on the Z_summary score. In the next step, a bipartite miRNA-gene network was constructed and hub miRNAs (let-7a-2-3p, let-7d-5p, let-7b-5p, let-7a-5p, and let-7b-3p) were selected. Finally, a drug-gene network was constructed while SUNITINIB, MEDROXYPROGESTERONE ACETATE, DOFETILIDE, HALOPERIDOL, and CALCITRIOL drugs were recognized as a beneficial drug in NSCLC. The hub miRNAs and repurposed drugs may act a vital role in NSCLC progression and treatment, respectively; however, these results must validate in further clinical and experimental assessments.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2006.10a
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• pp.203-212
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• 2006

The purpose of this research is to suggest the activation plan of Busan port. In the past years, Busan port enjoyed the golden days because of the China's rapid economic growth. But China's continuous development of ports, the trend of increasing container ship size and increasing direct call to China are coming threats to Busan port. So Korea needs to revise the 'Northeast Logistics Hub' strategy because it is considered that Korea ports continuously will handle China's transshipment cargoes. But now China's transshipment cargo share has decreased by direct call to China ports. It means that China has a lot of its local cargoes, so many ship companies change liner service route to handle China cargoes except Bussan ports although Busan port is included in the main trunk route. In the future, Bussan port will not be able to compete again about throughput with China ports if Busan port's transshipment cargo share decreases. So we must find out and develop Busan port's strength which is the competitive edge. By good luck, Busan port has a few opportunities such as the developed feeder network service and geographical advantages. Busan port has many feeder network service like spider's web in any northeast countries so we can suggest that if Japanese shippers use Busan port to distribute their cargoes to Japanese local areas, its transport costs are cheaper than when they use Japan's main ports. In this paper analyzed side of cost when they use Bussan port like hub to distribute their cargo to their local areas. Because most companies tried to reduce the total cost about logistics. Finally, this paper suggests when northeast shippers(China, Japan) use Bussan port which is more economical than their local main ports.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.24 no.9B
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• pp.1601-1607
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• 1999

LMDS(Local Multipoint Distribution Service) is a broadband wireless transmission system in millimeter wave frequency. LMDS system is consisted with relay system to connect between head-end and hub and distribution system to connect between hub and subscribers. In this study, we develop point-to-point relay system to use back-bone system n LMDS network. We develop STM-1 transceiver over 27GHz and analyze the system performance. We can get the similar measurement results comparing the theoretical results and then prove that this system can fit LMDS back-bone network requirement. This is the first system in Korea and we expect this system can apply the various network.

• International Journal of Computer Science & Network Security
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• v.24 no.5
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• pp.21-32
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• 2024

This study analyzes the global literature on the black open-access phenomenon from 2011 to 2023. A bibliometric analysis was conducted using the Scopus database. The search strategy employed advanced queries with multiple synonymous terms to ensure exhaustive retrieval of relevant documents. The VOSviewer software was employed to visualize the co-occurrence networks. The findings reported 90 papers published during the study period. An evolving scholarly landscape was revealed, with heightened attention from 2016 onwards, peaking in 2017, 2021, and 2023. Articles constitute 83.3% of the total published documents. Singh and Srichandan are prolific authors, with 11.2% of the total publications. The United States contributes 18.9% of the papers, followed by India and Spain. Information Development and Scientometrics are pivotal journals in scholarly discussions about this scope, contributing 4.4% of publications. Co-occurrence network visualization revealed "Sci-Hub" and "open access" as the most used keywords in the global literature. The findings underscore the need for additional research to discover innovative business models to safeguard intellectual property rights while meeting researchers' evolving needs. The importance of this paper comes from being the first bibliometric study analyzing international literature related to this phenomenon, which provides a basis for future research efforts and policymaking.

• Journal of Korean Society of Transportation
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• v.35 no.3
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• pp.247-259
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• 2017

This study analyzed the network of low cost carriers (LCCs) to investigate the structural characteristics of airport networks. 71 LCCs in Asian major airports from January 2010 to January 2016 were queried from the SRS Analyzer Schedule Database of IATA's Airport Intelligence Service, and analyzed international routes excluding domestic flights. We analyzed the network connection mechanism focusing on Incheon International Airport, Hong Kong, Singapore, Narita, Kansai, Pudong, Kaohsiung, Gimpo and Jeju airports as well as structural changes in the LCC network using four centrality analysis concepts. The outcomes showed that the LCC network is formed in these airports and the density of connectivity to other airports increased. In recent years, LCC has launched LCCs-Alliances and would be considered to operate a hub-and-spoke network.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.11B
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• pp.1363-1372
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• 2011

Flooding based routing protocols are usually used to disseminate information in wireless sensor networks. Those approaches, however, require message retransmissions to all nodes and induce huge collision rate and high energy consumption. In this paper, HoGoP (Hop based Gossiping Protocol) in which all nodes consider the number of hops from sink node to them, and decide own gossiping probabilities, is introduced. A node can decide its gossiping probability according to the required average reception percentage and the number of parent nodes which is counted with the difference between its hop and neighbors' ones. Therefore the decision of gossiping probability for network topology is adaptive and this approach achieves higher message reception percentage with low message retransmission than the flooding scheme. Through simulation, we compare the proposed protocol with some previous ones and evaluate its performance in terms of average reception percentage, average forwarding percentage, and forwarding efficiency. In addition, average reception percentage is analyzed according to the application requirement.

• Journal of Korean Society of Rural Planning
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• v.23 no.1
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• pp.1-10
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• 2017

The community bridge node finder, based on the stochastic method of network analysis, can compute hubs spot, which would enable the use of network structures with limited information. However, applying this node finder to heterogeneity networks, which are efficient to analyze the main farm complex in fields and the spread of infectious disease, is difficult. These problems, The most connected point that is called hub is often a major role in the heterogeneity network. In this study, we therefore improved the community bridge node finder to enable it to be applied to heterogeneity networks. We attempted to calculate the bridge node quantitatively by using the modularity of cohesion analysis method and the community bridge node finder. Application of the improved method to the HPAI(Highly Pathogenic Avian Influenza) spread in Korea 2008 produced a quarantine coefficient that was 4 - 37% higher than the quarantine coefficient obtained with the centrality method for the first 14 days after the HPAI outbreak. We concluded that the improved method has the ability to successfully calculate the bridge node in heterogeneity networks based on network structures with scant information, such as those describing the spread of infectious disease in domestic animals. And Our method should be capable to find main farm complex in fields.

• Bioinformatics and Biosystems
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• v.2 no.2
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• pp.71-74
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• 2007

Cell phenotypes are determined by groups of functionally related genes. Microarray profiling of gene expression provides us response of cellular state to its perturbation. Several methods for uncovering a cellular network show reliable network reconstruction. In this study, we present reconstruction of genetic regulatory network of inflammation bowel disease in human peripheral blood mononuclear cell. The microarray based on Affymetrix Gene Chip Human Genome U133 Array Set HG-U133A is processed and applied network reconstruction algorithm, ARACNe. As a result, we will show that inferred network composed of 450 nodes and 2017 edges is roughly scale-free network and hierarchical organization. The major hub, CCNL2 (cyclin A2), in inferred network is shown to be associated with inflammatory function as well as apoptotic function.

• Journal of Korean Society of Transportation
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• v.26 no.5
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• pp.117-127
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• 2008

After the deregulation of the aviation market in the United States in 1978, airlines took advantage of the possibilities of the liberalized market and reorganized their networks. Then, the hub-and-spoke networks became widely used in the aviation market. The framework of hub-and-spoke network made it feasible to amplify flight networks. Thus, a number of airlines were able to fly to more destinations than ever before through the networks. Amplification of networks can be implementing through the transfer of passengers, transshipment of cargo, or both most researches have been concentrated on the passenger aspect at airports worldwide. Air cargo, however, has become one of the most significant areas at hub airports to keep their leading position in terms of the provision of services and handling volumes. This paper investigates the connectivity of airfreight networks as the temporal concentrations in current network at Incheon International Airport. In order to evaluate airline flight schedule effects to stimulate hubbing at an airport, the indirect connectivity can be considered to be the number of direct frequencies, the minimum connecting times and the quality of the connection determine indirect connectivity. Therefore the connectivity of freight transshipment depends on both the quality of the connection at the hub airport and the quality of the indirect flight compared to the direct flight. In addressing these issues, this paper analyzes the connectivity of flight schedules using a temporal wave-system structure and estimates the degree of connectivity and quality of connectivity applying the NETSCAN model.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.5
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• pp.106-114
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• 2015

Wireless Body Area Network(WBAN) is a network standard around a human body which connects various medical sensor and devices It has to satisfy various demands such as data transmission rate, priority, and delay time. In this paper, considering a data priority and transmission delay time, is proposed to improve efficiency of WBAN service depending on congestion status of network. The proposed algorithm operates with adapted data removal probability according to data priority when the hub buffer is congested than before. And in the case of lower congestion within the hub buffer data is served considering data delay time. Through the comparison with other existing scheduling algorithms, it is confirmed that quality of WBAN service is improved due to lower data loss rate of medical data and less delay time in the proposed algorithm.