• Neonatal Medicine
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• 제25권4호
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• pp.178-185
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• 2018

Purpose: We aim to assess the Bayley Scales of Infant and Toddler Development, third edition (Bayley-III), Adaptive Behavior (AB) and Social-Emotional (SE) scales at 18 to 24 months of corrected age (CA) to examine their associations with school-age cognitive and behavioral outcomes in children born preterm. Methods: Eighty-eight infants born with a very low birth weight (<1,500 g) or a gestational age of less than 32 weeks who were admitted to the neonatal intensive care unit from 2008 to 2009 were included. Of the 88 children who completed school-age tests at 6 to 8 years of age, 37 were assessed using the Bayley-III, including the AB and SE scales, at 18 to 24 months of CA. Correlation, cross-tabulation, and receiver operating characteristic analyses were performed to assess the longitudinal associations. Results: A significant association was observed between communication scores on the Bayley-III AB scale at 18 to 24 months of CA and the Korean version of the Wechsler Intelligence Scale for Children (K-WISC) full-scale intelligence quotient (FSIQ) at school age (r=0.531). The total behavior problem scores of the Korean version of the Child Behavior Checklist (K-CBCL) at school age were significantly negatively related to the Bayley-III SE and AB scales but not to the cognitive, language, or motor scales. Conclusion: Our findings encourage AB and SE assessments during the toddler stage and have important implications for the early identification of children in need of intervention and the establishment of guidelines for follow-up with high-risk infants.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제26권4호
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• pp.15-26
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• 2020

Purpose: The purpose of this study is to derive a plan to establish a more sophisticated master plan so that the direction of master plan study can be sustained in the mid to long term. Methods:: Compare and analyze the differences between the master plan and the design to identify causes and problems. First, after establishing the master plan, compare the expansion area, net area per bed, and service area with the design drawing of the first project to determine the degree of recovery to the level required by the recent medical environment. Second, the possibility of responding to future internal changes is reviewed by comparing and analyzing the arrangement and connection method of extension buildings. Third, comparing the difference between the project following the first project and the phased of masterplan. Results: The first one is that continuous participation of person or group with high understanding of the master plan. Second, establishing a master plan and proceeding with the project through the determination of the correct business budget. Third, a specific area of the mechanical and electrical room suitable for the size and purpose of the hospital should be presented, and research on the arrangement method should be conducted. Finally, the feasibility of the hospital's own plan for securing parking facilities should be accurately investigated. Implications: It is important for the hospital to recover from the past to the present and respond to the future that the direction of the master plan continues after the establishment.

• 대한치매학회지
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• 제21권2호
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• pp.45-58
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• 2022

Recently, aducanumab, a beta amyloid targeted immunotherapy, has been approved by the US Food and Drug Administration for the treatment of Alzheimer's dementia (AD). Although many questions need to be answered, this approval provides a promising hope for the development of AD drugs that could be supported by new biomarkers such as blood-based ones and composite neuropsychological tests that can confirm pathologic changes in early stages of AD. It is important to elucidate the complexity of AD which is known to be associated with other factors such as vascular etiologies and neuro-inflammation. Through the second international conference of the Korean Dementia Association (KDA), researchers from all over the world have participated in the exchange of opinions with KDA members on the most up-to-date topics. The Academic Committee of the KDA summarizes lectures to provide the depth of the conference as well as discussions. This will be an important milestone to widen the latest knowledge in the research of AD's diagnosis, therapeutics, pathogenesis that can lead to the establishment of future directions.

• 한국병원경영학회지
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• 제9권3호
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• pp.71-97
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• 2004

This study conducted a comparative analysis of awareness level of review standards, continuing education, and awareness about the need for speciality and educational courses in order to improve quality of Korean health insurance review work and to present directions for policies of personnel development and continuing education to smoothly perform hospital's insurance claim work and Agency's review work. The analysis unit of the study is individuals, and survey was conducted among hospital's claim officers and Agency' review officers by distributing questionnaires. The major results of the study are as follows: First, it is found that hospital's claim officers and Agency's review officers have conflicting awareness about review standards; more Agency's review officers think that current review standards are universal and reasonable, while more hospital's claim officers believe that they need to be revised. Especially, hospital's claim officers replied that it is possible that review results can differ according to government's policies. Second, there is no significant difference between the two groups in the opinion that there are individual differences in awareness level of review standard. In particular, both groups share the opinion that review results can differ according to officer's interpretation of review standards. Third, Both review officer groups feel the need for further training and continuing education. Fourth, there is no difference between the two groups in the opinion that both groups members should be educated in review related educational institutions. However, while 81.5% of Agency's review officers the education should be offered at the Agency, only 45.2% of hospital's claim officers agreed to it. Fifth, both review personnel do not show any difference in awareness of needed experience to successfully perform review work; both groups replied that three to four years experience is necessary to smoothly perform claim work and review work. This study was tried in order to search for directions to improve Korean insurance review work in quality rather than to explore characteristics themselves of individual factors. In this sense, this study presupposed an intention that the educational subjects for further training and continuing education for the two groups should be the same in order to narrow the awareness gap between hospital's claim officers and Agency's review officers. Thus, this study suggests that it is desirable to offer beginner courses at junior colleges or in undergraduate courses and advanced courses in professional graduate school for six to twelve months. In that a comparison of awareness level of hospital's claim officers and Agency's review officers who are actually in practice should precede appropriate presentation of directions for the qualitative improvement of insurance review work in Korea, the significance of this study lies in comparatively analyzing the awareness level of hospital's claim officers and Agency's review officers and in presenting the establishment of future further training and continuing education.

• 정보과학회 컴퓨팅의 실제 논문지
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• 제23권6호
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• pp.359-370
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• 2017

해외병원 프로젝트는 정보통신기술과 첨단의료기기의 발전으로 원격진료, Smart-health, City Like Hospital 개념 확산과 IT 비중이 증가하는 디지털병원으로 변화하는 추세이다. 디지털병원에서 IT역할은 첨단화 되어가는 시공, 기계, 전기, 시스템, 의료장비를 연계하여 통합함으로써 병원운영의 효율성을 극대화 시키는 것이 핵심 요소이다. 본 연구에서는 해외에서 발주되었던 5개의 디지털병원 프로젝트를 대상으로 입찰요구서를 IT 관점에서 분석하고 디지털병원 성공요인을 제안한다. 연구방법은 문헌조사를 통해서 디지털병원 개념과 발전과정을 분석하며, 디지털병원 시스템은 입찰요구서를 분석해서 디지털병원에 적용된 시스템과 기술수준을 분석하고, 최종적으로 디지털병원 성공요인은 프로젝트 성공관리기법에서 제안하는 원가, 공기, 품질 측면에서 분석한다. 연구 성과는 원가측면에서는 IT 및 병원 인프라 운영관점에서 가치를 증대하는 가치공학(Value Engineering) 전략 수립이 필요하고, 공기측면에서는 병원 내 시스템을 통합 테스트하는 Integrated Test & Commissioning 단계에서의 공사기간 준수가 필요하며, 품질측면에서는 사용자 요구사항이 반영된 System Integration을 통해 디지털병원이 지향하는 서비스 성능을 보장하는 것이 디지털병원 수출사업의 성공요인이라고 제시한다.

• Tuberculosis and Respiratory Diseases
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• 제82권1호
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• pp.27-34
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• 2019

Background: Understanding the burden of disease is important to establish cost-effective treatment strategies and to allocate healthcare resources appropriately. However, little reliable information is available regarding the overall economic burden imposed by chronic obstructive pulmonary disease (COPD) in Korea. Methods: This study is a multicenter observational research on the COPD burden in Korea. Total COPD costs were comprised of three categories: direct medical, direct non-medical, and indirect costs. For direct medical costs, institutional investigation was performed at 13 medical facilities mainly based on the claims data. For direct non-medical and indirect costs, site-based surveys were administered to the COPD patients during routine visits. Total costs were estimated using the COPD population defined in the recent report. Results: The estimated total costs were approximately 1,245 million US dollar (1,408 billion Korean won). Direct medical costs comprised approximately 20% of the total estimated costs. Of these, formal medical costs held more than 80%. As direct non-medical costs, nursing costs made up the largest percentage (39%) of the total estimated costs. Costs for COPD-related loss of productivity formed four fifths of indirect costs, and accounted for up to 33% of the total costs. Conclusion: This study shows for the first time the direct and indirect costs of COPD in Korea. The total costs were enormous, and the costs of nursing and lost productivity comprised approximately 70% of total costs. The results provide insight for an effective allocation of healthcare resources and to inform establishment of strategies to reduce national burden of COPD.

• Journal of Gastric Cancer
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• 제20권3호
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• pp.290-299
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• 2020

Purpose: Recently, totally laparoscopic gastrectomy has been gradually accepted by surgeons worldwide for gastric cancer treatment. Complete dissection of the lymph nodes and the establishment of the surgical margin are the most important considerations for curative gastric cancer surgery. Previous studies have demonstrated that indocyanine green (ICG)-traced laparoscopic gastrectomy significantly improves the completeness of lymph node dissection. However, it remains difficult to identify the tumor location intraoperatively for gastric cancers that are staged ≤T3. Here, we investigated the feasibility of ICG fluorescence for lymph node mapping and tumor localization during totally laparoscopic distal gastrectomy. Materials and Methods: Preoperative and perioperative data from consecutive patients with gastric cancer who underwent a totally laparoscopic distal gastrectomy were collected and analyzed. The patients were categorized into the ICG (n=61) or the non-ICG (n=75) group based on whether preoperative endoscopic mucosal ICG injection was performed. Results: The ICG group had a shorter operation time and less intraoperative blood loss. Moreover, significantly more lymph nodes were harvested in the ICG group than the non-ICG group. No pathologically positive margin was found and there was no significant difference in either the proximal or distal surgical margins between the 2 groups. Conclusions: Near-infrared fluorescence imaging with ICG can be successfully used in totally laparoscopic distal gastrectomy, and it contributes to both the completeness of D2 lymph node dissection and confirmation of the gastric transection line. Well-designed prospective randomized studies are needed in the future to fully validate our findings.

• 대한치과교정학회지
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• 제53권2호
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• pp.77-88
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• 2023

Objective: To develop a method for generating three-dimensional (3D) digital models of the periodontal ligament (PDL) using 3D cone-beam computed tomography (CBCT) reconstruction and to evaluate the accuracy and agreement of the 3D PDL models in the measurement of periodontal bone loss. Methods: CBCT data collected from four patients with skeletal Class III malocclusion prior to periodontal surgery were reconstructed at three voxel sizes (0.2 mm, 0.25 mm, and 0.3 mm), and 3D tooth and alveolar bone models were generated to obtain digital PDL models for the maxillary and mandibular anterior teeth. Linear measurements of the alveolar bone crest obtained during periodontal surgery were compared with the digital measurements for assessment of the accuracy of the digital models. The agreement and reliability of the digital PDL models were analyzed using intra- and interexaminer correlation coefficients and Bland-Altman plots. Results: Digital models of the maxillary and mandibular anterior teeth, PDL, and alveolar bone of the four patients were successfully established. Relative to the intraoperative measurements, linear measurements obtained from the 3D digital models were accurate, and there were no significant differences among different voxel sizes at different sites. High diagnostic coincidence rates were found for the maxillary anterior teeth. The digital models showed high intra- and interexaminer agreement. Conclusions: Digital PDL models generated by 3D CBCT reconstruction can provide accurate and useful information regarding the alveolar crest morphology and facilitate reproducible measurements. This could assist clinicians in the evaluation of periodontal prognosis and establishment of an appropriate orthodontic treatment plan.

• Journal of Hospice and Palliative Care
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• 제19권3호
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• pp.240-248
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• 2016

목적: 호스피스완화의료의 목적은 환자와 가족의 고통을 줄이고 삶과 죽음의 질을 향상시키는데 있다. 편안한 임종을 맞이하는 것은 죽음의 질을 향상시키는데 역할을 한다. 이를 위해 환자와 보호자는 남은 삶 동안 임종을 준비할 수 있도록 임종과정 중 발생하는 다양한 문제와 요구에 대한 이해가 필요하다. 따라서 호스피스 환자와 가족을 위한 매뉴얼화된 임종교육 시청각 자료를 개발하고자 한다. 방법: 시청각 자료 개발을 위해서는 문헌고찰을 토대로 접근하기 쉬운 파워포인트 유인물로 초기 교육자료 개발하였고 다섯 차례에 걸친 전문의의 자문과 수정 및 보완, 평가 과정을 거쳐 완성하였다. 결과: 호스피스 환자와 가족들을 대상으로 한 시청각 교육자료는 3차시 5단계로 분류하였으며 교육 소요시간은 총 26분 34초이다. 최종 교육프로그램은 시청각 교육실 협력 하에 촬영하였으며 시청각 자료를 완성하였다. 결론: 본 연구는 완화의료병동의 구축과 전문성 증대를 위해 개발된 매뉴얼화 된 임종교육 시청각 자료로써 큰 의의가 있으며, 호스피스 환자와 가족뿐 아니라 호스피스 영역 전문 종사자들이 호스피스 환자와 가족을 대상으로 효율적인 임종교육 자료로 적극 활용되길 기대한다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.6135-6140
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• 2013

Background: Breast cancer is a common malignant tumor which affects health of women and multidrug resistance (MDR) is one of the main factors leading to failure of chemotherapy. This study was conducted to establish paclitaxel-resistant breast cancer cell line and nude mice models to explore underlying mechanisms of MDR. Methods: The breast cancer drug-sensitive cell line MCF-7 (MCF-7/S) was exposed in stepwise escalating paclitaxel (TAX) to induce a resistant cell line MCF-7/TAX. Cell sensitivity to drugs and growth curves were measured by MTT assay. Changes of cell morphology and ultrastructure were examined by optical and electron microscopy. The cell cycle distribution was determined by flow cytometry. Furthermore, expression of proteins related to breast cancer occurrence and MDR was tested by immunocytochemistry. In Vivo, nude mice were injected with MCF-7/S and MCF-7/TAX cells and weights and tumor sizes were observed after paclitaxel treatment. In addition, proteins involved breast cancer and MDR were detected by immunohistochemistry. Results: Compared to MCF-7/S, MCF-7/TAX cells had a higher resistance to paclitaxel, cross-resistance and prolonged doubling time. Moreover, MCF-7/TAX showed obvious alterations of ultrastructure. Estrogen receptor (ER) expression was low in drug resistant cells and tumors while expression of human epidermal growth factor receptor 2 (HER2) and Ki-67 was up-regulated. P-glycoprotein (P-gp), lung resistance-related protein (LRP) and glutathione-S-transferase-${\pi}$ (GST-${\pi}$) involved in the MDR phenotype of resistant cells and tumors were all overexpressed. Conclusion: The underlying MDR mechanism of breast cancer may involve increased expression of P-gp, LRP and GST-${\pi}$.