• Archives of Plastic Surgery
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• v.36 no.4
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• pp.500-502
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• 2009

Purpose: Cutaneous lipomatous neurofibroma is a rare variant of neurofibroma. Histologically, it includes adipose tissue. As far as we aware, only 11 cases of this variant were reported which was predominantly on head, neck and trunk, so we present a case of left pretibial area with literature review. Method: A 17 - year old female who showed a non - tender, protruding $4{\times}4{\times}2cm$ sized mass on the left pretibial area for several months. We totally excised the mass including skin and the subcutaneous fat layer. Results: Pathologic report showed cutaneous lipomatous neurofibroma which was well circumscribed and noncapsulated neoplasm present with focal fatty change. Adipose cells were entrapped in the whirls of spindle cells. There were no lipoblasts or atypical adipocytes. Conclusion: A cutaneous lipomatous neurofibroma on the lower extremity is very rare. In our patient, there were no trauma - related histopathologic changes. Therefore, focal fatty change can be a consequence of metaplasia from multipotential neural cells after migration.

• Korean Journal of Veterinary Research
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• v.37 no.3
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• pp.607-612
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• 1997

A case of neosporosis is described in a 6-month-old aborted bovine fetus. Grossly, numerous, well-demarcated, 2-3mm, yellowish white foci were scattered in the heart and skeletal muscle. Histopathologic changes were confined to the brain, heart, and skeletal muscle. Multifocal areas of necrotizing encephalitis were observed in the cerebrum as well as cerebellum. Severe multifocal to coalescing nonsuppurative inflammation was observed in the myocardium and skeletal muscle. The tachyzoites of Neospora caninum were demonstrated in the brain, myocardium and skeletal muscle with immunohistochemical method using Neospora caninum-specific antibody. Based on the histopathology and immunohistochemistry, this case was diagnosed as neosporosis in aborted Korean cattle. This is believed to be the first reported case of bovine neosporosis in Korea.

• Journal of fish pathology
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• v.30 no.1
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• pp.51-61
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• 2017

The effect of electromagnetic field on aquatic organisms has received little attention. In the current study, the effect of 50Hz electromagnetic field on muscle histopathology of Caspian Sea Cyprinus carpio, a species of economic importance, was investigated. A total of 120 healthy fish were used in this study. They were classified randomly in one of two groups as follows: Control or unexposed EMF group and experimental group with 5 different magnetic field intensities (0.1, 1, 3, 5 and 7mT) at 2 different exposure times including 30 and 60 minutes. Fish in the experimental group were exposed only once. Two weeks after exposure, dorsal muscles sectioned transversely, stained and were examined using a light microscope. Histopathologic assessments showed significant difference between control and EMF exposed groups at both 30 min. (p<0.01) and 60 min. (p<0.001) exposure times. We report for the first time that electromagnetic field in interaction with muscular tissue of Cyprinus carpio exhibits a dual effect which depends on the field intensity, and exposure time. At short exposure time (30 min.), EMF stimulates muscle growth process. At longer exposure time (60 min.), EMF can damage muscle tissue and result in muscle necrosis. More research is required to elucidate precise mechanisms involved in muscle hypertrophy and pathologic changes.

• Korean Journal of Veterinary Research
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• v.22 no.1
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• pp.37-52
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• 1982

This study was taken to clarify the histopathological changes of pigs naturally infected with hog cholera. Microscopic observations of the necrotic lesion and inclusion body in the lymphoid organs were carried out in the natural cases of hog cholera and experimental cases inoculated with ALD virus and isolated virus strains. Electron microscopic findings of the intranuclear inclusion bodies in the reticular cell of spleen and lymph node were also observed in the experimental cases. The results obtained are as follow, As the histological findings necrosis of lymphoid organs was observed mainly in the lymph follicle. The necrotic lymphoid organs were found to contain 35.0% in the natural and 37.5% in the experimental cases. Intranuclear inclusion bodies were found mainly in the reticular cells of lymphoid organ, the epithelium of bronchiole and alevolus, and the vascular endothelium of brain. These inclusion bodies were seen in 40.0% of the natural cases and all of the experiment. The inclusion body was appeared to compose of activated nucleoli and chromatin granules (interchromatin and perichromatin) by electron microscopy.

• Imaging Science in Dentistry
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• v.31 no.2
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• pp.121-127
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• 2001

Inflammatory pseudotumor was originally described in the lung, but recently has been recognized to occur in various sites. A 56-year-old female was referred to our department with a painless swelling of the right midfacial area since 3 months ago. Clinical examination showed non-specific intraoral findings, but asymmetric facial appearance and numbness of the right midfacial area. Plain radiographs and CT images showed aggressive destruction and irregular thickening of the right maxillary sinus wall, increased antral opacification, and destruction of the zygomatic arch. A relatively well-defined soft tissue mass occupied the right maxillary sinus, nasal cavity, zygoma, and infraorbital region. The soft tissue mass showed mild enhancement on CT. Radiographically, this lesion presented a rapidly enlarging mass demonstrating aggressive behavior, mimicking a malignant tumor. Histopathologic examinations showed plasma cells and inflammatory cells in variable fibrotic tissues and demonstrated positive reactivity for vimentin. No malignent changes could be found.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.16 no.2
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• pp.196-201
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• 1994

One case of an unusual form of carcinoma involving the submucosal gland and duct of tongue was reported and reviewed. According to Gerughty et al(1968) four distinct component parts were classified : ductal carcinoma in situ(involvement of the ductal epithelium by in situ carcinomatous changes), squamous cell carcinoma, and a mixed carcinoma(combination of glandular and squamous characteristics and occasionally consisted of large nests composed of "glassy" cell). This tumor was fond to be extremely aggressive and highly malignant. The histopathologic features and the clinical behavior of this tumor were sufficiently distinctive to warrant the designation adenosquamous carcinoma : exhibit concomitant glandular and squamous neoplasm. The mode of therapy was evaluated and the treatment of choice appears to be radical surgery. So, we has done the radical neck dissection and partial glossectomy. However, the limited number of cases indicated that collection and subsequent analysis of additional cases must be performed before any definitive conclusion can be drawn.

• Biomolecules & Therapeutics
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• v.6 no.2
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• pp.204-212
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• 1998

This study was conducted to evaluate the repeated dose toxicity of DA-1131/betamipron, newly developed carbapenem antibiotic, in rats. DA-1131/ betamipron was administered intravenously once a day for 4 weeks to 10 males and 10 females per group at the doses of 0(control),40, 160 and 640 mg/kg. Throughout the study period, all rats survived. The administration of DA-1131/betamipron induced soft stool or diarrhea in rats of both sexes receiving 160 or 640 mg/kg. The water consumption was increased with a statistical significance in 640 mg/kg during observation period. At the end of administration, hematological and serum biochemical examination showed no toxicological changes in DA-1131/betamipron treated groups compared with control group. Histopathologic examination revealed inflammatory cell infiltration, tubular dilatation and focal necrosis of kidney in two males and three females in 640 mg/kg. On the basis of these results, the noobserved-adverse-effect-level of DA-1131/betamipron was estimated to be 40 mgtg under the present test condition.

• Journal of Yeungnam Medical Science
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• v.7 no.1
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• pp.191-195
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• 1990

A case of sporotrichosis misdiagnosed as lupus vulgaris was presented. A 56-year-old woman had bean to pea sized, nontender pustules and a hypertrophic-sear-like nodule on the right thigh. She denied any trauma before the lesions developed. Histopathologic findings from the lesion showed tuberculosis-like granulomatous changes. And she was diagnosed as lupus vuagaris. She also had pulmonary tuberculosis and had been treated with antituberculous drugs for 1 year. But skin lesions was not cleared. We suspected the lesions as one of deep mycoses and could confirm sporotrichosis by mycologic studies. They showed characteristic gross colonies and microscopic findings of Sporothrix schenckii.

• Childhood Kidney Diseases
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• v.13 no.2
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• pp.99-117
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• 2009

Diabetic nephropathy is a major cause of chronic renal failure in developing countries, and the prevalence rate has markedly increased during the past decade. Diabetic nephropathy shows various specific histological changes not only in the glomeruli but also in the tubulointerstitial region. In the early stage, the effacement of podocyte foot processes and thickened glomerular basement membrane (GBM) is noticed even at the stage of microalbuminuria. Nodular, diffuse, and exudative lesions, so-called diabetic glomerulosclerosis, are well known as glomerular lesions. Interstitial lesions also exhibit fibrosis, edema, and thickened tubular basement membrane. Diabetic nephropathy is considered to be multifactorial in origin with increasing evidence that one of the major pathways involved in the development and progression of diabetic nephropathy as a result of hyperglycemia. Hyperglycemia induces renal damage directly or through hemodynamic alterations, such as, glomerular hyperfiltration, shear stress, and microalbuminuria. Chronic hyperglycemia also induces nonhemodynamic dysregulations, such as, increased production of advanced glycosylation endproducts, oxidative stress, activation of signal pathway, and subsequent various cytokines. Those pathogenic mechanisms resulted in extracellular matrix deposition including mesangial expansion and GBM thickening, glomerular hypertrophy, inflammation, and proteinuria. In this review, recent opinions on the histopathologic changes and pathophysiologic mechanisms leading to initiation and progression of diabetic nephropathy will be introduced.

• Korean Journal of Veterinary Service
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• v.25 no.4
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• pp.347-355
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• 2002

This experiment was performed to investigate apoptosis during undergoing pathogenesis of avian infectious bronchitis virus(IBV)-infected chicks. Sixteen days old chicks were infected with IBV, Massachusetts-41 strain(M-41, 10$^4$-10$^{5}$ EID$^{50}$ ) experimentally, they were autopsied to remove trachea, lung, kidney and cloacal bursa at 6hr, 12hr, 1 day, 3 day and 7 day post infection(PI) respectively for H-E and TUNEL staining. Grossly, mild serous, catarrhal exudate was observed in the trachea, nasal passages and sinuses nasal from 4 day PI. The cloacal bursa was swollen from 3 day PI. Histopathologically, the trachea was seen mild cellular infiltration, edema of the mucosa and submucosa, vascular congestion and mild hyperplasia of the epithelium from 6 hr PI and the changes were seen a little more severely on 7 day PI. It was observed that the cloacal bursa was getting more and more hyperplasia through the experiment. The nuclei degeneration were shown in the kidney on 7 day PI. No specific changes were seen in the lung. In TUNEL analysis, apoptotic cells showed sharp increasing at 12 hr PI and reaching a maximum on 1 day PI in the trachea, lung, kidney and cloacal bursa. And then apoptotic cells decreased gradually returning to a level of the control by 7 day PI in all the removed organs.