• 한국음향학회지
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• 제18권5호
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• pp.68-77
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• 1999

본 논문에서는 고강도 집속형 초음파의 주파수 특성(파형)에 따른 초음파 공동 현상을 억 제하는 효과를 살펴보았다. 본 연구에서는 세가지 파형, 즉, 정현파(1 MHz, 5 MPa), 주파수 변조파(10 ㎲ 동안 1 MHz에서 6 MHz까지 선형적으로 증가, 5 MPa), 비대칭 충격파(기 본 주파수 1 MHz, 양압 12 MPa, 음압 -4 MPa)를 고려하였다. 동일한 강도(833 W/㎠)를 가지는 각 초음파에 노출된 초기 반경이 1 ㎛인 물 속에 있는 공기 기포의 반응을Gilmore bubble dynamic model 및 Church's rectified gas diffusion equation을 이용하여 예측하였다. 기포 진동의 크기는, 정현파에 노출된 경우와 비교하여, 주파수 변조된 초음파의 경우 현저히 감소하였고, 비대칭 충격파의 경우 약간 감소함을 볼 수 있었다. 흥미롭게도 주파수 변조파에 대한 기포의 반응은 변조된 초음파의 주파수 성분이 기포의 공진 주파수(3 MHz) 이상에서는 거의 동일하게 유지되는 것으로 나타났다. 이 사실은 주파수 변조를 현재의 1 MHz부터 6 MHz까지에서 1 MHz부터 3 MHz까지로 줄여도 유사한 공동 억제 효과를 얻을 수 있음을 암시한다. 실용적으로, 비교적 좁은 밴드 폭을 가지는 범용 초음파 변환기를 이 용하여 초음파의 공동 현상 억제 효과를 얻기 위한 주파수 변조를 구현할 수 있음을 의미한다. 본 연구의 결과는 초음파의 적절한 주파수 성분 조절로 초음파의 공동 현상을 일정 수준 억제할 수 있음을 시사한다.

• Archives of Pharmacal Research
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• 제29권5호
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• pp.412-417
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• 2006

Triamcinolone acetonide (TA) is a corticosteroid that is used in the systemic and topical treatment of many inflammatory diseases. In this study, a phonophoretic drug delivery system was designed to enhance the TA permeability and the influence of ultrasound was examined. In order to establish the transdermal delivery system for TA, a hydrophilic carbopol gel containing TA was prepared after adopting phonophoresis. A permeation study through mouse skin was performed at $37^{\circ}C$ using a Franz diffusion cell, and the ultrasound treatment was carried out for 10 h. The level of TA permeation through the skin was evaluated under various ultrasound conditions including the frequency (1.0, 3.0 MHz), intensity (1.0, $2.5W/cm^2 $), and duty cycle (continuous, pulse mode) using a 0.5% TA gel. The highest permeation was observed under the ultrasound treatment conditions of low frequency, high intensity, and in continuous mode.

• 한국고분자학회:학술대회논문집
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• 한국고분자학회 2006년도 IUPAC International Symposium on Advanced Polymers for Emerging Technologies
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• pp.369-369
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• 2006

Compatibilizers contribute to many processes in polymer industry, such as manufacturing polymer blends and composites. They are usually designed to be block or graft form which is combined in polar and non-polar parts in the first synthesis process level, for example, the general form of maleic anhydride (MA) as a compatiblizer is a grafted counterpart. However, the process of making the compatibilizer is related to the first synthesis level and it has some problems, such as high cost, poor processability, limitation on use and properties, and so on. So, in order to improve its poor processability and overcome the limitation on use, we developed compatibilizers which have various chemical forms by high intensity ultrasound and super critical fluid nitrogen in polymer melt reactive extrusion.

• The Journal of Korean Physical Therapy
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• 제13권1호
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• pp.139-149
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• 2001

We found out that there exists threshold dose for the decreased platelet count when we apply change of the platelet count to the defense of the ultrasound experiment. Those diminution is definite effects from the defense of the ultrasound. The number of the platelet count is decreased when we are exposed to ultrasound simultaneously. This should not be occurred. It is easy to use the number of the platelet count in the measurement of the biological dosage and intensity in high dosage relatively due to definite quantative relationship. The biological index to understand synergic effects. which are present when two harmful environmental factors are operating at the same time is functionally assending and antagonistic. There are scattered many factors as physical, Chemical, or physiochemically elements which are harmful to human body in the environment in consideration of ultrasound and the other factors. This experiment is demonstrating that we can use the change of the platelet as an index representing synergic effects of ultrasound.

• 한국음향학회지
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• 제38권4호
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• pp.467-475
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• 2019

고출력의 초음파는 매질을 진행하면 음향 흐름과 음향 방사힘을 만들어낸다. 공기를 매질로 하는 3차원 공간상에 음향 방사힘을 발생시키면 입체적인 촉감을 형성할 수 있으므로 공간적인 정보를 직접 피부에 촉각으로 전달할 수 있다. 본 논문은 40 kHz의 작은 초음파 송신자 154개를 묶어 오목한 형태로 배열시켜서 초음파를 송신하여 집속초점에서 음향 방사힘을 발생시켰다. 초음파 음장의 초점의 근처에서 음향 방사힘에 의한 촉각을 확인하였다. 촉각 감도를 올리기 위하여 송신 초음파를 60 Hz의 구형파로 진폭 변조를 하였다. 초음파 촉각의 응용으로 음향 방사힘이 형성되는 허공에 촉각이 감지되는 영역을 형성시켜서, 손의 위치를 지정하는 지시자로 사용하였다. 촉각이 감지되는 초점위치에 있는 손의 모양을 영상 입력으로 받아서 손가락의 개수를 기계에 피드백하는 시스템을 구현함으로써 초음파를 이용한 촉각의 유용성을 확인하였다.

• 한국전문물리치료학회지
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• 제13권3호
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• pp.33-40
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• 2006

The purpose of this study was to assess the effects of High-Voltage Pulsed Current (HVPC) and ultrasound on adjuvant-induced arthritis in rats. Adjuvant arthritis was induced in female Sprauge-Dawley rats by the subcutaneous injection of a single dose of $.1m{\ell}$ of Complete Freund's Adjuvant (CFA) (1 mg of Mycobacterium Butyricum suspended in $.1m{\ell}$ paraffin oil) into the right hind paw. A randomized, parallel-groups design of 24 subjects was used. All rats were randomly assigned to control (n=8), ultrasound (n=8), and HVPC (n=8) were compared with those of injured rats. The rats in the pulsed ultrasound group were treated at 1 MHz frequency with $.5W/cm^2$ intensity in 1:4 mode for 5 minutes per day. The rats in the HVPC group were treated at 120 pulses per second and $50{\mu}s$ phase duration, 20 mA intensity for 30 min per day. Treatment was done in the left and right hind limb for 2 weeks. We evaluated clinical, radiographic, hematologic and histopathologic findings before and after treatment and obtained the following results. 1. Edema of the right hind paw was more significantly reduced in the ultrasound and HVPC groups than the control group on days 9, 12, and 14 (p<.05). Edema of the left hind paw was more significantly reduced in ultrasound and HVPC groups than the control group on days 12, 14 (p<.05). 2. WBC counts of the ultrasound and HVPC groups as compared with the control group were becoming remarkably decreased after the treatment. 3. In radiologic findings, arthritis formation was seen according to the score of arthritis, which was the highest in the control group, upon the observation of radiographs of the left and right hind paws. However, no statistically significant difference was present in the score within three groups. 4. In the histopathologic findings, ultrasound and HVPC groups had effectively suppressed erosions of articular cartilage and inflammatory cell infiltrations. Therefore, the results of the study show that rats that were treated with the ultrasound and HVPC effectively suppressed adjuvant arthritis. However, no statistically significant difference was present between the ultrasound group and the HVPC group.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2006년도 제11차 학술대회
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• pp.59-59
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• 2006

• 한국음향학회지
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• 제35권6호
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• pp.452-465
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• 2016

본 연구에서는 의료 치료용으로 고강도 집속 초음파를 발생시킬 수 있는 오목한 환상형 배열 트랜스듀서의 구조를 최적설계하였다. 트랜스듀서는 곡률반경으로 40 mm를 가지는 여러 개의 동심원 채널로 이루어진 위상배열 구조이다. 구조 설계를 위해 트랜스듀서의 음장을 해석할 수 있는 이론식을 유도하였으며, 이론식 계산 결과의 타당성을 유한요소해석 결과와 비교함으로써 검증하였다. 배열 트랜스듀서의 기하학적 초점 이외 지점에서의 동적 집속 가능 유무도 함께 확인하였다. 또한 음장 내 원하지 않는 지점에 발생하는 그레이팅 로브의 레벨은 트랜스듀서의 채널수와 주파수와의 관계를 이용하여 개선될 수 있음을 확인하였다. 따라서 정점으로부터 특정 범위 내에 주엽이 존재하면서 그레이팅 로브를 포함한 최대 부엽의 크기를 체계적으로 줄일 수 있도록 트랜스듀서 구조를 최적 설계하였다. 설계된 구조는 모든 집속 지점에서 목표를 만족하는 성능을 보였다.

• Medical Lasers
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• 제8권2호
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• pp.59-63
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• 2019

Background and Objectives High-intensity focused ultrasound (HIFU) has been developed as an effective, non-invasive, skin-tightening method in response to the increasing demand for improvements in skin laxity and tightening with minimal risk and recovery time. This study evaluated the efficacy and safety of HIFU for non-invasive skin tightening of crow's feet wrinkles, with the aim of determining how long the tightening can be maintained. Materials and Methods Between January and March 2019, 21 female patients with crow's feet wrinkles were treated with HIFU. The treatment involved 200 shots, three times every 2 weeks. Three blinded, experienced plastic surgeons and patients evaluated satisfaction at 2 weeks after the first procedure, 2 weeks after the second procedure, 2 weeks after the third procedure, and 6 weeks after the first procedure based on photographs according to the Global Aesthetic Improvement Scale (GAIS). The Friedman test was used to compare data. Results Of the 21 patients treated using HIFU, one was lost to follow-up for nonstudy-related reasons. Therefore, 20 patients were evaluated and ranged in age from 28 to 48 years. Plastic surgeons' GAIS scores were 2.6, 2.3, 1.7, and 1.3 and patients' GAIS scores were 2.6, 2.2, 1.8, and 1.4 at 2 weeks after the first procedure, 2 weeks after the second procedure, 2 weeks after the third procedure, and 6 weeks after the third procedure. No serious adverse effects were observed. Conclusion The aging face with crow's feet wrinkles can be improved by using HIFU, while minimizing epidermal and dermal injury.

• 대한통합의학회지
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• 제9권1호
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• pp.151-161
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• 2021

Purpose : This study was to investigate the effectiveness of ESWT and plantar fascia-specific stretching exercise vs ESWT and high-load strengthening exercise in patients with chronic plantar fasciitis. Methods : The subjects were randomized to extracorporeal shock wave therapy ( ESWT, for 3 weeks) and daily plantar-specific stretching (Group I: Stretch group) or ESWT and high-load progressive strength (Group II: Strength group) performed every second day. The main outcome measures were ultrasound, visual analogue scale (VAS), and Korean Foot Function Index (KFFI). The ultrasound (plantar fascia thickness), pain intensity I, II (the most painful of the day?, the pain when you first step in the morning?) and KFFI (functional performance) were compared between the groups. Results : No significant difference was observed between the groups in the plantar fascia thickness but pain intensity I, II was significantly lower in Group 2 than in Group 1 at only 12weeks and functional performance was also significantly increased in Group 2 compared to Group 1 at only 12 weeks. Conclusion : The high-load strengthening exercise consisting of the progressive exercise protocol, resulted in superior after 12 weeks compared with plantar-specific stretching. High-load strength exercise may aid in a quicker reduction in pain and improvements in functional performance.