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Effect of a five-week high-fat diet on serum-lipid composition and LPL mRNA expression in rat skeletal muscles

  • Cheon, Wookwang;Kim, Mijin
    • Korean Journal of Exercise Nutrition
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    • v.17 no.2
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    • pp.49-55
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    • 2013
  • Our purpose was to investigate the effect of a 5-week high-fat diet on the body weight, blood components [triglycerides (TGs), free fatty acids (FFAs), and glucose], and lipoprotein lipase (LPL) mRNA expression in the skeletal muscles of rats. Body weight increased overtime in experimental and control groups without significant differences. In terms of the blood components, the density of TG was significantly lower in the high-fat diet group compared to the control, whereas FFA and glucose levels were similar in the two groups. Although the levels of glyceraldehyde 3-phosphate dehydrogenase(GAPDH) mRNA expression were similar between the groups, LPL mRNA expression was significantly higher in the high-fat diet group than that in the control group. The results of this study suggest that a high-fat diet enhances LPL mRNA expression, as well as possibly increases fat metabolism. For a better understanding of the relationship between diet patterns and fat metabolism, further analysis of genes related to the fat metabolism is warranted.

A Study on the Catalytic Characteristics of Oxygen Reduction in an Alkaline Fuel Cell II. Characterization of La0.6Sr0.4Co1-xFexO3 by using XRD, TG, and TPR (알칼리형 연료전지에서 산소환원에 미치는 촉매 특성 연구 II. XRD, TG, TPR를 이용한 La0.6Sr0.4Co1-xFexO3의 특성 분석)

  • Moon, Hyeung-Dae;Lee, Ho-In
    • Applied Chemistry for Engineering
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    • v.7 no.3
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    • pp.554-564
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    • 1996
  • Oxygen reduction in an alkaline fuel cell was studied by using perovskite of $La_{0.6}Sr_{0.4}Co_{1-x}Fe_xO_3$(x=0.00, 0.01, 0.10, 0.20, 0.35, and 0.50) as an oxygen electrode catalyst. The changes in the catalytic properties as a function of Fe content were investigated by XRD, TG, and TPR. XRD patterns gave different lattice parameters of the catalysts. TG study revealed that Fe was so stabilized in the perovskite structure as to be hardly reduced even up to $900^{\circ}C$, and the amount of oxygen which was eliminated at high temperature increased with the fraction of Fe because Fe induced the increase of Co-O binding energy. From TPR study, ${\alpha}$-(low temperature peak) and ${\beta}$-(high temperature peak)states were observed. The bond strength of the ${\beta}$-species which was associated strongly with Co of the perovskite increased proportionally with the fraction of Fe. The ${\alpha}$-species, reversible oxygen, was the active species in the oxygen reduction. The ${\alpha}$-peak temperature which reflected the binding energy between Co and ${\alpha}$-state oxygen moved to lower temperature with the increase of lattice parameter of the catalytst due to the increase of Fe content. The decrease in the binding energy increased the activity in the oxygen reduction, but the decrease of ${\alpha}$-species with the increase of Fe content decreased the activity. The increase in the surface area with Fe content had little effect on the activity.

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Effect of Rice Bran Dietary Fiber Level on Serum Lipid Concentration, Bowel Function, and Mineral Absorption in Rats (미강 식이섬유 첨가량이 흰쥐의 혈청지질농도, 장 기능 및 무기질 흡수율에 미치는 영향)

  • Jin, Hyun-Jung;Lee, Sang-Sun
    • The Korean Journal of Food And Nutrition
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    • v.24 no.4
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    • pp.622-629
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    • 2011
  • This study was performed to investigate the effect of rice bran dietary fiber powder on serum lipid levels, bowel function, and mineral absorption in rats. Four weeks old male Sprague Dawley rats(SD rat) were divided into four groups : control group fed 5% cellulose as a fiber source, RB10 fed 5% of cellulose and 10% of rice bran dietary fiber powder, RB20 and RB30. The animals were fed the experimental diets for 4 weeks. Serum lipid levels were not significantly different among the groups. But, fecal total cholesterol(TC), triglycerides(TG), and high density lipoprotein cholesterol(HDL-c) excretion increased in the RB30 group. Fecal weight and fecal water content were higher in the rice bran added groups than those in the control group. Transit time was significantly shorter in the rice bran fiber-added groups than that in the control. Weight of the stomach and large intestine in the RB20 and RB30 groups were significantly greater than those in the other groups. Absorption rates of Ca, Mg, P, and Zn decreased significantly in the RB30 group compared to those in the other groups. A high amount of rice bran increased fecal lipids, including TC, TG and HDL-c. Rice bran increased fecal weight and fecal water content and shortened gastrointestinal transit time. However, a high level of rice bran diet decreased mineral absorption rates.

A Frequency Domain based Positioning Method using Auto Regressive Modeling in LR-WPAN (주파수 영역상의 AR 모델링 기반 이용한 LR-WPAN용 무선측위기법)

  • Hong, Yun-Gi;Bae, Seung-Chun;Choi, Sung-Soo;Lee, Won-Cheol
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.34 no.6C
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    • pp.561-570
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    • 2009
  • Ultra-wideband communication systems based on impulse radio have merits that are possible for the high data rate transmission, high resolution ranging are positioning system. Conventionally, in order to accomplish these features, the high-speed ADC (Analog to Digital Convertor) is necessary to apply radio determination system operating in time domain. However, considering low rate - wireless personal area network (LR-WPAN) aims to low-cost hardware implementation, the expensive ADC converting GHz sampling per second is not appropriate. So, this paper introduces a low complex AR (Auto Regressive) model based non-coherent ranging scheme operating in frequency domain with using low-speed ADC utilizing analog Voltage Control Oscillator (VCO) mode for the frequency domain transformation. To verify the superiority of the proposed ranging and location algorithm working in frequency domain, the suggested IEEE 802.15.4a TG channel model is used to exploit affirmative features of the proposed algorithm with conducting the simulation results.

Gender specific effect of major dietary patterns on the metabolic syndrome risk in Korean pre-pubertal children

  • Park, Soo Jin;Lee, Seung Min;Kim, Seon Mee;Lee, Myoungsook
    • Nutrition Research and Practice
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    • v.7 no.2
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    • pp.139-145
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    • 2013
  • There is a lack of data on metabolic risk factors during pre-puberty, which is important for identifying the subgroups of youth, at whom early interventions should be targeted. In this study, we evaluated the prevalence of metabolic risk factors and its subsequent relations with dietary patterns in Korean pre-pubertal children through a cross-sectional sample (n = 1,008; boys = 513) of pre-pubertal children (aged 8-9 years) from a sub-study of the Korea Metabolic Syndrome Research Initiatives (KMSRI) in Seoul, Korea. Measures of anthropometry and blood pressure as well as fasting blood samples were used in the analysis. A three-day food records were collected. The metabolic syndrome was defined according to the age-adjusted National Cholesterol Education Program Adult Treatment Panel III guidelines. An added metabolic risk score was calculated for each subject by summing the quintile values of the five individual risk factors. Among the 5 risk components of metabolic syndrome, high waist circumference (WC) was the major factor (P < 0.001). A significant increasing trend of the added metabolic syndrome risk score was observed with the increase of WC (P (trend) < 0.001) among both genders. The cutoff point for high WC for pre-pubertal children was 61.3 cm for boys and 59.9 cm for girls. The prevalence of high triglyceride (TG) values was significantly higher in girls than it was in boys (P < 0.01). Girls in the highest quintile of balanced dietary pattern scores had lower TG values (P (trend) = 0.032) than did those in the lowest quintile. Moreover, girls in the highest quintile of western dietary pattern scores showed increasing trend for the added metabolic risk score (P (trend) = 0.026) compared with those in the lowest quintile. Adverse associations exist between western dietary patterns and the accumulation of metabolic risks among girls, not in boys, even during pre-puberty.

Distributed Channel-Time Allocation for the Mesh Networking of the High-Rate WPAN (고속 WPAN의 Mesh 네트워킹을 위한 분산형 채널타임 할당)

  • Lee, Byung-Joo;Park, Moo-Sung;Rhee, Seung-Hyong;Choi, Woong-Chul;Chung, Kwang-Sue
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.32 no.3A
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    • pp.230-236
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    • 2007
  • This paper presents a resource management mechanism for the mesh networking in IEEE 802.15.3 High-rate WPAN. IEEE 802.15 TGS is standardizing the MAC and PHY for mese networking. This task group researches the mechanism that are extension of network coverage without increasing transmit power of receive sensitivity, and studies the enhanced reliability via route redundancy. In this paper we propose the distributed resource management scheme that is fairly using the channel resource in the piconet without centralized piconet coordinator. Each DEV reserves the channel time and broadcasts its information. This scheme has unfairness for later associated DEV because of preoccupation of earlier associated DEVs. This paper presents the method that fairly allocates the channel time in MAC layer. And we evaluate the performance enhancement using simple simulations.

A frequency Domain based High Resolution Positioning Method using Low Rate ADC in LR-WPAN (LR-WPAN에서 저속 ADC를 이용한 주파수 영역상의 고해상 무선 측위 기법)

  • Lee, Won-Cheol;Park, Woon-Yong;Hong, Yun-Gi;Choi, Sung-Soo
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.34 no.2C
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    • pp.145-152
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    • 2009
  • Ultra-wideband communication systems for impulse radio have merits that are possible for either high resolution ranging system or radio determination. Conventionally, in order to accomplish these functions, the rapid analog to digital convertor (ADC) is necessary to apply radio determination system operating in time domain. However, considering that low rate - wireless personal area network (LR-WPAN) aims to low-cost hardware implementation, the expensive ADC converting GHz sampling per second is not appropriate. So, this paper introduces the high resolution ranging system operating in frequency domain with using low sampling rate ADC, and a new non-coherent ranging scheme utilizing analog Frequency Modulation (FM) mode for the frequency domain transformation. To verify the superiority of the proposed ranging algorithm working in frequency domain, the suggested IEEE 802.15.4a TG channel model is used to exploit affirmative features of the proposed algorithm with conducting the simulation results.

Effect of swimming exercise therapy on a fatty liver in SD-Rat dosage high fat diet (수영운동 치료가 고지방식 투여 SD-Rat의 지방간에 미치는 영향)

  • Hwang, Ryong
    • Journal of Korean Physical Therapy Science
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    • v.6 no.2
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    • pp.1019-1040
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    • 1999
  • The purpose of this study is to clarify the repercussions of swimming exercise therapy that has an effect on lipid in blood and liver enzyme of the 3D-Rat dosage high fat diet. The object of this study consisted of two groups. One was the swimming exercise SD-Rat group, the other was the non-exercise SD-Rat group. Sample size was seven Rats repectively. Exercise period was ten week. Exercise group swimmed twenty minutes per a day and 5 times per a week. And then collecting blood from these two group's SD-Rats, making M Health center a request for a blood test on TC, TG, GOT, GPT, we come to a conclusion like below. The weight of the swimming exercise group has decreased 5.93% in comparison with non-exercise group. and has a significant difference(p<0.05). The liver weight of the swimming exercise group has decreased 7.83% in comparison with non-exercise group, and has not a significant difference. The TC of the swimming exercise group has decreased 39.22% in comparison with non-exercise group, and has a significant difference(p<0.05). The TG of the swimming exercise group has decreased 62.88% in comparison with non-exercise group, and has a significant difference(p<0.05). The GOT of the swimming exercise group has decreased 3.22% in comparison with non-exercise group, and has not a significant difference. The GPT of the swimming exercise group has decreased 16.14% in comparison with non-exercise group, and has a significant difference(p<0.05). In regard to above results, the regular swimming exercise therapy with dosage of high fat diet has an important role in healing and preventing a fattyliver, a hyperlipidemia, and an arteriosclerosis, intervening the lipid in blood.

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The Anti-Obesity Activity of Syzygium aromaticum L. in High-Fat Diet-induced Obese Mice (고지방식이로 유도된 비만 마우스에서 정향(丁香)의 항비만 효과)

  • Hui Yeon An;Seong-Soo Roh;Mi-Rae Shin
    • The Korea Journal of Herbology
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    • v.39 no.1
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    • pp.11-21
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    • 2024
  • Objectives : This study aims to analyze the anti-obesity effect of Syzygium aromaticum L. (SA) in obese mice made by a 60% high-fat diet (HFD). Methods : The antioxidant activities of SA were evaluated in vitro. To assess the anti-obesity effect of SA, male C57BL/6 mice were divided into five groups: Normal, Control, GC100 (Garcinia cambogia 100 mg/kg/day), SA100 (SA 100 mg/kg/day), SA200 (SA 200 mg/kg/day). All groups underwent a 6-week regimen of HFD and oral administration, except for the Normal group. Subsequently, we performed blood analysis, western blotting, and histopathological staining. Results : SA demonstrated effectiveness in antioxidant measurements. SA treatment resulted in a significant decrease in body weight gain, along with reductions in liver and epididymal fat weights. Serum triglyceride (TG), total cholesterol (TC), glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and leptin levels were reduced with SA treatment. Moreover, in the SA100 group, the reduction of both TG and TC synthesis was caused by inhibiting the sterol regulatory element-binding transcription factor 1 (SREBP-1) and sterol regulatory element-binding transcription factor 2 (SREBP-2) through the Sirtuin 1 (Sirt1)/phospho-AMP-activated protein kinase (p-AMPK) pathway. Furthermore, SA treatment at a dose of 100 mg/kg reduced the accumulation of lipid droplets in the liver and the adipocyte size of the epididymal fat. Conclusion : Our research reveals the anti-obesity effects of SA by demonstrating its ability to inhibit body weight gain and lipid accumulation, suggesting that SA might be promising for obesity treatment.

A Case-Control Study on Blood Lipids as a Risk Factor of Stroke (뇌졸중 위험지표로서의 혈중 지질에 대한 환자;대조군 연구)

  • Kim, Jung-Hyun;Kang, Kyung-Won;Yu, Byeong-Chan;Choi, Sun-Mi;Baek, Hye-Ki;Lim, Seung-Min;An, Jung-Jo;Seol, In-Chan;Kim, Yoon-Sik
    • The Journal of Internal Korean Medicine
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    • v.28 no.4
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    • pp.830-837
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    • 2007
  • Background and purpose : Stroke is one of the most deadly diseases and a leading cause of disability. Lipids confer an increased risk for cardiovascular morbidity and mortality. In spite of many studies on the relationship between stroke and lipids, their relationship is not clear. This study was undertaken to determine whether lipids were associated with stroke. Method : We compared the components of blood lipids between stroke patients group (n=217,Cases), non-stroke control group (n=160, Controls) and healthy control group without hypertension, diabetes mellitus, ischemic heart disease, or hyperlipidemia (n=140, Normals). These data were statically analyzed by general linear models and binary logistic regression analysis to get each adjusted odds ratio. Result : The results were as follows. The blood levels of total cholesterol (T-Chol), triglyceride (TG) and low density lipoprotein cholesterol (LDL-Chol) were significantly higher in patients of ischemic stroke, while the blood levels of T-Chol and LDL-Chol were significantly lower, and the blood levels of TG significantly higher in patients of hemorrhagic stroke. The blood level of high density lipoprotein cholesterol (HDL-Chol) was significantly lower in all cases. Conclusion : These results suggest that high TG and low HDL-Chol may be risk factors of hemorrhagic stroke and ischemic stroke, high T-Chol and LDL-Chol may be risk factors of ischemic stroke, and low T-Chol and LDL-Chol may be risk factors of hemorrhagic stroke in Koreans.

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