• The Journal of Internal Korean Medicine
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• v.40 no.6
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• pp.1035-1042
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• 2019

Background: Herbal medication is widely used in the Korean Medicine Hospital, and drug-induced liver injury (DILI) in Korea has increased proportionally. Herb-induced liver injury now accounts for approximately 40% of cases of hepatotoxicity in Korea, according to research data. Currently, however, the component responsible for the toxicity is usually unknown or can only be suspected. Objective: To study the hepatotoxicity of Cheongsimyeonja-tang in DILI. Methods: A retrospective review was conducted of 82 inpatients between April 2010 and March 2017 with suspected drug-induced liver injury (n=5). The standard criteria (RUCAM scale) for drug-induced liver injury (DILI) were applied. The electronic medical records (EMRs) were retrospectively reviewed to identify the relevant database. Aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin (T. Bili) were analyzed in blood samples before and after the administration of Cheongsimyeonja-tang. Results: Five cases out of 82 patients had a criterion-referenced probable (RUCAM) score ranging from 6 to 8 points DILI. However, statistical analysis of the liver function parameters results of the 82 patients did not show a statistically meaningful elevation after taking Cheongsimyeonja-tang. Conclusions: These data suggest a relationship between Cheongsimyeonja-tang and DILI. More studies are needed to validate these observations and to explore their implications.

• The Journal of Pediatrics of Korean Medicine
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• v.20 no.3
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• pp.129-141
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• 2006

Objectives : The purpose of this study is to determine clinical efficacy of herbal medicine by evaluating SCORAD Index and total level of ceramaides in the skin of 13 children with atopic dermatitis Methods : Subjects are divided into two groups : Group 1(non-differentiation children treated with Saenghyeoryunbueom) and group 2(differentiation children treated with either pyungwisan, onchungum or gamitongsungsan). We determine SCORAD Index and total level of ceramaides in the skin of 13 children with atopic dermatitis before and after taking each of herbal treatment for 12 weeks. Results : After herbal prescription for 12 weeks, A SCORAD index of both group 1 and group 2 was decreased. However, the total level of ceramides in group 1 and group 2 was not altered after 12 weeks. When the correlation between the alteration of SCORAD index and ceramides levels was determined, the SCORAD index in group 1 was inversely correlated with the total level of ceramides(r=-0.994, p=0.006) In contrast, the alteration of SCORAD index in group 2 was not correlated with ceramide levels. Conclusions : The clinical efficacy of Saenghyeoryunbueom for non-differentiation children with atopic dermatitis is paralleled with the increased level of ceramides in skin. The clinical efficacy of pyungwisan, onchungum or gamitongsungsan for differentiation children with atopic dermatitis is not correlated with ceramide level in skin.

• Journal of Sasang Constitutional Medicine
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• v.17 no.2
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• pp.121-128
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• 2005

1. Objectives In the western Medicine, UTI generally bring on fever, and treated by antibotics. In the traditional way of korean Medicine, our predecessors used the herb for the febrile disease that has the property of coldness. However, Lee Je-ma tried to make the Yang ascend with the herb, considering thar the febrile illness in Soeumin is made by the Exterior Heat not ascending. In the aspect of the Sasang Consititutional Medicine(SCM), Hwanggigyeji-tang(황지계지탕(黃芷桂技場)) & Palmoolgunja-tang (팔물군자탕(八物君子湯)) belongs to the kind of the warm medication. This study is reported to evaluate rhe effected of Hwanggigyeji-tang(황지계지탕(黃芷桂技場)), Palmulgoonja tang(팔물군자탕(八物君子湯)) to the febrile patient. 2. methods To heal the febrile patient who was diagnosed as UTI & Soeumin exterior disease, we used soeumin Hwanggigyeji-tang(황지계지탕(黃芷桂技場)), Palmulgoonja tang(팔물군자탕(八物君子湯)). 3. Results This parient's main symptoms are fever, sweating impotently feeling, anorexia. So we treated the patient with Hwanggigyeji-tang(황지계지탕(黃芷桂技場)), (팔물군자탕(八物君子湯)) in ${\ulcorner}$Dongyi Suse Bowon(동의수세보원(東醫壽世保元))${\lrcorner}$ and improved the patient?s symptoms. 4. Conclusions We suggest that Soeumin Hwanggigyeji-tang(황지계지탕(黃芷桂技場)), (팔물군자탕(八物君子湯)) are effective significantly to the patient with febrile illness, bur then we consider that the studies on the case like this are more needed to convince that Hwanggigyeji-tang(황지계지탕(黃芷桂技場)), (팔물군자탕(八物君子湯))are very much effective.

• The Journal of Internal Korean Medicine
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• v.22 no.2
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• pp.251-256
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• 2001

In western medicine, there are some reports about herbal medicine induced hepatitis, but in oriental medicine, there are few reports about that. We experienced one case of drug acute cholestatic-hepatitis in the treatment of oriental medicine for HNP. We treated the patient with acupuncture, physical therapy and herb medicine. The patient's symptoms improved after two weeks of treatment. In the course of treatment, the patient intermittently complained of general weakness, nausea, yellowish urin, dyspepsia, and abdominal discomfort. We recognized that total bilirubin(7.2mg/dl), direct bilirubin(5.5mg/dl), serum transaminase(AST 360U/L, ALT 354U/L), alkaline phosphatase(16.6 K/A), urobilinogen(++) and bilirubin(++) were elevated. We diagnosed drug induced hepatitis. We stopped giving herb medicine and began giving Saeng gan gunbi-tang and Injin-oryung-san. Saeng gan gunbi-tang and Injin-oryung-san have been used to treat hepatic disease and have been known to have beneficial effects. After 3weeks on medication, the clinical symptoms and liver function improved. So, we report this case to bring more attention to the safety and toxicity of herbal medicine.

• The Journal of Korean Obstetrics and Gynecology
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• v.19 no.4
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• pp.279-286
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• 2006

Purpose : The purpose of this study is to report the effect of oriental treatments to hyperemesis gravidarum in disturbed liver function. Methods : Hyperemesis gravidarum is a severe and intractable form of nausea and vomiting in pregnancy. It is a diagnosis of exclusion and may result in weight loss; nutritional deficiencies; and abnormalities in fluids, electrolyte levels, and acid-base balance. The peak incidence is at 4, 8-16 weeks of pregnancy. Interestingly, nausea and vomiting of pregnancy is generally associated with a lower rate of miscarriage. However disturbed diver dunction with Hyperemesis gravidarium is rare very and dangerous. Traditionally, oriental medical therapy has been used to patients with hyperemesis gravidarum and showed effective result. We treated 1 patient who had hyperemesis gravidarum in disturbed diver dunction at Se-Myung university Oriental Hospital in affiliation by Herbal medication, acupuncture and moxa therapy and got good result from them. Results : As a result, symptoms are remarkably alleviated and liver function test are improved. Conclusion : Therefore we would like to report that it is effective to cure the hyperemesis gravidarum in disturbed liver function through the herb-medication and acupuncture treatment.

• Journal of Oriental Neuropsychiatry
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• v.12 no.2
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• pp.1-15
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• 2001

According to ICD-10, The typical Depression are characterized by dejected mood, loss of interest and pleasure, feeling of helplessness. Also, other symptoms such as loss of attentiveness and concentration, guilty conscience, pessimistic attitude for the future, sleeping disorder, lack of appetite, thinking of or doing a self-injury or suicidal act may characterize Depression. These Symptoms of Depression are similar to Wool-Zeng(鬱證), Zeon-Zeng(癲證), Her-ro(虛勞), Bul-Sa-Sik(不思食), Tal-Young-Sil-Zeong(脫營失精), Bul-Myeon(不眠), Ki-Myeon(嗜眠) in Oriental Medicine. In general, Depression is classified into Wool-Zeng type and Zeon-Zeng type. The former is similar to the neurotic type of depression, the latter is similar to the psychopathic type of depression. The clear causes of Depression are not known yet. But psychodynamic and biological factors are assumed to cause Depression. Psychodynamic factors may correspond to Chil-Zeong(七情) and biological factors to Tae-Byeong(胎病) and Dam(痰) in Oriental medicine. In Occidental medicine, Depression is treated by psychotherapy and medication. Electrically-induced spasm therapy and phototherapy also used for the treatment of Depression. In Oriental medicine, Depression is treated by more various therapy such as herb medication, acupuncture and moxibustion, oriental psychotherapy and dirigation(Gi-Gong, 氣功). Depression is not easy to cure. When the treatments of Occidental medicine and Oriental medicine are mutually cooperated, more effective medical care might be expected. Therefore, futher study to treat depression by mutually cooperated therapy is necessary.

• Pediatric Infection and Vaccine
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• v.12 no.2
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• pp.208-212
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• 2005

It has been known that the eczema herpeticum is the one of most severe skin manifestation of external herpetic infection. It is developed by skin infection of Herpes simplex Virus(HSV) that superimposed on children with atopic dermatitis, and this could be fatal. The secondary bacterial infection happens frequently in eczema herpeticum. Staphylococcus aureus is the most frequently isolated aerobic strain. The important point of treatment of eczema herpeticum is the immediate start of systemic antiviral treatment and use of antibiotics to decrease the secondary infection. We report two cases of severe eczema herpeticum after herb medical treatment in atopic dermatitis. They have been improved after systemic acyclovir and antibiotic therapy with burn dressing.

• Journal of Acupuncture Research
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• v.15 no.2
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• pp.393-406
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• 1998

Twenty five cases of the patient admission-treatment from chiefly complained of neck pain observed clinically from first January 1997 to thirty first December 1997 in the Dept. of Acupuncture and Moxibustion, Oriental Hospital, Taejon University, Taejon, Korea. And the results were obtained as follows; 1. The distribution of sex was male 13(52%) cases, female 12(48%) cases and the male to female ratio was 1.1 : 1. The distribution of age was the most predominant as the fifties 6(24%) cases. 2. The contributing factors were the most predominant as the reason unknown 9(36%) cases, unstable position 5(20%) cases. 3. The distribution of duration was the most predominant of 9(36%) cases in a week. 4. The distribution of before admission-treatments were the most predominant as west-medication 13(32.5%) cases. 5. The distribution of patient's condition of first treatment was the most predominant as Gr.III 13(52%) cases. 6. The distribution of duration for admission was the most predominant as 13(52%) cases in a week. 7. The distribution of radiological studies were the nust predominant as the HIVD 26(63.4%) cases. 8. The distribution of clinical symptoms were the most predominant as neck pain 25(21.0%) cases, radiating pain to the upper extremities 23(19.3%) cases. 9. The distribution of located on clinical syrnptoms were the most predominant as neck-shoulder and back-upper extremities 11(44%) cases. 10. The distribution of clinical diagnosis was the most predominant as HIVD 16(45.7%) cases. 11. The distribution of methods of treatment were the most predominant as Acupuncture -­ Herb Medication - Electro Acupuncture treatment 8(32%) cases. 12. The effect of treatment by discharge was the most predominant of 11(44%) cases as Good result.

• Herbal Formula Science
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• v.14 no.2
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• pp.9-20
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• 2006

Objective & Methods : Irritable Bowel Syndrome is occurred frequently in daily life. Nevertheless. medical treatment of the Irritable Bowel Syndrome is almost dependent on western cure, but that cure is not effective enough. So we chose the oriental medicine textbook that were dealing with the oriental concept and the treatment of Irritable Bowel Syndrome. we got these results. Results were as follows : 1. Irritable Bowel Syndrome is characterised by recurrent or chronic abdominal pain, with distension, disturbed defecation and psychic problems without organic lesions. 2. The etiology of Irritable Bowel Syndrome include stress. disharmony of liver and spleen, the coldness of spleen and kidney and the lack of qi or yin, etc. 3. The oriental treatments of Irritable Bowel Syndrome are warming spleen and kidney, easing liver and stopping diarrhea. 4. The internal medication of Irritable Bowel Syndrome was the most used 11 times Tongsayobang(痛瀉要方) and 10 times Yijungtang(理中湯). 5. The most many used herb were Atractylodjs macrocephalae rhjzoma(白朮), Gjnseng Radix (人蔘), Cjnnamomj Cortex(肉桂), Polyporus(猪笭), etc.

• Journal of Sasang Constitutional Medicine
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• v.23 no.4
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• pp.533-540
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• 2011

In this case, we report a case of Soeumin rectal cancer patient who was mistreated with herb medication. This patient was 72 years old female diagnosed rectal cancer stage IV with multiple liver, lung, and LN metastases. She administered our cancer center in Sep. 2011 for cancer treatment, we diagnosed this patient as Taeyangin at first, and treated with Mihuedungsikjang-tang. After 1 week, she complained upper abdominal discomfort, severe abdominal pain, nausea and sweating. Considering several symptoms and conditions, the change of symptoms seemed to a adverse events caused by mistreatment. We re-diagnosed this patient as Soeumin, and treated with Soeumin herbal medication, Baekhaoleejung-tang(白何烏理中湯) and Hyangsayangyi-tang(香砂養胃湯). Several symptoms including abdominal pain were improved 2 weeks later. Therefore, we report this case as a reference that Soeumin misdiagnosed as Taeyangin and the improvement of adverse symptoms.