• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2707-2710
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• 2013

Background: This study used pre-hepatitis A vaccination era data in U.S. to study the relationship between serum hepatitis A antibody positivity with pancreas cancer mortality in adults. Patients and Methods: Public use National Health and Nutrition Examination Survey (NHANES III) data were employed. NHANES III uses complex probabilistic methods to sample nationally representative samples. Household adult laboratory and mortality data were merged. Sample persons who were available to be examined in the Mobile Examination Center (MEC) were included in this study. All results were obtained by using specialized survey software taking into account the primary sampling unit and stratification variables and the weights assigned to the sample persons examined in the MEC. Thus they are representative of the U.S. population. Results: The mean risk (95%CI) of death in the study population for pancreas cancer was 0.0014 (-0.000069 -.0029); their mean age (95%CI) at the mobile examination center (MXPAXTMR) was 473.43 (463.85-482.10); the follow up in months from their medical examination (permth_exm) was 170.12 (164.17-176.07). The odds ratios (S.E.) of the statistically significant univariables were: age, 1.007 (1.005-1.009); serum anti-hepatitis antibody status, 0.038 (0.004-0.376); and drinking hard liquor, 1.014 (1.004-1.023). The coefficients (S.E.) of the statistically significant variables after multivariate analysis were 0.006 (0.002-0.010) for age and -2.528 (-4.945--0.111) for serum anti-hepatitis A antibody negativity (using serum anti-hepatitis A antibody positivity as a reference). Conclusion: Serum hepatitis A antibody positivity correlates with higher pancreas cancer mortality in adults.

• 대한수의학회지
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• 제22권2호
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• pp.265-272
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• 1982

The traumatic hepatitis and splenitis were experimentally induced in Korean native goats. General examinations, hematological and blood biochemical findings were investigated up to 10 days after induction of traumatic hepatitis and splenitis. Body weight of goats with traumatic hepatitis and splenitis showed no change or only a slight decrease. Changes in body temperature and respiratory rate were not noted in both experimental groups. Heart rate hart not been changed in traumatic splenitis group but were a little increased in traumatic hepatitis group. Erythrocytic series such as erythrocyte counts, hemoglobin concentration and packed cell volume showed same variation within normal range during the period of observation. Total leucocyte counts showed the considerable increase in both experimental groups. The increase of the percentage of neutrophil and the decrease of the percentage of lymphocyte were more remarkable in traumatic hepatitis group than that of traumatic splenitis group. Serum aspartate transferase activity was increased in both experimental groups after surgery, while serum alkaline phosphatase activity has been decreased conciderably up to 7 days after surgery. Serum lactic dehydrogenase activity has been increased up to 3 days after operation and thereafter the activity has returned to normal level in traumatic hepatitis group and the activity increased only the first day after surgery in traumatic splenitis group. There were no changes in total protein and albumin contents in both experimental groups during the period of observation. Serum total cholesterol contents showed a slight increase in both experimental groups and the range of increase in traumatic hepatitis group was more wide. Serum bilirubin contents were net changed in traumatic hepatitis group, but showed a slight increase in traumatic splenitis group.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5463-5467
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• 2012

Hepatitis B virus (HBV) infection is contagious with transmissiobn vertically or horizontally by blood products and body secretions. Over 50% of Iranian carriers contracted the infection prenatally, making this the most likely route of transmission of HBV in Iran. To evaluate the resistance to adefovir (ADV) therapy in patients with chronic hepatitis B infection, a study was conducted on 70 patients (63 males and 7 females), who had received in first line lamivudine and second line adefovir. All were tested for the presence of hepatitis B surface antigen (HBsAg), hepatitis B envelope antigen (HBeAg), serum alanine amino transferase (ALT) level and HBV DNA load before and after treatment with ADV. In all samples, resistance to lamivudine and ADV was tested with real time PCR. Among seventy patients with chronic hepatitis B infection, 18 (25.7%) were resistant to LAM and 8 (11.4%) were resistant to ADV. Only one patient was negative for the presence of HBS-Ag (5.6%) and two were negative for HBe-Ag (11.1%). In this study we used a new method (ALLGIO probe assay) that has high sensitivity in detection of adefovir resistance mutants, which we recommend to other researchers. Mutant strains of the YMDD motif of HBV polymerase can be found in some patients under treatment with lamivudine and ADV. ADV has been demonstrated to be efficient in patients with lamivudine resistant HBV.

• 한국치위생학회지
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• 제14권1호
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• pp.85-93
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• 2014

Objectives : The purpose of the study is to investigate and compare the knowledge of hepatitis B in nursing and dental hygiene students in Busan. Methods : A self-reported questionnaire was filled out by 361 students in nursing and dental hygiene departments in Busan from August 25 to September 4, 2013. Data were analyzed by SPSS version 13.0 for descriptive statistical analysis, ${\chi}^2$-test, and t-test and set at p<0.05. Results : Knowledge in hepatitis B consisted of 25 questions including severity of hepatitis B, general knowledge, infection routes, and symptoms and treatment. There was no significant difference between nursing and dental hygiene students in knowledge; nursing students showed an average of $18.21{\pm}2.809$ and dental hygiene showed $17.71{\pm}3.23$. The average score was $17.96{\pm}3.03$ out of 25 questions. Conclusions : There is no significant difference between nursing and dental hygiene students in knowledge of hepatitis B. It is necessary to emphasize the education of hepatitis B periodically in addition to regular curricula.

• Neonatal Medicine
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• 제17권1호
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• pp.123-126
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• 2010

성인에서 A형 간염은 현증 감염이 대부분이지만, 소아에서는 무증상 또는 경한 증상을 보이는 경우가 많았다. 그동안 외국에서는 임신 및 분만 기간 동안에 발생한 A형 간염의 산모와 이로 인한 신생아 A형 간염에 대한 증례 보고가 드물지 않게 있었다. 국내에서는 20대와 30대의 젊은 성인에서 A형 간염에 대한 항체 양성률이 낮아지고 있는 가운데, 이들 산모들의 A형 간염에 대한 위험성이 증가하고 있는 상황이며, 아직까지 국내에서는 A형 간염에 이환된 신생아에 대한 증례 보고가 없었다. 이에 저자들은 A형 간염 산모로부터 이환된 것으로 보이는 급성 A형 간염 신생아를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 가정간호학회지
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• 제22권1호
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• pp.69-77
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• 2015

Purposes: The purpose of the study was to evaluate knowledge of hepatitis C and compliance with therapeutic guidelines and their correlation. Methods: Participants included a total of 197 subjects with chronic hepatitis C from 4 general hospitals. Subjects were asked 25 items of knowledge on hepatitis C and 17 items of compliance with therapeutic guidelines. The collected data was analyzed for frequency, percentage, average, standard deviation, t-test, ANOVA and Pearson's correlation coefficient. with the help of SPSS 21.0 program. Results: The subject's knowledge on chronic hepatitis C expressed as percentage was 67.1%. Compliance of the research participants gained $3.96({\pm}0.76)$ points in general on a 5-point scale. Learned compliance was higher when the patients were 45 years old and over. female and with spouse. There was a statistically significantly positive correlation between knowledge and compliances. Conclusions: Development of educational programs requires consideration of patient characteristics, particularly education on the male patients under 45 years of age.

• 디지털융복합연구
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• 제10권4호
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• pp.309-316
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• 2012

대학생들을 대상으로 건강신념모형을 이용하여 일부 대학생의 B형간염 예방접종 이행의도와 건강상태인식, 건강관련행위, 건강신념에 따른 B형간염 예방접종 이행여부에 영향을 미치는 요인을 확인하고자 연구를 시도하였다. 로지스틱 희귀분석을 통한 B형 간염 예방접종 이행의도와 관련된 요인은 대학생에 있어서 B형간염 예방을 위한 예방접종 이행의도는 B형간염에 대한 감수성, 심각성을 높게 인지한 군에서 장애성을 낮게 인지한 군에서 그리고 남자보다 여자가 간염 예방접종을 이행하는 경향이 높은 것으로 나타났다. 따라서 향후 B형간염예방에 대한 심각성과 유익함에 대한 적절한 홍보와 함께 통합적인 보건교육중재 프로그램 개발 및 효과평가에 대한 연구가 필요함을 제안한다.

• 대한의생명과학회지
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• 제17권1호
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• pp.27-37
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• 2011

Hepatitis A virus (HAV) is a causative agent of triggering acute hepatitis which is transmitted by person-to-person contact and or fecal-oral route. In previous studies, most hepatitis A virus (HAV) isolates had been genotype IA in Korea. Recently, a small number of different genotypes were reported with an upsurge of acute hepatitis by HAV. Therefore, the distribution of HAV genotypes was investigated. RNA was extracted from anti-HAV IgM positive sera which were collected from February to August 2009, at a tertiary care hospital in eastern Jeonnam, Korea. Nested reverse transcription PCR and direct sequencing for VP1/P2A region of the HAV were performed. A total of 365 cases with suspected acute hepatitis were tested for anti-HAV IgM and positive results were obtained in 24 sera (9.0%), which were collected 2 to 15 days (median, 7 days) after the onset of symptoms. Of the 24 seropositive samples, 14 (58.3%) samples were positive for HAV RNA, among which 4 isolates (28.6%) were genotype IA and the other 10 (71.4%) were genotype IIIA. Both IA and IIIA genotypes were isolated from 5~6 neighboring administrative districts throughout the year without geographic or seasonal restrictions. HAV genotypes (IA and IIIA) were observed from the eastern Jeonnam for the studied.

• 대한의생명과학회지
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• 제29권4호
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• pp.314-320
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• 2023

The purpose of this study was to provide basic data on hepatitis B infection control in the community through the results of the hepatitis B surface antigen and antibody tests conducted at the Cheongyang-County Health Medical Center. From 2012 to 2020, we retrospectively analyzed the HBsAg, HBsAb, HBeAg, HBeAb, and HBV DNA results of 7,329 hepatitis B-related testers. Among 7,329 subjects, the HBsAg positivity rate was 1.7%, and the positivity rate according to age was the highest at 4.4% in their 30s, 4.2% in their 40s, 4.1% in their 50s, 2.0% in their 60s, 1.9% in their 70s and over, and 10 it was shown in the order of 0.3% from less than large. The HBsAb positivity rate was 43.1% for men, 38.2% for men, and 46.7% for women (P<0.001). To summarize the above results, for infection control of hepatitis B in Cheongyang-County, hepatitis surface antigen proton management is required for those in their 30s or older, and it is thought that efforts to acquire immunity are necessary for those in their 20s or younger.

• Journal of Preventive Medicine and Public Health
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• 제30권2호
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• pp.267-278
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• 1997

The purpose of this study was to investigate the incidence rate of hepatitis B in the military service and to examine the effect of the asymptomatic hepatitis B surface antigen(HBsAG) carries on the incidence of hepatitis B. The subject were 223,270 men who were conscripted to the Korean Army from 1991 to 1994. According to the conscripted year, four conscription cohort were constructed. At the screening examination for military service no test for hepatitis B were performed in 1991 and 1992. In 1993, a screening test for hepatitis B were performed and those who were confirmed as HBsAg positive o. showed high titers $(\geqq100IU)$ of nm glutamic-pyruvic transaminase(SGPT) were excluded from conscription. In 1994, the criteria for conscription was changed and those who were HBsAg positive were not excluded from conscription. Only those who showed $\geq$ SGPT 100IU were excluded. The main results were as follows ; 1. The positive rate of HBsAg is 5.5% in the conscripted men. 2. The incidence rates of the hepatitis B in 1991 and 1992 conscription cohort were 9.96 and 8.10 per ten thousand person-year, respectively. The incidence rate of the hepatitis B was 1.34 per ten thousand person-year in 1993 conscription cohort which was confirmed as HBsAg negative at the screning test, and 7.41 per ten thousand person-year in 1994 conscription cohort which included the HBsAg positive. 3. The incidence rate of hepatitis B was 99.98 per ten thousand person-year in HBsAg positive group and 2.25 per ten thousand person-year in HBsAg negative group. The incidence rate of the group with high SGPT and HBsAg positive was 255 times higher than that of normal population. 4. The incidence of hepatitis B in HBsAg negative group did not increase even though the probability of personal contact with HBsAg positive had been increased. from the above results, the men who have high SGPT with HBsAg positive should be excluded from military service, and it can not be said that asymptomatic HBsAg carriers influence on the hepatitis B incidence among the HBsAg negative through personal contact.