• Archives of Pharmacal Research
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• 제7권1호
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• pp.47-52
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• 1984

Four polymorphic forms (I, II, III and IV) of hydrochlorothiazide have been characterized on the basis of x-ray diffractometry and differential thermal analysis. Form I was obtained by crystallization from N, N-dimethylformamide and Form II was crystallized from hot methanol. Form III was precipitated from sodium hydroxide aqueous solution by treatment with hydrochloric acid and Form IV was crystallized from 50% methanol. The metastable form I was a most stable form among four polymorphs, which was stable more than ten months at room temperature. The thermodynamic parameters such as heat of solution, enthalpy, entropy, free energy difference and transition temperature were determined by the measurement of intrinsic dissolution rate. The transition temperature and the heat of transition between the metastable Form I an Form II were determined to be $299.15^{\circ}$K and 5.03 Kcal/mole, respectively and free energy difference ($\delta$ F) was 302. 13 cal/mole. Diuretic action of these four polymorphic forms was also evaluated by monitoring the difference in urinary excretion of sodium, potassium and magnesium in rats.

• Journal of Mechanical Science and Technology
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• 제17권10호
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• pp.1572-1582
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• 2003

Hybrid rocket combustion has a manifestation of stable response to the perturbations compared to solid propellant combustion. Recently, it has revealed that the low frequency combustion instability about 10 Hz was occurred mainly due to thermal inertia of solid fuel. In this paper, the combustion response function was theoretically derived by use of ZN (Zeldovich-Novozhilov) method. The result with HTPB/LOX combination showed a quite good agreement in response function with previous works and could predict the low frequency oscillations with a peak around 10 Hz which was observed experimentally. Also, it was found that the amplification region in the frequency domain is independent of the regression rate exponent n but showed the dependence of activation energy. Moreover, the response function has shown that the hybrid combustion system was stable due to negative heat release of solid fuel for vaporization, even though the addition of energetic ingredients such as AP and Al could lead to increase heat release at the fuel surface.

• 한국식품조리과학회지
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• 제12권1호
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• pp.54-59
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• 1996

Immunoglobulins (IgY) were isolated from egg yolk of hens immunized with bovine serum albumin(BSA). The stability of anti-BSA IgY against heat and pH was investigated. Antibody activity was measured by enzyme linked immunosorbent assay. IgY was relatively heat-stable and most of the antibody activity remained after heating up 65$^{\circ}C$ for 30 minutes. IgY was stable at pH 5-11. However, inactivation of IgY was observed below pH 4, or above pH 12. Inactivation of IgY proceeded rapidly at low pHs(pH 2-3). Most of the antigen binding activity was lost at low pHs probably because of some conformational changes.

• 설비공학논문집
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• 제7권3호
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• pp.450-460
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• 1995

A modified circulating fluidized bed heat exchanger under severe fouling condition is developed. The effects of fouling deposits on the performance of a heat exchanger are investigated. The principle and operating characteristics of a circulating fluidized bed heat exchanger are dicussed. A modified circulating fluidized bed heat exchanger shows more stable operating than the other circulating fluidized bed heat exchanger. The characteristics of self cleaning and heat transfer enhancement of a circulating fluidized bed heat exchanger are studied. The movement of spherical particles in a tube is visualized and heat transfer enhancement and scale reduction mechanism by particles are investigated.

• 대한설비공학회지:설비저널
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• 제15권3호
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• pp.273-282
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• 1986

The purpose of this research was to study the characteristics of heat transfer in Heat Pipe which used the composition wick of screened groove - metallic mesh by ADI method and experimental results. As the results, the more than number of metallic mesh screen layers in a heat pipe increased, the fewer the effect of heat recovery decreased. In case of 1 - layer metallic mesh screen wick, the response of the effect in heat recovery was more rapidly showed than in case of other layers and in spite of high load, the evaporation section of Heat pipe with 1 - layer metallic mesh screen wick showed the stable response and did not show excessive super heat. There was a interrelation between thermal resistance and the variable layers, between thermal resistance and the variable gaps of metallic meshes, the heat transfer characteristics of Heat pipe were depended on the thermal resistance of composition wick.

• 한국연소학회지
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• 제15권3호
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• pp.74-81
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• 2010

In this study, soot formation characteristics on the instability of laminar diffusion flames were investigated experimentally using a concentric co-flow burner. When a small amount of air was supplied through an inner nozzle, a stable propane laminar diffusion flame became unstable and began to oscillate mainly due to the dilution effect. The increase of air flow rate transformed an oscillating non-sooting flame into a stable nonsooting flame. When the air flow rate was continuously increased an inner flame was formed and the flame was changed to an oscillating sooting flame, an oscillating non-sooting flame and finally a stable non-sooting hollow flame. When the air flow rate was decreased, a non-sooting hollow flame was eventually changed back to a stable non-sooting flame. The presence of an inner flame, however, altered the soot formation characteristics of a flame. More soot production was observed with the presence of an inner flame. The increased or decreased soot formation/oxidation rates, the radiation heat loss, and the heating effect of inner flames are most likely to be responsible for the observed instability of laminar diffusion flames.

• KIEAE Journal
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• 제14권4호
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• pp.127-131
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• 2014

The ground source heat pump (GSHP) system is a kind of the temperature differential energy system using relatively stable underground temperature as heat source of space heating and cooling. This system can achieve higher performance of system than it of conventional air source heat pump systems. However, its superiority of the system performance is different according to installation location or local climate, because the system performance depends on the underground condition which is decided by annual average air temperature. In this study, in order to estimate the feasibility of the ground source heat pump system according to the local climate, numerical simulation was conducted using the ground heat transfer model and the surface heat balance model. The case study was conducted in the condition of Seoul, Daejeon, and Busan, In the result, the heat exchange rate of Busan was 34.33 W/m as the largest in heating season and it of Seoul was 40.61 W/m as the largest in cooling.

• Asian-Australasian Journal of Animal Sciences
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• 제16권7호
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• pp.1041-1045
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• 2003

In order to study the reaction behaviors of bovine $\alpha$-lactalbumin ($\alpha$-La), $\beta$-lactoglobulin ($\beta$-Lg), and their mixtures during heat treatment, samples were analyzed using native-polyacrylamide gel electrophoresis (Native-PAGE), sodium dodecylsulfate (SDS)-PAGE, and two-dimensional (2-D)-PAGE. The electrophoresis demonstrated that the loss of native-$\alpha$-La increased as temperature increased, and that the loss of apo-$\alpha$-La was slightly higher than that of holo-$\alpha$-La. The tests also showed that during heat treatment, a mixture of $\alpha$-La and $\beta$-Lg was less stable than $\alpha$-La alone. As such, it was assumed that $\beta$-Lg induced holo-$\alpha$-La to be less stable than apo-$\alpha$-La during heat treatment. The reaction behavior of $\alpha$-La (holo-, apo-form) during heat treatment showed similar patterns in the 2-D-PAGE electropherogram, but the mixture of $\alpha$-La and $\beta$-Lg created new bands. In particular, the results showed a greater loss of native $\alpha$-La in the holo-$\alpha$-La and $\beta$-Lg mixture than in the apo-$\alpha$-La and $\beta$-Lg mixture. Thus, it can be concluded that the holo-$\alpha$-La and $\beta$-Lg mixture was more intensively affected by heat treatment than other samples, and that free sulphydryl groups took part in the heat-induced denaturation.

• 한국연소학회:학술대회논문집
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• 한국연소학회 2005년도 제31회 KOSCO SYMPOSIUM 논문집
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• pp.170-178
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• 2005

Multi-hole type oxygen combustion burner was developed for industrial gasification and smelting furnace. We investigated characteristics of flame, radiation transfer, and soot emission in the convectional oxygen burner with respect to the feeding condition of fuel and oxygen. Regarding the results of the conventional burner, we designed new burners which have larger fuel consumption rate and radiation heat transfer. We changed the size and hole number and shape of the exit plane of the burner. In addition, the performance of the burner was tested with respect to the feeding condition of the fuel and air: Normal Diffusion flame(NDF) and Inverse Diffusion Flame(IDF). We investigated the flame configuration, radiation heat transfer, and soot formation by using a CCD camera, heat flux meter, and Laser Induced Incadescence(LII), respectively. The stable operating condition was obtained by the flame configuration and the flame of the burner which has dented exit plane was more stable in whole operating conditions. The characteristics of radiative heat transfer were sensitive to the feeding condition of reactants and the flame of 75% primary oxygen and 25% secondary oxygen of the IDF case shows maximum radiation heat transfer. The soot volume fraction of the flame was measured in the axial direction of the flame and the amount of soot volume fraction is proportion to the radiation heat transfer. As a result, we can get the optimal operating condition of the newly designed burner which enhances the characteristics of flame stabilization and radiation heat transfer.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 춘계학술대회
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• pp.1406-1411
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• 2004

A series of experiments was conducted to examine characteristics of a grooved flat-strip heat pipe having multiple heat sources. The inner grooves of the heat pipe have the aspect ratio of 1 to $2.5(0.42{\times}1.05$ mm) whose pitch was 0.6 mm. Four block heaters ($10{\times}20$ mm) were placed in the evaporator section at intervals of 20 mm and six different heating modes were tested. The maximum surface heat flux of 80 $W/cm^2$ was achieved while the operating temperature was kept below $100^{\circ}C$, In the nearest heating mode (from the condenser location), the heat pipe exhibited more stable temperature distribution than the far heating mode where the heaters is located furthest from the condenser.