• 대한한의학방제학회지
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• 제25권4호
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• pp.553-574
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• 2017

The purpose of this study is to find out effects of prescriptions according to the formula, manipulation of Rhei Rhizoma, configuration. The following results were reached through investigations on the prescriptions using Rhei Rhizoma as a main component. Objectives : Analysis of prescriptions According to the formula : Liquid Extract Prescriptions were used widely on three parts to treat fever and damp heat in the interior organs. Powder Prescriptions were taken with hot water, thin porridge, tea etc. to treat damp heat, congestion of phlegm, acute episodes. Liquid Mixed Pill treat congestion of QI, damp heat, phlegm. Honey Mixed Pill treat accumulated fever, distension, acute excessive fever. Paste Pill treat blood stagnation, excessive toxic-fever, epidemic diseases. External Application treat inflammation by injury, swelling due to severe fever by internal damage. Methods : Analysis of prescriptions According to the manipulation of Rhei Rhizoma : Prescriptions including Liquor processed Rhei Rhizoma treat excessive toxic-fever, congestion of phlegm, blocking orifices on the upper side. Steamed Rhei Rhizoma strengthen effects of making evacuate and cooling of heat. Processed Rhei Rhizoma with vinegar strengthen effects of removing blood stagnation by activating blood movement, releasing gathering. Results : Analysis of prescriptions According to the Composition of Rhei Rhizoma : 41% of the total prescriptions were on the area of less than 20%. In case of lower groups show increased frequency of combination with Pharbitidis Semen, Persicae Semen, Scutellariae Radix and manipulation of baking, steaming, roasting. In case of higher groups show increased frequency of treating excess syndrome, critical illness, acute severe illness, and using proccesed Rhei Rhizoma with vinegar. Treatment of damp heat on the liver and gallbladder, disorder of the spleen and stomach is done mostly by prescriptions on the area of less than 30%. Conclusions : Rhei Rhizoma-Coptidis Rhizoma pair treat damp heat, heat toxins in blood, and Constipation caused by excessive heat. Rhei Rhizoma-Glycyrrhizae Radix pair relieve effects of Rhei Rhizoma passing blocked feces, removing the poison, activating blood movement, releasing gathering with the effects of Glycyrrhizae Radix relaxing tension by harmonizing Middle. Rhei Rhizoma-Magnoliae Cortex pair are used to treat damp heat in middle area, excessive heat in the stomach and intestine. Rhei Rhizoma-Pharbitidis Semen pair act on both blood system and QI system treating edema, damp, stagnation, heat toxins, feces. Rhei Rhizoma-Persicae Semen pair treat blood stagnation with fever on blood system.

• 대한한의학방제학회지
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• 제26권2호
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• pp.147-170
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• 2018

Objectivs : This report describes the studies as follows through the research of 163prescribtions in low-chapter from Bangyakhappyun. Methods : Analysis the 163prescribtions of basic prescribtions, therapeutic area, symptoms and pathology. Result : Many prescriptions are contained in the diseases areas such as defecate diseases, women diseases, internal diseases, exogenous febrile diseases. And prescriptions in the low-chapter are used in the areas such as eye, aggregation, mouth and tongue, teeth, hand, back, neck, emergency. Eighty-five basic prescriptions are analyzed from the low-chapter and the ratio of nineteen prescriptions containing Ijintang, Pyeongwisan, Oryungsan, Samultang, Sunggitang, Jichultang are over 60%. The efficacy classifications containing basic prescriptions frequently used are researched in the following order: heat-clearing and fire-purging formulae, digestant formulae, phlegm-dispelling formulae, qi-regulating formulae and blood-activating formulae. And tonifying and replenishing formulae are rarely used. Most of the prescriptions in the low-chapter are used for the excess syndrome and few of them are used for the deficiency syndrome. And six excesses, food damage, phlegm are the major causes of excess syndrome. Conclusions : As s result of study on analysis all prescriptions in low-chapter from Bangyakhappyun. We can understand more about basic prescriptions, symptoms of prescriptions and pathology.

• 한국임상수의학회지
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• 제32권2호
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• pp.191-195
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• 2015

7년령, 중성화 수컷 고양이가 무기력과 식욕부진으로 내원하였다. 실험실 검사는 말초혈액 호중구에서 중등도의 퇴행성 변화, free 및 total thyroxine의 농도 감소 및 혈액배양에서 세균증식이 관찰되었다. 16S ribosomal RNA 및 heat shock protein 60 유전자 검사 결과 세균은 Enterobacter cloacae로 확인되었다. 항생제 최소억제농도 평가결과 16개 항생제에 대한 다약제 내성이 관찰되었다. 중합효소연쇄반응 및 시퀀싱 결과 $bla_{TEM-1}$, $bla_{CTX-M-15}$ 및 플라스미드 유래 $bla_{ACT-1}$ 유전자에 대한 양성 반응이 관찰되었으며, 결과적으로 확인된 세균이 광범위 beta-lactamase 및 ampC beta-lactamase를 합성하는 플라스미드를 보유한 것을 확인하였다. 환자는 1개월 간 항생제와 levothyroxine 치료를 받은 후 증상이 호전되었고, 치료 후 갑상선 기능검사와 혈액배양 결과 이상소견은 소실되었다. 이 증례는 고양이의 지역사회획득 다약제내성 E. cloacae에 의한 정상 갑상샘 질환 증후군의 첫 예이다. 신속한 진단과정과 적절한 항생제 선택에 의해 이환된 고양이는 패혈증으로부터 회복되었다.

• Clinical and Experimental Reproductive Medicine
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• 제26권1호
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• pp.103-109
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• 1999

Objective: Heat shock protein 70-2 (Hsp70-2) gene knockout mice are found to have premeiotic arrest at the primary spermatocyte stage with a complete absence of spermatids and spermatozoa. This observation led to the hypothesis that hspA2 may be disrupted in human testes with abnormal spermatogenesis. To test this hypothesis, we studied the mRNA expression of hspA2 in infertile men with azoospermia. Design: The mRNA expression were analyzed by competitive RT-PCR among testes with normal spermatogenesis, pachytene spermatocyte arrest, and sertoli-cell only syndrome. Materials and methods: Testicular biopsy was performed in men with azoospermia (n=15). Specimens were subdivided into three groups: (group 1) normal spermatogenesis (n=5), (group 2) spermatocyte arrest (n=5), (group 3) Sertoli-cell only syndrome (n=5). Total RNA was extracted by Trizol reagent. Total extracted RNA was reverse transcribed into cDNA and amplified by PCR using specific primers for hspA2 target cDNAs. A competitive cDNA fragment was constructed by deleting a defined fragment from the target cDNA sequence, and then coamplified with the target cDNA for competitive PCR. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene was used as an internal control. Results: On Competitive RT-PCR analyses for hspA2 mRNA, significant amount of hspA2 expression was observed in group 1, whereas a constitutively low level of hspA2 was expressed in groups 2 and 3. Conclusion(s): The study demonstrates that the hspA2 gene expression is down-regulated in human testes with abnormal spermatogenesis, which in turn suggests that hspA2 gene may play a specific role during meiosis in human testes.

• 대한한방부인과학회지
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• 제34권1호
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• pp.1-14
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• 2021

Objectives: We studied for the adjustment of the patterns of 'The Diagnostic Tool for Climacteric and Postmenopausal Syndrome Pattern Identification (hereinafter CaPSPI)' (studyI) and the correlation between CaPSPI and Korean medicine doctors' diagnosis which was carried out without knowing the results of CaPSPI (studyII). Methods: The studyI followed the previous study method in 2018 (2018-3). The studyII was conducted from June 1, 2019 to July 10, 2020 with ◯◯ University Korean Medicine Hospital IRB's approval (2019-4). Doctors' diagnosis was conducted face-to-face with the subjects. Doctors' diagnosis was carried out based on the Kupperman's questionnaire, 'Diagnosis System of Oriental Medicine (hereinafter DSOM)' and four examinations (四診) records. The diagnosis was marked with 0 for 'no', 1 for 'somewhat', 2 for 'yes' and 3 for 'very yes'. The correlation between CaPSPI and the mean of doctors diagnostic scores were investigated statistically. Results: The studyI showed that heart-heat (心火) pattern was added. The Factor loading coefficient for heart-heat was 0.551 to 0.789, and the Cronbach's coefficient was 0.896. The studyII showed that the diagnosis (Kappa statistic) of two doctors showed statistically significant concordance (all eight patterns), with correlation of them were 0.3 or higher. And the correlation between the CaPSPI score and the mean of doctors' diagnostic score showed a statistically significant correlation, with liver qi depression (肝鬱) being the highest at 0.552 and dual deficiency of the heart-spleen (心脾兩虛) being the lowest at 0.301. Conclusions: Since the diagnosis results of CaPSPI showed a significant correlation with the diagnosis of Korean traditional medicine experts, it was believed that the CaPSPI results can be trusted and used for clinical purposes.

• 사상체질의학회지
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• 제11권1호
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• pp.79-102
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• 1999

1. 목적 네 가지 유형의 사상체질에 대한 한열증을 알아보고, 이것이 각 체질에 대한 생리, 병리의 이해와 진단, 치료에 도움을 주고자 하였다. 2. 방법 동의수세보원에 나타난 생리, 병리와 몇 가지 증후를 통한 한열증의 개념과, 기존의학에서의 한열증의 개념을 고찰해 보았다. 3. 결과 및 결론 병증과 편명을 중심으로, 비신의 수곡출납의 과정에 따라, 소음인은 '이한'한 체질적 소인을 바탕으로 표열 이한증으로 소양인은 '이열'한 체질적 소인을 바탕으로 표한 이열증으로 나타난다. 한편, 간폐의 기액내외 호산에 따라, 태음인은 '소병한다자'와 '소병열다자'로 나누어지는 경향이 있으며, 태양인은 한증이나 열증으로 치우쳐진 경향이 아닌 '불한불열'의 특정을 나타낸다. 몇가지 증후(편비, 설사, 한출, 소변, 구토)를 중심으로 각 체질의 한열 속성에 따라 각 증후의 한열 개념이 정해지는 것을 알 수 있는데, 이러한 것은 '체질적' 변증 방법을 제시한 것으로 사료된다.

• 대한한방내과학회지
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• 제23권2호
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• pp.280-285
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• 2002

Pruritus is [CHECK DEFN] itchy feeling of one's skin. We often face stroke patients who complain about Pruritus. They occasionally fail to fall asleep or have a secondary infection as a result of scratching. For these reasons, severe Pruritus brings down general condition and interferes with recovery. The causes of Pruritus are distributed to from skin diseases and from internal diseases. Especially among the skin diseases, Xerotic Eczema, which is called Senile Eczema causes the dry skin in the elderly, especially lower limb's extensor part. According to the epidemiology, 20% of the old have Xerotic Eczema. In oriental medicine, Pruritus is called Pungsoyang(風瘙痒), Pungyang(風痒), Yangpung(痒風), Sinyang(身痒). The cause of Pruritus is divided into two. One is endogenous factors and the other is exogenous factors. The former are deficiency of blood(血虛), blood fever(血熱), wind-heat due to internal damage(內傷風熱), damp-heat in the liver and gallbladder(肝膽濕熱), endogenous wind stirring in the liver(肝風內動), deticiency syndrome of the spleen(脾虛), deficiency of Yin of the liver and kidneys(肝腎陰虛) and deficiency of the Penetration and Conception Vessels(衝任不足). The latter are wind-cold due to exogenous affection(外感風寒) and wind-heat due to exogenous affection(外感風寒). We report two stroke patients who complained of severe Pruritus They were diagnosed as having Xerotic Eczema by a dermatologist. We regarded their Pruritus as blood fever(血熱) and wind-heat(風熱) and prescribed Sopung-San to these patients. These patients showed significant improvement.

• 대한한방내과학회지
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• 제32권2호
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• pp.232-242
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• 2011

Objectives : The purpose of this study was to develop the Korean standard pattern identifications for stroke-III (KSPIS-III). KSPIS-III includes 4 major pattern identifications (PIs) and clinical indicators for each. Methods : To extract the indicators for 4 major PIs, we analyzed 1548 clinical data from 15 traditional Korean medicine hospitals. Patients got acute stroke within 30 days from onset. Two physicians independently checked 65 indicators and performed pattern diagnosis. If the PI were diagnosed the same, PI would be confirmed. First we built an assumption model that set up the relationship among pattern identifications. Second, we extracted the indicators for fire-heat pattern and qi deficiency pattern by comparison between excessive and deficiency group, heat and non-heat group. By comparing yin deficiency pattern and 3 other patterns respectively, we extracted the indicators for yin deficiency pattern. Dampness-phlegm pattern indicators were extracted by the same method. Results : After cross tabulation with 65 indicators on the basis of our assumption model, we finally extracted 19 indicators for fire-heat pattern, 11 for qi deficiency pattern, 7 for yin deficiency pattern, and 7 for dampness-phlegm pattern. Conclusions : KSPIS-III was more improved than KSPIS-II because it was based on more clinical data. Further study to establish the PI diagnostic model would be required for practical use in the clinical field.

• 사상체질의학회지
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• 제18권2호
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• pp.1-14
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• 2006

1. Objectives This study is purposed to classify deficiency syndrome(虛證) and Excess syndrome(實證) of chief lung-disorder diseases. 2. Methods It was researched on the comparative and literal study about the relation to Yeong-Chu Gyeong-maek Chapter (${\ulcorner}$靈樞 經脈編${\Ircorner}$) and Dongui-Bogam (${\ulcorner}$東醫寶鑑${\Ircorner}$) and Dongui-Susebowon (${\ulcorner}$東醫壽世保元${\Ircorner}$) in chief lung-disorder symptoms or diseases. 3. Results and Conclusions (1) The chief lung-disorder diseases of Yeong-Chu Gyeong-maek Chapter (${\ulcorner}$靈樞 經脈編${\Ircorner}$), Dongui-Bogam (${\ulcorner}$東醫寶鑑${\Ircorner}$) and Dongui-Susebowon (${\ulcorner}$東醫壽世保元${\Ircorner}$) are asthma(喘), coughing(咳), fullness in the chest(胸滿), sweating symptoms(汗出), cold-heat symptoms(寒熱), dysphoria(煩躁) and sneezing. (2) Asthma symptom(喘) was shown to Soeumin's 4 exterior deficiency diseases, Taeumin's 1 exterior deficiency disease and 1 interior excess disease, and Soyangin's 1 interior excess disease. (3) Coughing symptom(咳) was shown to Soeumin's 1 extrerior deficiency disease and Taeumin's 1 interior excess disease. (4) Fullness in the chest(胸滿) was shown co Soyangin's 4 exterior excess diseases. (5) Sweating symptoms(汗出) was shown to Soeumin's 10 exterior deficiency diseases, Taeumins's 1 exterior deficiency disease, and Soyangin's 1 exterior defecieny disease. (6) Cold-heat symptoms(寒熱) was shown to Soyangin's 4 exterior excess diseases. (7) Dysphoria(煩躁) was shown co Soeumin's 1 exterior deficiency disease and 8 interior deficiency diseases, Taeumin's 1 interior excess disease, and Soyangin's 4 exterior excess and interior excess diseases. (8) Sneezing symptom was shown to Taeumin's 1 exterior excess disease.

• 동의생리병리학회지
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• 제22권2호
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• pp.487-496
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• 2008

The purpose of this study is to investigate clinical frequency and priority of five pattern identification settled by Korean Standard Differentiation of the Symptoms and Sign for Stroke. The present study was done over 177 hospitalized patient with stroke in the Daejeon University Oriental Medical Hospital in the period of November 2006 to July 2007. Stroke patients had been interviewed by residents and specialists who studied standard operation procedures in Fundamental study for Standardization and Objectification of Differentiation and Pattern Identification of Syndrome of Oriental Medicine for Stroke. In Heat-transformation pattern group, men showed significantly high frequency and in Deficiency of Gi pattern group, women showed significantly high frequency. In Heat-transformation pattern group, the indicators such as 'aversion to heat during fever', 'flushed face', 'full and rapid pulse', 'dryness of the eyes, 'yellow coating of the tongue', 'feverishness of the limbs', 'dryness of the eyes' showed significantly high frequency. In Dampphlegm syndrome group, the indicators such as 'white coating of the tongue', 'yellowish face', 'thick coating of the tongue', 'wheezing in the throat with sputum', 'swollen tongue', 'slippery pulse' showed significantly high frequency. In Deficiency of Gi pattern group, the indicators such as 'pale tongue', 'lassitude', 'pale face', 'weakness pulse' showed significantly high frequency. In Deficiency of Eum group, the indicators such as 'short and rapid pulse', 'mirror-like tongue' showed significantly high frequency. For more sensitive Korean Standard Differentiation of the Symptoms and Signs for Stroke, Large scale study is to be done, giving weight on the important indicators.