• Toxicological Research
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• 제26권4호
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• pp.301-313
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• 2010

Growth promoters including hormonal substances and antibiotics are used legally and illegally in food producing animals for the growth promotion of livestock animals. Hormonal substances still under debate in terms of their human health impacts are estradiol-$17\beta$, progesterone, testosterone, zeranol, trenbolone, and melengestrol acetate (MGA). Many of the risk assessment results of natural steroid hormones have presented negligible impacts when they are used under good veterinary practices. For synthetic hormonelike substances, ADIs and MRLs have been established for food safety along with the approval of animal treatment. Small amounts of antibiotics added to feedstuff present growth promotion effects via the prevention of infectious diseases at doses lower than therapeutic dose. The induction of antimicrobial resistant bacteria and the disruption of normal human intestinal flora are major concerns in terms of human health impact. Regulatory guidance such as ADIs and MRLs fully reflect the impact on human gastrointestinal microflora. However, before deciding on any risk management options, risk assessments of antimicrobial resistance require large-scale evidence regarding the relationship between antimicrobial use in food-producing animals and the occurrence of antimicrobial resistance in human pathogens. In this article, the risk profiles of hormonal and antibacterial growth promoters are provided based on recent toxicity and human exposure information, and recommendations for risk management to prevent human health impacts by the use of growth promoters are also presented.

• Journal of Preventive Medicine and Public Health
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• 제52권1호
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• pp.21-29
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• 2019

Objectives: The Regional Cardiocerebrovascular Center (RCCVC) Project designated local teaching hospitals as RCCVCs, in order to improve patient outcomes of acute cardiocerebrovascular emergencies by founding a regional system that can adequately transfer and manage patients within 3 hours. We investigated the effects of RCCVC establishment on treatment volume and 30-day mortality. Methods: We constructed a panel dataset by extracting all acute myocardial infarction cases that occurred from 2007 to 2016 from the Health Insurance Review and Assessment Service claims data, a national and representative source. We then used a panel fixed-effect model to estimate the impacts of RCCVC establishment on patient outcomes. Results: We found that the number of cases of acute myocardial infarction that were treated increased chronologically, but when the time effect and other related covariates were controlled for, RCCVCs only significantly increased the number of treatment cases of female in large catchment areas. There was no statistically significant impact on 30-day mortality. Conclusions: The establishment of RCCVCs increased the number of treatment cases of female, without increasing the mortality rate. Therefore, the RCCVCs might have prevented potential untreated deaths by increasing the preparedness and capacity of hospitals to treat acute myocardial infarction patients.

• 보건행정학회지
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• 제24권2호
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• pp.120-127
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• 2014

Background: Since December 2010, online computerized prospective drug utilization review (pDUR) has been implemented in Korea. pDUR involves the review of each prescription before the medication is dispensed to the individual patient. The pDUR is performed electronically by Health Insurance Review & Assessment Service (HIRA), which is a Korean governmental agency, and then HIRA provides medical institutions and pharmacies with information that can be helpful to them in preventing potential drug problems such as drug/drug interactions or ingredient duplication. The aim of this study was to assess the impact of the Korean pDUR implementation on the proportion of drug-drug interactions (DDIs) using claims data from HIRA. Methods: A before-after comparison of the prevalence of DDIs between prescription was conducted, using HIRA administrative claims data of medical institution from January 2010 to December 2011. The analysis unit was the prescription issued and pairs before and after. The main outcome measures were the proportion of DDIs within- (control group) or between- physician encounters. To examine the difference, a paired t-test was applied. Results: We found that DDIs proportion between prescription decreased significantly (t=3.04, p=0.0026) after the implementation of pDUR, whereas there is no significant reduction within prescription (t=1.15, p=0.2518). With respect to the prevalence of DDIs between drug groups, the most dramatic reduction was occurred between 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and anti-fungal agents. Conclusion: It seems effective that giving a direct feedback to prescribers by a prospective DUR. Further research is needed to assess the impact of DUR to final outcomes such as hospitalization.

• 환경영향평가
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• 제4권1호
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• pp.17-23
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• 1995

To assess preliminarily the contamination potential of water resources including groundwater owing to the hydrogeological characteristics of landfill site and the potential impact to humans and animals through contamination of water resources by leachate, "Landfill Site Preliminary Assessment Model(LASPAS)" was contrived. LASPAS could help them proritization of remediation of landfil sites by the convenient and relatively simple evaluation method of landfill site features. LASPAS was designd to aliot numerical ratings to landfill site related factors undermentioned; 1) hydrogeological factors such as hydraulic conductivity of aquifer, thickness of confining layer over aquifer, topographical slope, net recharge, and subsurface containment 2) water resources contamination factors of impacts on receptors such as proximity to drinking water supply, substitutability of drinking water supply, type of use of water resources, known impact on drinking water supply, and flood potential.

• 웰빙융합연구
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• 제7권3호
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• pp.73-95
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• 2024

Purpose: Since August 2000, the small-scale environmental impact assessment system has prevented indiscriminate development. However, its qualitative reports lack objectivity and consistency. This study analyzes these issues through literature and expert surveys and proposes improvements. Research Methodology: Samples were selected based on regional consultation numbers. Mitigation measures were categorized into qualitative and quantitative factors. Issues were identified, and improvements suggested. The Delphi method helped select evaluation items and propose a scoring table. Results and Conclusions: The Delphi method selected 14 absolute and 22 relative evaluation items, excluding 3 invalid ones. A 100-point scoring table was created, with points assigned based on element significance. A 1-point bonus was added for top-scoring elements to promote eco-friendly planning.

• Toxicological Research
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• 제17권
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• pp.17-24
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• 2001

Risk assessment is useful tool making good decisions on the risks of certain hazardous com-pound and suggests safe margin through scientific process using toxicological data, statistical tool, exposure value and relevant variants. The goal of risk management is to protect the public health from hazardous compound based on result of risk assessment having reality. For the suggestion of exact man-aging information, risk assessment must be designed to represent a "plausible estimate" of the exposure to the individuals and to minimize uncertainty. Risk assessment methodology and knowledge are expected to change more rapidly than before and up-to-date methodology should be applied in regulatory aspects through the Agency. For the useful application of risk assessment, the communication between the risk assessor and the risk manager is needed before the initiation of the risk assessment and upon its completion. Generally, the risk assessment itself as a practical tool in the regulatory decision making process would be regarded with social economic impact.ic impact.

• 환경영향평가
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• 제30권2호
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• pp.61-74
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• 2021

본 연구에서는 해양에서 진행되는 개발사업으로 인하여 해양환경에 미치는 영향을 효율적으로 판단할 수 있는 평가지수들을 비교·검토하였다. 해양수질 분야에는 수질평가지수(WQI), 해양저질 분야에는 유해화학물질 정화지수(CIHC), 부영양화 정화지수(CIET), 농축계수(EF), 해양저서생물 분야에는 저서건강도지수(BHI), 저서오염지수(BPI)를 선정하였다. 개발사업에서 관측된 자료를 각각의 평가지수에 적용하여 평가지수의 특성 및 효용성을 파악하였다. 수질평가지수, 유해화학물질 정화지수, 저서건강도지수가 평가방법 및 평가기준이 명확히 정의되어 있으며, 통합적인 환경영향 분석이 가능하였다. 동 연구에서 제시된 지수이외에도 해양환경을 평가하는 다양한 지수가 있으며, 사업별 특성에 따라 적합한 지수를 활용하는 것도 중요하다.

• 웰빙융합연구
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• 제6권3호
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• pp.13-18
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• 2023

Purpose: The small-scale environmental impact assessment has been in operation since its implementation in August 2000, and is a system that meets the purpose of sustainable development in consideration of the environment in areas requiring conservation. However, when preparing a small environmental impact assessment report, the contents of the reduction measures are too qualitative, or reports are prepared to simply list the compliance stipulated by individual laws, and the contents of consultations prepared by consultative agencies and review agencies are not much different. In addition, the direction of consultation on development projects for similar locations of the same project type is frequently changed by reflecting the subjective judgment of the consultative officer of the Ministry of Environment (Environment Agency). Therefore, this study attempted to improve the establishment of measures to reduce the existing simple listing of qualitative contents and the inconsistent presentation of review opinions by consultative agencies and review agencies. Research design, data and methodology: The research method extracted absolute evaluation items and relative evaluation items among small environmental impact assessment items, analyzed and presented detailed items, and prepared a distribution table for each section according to the details of the relative evaluation items, and presented them as a table. Results: This study was conducted to derive uniform results with objective indicators in the preparation and consultation process of a small-scale environmental impact assessment. Conclusions: Once a quantitative evaluation is established, the consultant can objectively determine and process the environmental impact.

• 환경영향평가
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• 제21권5호
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• pp.631-648
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• 2012

The integrative ecological approaches of chemical assessments, physical habitat modelling, and multi-metric biological health modelling were applied to Gwanpyeong Stream within Gap-Stream watersheds to evaluate environmental impacts on the constructions of residential and commercial complex. For the analysis, the surveys conducted from 45 sites of reference streams within the Gap-Stream watershed and 3 regular sites during 2009 - 2010. Physical habitat health, based on the habitat model of Qualitative Habitat Evaluation Index(QHEI) declined from the headwaters(good - fair condition) to the downstream(poor condition). Chemical water quality, based turbidity and electric conductivity(EC), was degraded toward to the downstream, and especially showed abrupt increases, compared to the values of control streams(CS). Also, concentrations of chlorophyll-a in the downstreams were greater compared to the control stream(CS), indicating an eutrophication. Biological health conditions, based on the Index of Biological Integrity(IBI) using fish assemblages, averaged 19.3 which is judged as a fair condition by the biological criteria of the Ministry of Environment, Korea. The comparisons of model metric values in sensitive species and riffle-benthic species on the Maximum Species Richness Line(MSRL) of 45 reference streams indicated a massive disturbances in all sampling locations. Also, tolerance guild and trophic guild analyses suggest that dominances of tolerant species and omnivores were evident, indicating a biological degradation by habitat disturbances and organic matter pollutions. There was no distinct longitudinal variations of IBI model values from the headwater to the downstream in spite of slight chemical and habitat health gradients among the sampling sites. Overall, integrative ecological health(IEH) scores, based on the chemical, physical, and biological parameters, were low compared to the 45 reference streams due to physical and chemical disturbances of massive constructions of the residential and commercial complex. This stream, thus showed a tendency of typical urban streams which are disturbed in the chemical water quality, habitat structures, and biological integrity. Effective stream management plans and restoration strategies are required in this urban stream for improving integrative stream health.

• 한국지역지리학회지
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• 제20권4호
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• pp.444-453
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• 2014

환경위험의 피해가 환경불평등과 사회불평등의 상호작용으로 인해 환경약자가 더 많이 피해를 받게 되는 환경 피해 불평등이 심화될 것으로 전망되고 있다. 본 연구는 서울시를 대상으로 미국 캘리포니아 환경보호청에서 개발한 환경보건 스크리닝 툴을 적용하여 통합적인 지역 규모의 누적영향을 평가하였다. 환경보건 취약지역을 스크리닝하기 위하여 환경노출과 건강영향의 환경부담, 민감집단과 사회경제적 요인의 인구특성에 따라 10개 지표를 선정하였다. 환경보건 스크리닝 툴을 통하여 2009~2011년 서울시 누적영향평가를 실시한 결과, 서울의 강서와 강남지역에서 위험요인이 높게 나타났며 강서지역은 환경부담과 인구특성 모두에서 위험요인이 높았고, 강남지역은 환경부담요인이 높은 것으로 나타났다. 연구결과는 민감 취약계층 등 환경약자를 고려한, 공정하고 효율적인 환경정책을 추진하기 위한 과학적인 근거를 제공할 수 있다.