• 한국물환경학회지
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• 제22권5호
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• pp.737-747
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• 2006

Ministry of Environment (MOE) of Korea has been implementing the water quality management policy to focus on the control of organic matters (BOD and COD) for 28 years since 1978 when the water quality standards had been established. However, the government and the public have begun to recognize the necessity of creating the best water environment for people and aquatic life, and also formulating the various measures of water pollution, Consequently, MOE of Korea is establishing the basic plan of water environment management, with the vision of "Clean Water, Eco River 2015." The major targets of water environment management plan are to maintain ecosystem health and to protect water quality from various hazardous substances in water bodies. In order to achieve the major targets, it is essential to amend the water quality standards, which bring about the systematic management of various pollutants and healthy ecosystem. Introduction of the new techniques of water environment assessment is also prerequisite to maintain sustainable water environment. These can be accomplished under the consideration of following suggestions in environmental quality standards. First, several criteria should be complemented in water quality standards; they include the improvement of the current water quality classification system, the strengthening and supplement of relevant parameters considering human health in the standards, the introduction of biotic indices, and management standards on eutrophication. Secondly, it should be considered to introduce the biological water quality standards using biotic indices and the management standards for sediments. Lastly, it needs to introduce or develop an ecological status classification which could be used in the assessment of the water environment as a whole.

• 한국물환경학회지
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• 제23권1호
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• pp.161-168
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• 2007

The main aim of this work is focus on the Geum river water quality evaluation of pollution data obtained by monitoring measurement during the period 2001-2005. The complex data matrix 19 (entire monitoring stations)*13 (parameters), 60 (month)*13 (parameters) and 20 (season)*13 (parameters) were treated with different multivariate techniques such as factor analysis/principal component analysis (FA/PCA). FA/PCA identified two factor (19*13) classified pollutant Loading factor (BOD, COD, pH, Cond, T-N, T-P, $NH_3$-N, $NO_3$-N, $PO_4$-P, Chl-a), seasonal factor (water temp, SS) and three Factor (60*13, 20*13) classified pollutant Loading factor (BOD, COD, Cond, T-N, T-P, $NH_3$-N, $NO_3$-N, $PO_4$-P), seasonal factor (water temp, SS) and metabolic factor (Chl-a, pH). Loadings of pollutant factor is potent influence main factor in the Geum river which is explained by loadings of pollutant factor at whole sampling stations (71.16%), month (52.75%) and season (56.57%) of main water quality stations. Result of this study is that pollutant loading factor is affected at Gongju 1, 2, Buyeo 1, 2, Gangkyeong, Yeongi stations by entire stations and entire month (Gongju 1, Cheongwon stations), April, May, July and August (buyeo 1) by month. Also the pollutant Loading factor is season gives an influence in winter (Gongju 1, buyeo 1) from main sampling stations, but Cheongwon characteristic is non-seasonal influenced. This study presents necessity and usefulness of multivariate statistic techniques for evaluation and interpretation of large complex data set with a view to get better information data effective management of water sources.

• 대한한의정보학회지
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• 제15권1호
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• pp.67-76
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• 2009

Quality management is a recent phenomenon. Advanced civilizations that supported the arts and crafts allowed clients to choose goods meeting higher quality standards than normal goods. There are many methods for quality improvement. Health care, refers to the treatment and management of illness, and the preservation of health through services offered by the medical, dental, complementary and alternative medicine, pharmaceutical, clinical laboratory sciences (in vitro diagnostics), nursing, and allied health professions. Health care embraces all the goods and services designed to promote health, including "preventive, curative and palliative interventions, whether directed to individuals or to populations. The overall impact of managed care remains widely debated. Proponents argue that it has increased efficiency, improved overall standards, and led to a better understanding of the relationship between costs and quality. Practices can solicit feedback from patients in a variety of ways: phone surveys, written surveys, focus groups or personal interviews. What do I do with the results? While you don't have to act on every suggestion that your patients give you, you should take action on the key items that are causing dissatisfaction.

• 동의생리병리학회지
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• 제27권3호
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• pp.331-335
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• 2013

This study investigated the relationship between drinking and health factors including vaso-aging degree, stress index, stress resistance, fatigue and activity of autonomic nerve system etc. The subjects were 20,925 persons who had received health examination by Korean Medicine and submitted questionnaires about drinking history, for 8 months from March to November. The vaso-aging degree were measured by APG (Accelerated Photoplethysmograph). The stress index and resistance, fatigue and activity of autonomic nerve system were measured by HRV (Heart Rate Variability). We analyzed the relationship between drinking and various variables by chi-square test with SPSS ver. 19.0. Regarding the relationship between drinking and vaso-aging degree, there was significant differences(p<0.05). But regarding the relationship between drinking and the other factors, there were no statistically differences. This study suggests that the vaso-aging degree is affected by drinking alcohol.

• 한국보건교육건강증진학회:학술대회논문집
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• 한국보건교육건강증진학회 2005년도 제30회 보건학종합학술대회
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• pp.234-243
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• 2005

상당히 성공적인 사람병원체인 결핵균을 Robert Koch가 발견한 이래, 결핵 방제의 상당한 진보에도 불구하고, 결핵의 발생은 현재까지 계속되어오고 있다(Tiruviluamala and Reichman 2002). 그러므로, 완전한 민감성과 특이성을 갖는 신속한 진단방법이 결핵과 결핵의 잠복감염을 진단하는데 요구되어지며(Tiruviluamala and Reichman 2002), 계속적으로 결핵균과 BCG의 유전체와 단백질체 연구를 통하여 결핵 방제수단이 발전되어질 것이다 (Jungblut et al. 1999). 본 연구는 PPD가 결핵을 진단하는 특이한 항원만으로 정확하게 조화를 이루고 있지 않다는 것을 보여주었으며, 그것의 역가는 결론적으로 생물학적으로 평가되어져야 하지만, PPD의 제조는 단백질체 분석 기법에 의해 분석되고 표준화될 수 있음을 보여주었다. 이를 통하여 결핵 피내진단의 일괄된 결과를 위해 PPD 사용 전에 이와같은 단백질체 분석기법을 적용할 수 있을 것으로 사료되며, 본 연구에서 밝혀진 특이 항원은 새로운 피내진단항원으로 적용될 수 있을 것으로 사료된다.

• 센서학회지
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• 제31권2호
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• pp.71-78
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• 2022

Wearable devices have the potential to revolutionize future medical diagnostics and personal healthcare. The integration of biosensors into scalable form factors allow continuous and noninvasive monitoring of key biomarkers and various physiological indicators. However, conventional wearable devices have critical limitations owing to their rigid and obtrusive interfaces. Recent developments in functional biocompatible materials, micro/nanofabrication methods, multimodal sensor mechanisms, and device integration technologies have provided the foundation for novel skin-interfaced bioelectronics for advanced and user-friendly wearable devices. Nonetheless, it is a great challenge to satisfy a wide range of design parameters in fabricating an authentic skin-interfaced device while maintaining its edge over conventional devices. This review highlights recent advances in skin-compatible materials, biosensor performance, and energy-harvesting methods that shed light on the future of wearable devices for digital health and personalized medicine.

• 대한한의진단학회지
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• 제15권2호
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• pp.175-190
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• 2011

Objectives: Even though there has been no consensus on the concept of viscera organ between the oriental and western medicine, we tried to investigate the correlation between clinical biomarkers of five Jang and chronological age and develop the models for predicting five Jang biological ages by statistical analysis. Methods: We obtained data from about 120,000 subjects who visited health promotion centers for health promotion and disease prevention from January 2004 to June 2009. Participants were included if they were over 20 years old, and excluded if reported to have cardiovascular disease or other serious medical illness such as cancer, malignant hypertension, uncontrolled diabetes, cardiopulmonary insufficiency, liver disease, pancreatic disease or renal disease. Among the clinical biomarkers obtained, we selected the biomarkers which were associated with the function of 5 Jang in previous studies, or showed statistically significant correlation with age. Multiple regression models were used for building prediction models of biological age after adjusting for potential confounders for men and women, respectively. Pearson correlation coefficient was calculated to examine the linear relationship between age and various biomarkers, and multiple regression analysis was used for building the prediction models of five Jang biological ages for men and women, respectively. All statistical data analysis was performed by using SPSS Version 12.0 software and statistical significance was obtained if p<0.05. Results: For males, the best models were developed using 12, 2, 8, 3, and 4 biomarkers for predicting biological ages of heart, lung, liver, pancreas, and kidney, respectively (R2 = 0.57, 0.43, 0.11, 0.24, and 0.93, respectively). Similar to males, for the females, 10, 2, 8, 3, and 4 biomarkers were selected as the models respectively (R2 = 0.76, 0.44, 0.14, 0.38, and 0.89, respectively). Conclusions: As we have developed for the first time the models for predicting five Jang biological ages with common clinical biomarkers, it is expected that these models may be used as clinical supplementary tools in the evaluation of aging status and functional decline of five Jang according to age in health promotion centers and private clinics. At the same time, it is considered that the use as objective tools to evaluate aging status and functional decline of each Jang.

• 대한의생명과학회지
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• 제25권4호
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• pp.426-430
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• 2019

Currently, molecular diagnostic assays based on nucleic acid amplification tests have been shown to effectively detect mycobacterial infections in various types of specimen, however, variable sensitivity was shown in FFPE samples according to the kind of commercial kit used. The present study therefore used automated PCR-reverse blot hybridization assay (REBA) system, REBA Myco-ID HybREAD 480^®, for the rapid identification of Mycobacterium species in various types of human tissue and compared the conventional one-tube nested-PCR assay for detecting Mycobacterium tuberculosis (MTB). In conventional nested-PCR tests, 25 samples (48%) were MTB positive and 27 samples (52%) were negative. In contrast, when conducted PCR-REBA assay, 11 samples (21%) were MTB positive, 20 samples (39%) were NTM positive, 8 samples (15%) were MTB-NTM double positive, and 13 samples (25%) were negative. To determine the accuracy and reliability of the two molecular diagnostic tests, the one-tube nested-PCR and PCR-REBA assays, were compared with histopathological diagnosis in discordant samples. When conducted nested-PCR assay, 10 samples (59%) were MTB positive and seven samples (41%) were negative. In contrast, when conducted PCR-REBA test, three samples (17%) were MTB positive, 10 samples (59%) were NTM positive and four samples (24%) were negative. In conclusion, the automated PCR-REBA system proved useful to identify Mycobacterium species more rapidly and with higher sensitivity and specificity than the conventional molecular assay, one-tube nested-PCR; it might therefore be the most suitable tool for identifying Mycobacterium species in various types of human tissue for precise and accurate diagnosis of mycobacterial infection.

• Journal of Microbiology and Biotechnology
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• 제29권9호
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• pp.1488-1493
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• 2019

The rising cases of multidrug-resistant Acinetobacter baumannii (Ab) and the lack of effective drugs call for quick attention. Here, based on a Tn7 transposon and Xer/dif system, we constructed a stable, selectable marker-free autoluminescent Ab capable of producing visible light without extra substrates. Utilization of this autoluminescent reporter strain has the potential to reduce the time, effort and costs required for the evaluation of activities of anti-Ab drug candidates in vitro.

• Clinical and Experimental Pediatrics
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• 제55권3호
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• pp.77-82
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• 2012

Human astrovirus (HAstV) is a major cause of acute diarrhea among children, resulting in outbreaks of diarrhea and occasionally hospitalization. Improved surveillance and application of sensitive molecular diagnostics have further defined the impact of HAstV infections in children. These studies have shown that HAstV infections are clinically milder (diarrhea, vomiting, fever) than infections with other enteric agents. Among the 8 serotypes of HAstV identified, serotype 1 is the predominant strain worldwide. In addition to serotype 1, the detection rate of HAstV types 2 to 8 has increased by using newly developed assays. HAstV is less common compared with other major gastroenteritis viruses, including norovirus and rotavirus; however, it is a potentially important viral etiological agent with a significant role in acute gastroenteritis. A better understanding of the molecular epidemiology and characteristics of HAstV strains may be valuable to develop specific prevention strategies.