• Journal of Preventive Medicine and Public Health
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• v.35 no.2
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• pp.83-91
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• 2002

Bioinformatics is a rapidly emerging field of biomedical research. A flood of large-scale genomic and postgenomic data means that many of the challenges in biomedical research are now challenges in computational sciences. Clinical informatics has long developed methodologies to improve biomedical research and clinical care by integrating experimental and clinical information systems. The informatics revolutions both in bioinformatics and clinical informatics will eventually change the current practice of medicine, including diagnostics, therapeutics, and prognostics. Postgenome informatics, powered by high throughput technologies and genomic-scale databases, is likely to transform our biomedical understanding forever much the same way that biochemistry did a generation ago. The paper describes how these technologies will impact biomedical research and clinical care, emphasizing recent advances in biochip-based functional genomics and proteomics. Basic data preprocessing with normalization, primary pattern analysis, and machine learning algorithms will be presented. Use of integrated biochip informatics technologies, text mining of factual and literature databases, and integrated management of biomolecular databases will be discussed. Each step will be given with real examples in the context of clinical relevance. Issues of linking molecular genotype and clinical phenotype information will be discussed.

• Progress in Medical Physics
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• v.33 no.2
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• pp.11-24
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• 2022

X-ray detection has widely been applied in medical diagnostics, security screening, nondestructive testing in the industry, etc. Medical X-ray imaging procedures require digital flat detectors operating with low doses to reduce radiation health risks. Recently, metal halide perovskites (MHPs) have shown great potential in high-performance X-ray detection because of their attractive properties, such as strong X-ray absorption, high mobility-lifetime product, tunable bandgap, low-temperature fabrication, near-unity photoluminescence quantum yields, and fast photoresponse. In this paper, we review and introduce the development status of new perovskite X-ray detectors and imaging, which have emerged as a new promising high-sensitivity X-ray detection technology. We discuss the latest progress and future perspective of MHP-based X-ray detection in medical imaging. Finally, we compare the conventional detection methods with quantum-enhanced detection, pointing out the challenges and perspectives for future research directions toward perovskite-based X-ray applications.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5325-5329
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• 2013

Objectives: Although there are many reports about the risk of breast cancer, few have reported clinical factors including history of breast-related or other diseases that affect the prevalence of breast cancer. This study explores these risk factors for breast cancer cases reported in Beijing in 2009. Materials and Methods: Data were derived from a Beijing breast cancer screening performed in 2009, of 568,000 women, from 16 districts of Beijing, all aged between 40 and 60 years. In this study, multilevel statistical modeling was used to identify clinical factors that affect the prevalence of breast cancer and to provide more reliable evidence for clinical diagnostics by using screening data. Results and Conclusion: Those women who had organ transplants, compared with those with none, were associated with breast cancer with an odds ratio (OR)=65.352 [95% confidence interval (CI): 8.488-503.165] and those with solid breast mass compared with none had OR=1.384 (95% CI: 1.022-1.873). Malignant tendency was strongly associated with increased risk of breast cancer, OR=207.999(95% CI: 151.950-284.721). The risk of breast cancer increased with age, $OR_1$=2.759 (95% CI: 1.837-4.144, 56-60 vs. 40-45), $OR_2$=2.047 (95% CI: 1.394-3.077, 51-55 vs. 40-45), $OR_3$=1.668 (95% CI: 1.145-2.431). Normal results of B ultrasonic examination show a lower risk among participants, OR= 0.136 (95% CI: 0.085-0.218). Those women with ductal papilloma compared with none were associated with breast cancer, OR=6.524 (95% CI: 1.871-22.746). Therefore, this study suggests that clinical doctors should pay attention to these high-risk factors.

• The Journal of the Korean dental association
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• v.50 no.1
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• pp.31-37
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• 2012

Objective : This research compared stabilities between two types of dental implant ($SLA^{TM}$, Institut Straumann AG, Waldenburg, Switzerland and $SSII^{TM}$, Osstem co, Busan, Korea) using Osstell Mentor (Integration Diagnostics AB, Goteborg, Sweden) considering surgery methods, surgery area, diameter of implant, systemic disease, and smoking for obtaining prognosis information when installing fixture of dental implant. Materials & Methods : 206 implants of 131 patients taken by resonance frequency analysis (RFA) were determined as a final sample. Dental implants were installed as protocol of supplier by a excellent dentist who had 10 years experience about dental implants. Before connecting abutments (3 months after installation of fixture), RFA were measured twice for buccal and lingual direction to obtain average value. Results : Dental implants at mandible showed significantly higher stabilities significantly than at maxilla (p<0.001). Diameter 4.8 implants had also higher stabilities than diameter 4.1 in case of $SLA^{TM}$ implants (p<0.001). $SLA^{TM}$ implants showed more excellent stabilities than $SSII^{TM}$ implants, especially at posterior area of mandible (p=0.045) and premolar area of maxilla (p=0.032). Conclusions : This research revealed higher stabilities of $SLA^{TM}$ implants than $SSII^{TM}$ implant, especially at posterior area of mandible (p=0.045) and premolar area of maxilla (p=0.032).

• Journal of the Korean Society for Nondestructive Testing
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• v.23 no.5
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• pp.445-454
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• 2003

Health monitoring is a major concern not only in the design and manufacturing but also in service stages for composite laminated structures. Excessive loads or low velocity impact can cause matrix cracks and delaminations that may severely degrade the load carrying capability of the composite laminated structures. To develop the health monitoring techniques providing on-line diagnostics of smart composite structures can be helpful in keeping the composite structures sound during their service. In this study, we discuss the signal processing techniques and some applications for health monitoring of composite structures using piezoceramic sensors and fiber optic sensors.

• Journal of Society of Preventive Korean Medicine
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• v.14 no.3
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• pp.37-49
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• 2010

Objective : Qigong has been reported as an effective for post-mastectomy women. It consists of a series of postures combined with slow, smooth, graceful movements, and is considered a low intensity exercise. In this study, a specialist of Qigong developed a Qigong program for post-mastectomy women in a community. The object of this research is to evaluate the effect of Qigong on a subjective symptom scale, on the grade of discomfort and pain in everyday life, BMI, fat(%), muscular strength, shoulder joint movement, in post-mastectomy women. Methods : The study used a non-equivalent control group non-synchronized design. The experimental group received a Qigong 3 times a week for 12 weeks from September 7th to December 28th in 2009. The subjects were 40 patients are divided into 25 persons in experimental groups and 15 persons in contrastive group. The data were analyzed with descriptive statistics, chi-square test, t-test, Mann-Whitney U test. A P-value less than .05 was considered significant by 2-tailed test. All statistical analyses were performed with SPSS win(ver 12.0). Results : The results were as follows : The score in the subjective symptom(p=.040), and score of anxiety (p=.024), fat(%)(p=.007) were significantly decreased after Qigong program. The values for shoulder flexibility (left : p=.010, right : p=.008), and Muscular strength(grip power)(left : p=.021, right : p=.029) significantly increased after Qigong program. And Flexion(left ; p=.029), Extension(left : p=.001, right : p=.038), Adduction(left ; p=.001, right ; p<0.001) were also significantly increased after Qigong Conclusions : The Qigong is an effective health promotion program for post-mastectomy women.

• The Korean Journal of Cytopathology
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• v.19 no.2
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• pp.144-151
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• 2008

Fine needle aspiration (FNA) cytology is the decisive test in the pre-operative diagnostics of thyroid nodules. Here we share our institutional experience about thyroid aspiration and give suggestions for suspicious cytology results. Three hundred twenty-two cases in 270 patients (mean age 47.4 years, 243 women and 27 men) who underwent thyroidectomy were reviewed. Among the 322 cases, the FNA diagnosis of "positive for malignancy" was 87 cases (27.0%), "suggestive of malignancy" 30 cases (9.3%), "suspicious for malignancy" 61 cases (18.9%), "negative for malignancy" 102 cases (31.7%), and "unsatisfactory smear" 42 cases (13.0%). Eighty seven cases (100%) out of "positive for malignancy", 29 cases (96.7%) out of "suggestive of malignancy", and 39 cases (64.0%) out of "suspicious for malignancy" were papillary carcinoma (148 cases, 95.5%), or follicular carcinoma (2 cases, 1.3%), or metastatic carcinoma (1 case, 0.6%). Seventeen patients who had only negative or unsatisfactory cytology underwent thyroidectomy and nine cases (52.9%) were papillary carcinoma. We suggest that: the cytology diagnosis of "suggestive of malignancy" could be regarded as "positive for malignancy", the cytology diagnosis of "suspicious of malignancy" should be carefully correlated with clinico-radiologic manifestation, and even a negative or unsatisfactory smear should be carefully followed up.

• The Journal of the Korea Contents Association
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• v.17 no.9
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• pp.476-485
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• 2017

This study was analyzed obesity status by divided into six classification based on the body mass index(BMI) established by World Health Organization-Western Pacific Regional Office(WHO-WPRO) through National Health Insurance Service(NHIS). In the middle of process, problems of outlier solved by presenting the median repeated interpolation. Unlike linear and Lagrange interpolation, median repeated interpolation may be useful in multiple outlier contained dataset. As a result, we found that extreme low and obesity weight gradually increased and the frequency of normal body weight gradually decreased. Especially, the increase of obesity in men and women of lower age group is increasing. Overall, this study suggests that national measures need to be taken before health problems arising from obesity can spread to other social problems.

• Korean Journal of Clinical Laboratory Science
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• v.53 no.1
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• pp.11-18
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• 2021

Respiratory viruses (RVs) cause infections in hospital environments through direct contact with infected visitors. In infection control, it causes major problems of acquired infections in hospitals by respiratory viruses. The surveillance data derived from clinical laboratories are often used to properly allocate medical resources to hospitals and communities for treatment, consumables, and diagnostic product purchases in the institutions and public health sectors that provide health care. An early diagnosis is essential in infection with respiratory viruses, and methods that can be used in diagnostic methods using respiratory samples include virus culture, molecular diagnosis, and analysis. A microchip provides a new strategy for developing a more diverse and powerful technology called point-of-care testing. The importance of the respiratory system should be applied strictly to the infection control guidelines to ensure the occupational health and safety of health care workers. Evidence of clinical efficacy, including this study, is challenging the long-standing paradigm for infection propagation. Additional assistance will be needed for frequent tests to detect respiratory viruses in inpatients who have begun to show new respiratory symptoms indicating infections requiring efforts to control the infection.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.10 no.1
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• pp.36-45
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• 2006

Background and purpose: Well being which emphasizes peace of mind and richness of spirit, has been already used from several thousands years ago, as the name of Yangsaeng(養生) when we regard it in the view point of oriental medicine. Yangsaeng means a person's daily life according to natural rules in order to compensate his essence qi spirit(精氣神) and to prevent and cure his disease for his long life, and there are environment, spirit, qigong, food, dwelling labor, sleeping and sexual intercourse as its methods. But in Korea, we are mainly using the health and concept of the health management and use of it, with the one developed in Western. Thus, in this study, literature study was made for the situation of research and feature of Yangsaeng method. Among them, I tried to study mainly on adapting method of Exercise Yangsaeng and its possibility which can derive harmonious development of Spirit and body for human body, in the view point of identity(整體觀). Methods: Diploma thesis and words of 'Yangsaeng', 'exercise cure', 'exercise therapy', and 'exercise prescription', in 'KERIS(Korea Education & Research Iformation Service).' Results and conclusion: In this study, in order to adapt oriental method of Yangsaeng to the reality, I selected and researched only Exercise Yangsaeng among various Yangsaeng methods including environment, spirit, qigong, food, dwelling labor, sleeping and sexual intercourse. The Exercise Yangsaeng has its advantage that it ran train both mind and body as well as it has various programs, but it is regarded at it is in need of more study as lows; First, it requires assessment on the effect of construction itself as well as degree management of Excercise Yangsaeng as a method of exercise which is being done in daily life or in the literature. Second, above all, standardization of Yangsaeng Exercise and specialized programs are required in order to introduce the Exercise Yangsaeng which was verified for its effect, to the cure of disease. Third, researches are required for the system of assessment management for measurement of relative effect of standardized programs. fourth, continuous compensation is required in the future by adapting researched and developed programs into the field.