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http://dx.doi.org/10.15324/kjcls.2021.53.1.11

Diagnostic Methods of Respiratory Virus Infections and Infection Control  

Park, Chang-Eun (Department of Biomedical Laboratory Science, Molecular Diagnostics Research Institute, Namseoul University)
Publication Information
Korean Journal of Clinical Laboratory Science / v.53, no.1, 2021 , pp. 11-18 More about this Journal
Abstract
Respiratory viruses (RVs) cause infections in hospital environments through direct contact with infected visitors. In infection control, it causes major problems of acquired infections in hospitals by respiratory viruses. The surveillance data derived from clinical laboratories are often used to properly allocate medical resources to hospitals and communities for treatment, consumables, and diagnostic product purchases in the institutions and public health sectors that provide health care. An early diagnosis is essential in infection with respiratory viruses, and methods that can be used in diagnostic methods using respiratory samples include virus culture, molecular diagnosis, and analysis. A microchip provides a new strategy for developing a more diverse and powerful technology called point-of-care testing. The importance of the respiratory system should be applied strictly to the infection control guidelines to ensure the occupational health and safety of health care workers. Evidence of clinical efficacy, including this study, is challenging the long-standing paradigm for infection propagation. Additional assistance will be needed for frequent tests to detect respiratory viruses in inpatients who have begun to show new respiratory symptoms indicating infections requiring efforts to control the infection.
Keywords
Droplet; Infection control; Laboratory detection; Respiratory viruses;
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1 MacIntyre CR, Chughtai AA, Seale H, Richards GA, Davidson PMl. Respiratory protection for healthcare workers treating Ebola virus disease (EVD): are facemasks sufficient to meet occupational health and safety obligations? Int J Nurs Stud. 2014;51:1421-1426. https://doi.org/10.1016/j.ijnurstu.2014.09.002   DOI
2 Osterholm MT, Moore KA, Kelley NS, Brosseau LM, Wong G, Murphy FA, et al. Transmission of ebola viruses: what we know and what we do not know. MBio. 2015;6:e00137-15. https://doi.org/10.1128/mBio.00137-15   DOI
3 Otter JA, Yezli S, French GL. The role played by contaminated surfaces in the transmission of nosocomial pathogens. Infect Control Hosp Epidemiol. 2011;32:687-699. https://doi.org/10.1086/660363   DOI
4 Center for Disease Control and Prevention (CDC). Prevention Strategies for Seasonal Influenza in Healthcare Settings [Internet]. Atlanta: Center for Disease Control and Prevention; 2018 [cited 2020 November 16]. Available from: http://www.cdc.gov/flu/professionals/infectioncontrol/healthcaresettings.html
5 Sun Y, Deng J, Qian Y, Zhu R, Wang F, Tian R, et al. Laboratory evaluation of rapid antigen detection tests for more-sensitive detection of respiratory syncytial virus antigen. Jpn J Infect Dis. 2019;72:394-398. https://doi.org/10.7883/yoken.JJID.2018.528   DOI
6 Cho CH, Lee CK, Nam MH, Yoon SY, Lim CS, Cho Y, et al. Evaluation of the AdvanSure real-time RT-PCR compared with culture and Seeplex RV15 for simultaneous detection of respiratory viruses. Diagn Microbiol Infect Dis. 2014;79:14-18. https://doi.org/10.1016/j.diagmicrobio.2014.01.016   DOI
7 Gharabaghi F, Hawan A, Drews SJ, Richardson SE. Evaluation of multiple commercial molecular and conventional diagnostic assays for the detection of respiratory viruses in children. Clin Microbiol Infect. 2011;17:1900-1906. https://doi.org/10.1111/j.1469-0691.2011.03529.x   DOI
8 Shirato K, Yano T, Senba S, Akachi S, Kobayashi T, Nishinaka T, et al. Detection of Middle East respiratory syndrome coronavirus using reverse transcription loop-mediated isothermal amplification (RT-LAMP). Virol J. 2014;11:139. https://doi.org/10.1186/1743-422X-11-139   DOI
9 Song Q, Zhu R, Sun Y, Zhao L, Wang F, Deng J, et al. Identification of human metapneumovirus genotypes A and B from clinical specimens by reverse transcription loop-mediated isothermal amplification. J Virol Methods. 2014;196:133-138. https://doi.org/10.1016/j.jviromet.2013.10.037   DOI
10 Liu J, Nian QG, Li J, Hu Y, Li XF, Zhang Y, et al. Development of reverse-transcription loop-mediated isothermal amplification assay for rapid detection of novel avian influenza A (H7N9) virus. BMC Microbiol. 2014;14:271. https://doi.org/10.1186/s12866-014-0271-x   DOI
11 Gadsby NJ, Hardie A, Claas EC, Templeton KE. Comparison of the Luminex respiratory virus panel fast assay with in-house real-time PCR for respiratory viral infection diagnosis. J Clin Microbiol. 2010;48:2213-2216. https://doi.org/10.1128/JCM.02446-09   DOI
12 Landry ML, Ferguson D. Comparison of Simplexa Flu A/B & RSV PCR with cytospin-immunofluorescence and laboratory-developed TaqMan PCR in predominantly adult hospitalized patients. J Clin Microbiol. 2014;52:3057-3059. https://doi.org/10.1128/JCM.00738-14   DOI
13 Mahony J, Chong S, Merante F, Luinstra K, Sinha T, Petrich A, et al. Development of a respiratory virus panel (RVP) test for the detection of twenty human respiratory viruses using multiplex PCR and a fluid microbead-based assay. J Clin Microbiol 2007;45:2965-2970. https://doi.org/10.1128/JCM.02436-06   DOI
14 Centers for Disease Control and Prevention. Overview of Influenza Testing Methods [Internet]. Atlanta: Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases (NCIRD); 2020 [cited 2021 January 25]. Available from: https://www.cdc.gov/flu/professionals/diagnosis/overview-testing-methods.htm
15 Dawson ED, Moore CL, Dankbar DM, Mehlmann M, Townsend MB, Smagala JA, et al. Identification of A/H5N1 influenza viruses using a single gene diagnostic microarray. Anal Chem. 2007;79:378-384.   DOI
16 Syrmis MW, Whiley DM, Thomas, Mackay IM, Williamson J, Siebert DJ, et al. A sensitive specific and cost-effective multiplex reverse transcriptase-PCR assay for the detection of seven common respiratory viruses in respiratory samples. J Mol Diagn 2004;6:125-131. https://doi.org/10.1016/S1525-1578(10)60500-4   DOI
17 Mesquita FDS, Oliveira DBL, Crema D, Pinez CMN, Colmanetti TC, Thomazelli LM, et al. Rapid antigen detection test for respiratory syncytial virus diagnosis as a diagnostic tool. J Pediatr (Rio J). 2017;93:246-252. https://doi.org/10.1016/j.jped.2016.06.013   DOI
18 MacIntyre CR, Chughtai AA, Seale H, Richards GA, Davidson PM. Uncertainty, risk analysis and change for Ebola personal protective equipment guidelines. Int J Nurs Stud. 2015;52:899-903. https://doi.org/10.1016/j.ijnurstu.2014.12.001   DOI
19 Yang S, Li H, Tang Y, Yu F, Ma C, Zhang H, et al. Multiplex tests for respiratory tract infections: the direct utility of the FilmArray respiratory panel in emergency department. Can Respir J. 2020;2020:6014563. https://doi.org/10.1155/2020/6014563   DOI
20 Center for Disease Control and Prevention. Interim infection prevention and control recommendations for hospitalized patients with Middle East respiratory syndrome CoronaVirus (MERS-CoV) [Internet]. Atlanta: Center for Disease Control and Prevention; 2014 [cited 2021 Jan 02]. Available from: http://www.cdc.gov/coronavirus/mers/infection-prevention-control.html.
21 Chowell G, Fenimore PW, Castillo-Garsow MA, Castillo-Chavez C. SARS outbreaks in Ontario, Hong Kong and Singapore: the role of diagnosis and isolation as a control mechanism. J Theor Biol. 2003;224:1-8. https://doi.org/10.1016/s0022-5193(03)00228-5   DOI
22 Hall CB, Douglas RG, Jr, Geiman JM, Messner MK. Nosocomial respiratory syncytial virus infections. N Engl J Med. 1975;293:1343-1346.   DOI
23 Lessler J, Reich NG, Brookmeyer R, Perl TM, Nelson KE, Cummings DA, et al. Incubation periods of acute respiratory viral infections: a systematic review. Lancet Infect Dis. 2009;9:291-300. https://doi.org/10.1016/S1473-3099(09)70069-6   DOI
24 Haas LE, de Rijk NX, Thijsen SF. Human metapneumovirus infections on the ICU: a report of three cases. Ann Intensive Care. 2012;2:30. https://doi.org/10.1186/2110-5820-2-30   DOI
25 Ralston SL, Lieberthal AS, Meissner HC, Alverson BK, Baley JE, Gadomski AM, et al. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics. 2014;134:e1474-1502. https://doi.org/10.1542/peds.2014-2742   DOI
26 Gralton J, Tovey E, McLaws ML, Rawlinson WD. The role of particle size in aerosolised pathogen transmission: a review. J Infect. 2011;62:1-13. https://doi.org/10.1016/j.jinf.2010.11.010   DOI
27 Musher D.M. How contagious are common respiratory tract infections? N Engl J Med. 2003;348:1256-1266. https://doi.org/10.1056/NEJMra021771   DOI
28 Somerville LK, Ratnamohan VM, Dwyer DE, Kok J. Molecular diagnosis of respiratory viruses. Pathology. 2015;47:243-249. https://doi.org/10.1097/PAT.0000000000000240   DOI
29 MacIntyre CR, Chughtai AA, Rahman B, Peng Y, Zhang Y, Seale H, et al. The efficacy of medical masks and respirators against respiratory infection in healthcare workers. Influenza Other Respir Viruses. 2017;11:511-517. https://doi.org/10.1111/irv.12474   DOI
30 Vemula SV, Zhao J, Liu J, Wang X, Biswas S, Hewlett I. Current approaches for diagnosis of influenza virus infections in humans. Viruses. 2016;8:96. https://doi.org/10.3390/v8040096   DOI
31 Public Health Agency of Canada. Human parainfluenza virus [Internet]. Ottawa, Public Health Agency of Canada; 2011 [cited 2021 January 25]. Available from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/parainfluenza-eng.php
32 French CE, McKenzie BC, Coope C, Rajanaidu S, Paranthaman K, Pebody R, et al. Risk of nosocomial respiratory syncytial virus infection and effectiveness of control measures to prevent transmission events: a systematic review. Influenza Other Respir Viruses. 2016;10:268-290. https://doi.org/10.1111/irv.12379   DOI
33 Public Health Agency of Canada. Adenovirus [Internet]. Ottawa, Public Health Agency of Canada; 2011 [cited 2021 January 25]. Available from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/adenovirus-eng.php
34 Public Health Agency of Canada. Human coronavirus [Internet]. Ottawa, Public Health Agency of Canada; 2020 [cited 2021 January 25]. Available from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/coronavirus-eng.php
35 Public Health Agency of Canada. Influenza virus type A [Internet]. Ottawa, Public Health Agency of Canada; 2011 [cited 2021 January 25]. Available from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/influenza-a-eng.php
36 Public Health Agency of Canada. Influenza virus type B [Internet]. Ottawa, Public Health Agency of Canada; 2012 [cited 2021 January 25]. Available from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/influenza-grippe-b-c-eng.php
37 Public Health Agency of Canada. Respiratory syncytial virus [Internet]. Ottawa, Public Health Agency of Canada; 2011 [cited 2021 January 25]. Available from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/pneumovirus-eng.php
38 Public Health Agency of Canada. Rhinovirus [Internet]. Ottawa, Public Health Agency of Canada; 2011 [cited 2021 January 25]. Available from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/rhinovirus-eng.php
39 Damasio GA, Pereira LA, Moreira SD, Duarte dos Santos CN, Dalla-Costa LM, Raboni SM. Does virus-bacteria coinfection increase the clinical severity of acute respiratory infection? J Med Virol. 2015;87:1456-1461. https://doi.org/10.1002/jmv.24210   DOI
40 Jiang W, Wang T, Li L, Ji W, Wang Y, Yan Y. Impact of bacteria in nasal aspirates on disease severity of bronchiolitis. Infect Dis (Lond). 2016;48:82-86. https://doi.org/10.3109/23744235.2015.1082621   DOI
41 Griffiths C, Drews SJ, Marchant DJ. Respiratory syncytial virus: Infection, detection, and new options for prevention and treatment. Clin Microbiol Rev. 2017;30:277-319. https://doi.org/10.1128/CMR.00010-16   DOI
42 Thorburn K, Harigopal S, Reddy V, Taylor N, van Saene HK. High incidence of pulmonary bacterial co-infection in children with severe respiratory syncytial virus (RSV) bronchiolitis. Thorax. 2006;61:611-615. https://doi.org/10.1136/thx.2005.048397   DOI
43 Ginocchio CC, Swierkosz E, McAdam AJ, Marcon M, Storch GA, Valsamakis A, et al. Multicenter study of clinical performance of the 3M rapid detection RSV test. J Clin Microbiol. 2010;48:2337-2343. https://doi.org/10.1128/JCM.00130-10   DOI
44 Schwartz RH, Selvarangan R, Zissman EN. BD Veritor system respiratory syncytial virus rapid antigen detection test: point-of-care results in primary care pediatric offices compared with reverse transcriptase polymerase chain reaction and viral culture methods. Pediatr Emerg Care. 2015;31:830-834. https://doi.org/10.1097/PEC.0000000000000371   DOI
45 Piche-Renaud PP, Turcot J, Chartrand C, Gravel J, Labrecque M, Vallieres E, et al. Evaluation of a fluorescent immunoassay rapid test (Sofia) for detection of influenza A+B and RSV in a tertiary pediatric setting. Diagn Microbiol Infect Dis. 2016;84:304-308. https://doi.org/10.1016/j.diagmicrobio.2015.10.025   DOI
46 Leonardi GP, Wilson AM, Dauz M, Zuretti AR. Evaluation of respiratory syncytial virus (RSV) direct antigen detection assays for use in point-of-care testing. J Virol Methods. 2015;213:131-134. https://doi.org/10.1016/j.jviromet.2014.11.016   DOI
47 Salez N, Nougairede A, Ninove L, Zandotti C, de Lamballerie X, Charrel RN. Prospective and retrospective evaluation of the Cepheid Xpert(R) Flu/RSV XC assay for rapid detection of influenza A, influenza B, and respiratory syncytial virus. Diagn Microbiol Infect Dis. 2015;81:256-258. https://doi.org/10.1016/j.diagmicrobio.2015.01.008   DOI
48 Popowitch EB, Miller MB. Performance characteristics of Xpert Flu/RSV XC assay. J Clin Microbiol. 2015;53:2720-2721. https://doi.org/10.1128/JCM.00972-15   DOI
49 Jonckheere S, Verfaillie C, Boel A, Van Vaerenbergh K, Vanlaere E, Vankeerberghen A, et al. Multicenter evaluation of BD Veritor System and RSV K-SeT for rapid detection of respiratory syncytial virus in a diagnostic laboratory setting. Diagn Microbiol Infect Dis. 2015;83:37-40. https://doi.org/10.1016/j.diagmicrobio.2015.05.012   DOI