• Biomedical Science Letters
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• v.20 no.4
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• pp.194-200
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• 2014

Ginsan, polysaccharide isolated from the root of Panax ginseng C.A. Meyer, has been shown to be a potent immunomodulator, producing several cytokines and stimulating lymphoid cells to proliferate. In this study, ginsan was orally inoculated into BALB/c mice up to 39 days and the activity of immune cells containing macrophages and T cells was analyzed. Moreover, the production of cytokines, e.g., tumor necrotic factor-${\alpha}$ (TNF-${\alpha}$), interferon-${\gamma}$ (IFN-${\gamma}$), GM-CSF and IL-12 was also analyzed. In results, the phagocytosis of macrophages was increased. About 13% cytotoxicity of NK cells was observed in 22 days and 29 days of administration. But, oral administration did not highly affect the proliferation of T cells. In cytokine analysis, 150 mg/kg and 300 mg/kg at 22 days and 29 days showed three times more increase in TNF-${\alpha}$ than the controls. IFN-${\gamma}$ showed 1.07 and 1.16 times more increase at 150 mg/kg and 300 mg/kg over 22 days, respectively more than the controls. 32 days of 150 mg/kg and 300 mg/kg induced GM-CSF of about 1.3 times more than the controls. IL-12 was not induced in samples more than the controls. Ginsan could be a potential immunostimulator. Therefore, our study suggests that it can be adapted as an immunostimulator that requires a relatively short oral administration.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.12 no.2
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• pp.1-7
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• 2008

Objectives: The basis research of aged people's healthcare technology is very important, because our nation goes into an aged society rapidly. Especially in traditional medicine, pulse shapes of aged people were supposed to weak and empty pulse until now, but any objective measurement and compare research do not taken. Methods and Results: Therefore in this study we design observation study to find characteristic of pulse between younger group (age $20{\sim}30$) and elder group (age $43{\sim}80$) in Busan area. We used 3-dimensional pulse analyzer '3-D MAC' (Daeyomedi Co., Ltd.). And major parameters for comparison are 1) pulse height (h1), 2) applied pressure, 3) pulse power (energy), 4) high pressure duration (w) and 5) R-AI. Conclusions: According to analysis result, elder people's pulse has more large value in pulse height, applied pressure and pulse power than younger's that. It reveals that elder people in modernized lifestyle has Yang symptoms as well Yin symptoms. Consequently we need new method to care elder people's health, and this means more important direction than old text book. From now on verification research with objective diagnosis device like 3-D MAC, must be activated to build of evidence in traditional medicine. Cause traditional medicine's spirit of care and prevention is suitable to care elder people's cardiac and cerebral vascular disease those are have close relation with elder people.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.17 no.2
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• pp.122-130
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• 2013

Objectives This study investigated the relationship between exercise and health factors including vaso-aging degree, stress index, stress resistance, fatigue and activity of autonomic nerve system etc. Methods The subjects were 20,509 persons who had received health examination by Korean Medicine and submitted questionnaires about exercise history, for 8 months from March to November in 2011. The vaso-aging degree were measured by APG (Accelerated Photoplethysmograph). The stress index and resistance, fatigue and activity of autonomic nerve system were measured by HRV (Heart Rate Variability). We analyzed the relationship between exercise and various variables by chi-square test with SPSS ver. 19.0. Results Regarding the relationship between exercise and vaso-aging degree, stress index, stress resistance, fatigue and activity of autonomic nerve system, there were significant differences(p<0.05). Conculsions This study suggests that vaso-aging degree, stress index, stress resistance, fatigue and activity of autonomic nerve system are affected by exercise.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.20 no.1
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• pp.1-13
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• 2016

Objectives The aim of this study is to develop diagnostic and assessable questionnaires for cervical movement system impairment syndromes. Methods We reviewed the previous study and literature, and organized various checkable items for differential diagnosis of four different cervical movement system impairment syndromes. Next, we selected items which can be developed as questionnaire items. Finally, we conducted a face validity study with twelve Korean medical doctors and carried out survey research to evaluate the importance score of the items with three experts. Results We developed a diagnostic and assessable questionnaire as follows: 9 items for cervical extension syndrome; 5 items for cervical flexion syndrome; 9 items for cervical rotation syndrome. By conducting 2 rounds of survey research, we were able to bridge the differences in the importance score of each item. Conclusions A questionnaire for the diagnosis and assessment of movement system impairment syndromes was developed. This questionnaire holds promising applications for objective diagnosis and assessment of cervical movement system impairment syndromes. This tool may also be used for detecting the sub-health status of musculoskeletal systems.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.289-294
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• 2016

Background: S100A10, of the S100 protein family, is reported to be involved in cancer cell invasion and metastasis. The aims of the present study were to immunohistochemically examine S100A10 expression in surgically resected lung adenocarcinomas, and evaluate any relationships with clinicopathological parameters and prognosis of patients. Materials and Methods: S100A10 expression was immunohistochemically studied in 202 consecutive resected lung adenocarcinomas, and its associations with clinicopathological parameters were evaluated. Kaplan-Meier survival analysis and Cox proportional hazards models were used to estimate the effect of S100A10 expression on survival. Results: S100A10 expression was detected in 65 of the 202 (32.2%) lung adenocarcinomas, being significantly correlated with poorer differentiation (P =0.015), a higher pathological TNM stage (stages II and III) (P=0.004), more frequent and severe intratumoral vascular invasion (P=0.001), and a poorer prognosis (P=0.030). However, S100A10 expression was not an independent predictor of survival after controlling for clinicopathological factors. Conclusions: The present study reveals that S100A10 is expressed in a subset of lung adenocarcinomas, and this is related to some clinicopathological parameters, although further studies are required to confirm the correlation between S100A10 expression and prognosis of lung adenocarcinoma patients.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• v.y2005m4
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• pp.248-251
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• 2005

In this paper, health monitoring technique has been studied for performance deterioration caused by the defects of the gas turbine. The parameters for performance diagnostics have been extracted by using GSP program for modeling the target engine. The virtual sensor model for the health monitoring has been built of those data. The position and magnitude of the defects of the engine components have been determined by using Multiple Linear Regression technique and the method using the weight in order to diagnose the single and multiple defects.

• Smart Structures and Systems
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• v.6 no.5_6
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• pp.661-673
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• 2010

This paper presents recent developments in an extremely compact, wireless impedance sensor node (the WID3, $\underline{W}$ireless $\underline{I}$mpedance $\underline{D}$evice) for use in high-frequency impedance-based structural health monitoring (SHM), sensor diagnostics and validation, and low-frequency (< ~1 kHz) vibration data acquisition. The WID3 is equipped with an impedance chip that can resolve measurements up to 100 kHz, a frequency range ideal for many SHM applications. An integrated set of multiplexers allows the end user to monitor seven piezoelectric sensors from a single sensor node. The WID3 combines on-board processing using a microcontroller, data storage using flash memory, wireless communications capabilities, and a series of internal and external triggering options into a single package to realize a truly comprehensive, self-contained wireless active-sensor node for SHM applications. Furthermore, we recently extended the capability of this device by implementing low-frequency analog-to-digital and digital-to-analog converters so that the same device can measure structural vibration data. The compact sensor node collects relatively low-frequency acceleration measurements to estimate natural frequencies and operational deflection shapes, as well as relatively high-frequency impedance measurements to detect structural damage. Experimental results with application to SHM, sensor diagnostics and low-frequency vibration data acquisition are presented.

• The Journal of Korean Medicine
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• v.44 no.1
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• pp.1-15
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• 2023

Objectives: National health insurance herbal prescription of Korean medicine has been serving important role in public healthcare in spite of continuous demand on revision of system. However, the categories of insurance herbal prescriptions are not equally distributed throughout the KCD-based major disease categories. We analyzed statistical database of claimed national health insurance classified as major disease categories by years. We classified all 56 herbal prescriptions as per their total medical indications into 22 major disease categories to analyze their distribution. Significant increase of M and S-T code claims were found, whereas decrease of U code claims by years. We figured out that the 56 prescriptions were unequally distributed along with enrichment of certain codes such as K and J. Meanwhile, the insurance claim of each prescription was positively correlated with number of code types of their indications. As a result, we believe that the reform of national health insurance herbal prescription list is necessary to promote use of it in clinic.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.16 no.3
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• pp.11-22
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• 2012

Objectives: The aim of this study was to elucidate the relationship between pulse types measured by pulse analyzer and several factors including smoking, drinking alcohol, exercises etc. Methods: The subjects were 71 persons who were tested by oriental health examination. A self-reported questionnaire was used to gather age, smoking, drinking alcohol, exercise state and gender. The pulse types were measured by DMP 1000. The index of stress and fatigue were measured by SA 3000. We analyzed the frequency of pulse types according to gender, ages, smoking, drinking alcohol etc by chi-square test with SPSS ver. 19.0. Results: In the main pulse types, there were significant differences according to age(p<0.05) and marginal differences according to drinking alcohol(p<0.1). In the secondary pulse types, there were marginal differences according to exercise, ages. But there was no significant differences according to gender, smoking, body mass index (BMI), accelerated photoplethysmography (APG) feature, stress and fatigue. Conclusions: This study suggests that the pulse types are affected by drinking alcohol, ages, exercise.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2013.10a
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• pp.799-804
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• 2013

The sensor/actuator active sensor diagnostics procedure, where the sensors/actuators are confirmed to be functioning properly during operation, is a critical component to successfully complete the structural health monitoring (SHM) process with large numbers of active sensors typically installed in a structure. The basis of this process is to track the changes in the capacitive value of piezoelectric materials, which shows up in measured admittance. Due to the temperature dependent nature of piezoelectric materials, we investigated the effects of temperature variations on sensor diagnostic process. The effect of temperature variations found to be remarkable, modifying the measured capacitive values significantly. In addition we analyzed the effect of bonding agents between a PZT patch and a host structure. This paper summarizes considerations needed to develop such sensor diagnostic processes, experimental procedures and results, and additional issues that can be used as guidelines for future investigations.