• Carbon letters
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• v.23
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• pp.17-21
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• 2017

Polyurethane (PU) nanofibers containing graphene oxide (GO) and Ag doped functionalized reduced graphene oxide (Ag-RGO) were successfully prepared via the electrospinning technique. The uniform distribution of GO sheets along with Ag nanoparticle in the nanofibers was investigated by scanning electron microscopy and the elemental mapping technique. X-ray diffraction and thermal gravimetric analysis verified the presence of GO and Ag in the bicomposite nanofibrous mats. Antibacterial tests against Escherichia coli demonstrated that the addition of GO and Ag-RGO to the PU nanofiber greatly enhanced bactericidal efficiency. Overall, these features of the synthesized nanofibers make them a promising candidate material in the biomedical field for applications such as tissue engineering, wound healing, and drug delivery systems.

• Korean Journal of Materials Research
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• v.33 no.11
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• pp.458-464
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• 2023

In order to develop catechin patches for skin regeneration at wound sites, patches with varying concentrations of catechin and chitosan were manufactured. An optimal composition ratio was determined by adjusting the drug release rate and amount, to maximize efficiency. The catechin used in this study was extracted from green tea leaves using a solvent/ultrasonication method, and its characteristics were confirmed through Fourier transform-infrared spectroscopy (FT-IR) and high-performance liquid chromatography (HPLC) analyses. Patches were prepared with different concentrations of catechin and chitosan, and various properties were analyzed using techniques such as FT-IR, water contact angle analysis, and UV-Vis spectroscopy. It was observed that as the chitosan concentration increased, the release of catechin slowed down or almost ceased. A patch manufactured with 1.5 mg/cm² of catechin at a 1 % chitosan concentration exhibited a high initial release rate over 24 h and demonstrated cellular biocompatibility. Consequently, these patches, with tailored release characteristics based on the concentrations of chitosan and catechin, hold promise for use as drug delivery systems in wound healing applications.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.15 no.6
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• pp.187-193
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• 2015

The ICT healing platform sets a couple of goals including preventing chronic diseases and sending out early disease warnings based on personal information such as bio-signals and life habits. The 2-step open system(TOS) had a relay designed between the healing platform and the storage of personal health data. It also took into account a publish/subscribe(pub/sub) service based on large-scale connections to transmit(monitor) the data processing process in real time. In the early design of TOS pub/sub, however, the same buffers were allocated regardless of connection idling and type of message in order to encode connection messages into a deflate algorithm. Proposed in this study, the dynamic buffer allocation was performed as follows: the message transmission type of each connection was first put to queuing; each queue was extracted for its feature, computed, and converted into vector through tf-idf, then being entered into a k-means cluster and forming a cluster; connections categorized under a certain cluster would re-allocate the resources according to the resource table of the cluster; the centroid of each cluster would select a queuing pattern to represent the cluster in advance and present it as a resource reference table(encoding efficiency by the buffer sizes); and the proposed design would perform trade-off between the calculation resources and the network bandwidth for cluster and feature calculations to efficiently allocate the encoding buffer resources of TOS to the network connections, thus contributing to the increased tps(number of real-time data processing and monitoring connections per unit hour) of TOS.

• Proceedings of the Korea Society of Design Studies Conference
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• 2001.10a
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• pp.9.1-9
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• 2001

Concerning the development of suitable healthcare equipment for a aged people at their homes in order to reduce the labor and increase the efficiency in the homehelpers' work, we conducted a study on the actual conditions of healthcare in Kyoto city (healthcare in taking a meal and excretion, moving and taking a bath by using a hand-powered lift, moving by a wheelchair, shower carrier healthcare, assistance in body care and housework) by digital video filming, interviews and layout investigations. On the base of those investigations by using methods for analysis of video pictures, we divided the healthcate work into scenes and e exctracted the main problems in terms of health care equipment, information, environment, healthcare skills, mental burden, social s system, family burden, ete. Furthermore the questionnaire survey of home helpers (18 persons - 50% answers) clarified that more than half of them have lumbago pains and the biggest load in the everyday healthcare c comes from moving the patients or getting them into or out of t the equipment for moving. Finally we considered concrete proposals appropriate for each h healthcare scene image, based on evaluation toward efficiency (design guidelines) for suitable healthcare equipment for aged people at their homes: 1) Design toward a proper posture 2) Design toward self-help possibility 3) Design toward patient active participation 4) Design toward rationality of the whole process 5) Design toward place-appropriate healthcare equipment 6) Design toward healing of mind 7) Good level of healthcare skills 8) Economic, systematic rationality

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.2
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• pp.571-578
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• 2015

Prostate cancer is the most common cancer in men. In this study, we investigated immune responses of cytotoxic T lymphocytes (CTLs) against TRAMP-C2 prostate cancer cells after activation by dendritic cells (DCs) loaded with TRAMP-C2 freeze-thaw antigen and/or PEP-3 peptide in vitro. Bone marrow-derived DC from the bone marrow of the C57BL/6 were induced to mature by using the cytokine of rhGM-CSF and rhIL-4, and loaded with either the freeze-thaw antigen or PEP-3 peptide or both of them. Maturation of DCs was detected by flow cytometry. The killing efficiency of the CTLs on TRAMP-C2 cells were detected by flow cytometry, CCK8, colony formation, transwell migration, and wound-healing assay. The levels of the IFN-${\gamma}$, TNF-${\beta}$ and IL-12 were measured by enzyme-linked immunosorbent assay (ELISA). Compared with the unloaded DCs, the loaded DCs had significantly increased expression of several phenotypes related to DC maturation. CTLs activated by DCs loaded with freeze-thaw antigen and PEP-3 peptide had more evident cytotoxicity against TRAMP-C2 cells in vitro. The secretion levels of IFN-${\gamma}$, TNF-${\beta}$ and IL-12, secreted by DCs loaded with antigen and PEP-3 and interaction with T cells, were higher than in the other groups. Our results suggest that the CTLs activated by DCs loaded with TRAMP-C2 freeze-thaw antigen and PEP-3 peptide exert a remarkable killing efficiency against TRAMP-C2 cells in vitro.

• Journal of Digital Convergence
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• v.12 no.9
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• pp.209-217
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• 2014

As an idea of healing or fatigue recovery, a desire for massage therapy has increased for modern people who complain of pain such as knotted muscles or shoulder discomfort due to fatigue accumulation and stress. To resolve this, although a massage chair has been developed, it does not provide the most efficient massage as it is not suitable for Korean body types. In this paper, this research analyzed massage, assembly, massage intensity, Korean body types and functions of the massage for maximized efficiency to design critical functions. Also, we implemented the action control and algorithm of the massage chair for localization.

• Journal of The Korea Institute of Healthcare Architecture
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• v.9 no.1
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• pp.17-23
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• 2003

Among the countless elements for healing environment in healthcare facility, 'privacy' has been rather neglected in general hospital designs in Korea. The fact may be due either to present situation of excessively crowded patients or to cultural origin which more stresses on the mass than on individuals. However, as patient amenity has increasingly become important, privacy should be viewed as one of the key elements in the general hospital design, in order to improve the quality of patient service as well as to compete with other hospitals. Also it is very important that those methods for privacy improvement should be not only theoretically correct but also practical enough to be compatible with medical efficiency, space availability or construction cost within a particular hospital. The purpose of this case study is to present an actual examples to improve patients' privacy adopted in the schematic design of the Seoul Asan Hospital renovation project, along with comparisons with other hospital cases.

• New & Renewable Energy
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• v.1 no.2 s.2
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• pp.53-59
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• 2005

Objective of the research is to demonstrate solar thermal space and ground heating system which is integrated to a green-house culture facility for reducing healing cost, Increasing the value of product by environment control, and developing advanced culture technology by deploying solar thermal system. Field test for the demonstration was carried out in horticulture complex In Jeju Island. Medium scale solar hot water system was installed in a ground heating culture facility. Reliability and economic aspect of the system which was operated complementary with thermal storage and solar hot water generation were analyzed by investigating collector efficiency, operation performance, and control features. Short term day test on element performance and Long term test of the whole system were carried out. Optimum operating condition and its characteristics were closely Investigated by changing the control condition based on the temperature difference which Is the most important operating parameter For establishing more reliable and optimal design data regarding system scale and operation condition, continuous operation and monitoring on the system need to be further carried out. However, It is expected that, in high-insolation areas where large-scale ground storage is adaptable, solar system demonstrated in the research could be economically competitive and promisingly disseminate over various application areas.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.1
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• pp.153-155
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• 2015

Background: The aim of this study was to establish the feasibility and efficiency of different pelvic drainage routes after laparoscopic abdominoperineal resection (LAPR) for rectal cancer by assessing short-term outcomes. Materials and Methods: Clinicopathological data of 76 patients undergoing LAPR for very low rectal cancer were reviewed retrospectively between June 2005 and June 2014. Outcomes were evaluated considering short-term results. Results: Of 76 relevant patients at our institution in the period of study, trans-perineal drainage of the pelvic cavity was performed in 17 cases. Compared with the trans-perineal group, the length of hospital stay was shorter in the trans-abdominal group, while the duration of drainage and the infection rates of the perineal wounds between two groups showed no significant differences. Conclusions: The outcomes of this study suggest that trans-abdominal drainage of pelvic cavity is a reliable and feasible procedure, the duration of drainage, infection rates and the healing rates of the perineal wounds being acceptable. Trans-abdominal drainage has a more satisfactory effect after laparoscopic abdominoperineal resection for rectal carcinoma.

• Macromolecular Research
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• v.16 no.4
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• pp.303-307
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• 2008

A series of biodegradable polymeric scaffolds was prepared by using a combination of natural (collagen) and synthetic (poly(caprolactone)) (PCL) polymers in various compositions. These scaffolds were soft, spongy, porous and transparent in nature and were characterized by thermogravimetric analysis (TGA) and Fourier transform infrared (FT-IR) spectroscopy. The entrapment efficiency and drug release activity of the scaffolds were analyzed using penicillin and tetracycline as antimicrobial drugs. The drug release activity of the scaffolds with various combinations of collagen and PCL were studied by measuring the optical density in a spectrophotometer at the following time intervals: 1,4, 24, 48 and 60 h. These scaffolds showed better and continuous drug release for up to 60 h. Even after such a long duration, a portion of the drug remained entrapped in the scaffolds, indicating that they can be utilized for wound healing applications.