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Antimicrobial Drug Release Scaffolds of Natural and Synthetic Biodegradable Polymers  

Prabu, Periasamy (Department of Bionanosystem Engineering, Chonbuk National University)
Kim, Kwan-Woo (Department of Bionanosystem Engineering, Chonbuk National University)
Dharmaraj, Nallusamy (Department of Chemistry, Bharathiar University)
Park, Jong-Hoon (Department of Textile Engineering, Chonbuk National University)
Khil, Myung-Seob (Department of Textile Engineering, Chonbuk National University)
Kim, Hak-Yong (Department of Textile Engineering, Chonbuk National University)
Publication Information
Macromolecular Research / v.16, no.4, 2008 , pp. 303-307 More about this Journal
Abstract
A series of biodegradable polymeric scaffolds was prepared by using a combination of natural (collagen) and synthetic (poly(caprolactone)) (PCL) polymers in various compositions. These scaffolds were soft, spongy, porous and transparent in nature and were characterized by thermogravimetric analysis (TGA) and Fourier transform infrared (FT-IR) spectroscopy. The entrapment efficiency and drug release activity of the scaffolds were analyzed using penicillin and tetracycline as antimicrobial drugs. The drug release activity of the scaffolds with various combinations of collagen and PCL were studied by measuring the optical density in a spectrophotometer at the following time intervals: 1,4, 24, 48 and 60 h. These scaffolds showed better and continuous drug release for up to 60 h. Even after such a long duration, a portion of the drug remained entrapped in the scaffolds, indicating that they can be utilized for wound healing applications.
Keywords
biodegradable polymers; poly(caprolactone); collagen; scaffolds; penicillin; tetracycline;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 5  (Related Records In Web of Science)
Times Cited By SCOPUS : 5
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