• YAKHAK HOEJI
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• v.54 no.2
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• pp.142-149
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• 2010

Development of alternative testing methods for the replacement of hazardous reagents with less hazardous ones is strongly enforced because exposure of human and environment to hazardous reagents are restricted and hazardous reagents are gradually prohibited from using in various testing methods. Thus, in this study, we developed 8 monographs from the Korean Pharmaceutical Codex by substituting the use of the hazardous reagents including ICH class 1 such as benzene, chloroform and dioxane to the use of less toxic ones like ICH class 2 or 3 reagents. We also improved their qualification and quantification performance. Among 8 monographs, the 6 newly developed TLC methods for the identification of nifedipine, oxolamine citrate, ketoprofen lysinate, chlorquinaldol, retinol acetate, and riboflavin showed a clear spot of corresponding material without any interference in spite of the replacement with ICH class 2 or 3 reagents. For the quantification of domperidone and trimebutine, HPLC methods were developed for the substitution of UV/VIS spectrometry and titrimetry, respectively. These HPLC methods were validated for the linearity, recovery, reproducibility, and inter-laboratory variations. In conclusion, the newly developed methods could be expected to become valuable tools for revising the Korean Pharmaceutical Codex.

• Journal of Environmental Health Sciences
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• v.46 no.4
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• pp.423-432
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• 2020

Objectives: In this study, we analyzed the current state of delivery containers and packages and established handling guidelines to safely transport delivery containers and packages for use in research, testing, and examination reagents. Methods: Handling guidelines were revised in such categories as maintenance of the handling facilities, storage, loading and unloading, containers and packages, transportation, etc. In addition, we analyzed the current state of domestic sales for hazardous chemicals used for research, testing, and examination reagents, and investigated the handling guidelines related to delivery transportation in the USA, EU, and Japan by chemical property. Results: There are 6,160 companies selling hazardous chemicals. Among them, the 476 companies selling reagents for use in research, testing, and examination were investigated. Total amounts handled reached 425,000 tons, contributing to 0.2% of the total. For delivery transportation, internal containers and packaging was specified for chemical properties as follows: within 1 L for flammable gas, within 5 L for flammable liquid, and within 18 L for others. In addition, the maximum size of the outer package was set within 130 cm for total length, width, and height, and no dimension of the packaging could exceed 60 cm. Sixty-four hazardous chemicals with explosiveness or acute inhalation toxicity were prohibited for delivery transportation. Conclusion: Specified handling guidelines for inner and outer containers as well as packaging were regulated for delivery transportation of hazardous chemicals used for reagents. In addition, 64 hazardous chemicals were prohibited for delivery transportation. These are designed to prevent transportation accidents involving hazardous chemicals for reagents and thus protect the safety and health of transporters who handle hazardous chemicals.

• YAKHAK HOEJI
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• v.58 no.2
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• pp.125-128
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• 2014

We developed an alternative assay method without hazardous reagent of chloroform for urazamide tablets in Korean Pharmaceutical Codex. The HPLC analytical method was validated by system suitability, linearity, precision, accuracy and robustness. The linearity of the calibration curves in the desired concentration range is good ($r^2$ >0.999). Precision was obtained less than RSD 1.17%. Accuracy was obtained with recoveries in range of 98.12% and 99.47%. The developed assay could be expected to become valuable tools for revising the Korean Pharmaceutical Codex.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.10a
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• pp.790-791
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• 2016

The system used in the laboratory of chemistry and medical is management only by measuring the temperature inside the reagent management within and recording in handwriting. When you hold the reagent, it can not recognize in real time the problems that occur in the interior, an accident occurs. you can not find a use record reagent storage, a problem with the management of an efficient reagent can be generated. In this paper, we propose a reagent management system that leverages the embedded boards and sensors in the laboratory reagents effectively manage to resolve it. As a result, Converting the information of the reagent to the data using the NFC, the administrator can identify the reagent user to register and manage hazardous reagents. Converted by using the NFC information of the reagent to the data, the administrator can identify the reagent user to register and manage hazardous reagents, temperature, humidity, so that it can be controlled by utilizing the VOC sensor to. Also it is passes the message to the administrator in the event of a particular risk situation. This is believed to enable the effective administration in a laboratory reagent.

• Analytical Science and Technology
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• v.27 no.4
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• pp.196-200
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• 2014

Currently nonaqueous titration method for the assay method using the hazardous reagent, mercury acetate for difemerine hydrochloride has been used in Korean Pharmaceutical Codex. We developed an alternative titration assay method by substituting the use of the hazardous reagent, mercury acetate to the use of less toxic ones like ethyl alcohol. The linearity of the calibration curves in the desired concentration range was good (r>0.999). Precision was less than 0.64%. Accuracy was obtained with recoveries in range of 99.10% and 99.71%. The developed assay could be expected to become valuable tools for revising the Korean Pharmaceutical Codex.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.10a
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• pp.651-653
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• 2015

Common Embedded boards like the Arduino, Raspberry Pi, BeagleBone Black, leverages smart home systems, machine tools and various products in our day to day life. Managing and dealing frequent large scale incidents involving recent reagents and hazardous materials can be dangerous and difficult to detect in advance like in an event of an accidents or fires. In this paper I have done research by utilizing an Embedded (BeagleBone Black) boards sensors and RFID management system to detect a hazardous situation like fire in real time and avoiding it by sending out an alert message to the admin user to minimizing the risk. This system provides immediate information to the administrator of any hazardous situation and prevents any accidents from occurring.

• Journal of the Korean Chemical Society
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• v.54 no.4
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• pp.447-450
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• 2010

In this study, the improved large-scale synthetic route for epinastine hydrochloride, the second-generation antihistamine, was developed. The original synthetic route involves the synthesis of an aminomethyl derivative, the main intermediate, and in this process hazardous materials such as very toxic phosgene and sodium cyanide along with the explosive and expensive aluminum chloride and lithium aluminum hydride were used. In order to improve the synthetic route, we developed industrially very useful process to prepare the aminomethyl intermediate by the synthesis of the phthalimidomethyl derivative first and easy removal of the phthalyl group using hydrochloric acid or methyl hydrazine, and hazardous materials and expensive reagents were excluded in this process.

• Analytical Science and Technology
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• v.27 no.3
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• pp.161-166
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• 2014

Currently oxidation-reduction titration method for the assay method using the hazardous reagent, carbon tetrachloride, for cefroxadine capsules has been used in Korean Pharmaceutical Codex. We developed and validated an alternative HPLC assay method by substituting the use of the hazardous reagent, carbon tetrachloride, to the use of less toxic ones like acetonitrile. The linearity of the calibration curves in the desired concentration range was good ($r^2$ > 0.999). Relative standard deviations of intra-day precision were ranged between 0.30% and 0.69% and inter-day precision were ranged between 0.47% and 0.82%. Accuracy was obtained with recoveries in range of 100.20% and 100.56%. Developed method was applied to the determination of cefroxadine in commercial cefroxadine capsule and could be expected to become valuable tools for revising the Korean Pharmaceutical Codex.

• Analytical Science and Technology
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• v.9 no.4
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• pp.392-398
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• 1996

Eleven organic chemical substances, tetrachloroethylene, ethyl benzene, p-xylene, o-xylene, isopropyl benzene, n-propyl benzene. 1,2,4-trimethyl benzene, 1,3,5-trimethyl benzene, p-isopropyl toluene. see-butyl benzene, and naphthalene, which have hazardously influenced to human, were extracted from untreated wastewater collected at 26 companies of 8 types industry in the basin of Kwangju stream. Their structures were elucidated by Gas Chromatography/Mass Spectrometry(GC/MS) and in comparison with each standard reagents.

• Applied Chemistry for Engineering
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• v.17 no.6
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• pp.633-637
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• 2006

In this study, the efficient large-scale synthetic route for itraconazole, triazole antifungal agent, was developed. The original synthetic route for medicinal chemistry reported by Janssen Pharmaceutica was linear (14 linear steps) starting from 2,4-dichloroacetophenone with the total yield of 1.4%, and potential hazardous materials such as methanesulfonyl chloride ($CH_{3}SO_{2}Cl$), hydrogen gas, and sodium hydride (NaH) were used. Furthermore, the expensive 1-acetyl-4-(4-hydroxyphenyl)piperazine and palladium were used in this medicinal chemistry route, thus the manufacturing cost would be practically high. In order to improve the commercial route, we developed the process of 12 step convergent synthesis combining two intermediates which are roughly halves of itraconazole with the total yield of 12.0%, and hazardous materials and expensive reagents were excluded in this process, thus the manufacturing cost could be cut down to a great extent.