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Recent Trends of Immunologic Studies of Herbal Medicine on Rheumatoid Arthritis (류마티스 관절염에 대한 한약의 면역학적 연구동향)

  • Choi, Do-young;Lee, Jae-dong;Back, Yong-hyeon;Lee, Song-shil;Yoo, Myung-chul;Han, Chung-soo;Yang, Hyung-in;Park, Sang-do;Ryu, Mi-hyun;Park, Eun-kyung;Park, Dong-seok
    • Journal of Acupuncture Research
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    • v.21 no.4
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    • pp.177-196
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    • 2004
  • Objective : Rheumatoid arthritis is an autoimmune disease that pathogenesis is not fully understood and one of the most intractable musculoskeletal diseases. The concern in the immunopathogenesis of rheumatoid arthritis has been increased since 1980's and many immunotherapeutic agents including disease-modifying antirheumatic drugs (DMARDs) were developed and became the mainstay of treatment of rheumatoid arthritis. However, the cure of the disease has hardly been achieved. In oriental medicine, rheumatoid arthritis is related to Bi-Zheng(痺證), that presents pain, swelling, andlor loss of joint function as major clinical manifestations, and also known to be deeply involved in suppression of immune function related to weakness of Jung-Ki(正氣). The herbal medicine, empirically used, could be a potential resource of development of new immunotherapeutic agents for rheumatoid arthritis. Methods : We developed a search strategy using terms to include "rheumatoid arthritis and herbal medicine" combined with "Chinese medicine" and/or "Oriental medicine". The search was focused on experimental studies of herbal medicine (January 1999 to May 2004), which is known to have effects on immune function of patients with rheumatoid arthritis. Computerized search used Internet databases including KISS and RISS4U (Korea), CNKI (China), MOMJ (Main Oriental Medicine Journal, Japan), and PubMed. The articles were selected from journals of universities or major research institutes. Results : The literature search for experimental studies on effects of herbal medicine on immunity of rheumatoid arthritis retrieved a total of 21 articles (Korea; 8, China ; 12, Japan ; 1). Of 21 articles, 10 were related to single-drug formula, 2 to drug interaction, and 9 to multi-drug formula. Single-drug formula was mainly used for aqua-acupuncture and researches on active components. Studies of drug interaction emphasized harmony of Ki-Hyul(氣血) and balance of Han-Yeul(寒熱). Multi-drug regimen was mainly found among formulas for Bo-Ki-Hyul(補氣血) and Bo-Sin(補腎). Conclusion : Studies on rheumatoid arthritis were performed both in vitro and in vivo in vitro study, LPS-stimulated splenocytes and synoviocytes were treated with herbal medicine, resulting in proliferation and activation of immune cells and suppression of cytokine activities in vivo study CIA animal model demonstrated that herbal medicine decreased antibody production and improved function of immune cells. In cellular and molecular study herbal medicine showed profound effects on the level of mRNA expression of certain cytokines related to immune function. This study revealed that herbal medicine has significant immune modulatory action and could be used for recovery of immune dysfunction of rheumatoid arthritis patients.

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An Analysis of Value and Personality for the Crippled Person's Psychological Rehabilitation (지체장애인의 심리적 재활을 위한 성격 및 가치관 분석)

  • Eum Ik-Gon;Kim Kyu-Soo
    • The Journal of Korean Physical Therapy
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    • v.4 no.1
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    • pp.79-93
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    • 1992
  • This study is search for analyzed the primary factor of psychological characters of crippled person toward psychological rehabilitation that is the most foundmental to all rehabilitation for a crippled person. The research is, make a comparative analyze to personality character, value character, and motion, and then examined the relation of among then, by applies to high school's crippled students. First. in the personality character aspect, a group of crippled student's is shown that the factor of family relations is lack harmony than normal group, that is, shown up that a parents and family members is oversensitiveness to crippled person, So sometimes they overprotectiveness, unconcered, and not accept it is. Also, in the factor of confrontability aspect, a group of crippled person's average is shown to high as compared with normal group, and then, it shown that they are irresponsible, have a weak self-control, and show a marked trend toward self-control. This is means that crippled person have scruples about psychological and social adaptation. But friendship, adaptability, cheefulness. and emotonal stability is shown no difference with normal person. Accordingly, in the personality aspect, the falter of family-relation and confrontability can be know that the object of psychological rehabilitation. Second, in the sence of value aspect, crippled students is show that the average score had higher than normal group toward the factor of variety, therefor we can know that they have purpose to more pursur of variety in the living. This is consideration that a raise from the limited of social contact chance and badly informed and experience. Also, the factor of purpose-intention is shown that crippled students had low non than normal group, then, that means that they have a weak will toward cope with various problems in daily living. Crippled student is, in contrast to lacked fixed purpose with self-living, and also insufficient tring to accomplish their objects. Third, crippled students motion shown that related to low level of personality character and a sence of value factor. Daily living activity is show that related to the factors of confrontability and cheerfulness. This means that rehabilitation service given a change to confrontability and cheerfulness that can be effect is related. And the activity of home is related with confrontability, psychological rehabilitation for the change of activity is can say that it should be contribute to strengthen toward responsibility and self-control from self-central to intention at rho others. Fourth, the relation between an motion and a value of crippled student is shown low level of regulations that can be ignore. In sum, in the rehabilitation of crippled person, hereafter, a study subject is if which search to character factor and to find out effect inter-factors within the the factor of psychological rehabilitation as medical, occupational, social rehabilitation, then probably more effective development toward rehabilitation programs. Conseguently, hereafter for the crippled person's rehabilitaton, the study should be rquirement for establish a character and factors each filed of rehabilitation. The study sibject toward crippled person's rehabilitation for the fature is search for character factor toward medical. occupational, and social rehabilitation. and find out inter-relation among then like as search of this study for psychological rehabilitation. For the rehabilitation of crippled person, if is not preceding of study like this, it ought to be difficult to creation service as well as development to effective program.

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A Study on Environment-friendly Expressional Characteristics; As Shown in Interior Design of Public Facilities in Ulsan (울산광역시 공공시설 실내디자인의 환경친화적인 표현특성에 관한 연구)

  • 정지향;이규백
    • Archives of design research
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    • v.16 no.4
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    • pp.395-404
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    • 2003
  • Contemporary human beings have tendency to orient themselves to a natural environment while they have adapted themselves to artificial surroundings, which implies that a development of interior space where man, nature and space are in a sympathetic harmony with one another through overcoming non-naturalness and non-humanization is seriously needed. There are two methods in that; one concerns an introduction of environment-friendly expressions into the interior space as its natural factor, and the other involves expressing natural objects or beauties with orderly change commonly seen around in form of artificial design. On this study, the definition of ″Environment-friendliness″ and how it has evolved itself with time are first considered to search out for environment-friendly characteristics in the interior design. And then, among the characteristics of environment$.$friendly expressions widely observed in the interior space, the two aspects are studied for our purpose; an introduction of natural factors and an expression with artificial design. For the study, public facilities located in Ulsan were proposed since they accommodated lots of people. To meet the needs of the times that the development of environment-friendly space should reflect the factors of beauty and comfort enough to live in, relevant studies should be more activated and specialized. When there are a wide understanding of and a profound work upon introducing natural factors as well as ones of sound design into the interior space, a desirable environment-friendly expression could be created.

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Caring related to Health in Korea - Ethncgraphy centered Wichon-ri, Kangwon-do - (한국인의 건강과 관련된 돌봄 - 강원도 위촌리 지역민을 중심으로 한 문화기술지 -)

  • 황혜연
    • Journal of Korean Academy of Nursing
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    • v.30 no.1
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    • pp.194-201
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    • 2000
  • The propose of the study is to try to support the practice of caring suitable for our cultural emotion by cognating the meaning of caring related to health which is melted in korean culture. Concrete purposes were as followings; to first, confirm the caring of civilian in Kangwon-do, to secondly search the caring in the traditional culture idea, and to thirdly present the conceptual frame about the caring. The methodology of this research is the ethnography to use the depth interview and the participative observation. The geographical area of this research was in Wichon-ri, Songsan- myon, Study participants were, 6men and 18women, totally 24 persons. Their average age was 72.6 years old. The period of data collection was from January, 1998 to April, 1999, which original data became saturation. Data collection was done after accept allowance of the participants, their stories were recorded in cassettee, by the way of the Spradley analysis was applied and adjusted. The results which was analyized as domain, category and property were as following; First, the category was the life serving other persons, which is the for mind, the benefiting one, the comprehensive one, the respective one, on soon. Second, the category was the controling life, and its property was the moderate mind, that is, vegetables were tried to be fed moderately, pleasantly and comfortable. Thirdly, the category was the eagerness life, and the properties were diligent mind, and mind which accomplished the complete resposibility. Fourth, the category was a happy life, and the properties were positive mind, satisfying one, thankful one, one of their ancestors benefit, and supplicatory one. Fifth, the category was the accepting life, and the properties were the submissive mind, resign one. Sixth, the category was the joint life all together and the properties were the harmonized mind, and the mutual helping one. Seventh, the category was the ruling life, and the properties were the pure mind, the ones which controls the body, the mind, the nature; which could surely confirmed the source of the life that lived with the nature, the native idea of our people. Eighth, the category was the retaining life, and the properties were the inherits the native custom, and the one that keep public morals. According to the result of examining the caring in ethnography, the general caring was performed the conceptual frame about the caring which is related to health was found in the principle of consideration, harmony, compliance, and transcendence.

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The Analysis of Public Awareness about Literary Therapy by Utilizing Big Data Analysis - The aspects of convergence literature and statistics (빅데이터 분석을 통한 문학치료의 대중적 인지도 분석 - 국문학과 통계학의 융합적 측면)

  • Choi, Kyoung-Ho;Park, Jeong-Hye
    • Journal of Digital Convergence
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    • v.13 no.4
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    • pp.395-404
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    • 2015
  • This study is exploring objective awareness of literary therapy by consideration of popular perception about literary therapy through analysis of big data. The purpose of this study is the deduction of meaning information through analysis in the viewpoint of big data at online social network service(SNS) about 'literary therapy'. Accordingly, the main way of research became content analysis of keyword linked to literary therapy by utilizing opinion mining method related to text mining. The study mainly grasped 'literary therapy' and analyzed 'bibliotherapy' comparatively. The period of study was from Oct. 10th to Nov. 10th, 2014(during 30 days), and SNS such as blog or twitter became the subject of search. Through the result of study analysis, the conclusion that the spread of literary therapeutic prospect, structural harmony of literary therapeutic field, and the solidity of perceptional axis about literary therapy are needed can be drawn. This study is worthwhile because it can investigate popular awareness about literary therapy and can suggest alternative for invigoration of literary therapy.

A Study on Sound Design to Improve Regional Image -Focused on the Jeonju Area- (지역이미지 활성을 위한 사운드 디자인에 관한 연구)

  • Kim, Mee-Shuk;Chung, Sung-Whan;Hyoun, Sung-Eun
    • Science of Emotion and Sensibility
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    • v.10 no.4
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    • pp.613-622
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    • 2007
  • Recently, sound design is being made by corporations for the production as well as for marketing and web with consideration of image of productions and attributes to improve corporational image through the design of melody which would remain in users. And sound is becoming an important factor to establish the identity of each area such as life environment and public facilities. At present, our local governments are promoting active business like as CIP to improve urban image but there is a limit to establish identity as the result of its partial focus on visual sense or insufficient recognition about it. Jeonju, the place of sound, has many festivals and great meetings related with sound but it has not identity in the sense of sound. So the purpose of this study is to suggest the condition of sound which has the trait of Jeonju and to provide data for the trait to be used as a necessary element to establish identity in order to activate regional image. For the method of research, sampling Korean beautiful 100 sounds among the natural sounds of residents. most favorite as the samples of sound to search the sound of regional image. Selecting favorite samples among them and analyzed the factors through the questionnaire on the image of adjective in each sample. As the result of analysis, it has been shown that the factor of sound to reveal trait of Jeonju is the image of bright, delight, and cozy with consideration of harmony, dynamics, contrast, and culture. For this study is to provide data so it can be used to actively establish and identify the local image.

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The Origin and Emotion of Saekdong in Our Surroundings (주변에서 찾은 우리 색동의 기원과 감성에 대한 고찰)

  • Kim, Jisu;Na, Youngjoo
    • Science of Emotion and Sensibility
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    • v.21 no.1
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    • pp.99-114
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    • 2018
  • Saekdong is a unique Korean fabric that has been used since ancient times, and it is woven with the plain or satin weave so that vertical stripes appear by various colored warp threads of equal spacing. Saekdong means pleasure, joy, serenity, heavenly blessing, spirituality, wind, and abundance, expressing the optimistic and positive sentiment of Korea's forefathers. This study investigated how ancient Saekdong occurred with meanings. As a research method, this study used literature review and surfing newspapers and photographs, museum and internet search, even from other fields such as earthenware, bronze, and traditional dance. We collected Saekdong and the lifestyles of ethnic Koreans living in China, investigated the Asuka culture of Japan, and the tomb murals of Takamatsu-Chong, which are Baekje and Goguryeo settlement areas. The results are as follows: First, it expresses happy occasion, pleasure, and joy, and expresses a desire for good things to be repeated and lasting. Second, it symbolizes simple beauty, order, equality and harmony of many tribes. Third, Saekdong is life and power which represent a sacred, heavenly, mysterious bird. Fourth, it symbolizes abundance and wealth, rain, wind or fields. Finally, this study showed the brilliance and pride of Korean hanbok through Saekdong. The significance of this study is to examine the symbolism and inherent aesthetic characteristics of Saekdong and to show the unique value and spiritual heritage of the Korean people.

Case study of Music & Imagery for Woman with Depression (우울한 내담자를 위한 MI(Music & Imagery) 치료사례)

  • Song, In Ryeong
    • Journal of Music and Human Behavior
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    • v.5 no.1
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    • pp.67-90
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    • 2008
  • This case used MI techniques that give an imagery experience to depressed client's mental resource, and that makes in to verbalism. Also those images are supportive level therapy examples that apply to positive variation. MI is simple word of 'Music and Imagery' with one of psychology cure called GIM(Guided Imagery and Music). It makes client can through to the inner world and search, confront, discern and solve with suitable music. Supportive Level MI is only used from safety level music. Introduction of private session can associate specification feeling, subject, word or image. And those images are guide to positive experience. The First session step of MI program is a prelude that makes concrete goal like first interview. The Second step is a transition that can concretely express about client's story. The third step is induction and music listening. And it helps to associate imagery more easily by used tension relaxation. Also it can search and associate about various imagery from the music. The last step is process that process drawing imagery, talking about personal imagery experience in common with therapist that bring the power by expansion the positive experience. Client A case targets rapport forming(empathy, understanding and support), searching positive recourse(child hood, family), client's emotion and positive support. Music must be used simple tone, repetition melody, steady rhythm and organized by harmony music of what therapist and client's preference. The client used defense mechanism and couldn't control emotion by depression in 1 & 2 sessions. But the result was client A could experience about support and understanding after 3 sessions. After session 4 the client had stable, changed to positive emotion from the negative emotion and found her spontaneous. Therefore, at the session 6, the client recognized that she will have step of positive time at the future. About client B, she established rapport forming(empathy, understanding and support) and searching issues and positive recognition(child hood, family), expression and insight(present, future). The music was comfortable, organizational at the session 1 & 2, but after session 3, its development was getting bigger and the main melody changed variation with high and low of tune. Also it used the classic and romantic music. The client avoids bad personal relations to religious relationship. But at the session 1 & 2, client had supportive experience and empathy because of her favorite, supportive music. After session 3, client B recognized and face to face the present issue. But she had avoidance and face to face of ambivalence. The client B had a experience about emotion change according depression and face to face client's issues After session 4. At the session 5 & 6, client tried to have will power of healthy life and fairly attitude, train mental power and solution attitude in the future. On this wise, MI program had actuality and clients' issues solution more than GIM program. MI can solute the issue by client's based issue without approach to unconsciousness like GIM. Especially it can use variety music and listening time is shorter than GIM and structuralize. Also can express client's emotion very well. So it can use corrective and complement MI program to children, adolescent and adult.

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Color Analyses on Digital Photos Using Machine Learning and KSCA - Focusing on Korean Natural Daytime/nighttime Scenery - (머신러닝과 KSCA를 활용한 디지털 사진의 색 분석 -한국 자연 풍경 낮과 밤 사진을 중심으로-)

  • Gwon, Huieun;KOO, Ja Joon
    • Trans-
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    • v.12
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    • pp.51-79
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    • 2022
  • This study investigates the methods for deriving colors which can serve as a reference to users such as designers and or contents creators who search for online images from the web portal sites using specific words for color planning and more. Two experiments were conducted in order to accomplish this. Digital scenery photos within the geographic scope of Korea were downloaded from web portal sites, and those photos were studied to find out what colors were used to describe daytime and nighttime. Machine learning was used as the study methodology to classify colors in daytime and nighttime, and KSCA was used to derive the color frequency of daytime and nighttime photos and to compare and analyze the two results. The results of classifying the colors of daytime and nighttime photos using machine learning show that, when classifying the colors by 51~100%, the area of daytime colors was approximately 2.45 times greater than that of nighttime colors. The colors of the daytime class were distributed by brightness with white as its center, while that of the nighttime class was distributed with black as its center. Colors that accounted for over 70% of the daytime class were 647, those over 70% of the nighttime class were 252, and the rest (31-69%) were 101. The number of colors in the middle area was low, while other colors were classified relatively clearly into day and night. The resulting color distributions in the daytime and nighttime classes were able to provide the borderline color values of the two classes that are classified by brightness. As a result of analyzing the frequency of digital photos using KSCA, colors around yellow were expressed in generally bright daytime photos, while colors around blue value were expressed in dark night photos. For frequency of daytime photos, colors on the upper 40% had low chroma, almost being achromatic. Also, colors that are close to white and black showed the highest frequency, indicating a large difference in brightness. Meanwhile, for colors with frequency from top 5 to 10, yellow green was expressed darkly, and navy blue was expressed brightly, partially composing a complex harmony. When examining the color band, various colors, brightness, and chroma including light blue, achromatic colors, and warm colors were shown, failing to compose a generally harmonious arrangement of colors. For the frequency of nighttime photos, colors in approximately the upper 50% are dark colors with a brightness value of 2 (Munsell signal). In comparison, the brightness of middle frequency (50-80%) is relatively higher (brightness values of 3-4), and the brightness difference of various colors was large in the lower 20%. Colors that are not cool colors could be found intermittently in the lower 8% of frequency. When examining the color band, there was a general harmonious arrangement of colors centered on navy blue. As the results of conducting the experiment using two methods in this study, machine learning could classify colors into two or more classes, and could evaluate how close an image was with certain colors to a certain class. This method cannot be used if an image cannot be classified into a certain class. The result of such color distribution would serve as a reference when determining how close a certain color is to one of the two classes when the color is used as a dominant color in the base or background color of a certain design. Also, when dividing the analyzed images into several classes, even colors that have not been used in the analyzed image can be determined to find out how close they are to a certain class according to the color distribution properties of each class. Nevertheless, the results cannot be used to find out whether a specific color was used in the class and by how much it was used. To investigate such an issue, frequency analysis was conducted using KSCA. The color frequency could be measured within the range of images used in the experiment. The resulting values of color distribution and frequency from this study would serve as references for color planning of digital design regarding natural scenery in the geographic scope of Korea. Also, the two experiments are meaningful attempts for searching the methods for deriving colors that can be a useful reference among numerous images for content creator users of the relevant field.