• Journal of Applied Biological Chemistry
• /
• 제56권4호
• /
• pp.191-197
• /
• 2013

To classify the chemical hazard according to globally harmonized system of classification and labeling of chemicals (GHS), we investigated the genotoxicity of three chemicals, methyl myristate, 2-ethylhexanoic acid zinc salt, N,N,N',N'-tetrakis(2-hydroxyethyl) ethylenediamine, using male ICR mice bone marrow cells for the screening of micronucleus induction. Although these three chemicals have already been tested numerous times, a micronucleus test has not been conducted. The seven week-old male ICR mice were tested at three dosages for the three chemicals, respectively. After 24 h of oral administration with the three chemicals, the mice were sacrificed and their bone marrow cells were prepared for smearing slides. As a result of counting the micronucleated polychromatic erythrocyte (MNPCE) of 2,000 polychromatic erythrocytes, all treated groups expressed no statistically significant increase of MNPCE compared to the negative control group. There were no clinical signs related with the oral exposure of these three chemicals. It was concluded that these three chemicals did not induce micronucleus in the bone marrow cells of ICR mice, and there was no direct proportion with dosage. These results indicate that the three chemicals have no mutagenic potential under each test condition, and it is not classified these chemicals as mutagens by GHS.

• 생명과학회지
• /
• 제24권7호
• /
• pp.804-811
• /
• 2014

Cyclohexanone의 GHS 분류 기준에 따른 화학물질의 변이원성 구분을 위해, 다른 연구에서는 아직까지 수행된 바 없는 ICR계 마우스의 골수세포를 이용하는 in vivo 소핵시험을 수행하였다. 7주령의 수컷 ICR계 마우스에 동 시험물질의 3가지 농도를 투여하였으며, 경구투여 24시간 후에 도살, 골수세포를 채취하여 슬라이드 표본을 제작하였고, 2,000개의 다염성적혈구 중 소핵을 갖는 다염성 적혈구(MNPCE)를 계수하였다. 모든 투여군에서 cyclohexanone은 골수세포의 증식을 억제하지 않았으며, 소핵을 유발하였다. 이 골수세포를 이용한 소핵시험의 결과로 동 시험물질(cyclohexanone)은 GHS 분류기준에 의거, 변이원성 구분2로 분류하였다.

• Environmental Analysis Health and Toxicology
• /
• 제21권2호
• /
• pp.197-208
• /
• 2006

The hazards of chemicals can be classified using classification criteria that are based on physical, chemical and ecotoxicological endpoints. These criteria may be developed be iteratively, based on scientific or regulatory processes. A number of national and international schemes have been developed over the past 50 years, and some, such as the UN Dangerous Goods system or the EC system for hazardous substances, are in widespread use. However, the unnecessarily complicated multiplicity of existing hazard classifications created much unnecessary confusion at the user level, and a recommendation was made at the 1992 Rio Earth summit to develop a globally harmonized chemical hazard classification and compatible labelling system, including material safety data sheets and easily understandable symbols, that could be used for manufacture, transport, use and disposal of chemical substances. This became the globally harmonized system for the Classification and Labelling of Chemicals (GHS). The developmental phase of the GHS is largely complete. Consistent criteria for categorizing chemicals according to their toxic, physical, chemical and ecological hazards are now available. Consistent hazard communication tools such as labelling and material safety data sheets are also close to finalizations. The next phase is implementation of the GHS. The Intergovernmental Forum for Chemical Safety recommends that all countries implement the GHS as soon as possible with a view to have the system fully operational by 2008. When the GHS is in place, the world will finally have one system for classification of chemical hazards.

• 지능정보연구
• /
• 제29권1호
• /
• pp.203-214
• /
• 2023

우리나라 관세청은 효과적인 원스톱(One-stop) 업무 처리가 가능한 전자통관 시스템으로 효율적으로 업무처리를 하고 있지만 기술의 발달과 비대면 서비스의 증가로 매년 수출입건수가 증가하고 있으며 그에 따른 업무량도 폭증하고 있는 실정으로 이에 따른 보다 효과적인 방법이 매우 필요하다. 수입과 수출은 모든 물품에 대한 분류 및 세율 적용을 위한 HS Code(Harmonized system code)가 필요하고 해당 HS Code를 분류하는 품목 분류는 전문지식과 경험이 필요한 업무 난이도가 높고 관세 통관절차에서 중요한 부분이다. 이에 본 연구는 품목 분류 의뢰서의 물품명, 물품상세설명, 물품 이미지 등의 다양한 유형의 데이터 정보를 활용하여 멀티모달 표현 학습(Multimodal representation learning) 기반으로 정보를 잘 반영할 수 있도록 딥러닝 모델을 학습 및 구축하여 HS Code를 분류 및 추천해 줌으로써 관세 업무 부담을 줄이고 신속한 품목 분류를 하여 통관절차에 도움을 줄 것으로 기대한다.

• 한국환경독성학회:학술대회논문집
• /
• 한국환경독성학회 2006년도 춘계학술대회 논문집
• /
• pp.53-77
• /
• 2006

• 한국화재소방학회:학술대회논문집
• /
• 한국화재소방학회 2005년도 공동추계학술논문발표회 논문집
• /
• pp.21-34
• /
• 2005

• 대한조선학회 특별논문집
• /
• 대한조선학회 2015년도 특별논문집
• /
• pp.46-49
• /
• 2015

Common Structural Rules (CSR) about bulk carriers and double-hull oil tankers of International Association of Classification Societies (IACS) has been applied to ships contracted for construction since April 2006. By unifying each society's rules, the difference of opinion in the between shipyard and ship owners, classification was reduced, and CSR has been evaluated by rules the safety structure more enhanced. However, The CSR about the bulk carriers and double hull oil tankers, important design content standards, such as the local scantling calculation, static/dynamic load case and corrosion margin and etc., are different. Therefore in order to combine the CSR, the Harmonized CSR for bulk carriers and double hull oil tankers (H-CSR) was issued on 1, January, 2014, and will be apply to ships contracted for construction after 1st July 2015. It is necessary to verify the H-CSR to optimize the structural arrangement because effective date is not far off. In this study, we compared the impact by rule change for the hull girder shear strength of bulk carriers between CSR and H-CSR in respect of the yielding and buckling strength.

• 한국산업보건학회지
• /
• 제24권4호
• /
• pp.425-435
• /
• 2014

Objectives: This study was performed in order to establish reliable and relative selection criteria for hazardous substances requiring management(HSRM) in the Occupational Safety and Health Act in Korea. Methods: To determine the relative criteria and weight of evidence for HSRM, we analyzed the difference between the selection method of priority substances in studies by KOSHA(Korea Occupational Safety and Health Agency) and the European Union Risk Ranking Method(EURAM). In addition, 597 hazardous substances with exposure limit valueswereanalyzed and the posted health hazards classification by MOEL(Ministry of Employee and Labor), MOE(Ministry of Environment), and EU CLP(Classification, Labelling and Packaging regulation) were compared based on GHS(Globally Harmonized System of classification and labelling of chemicals) criteria. The existing HSRM(167 substances) were evaluated for suitability by the proposed criteria in this study. Results: As a result of this study, the criteria and procedures for selecting HSRM in the Occupational Safety and Health Act were arranged utilizing GHS health hazard classification results, occupational disease cases and domestic use situations. Conclusions: The applicability of the proposed criteria was proved via the evaluation of existing HSRM(167 substances). Most HSRM (161 substances) were found to correspond to a significant health effect or substantial health effect. The question of whether to include the six substances that have been found to have general health effects as HSRM would be require further research.

• 한국산업보건학회지
• /
• 제24권1호
• /
• pp.91-102
• /
• 2014

Objectives: This study was performed in order to devise a procedure for supplementing the Special Management Materials in the Occupational Safety and Health Act and recommend candidate materials. The results are expected to be used as fundamental data for classification and criteria necessary to manage Special Management Materials in workplaces. Also, they are expected to be used as a basis for selecting target materials to nominate as additional Special Management Material. Methods: We investigated the selection standards for candidates and review ranges of data sources to nominate Special Management Materials. The substances classified as GHS(Globally Harmonized System of classification and labeling of chemicals) category 1A(known to have carcinogenic potential and reproductive toxicity for humans) or 1B(presumed to have carcinogenic potential and reproductive toxicity for humans) carcinogens and reproductive toxicants among the Controlled Hazardous Substances of the Regulation on Occupational Safety and Health Standards and substances with OELs(Occupational Exposure Limits) were inspected as the candidates for Special Management Materials. Conclusions: A seven-step procedure for selecting candidates to designate as Special Management Materials was suggested, including the setting of target chemicals for evaluation, classification of CMR(Carcinogens, Mutagens or Reproductive toxicants) by GHS classification and criteria, suggestion and selection of the candidates, and more. This study recommends 58 chemicals as qualified candidates to supplement the Special Management Materials.

• 한국산업보건학회지
• /
• 제23권4호
• /
• pp.384-392
• /
• 2013

Objective: This study inspected incident cases, legal control levels, and GHS(Globally Harmonized System of Classification and Labeling of Chemicals) classification results of strong acids such as hydrogen fluoride, hydrogen chloride, nitric acid, and sulfuric acid, which have been responsible for many recent chemical accidents. As a result, it is deemed necessary for legal control levels of these strong acids to be revised and GHS classification be managed nation-wide. Methods: This study inspected incident cases and legal control levels for strong acids such as hydrogen fluoride, hydrogen chloride, nitric acid, and sulfuric acid. The study analyzed and compared chemical information status and GHS classification results. Results: There were 76 domestic incidents involving strongly acidic hazardous materials over the five years between 2007 and 2011. They include 37 leakage incidents(46.7%) within a workplace, 30 leakage incidents(39.5%) during transportation, and nine leakage incidents(13.8%) following an explosion. The strongly acidic materials in question are defined and controlled as toxic chemicals according to the classes of Substances Requiring Preparation for Accidents, Managed Hazardous Substance, Hazardous Chemical(corrosive) as set forth under the Enforcement Decree of the Toxic Chemicals Control Act and Rules on Occupational Safety and Health Standards of Occupational Safety and Health Act. Among them, nitric acid is solely controlled as a class 6 hazardous material, oxidizing liquid, under the Hazardous Chemicals Control Act. The classification results of the EU ECHA(European Chemicals Agency) CLP(Commission Regulation(EC) No. 790/2009 of 10 August 2009, for the purposes of its adaptation to technical and scientific progress, Regulation(EC) No 1272/2008 of the European Parliament and of the Council on classification, labeling and packaging of substances and mixtures) and NIER (National Institute of Environmental Research) are almost identical for the three chemicals, with the exception of sulfuric acid. Much of the classification information of NITE (National Institute of Technology and Evaluation) and KOSHA(Korea Occupational Safety and Health Agency, KOSHA) is the same. NIER provides 12(41.4%) out of 29 classifications, as does KOSHA.