• Food Engineering Progress
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• v.21 no.2
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• pp.158-166
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• 2017

Although Semisulcospira libertina is generally regarded as a supplement for the alleviation of alcohol hangover, little is known about its effects on cell metabolism. Therefore, this study was conducted to analyze the constituents of the extracts prepared using different extraction methods and to compare their biochemical properties. The amino acid contents were found to be much higher in acidic and enzymatic hydrolysates than hot water extracts from S. libertina. DPPH radical scavenging activities in acidic and enzymatic hydrolysates were higher than those of hot water extracts. Three types of S. libertina hydrolysate was added to HepG2 cells damaged by acetaminophen (AAP), after which the survival rate of HepG2 cell were measured. In addition, lactate dehydrogenase (LDH) activities in the culture media were evaluated. The survival rates of HepG2 cells were $77.0{\pm}4.3%$ and $81.5{\pm}1.3%$ at 3 h and 5h enzymatic hydrolysates, respectively. These cell survival rates were higher compared to those of the negative control group ($67.8{\pm}4.3%$) treated only with acetaminophen. Cellular toxicities induced by treatment with AAP were also significantly alleviated in response to treatment with the extracts of S. libertina. In addition, the activities of 2 key enzymes that metabolize ethanol, alcohol dehydrogenase and aldehyde dehydrogenase, were upregulated by 4.7- and 2.7-fold respectively in response to treatment with a 3 h enzymatic hydrolysate of S. libertina. Taken together, these results provide biochemical evidence of the method by which S. libertina exerts its biological functions, including the alleviation of alcohol hangover and the protection of liver cells against toxic insults.

• The Journal of the Convergence on Culture Technology
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• v.6 no.3
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• pp.381-392
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• 2020

This study is purposed to check up the natural 12 kinds of herbal extracts suitable for hangover and based on the results of contents of phenolic compounds, ABTS radical scavenging activity, alcohol dehydrogenase (ADH), and acetaldehyde dehydrogenase (ALDH). Selected 8 kinds of herbal extracts are blended according to the efficacy and the pearson's correlation between each content and activity. C. sinensis var. sinensis, P. densiflora Gnarl and P. lobata Ohwi showed excellent ADH activity, P. lobata Ohwi had a strong correlation between the content and efficacy, and C. sinensis var. sinensis, P. densiflora Gnarl had a negative correlation. Through the ADH and ALDH activity test of F.1 to F.7, the F.7 showed the highest synergic effect and selected as an optimal formulation. F.7 intake-group, the breath alcohol concentration was significantly reduced to 58% after 30 minutes and 27% after 120 minutes, compared to right after alcohol consumption. After alcohol consumption, there was a significant improvement effect (p<0.05) in tired and thirst in the intake group compared to the non-intake group.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.11
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• pp.5043-5048
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• 2011

The purpose of this study was to examine the drinking awareness of medical and health-related majors in a bid to find out the impact of their drinking awareness on drinking. The subjects in this study were 153 students who were selected by rendem sampling from colleges located in two different cities in the province. Data collection was performed from may 1 to september 20, 2011 with total 153 college students. Out of them, 86 students majored in medical departments, and 67 students were in the health-related departments. After a self-administered survey was conducted, the following findings were given: A great deal of the students who accounted for 75.8 percent were ever disturbed in daily routine life by drinking over the past year. As for the influence of drinking awareness on the amount of drinking, the amount of drinking was under the significant influence of the following five items. The first was that alcohol was an energizer(p<.001), and the second was that drinking led to a sound sleep(p<.01). The third was that I drank too much with my close friends often(p<.05), and the fourth was that alcohol used as a hangover-chaser was conducive to a hangover(p<.05). The fifth was that alcohol had the largest impact on the liver(p<.05). All the variables made a 43.4% prediction of the amount of drinking. In conclusion, the medical and health-related majors who learned about the impact of drinking on the human body in a firsthand or secondhand manner had a tendency to drink a less amount of alcohol and do less binge drinking. It's advisable to take advantage of the knowledge of medical and health-related majors on the human body and drinking as resources of anti-drinking education.

• Journal of Apiculture
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• v.32 no.3
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• pp.269-273
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• 2017

We investigated whether purified bee venom increases the enzymatic activity of the alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). ADH and ALDH assay were tested by in vitro kits. The purified bee venom was assayed by ultra performance liquid chromatography, The contents of melittin, apamin and phospholipase A2, as main component of purified bee venom, were 63.9%, 2.3%, and 10.9%, respectively. The ADH and ALDH acitivity of purified bee venom(at 1mg/ml) were $88.6{\pm}7.34%$ and $94.6{\pm}0.57%$, respectively compared with positive control at 2mg/ml. These results showed that purified bee venom induces the activity of ADH and ALDH which reduce the aldehyde concentration in the blood, suggesting the possibility of purified bee venom as resource of medicine or functional beverage for hangover relieving.

• Proceedings of the Acoustical Society of Korea Conference
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• 1998.08a
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• pp.142-147
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• 1998

Recently, 8 kb/s CS-ACELP coder of G.729 is atandardized by ITU-T SG15 and it has been reported that the speech quality of G729 is better than or equal to that of 32kb/s ADPCM. However G.729 is the fixed rate speech coder, and it does not consider the property of voice activity in mutual conversation. If we use the voice activity, we can reduce the average bit rate in half without any degradations of the speech quality. In this paper, we propose an efficient variable rate algorithm for G.729. The variable rate algorithm consists of two main subjects, the rate determination algorithm and algorithm, we combine the energy-thresholding method, the phonetic segmentation method by integration of various feature parameters obtained through the analysis procedure, and the variable hangover period method. Through the analysis of noise features, the 1 kb/s sub rate coder is designed for coding the background noise signal. So, we design the 4 kb/s sub rate coder for the unvoiced parts. The performance of the variable rate algorithm is evaluated by the comparison of speed quality and average bit rate with G.729. Subjective quality test is also done by MOS test. Conclusively, it is verified that the proposed variable rate CS-ACELP coder produced the same speech quality as G.729, at the average bit rate of 4.4 kb/s.

• Herbal Formula Science
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• v.28 no.2
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• pp.179-187
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• 2020

Objectives : This study investigated the hepatoprotective effects effects of Jageum-jung extract on alcohol-induced liver disease mice model. Methods : Alcoholic liver disease was induced by Ethanol in C57/BL6 male mice, which were fed Lieber-DeCarli liquid diet containing ethanol. Jageum-jung (100,200 and 300 mg/kg bw/day) were orally administered daily in the alcoholic fatty liver disease mice for 16 days. Results : The results indicate that Jageum-jung promotes hepatoprotective effects by significantly reducing aspartate transaminase (AST) and alanine transaminase (ALT) levels as indicators of liver damage in the serum. Furthermore, Jageum-jung decreased accumulation of triglyceride and total cholesterol, increased levels of superoxide dismutase (SOD) and glutathione (GSH) in the serum of the alcoholic fatty liver disease mice model. Additionally, it improved the serum alcohol dehydrogenase (ADH) activity. Conclusions : This study confirmed the anti-oxidative and hangover elimination effects of Jageum-jung extract, and suggests the possibility of using Jageum-jung to treat alcholic liver disease.

• Journal of the Korean Society of Food Science and Nutrition
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• v.27 no.1
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• pp.168-174
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• 1998

This study was conducted to determine whether Mildronate, an analogue of carnitine, influences blood alcohol concentration and hang-over syndrome in rabbits and healthy college male students. In the animal study, ten rabbits were randomly divided into two groups. One hundred mg per 1kg body weight of Mildronate was injected twice into five rabbits before injecting 50% ethanol; the rest of rabbits were injected with saline. The human study was performed with two sections. Each section of the study was conducted by a two-phase cross-over design with a four day wash-out period. All volunteers took Mildronate in one phase, and took a placebo in the next phase. The difference between the two sections was related to the time of taking the Mildronate pill and the amount of alcohol consumed. Blood alcohol concentrations were not significantly different between in those taking Mildronate and in those taking the placebo in both the human and the animal study. However, the concentration of serum aspartate aminotransferase(AST, GOT), the indicator of liver cell damage, was lowered in those taking Mildronate, compared to those taking the placebo. Also, headache and heartburn among hang-over syndrome patients were less severe with Mildronate. In conclusion, taking Mildronate prior to drinking alcohol can somewhat reduce liver cell damage and hang-over syndrome without stimulating alcohol metabolism.

• BMB Reports
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• v.42 no.8
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• pp.482-485
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• 2009

The effect of water dropwort (Oenanthe javanica DC) extract in eliminating ethanol was evaluated in New Zealand white rabbit and ICR mice. When a hot-water extract of water dropwort extract and ethanol was injected into New Zealand white rabbit, the plasma ethanol level was rapidly reduced, similar to metadoxine treatment. Specifically, the n-butanol fraction of hot-water extract was the strongest in eliminating plasma alcohol in ICR mice. When ethanol was orally ingested, administration of the hot-water extract eliminated up to 44% of the plasma ethanol in mice while the n-butanol fraction eliminated around 70%. Alcohol removal behaved in a dose-dependent manner in response to 50-200 mg/kg of n-butanol fraction. These data show O. javanica extract is effective in overcoming alcohol intoxication by the accelerating ethanol metabolism.

• KSBB Journal
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• v.26 no.5
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• pp.433-438
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• 2011

These studies were conducted to investigate the alcohol degradation effects of the extract of herbal composition (DTS20) containing Viscum album L., Lycium chinense L., Inonotus obliquus and Acanthopanax senticosus H., on the alcohol administered mice. To investigate anti-hangover effect, alcohol and alcohol dehydrogensae (ADH) concentration of blood were measured after oral administration of ethanol. The administration of DTS20 (200-500 mg/kg) had beneficial actions toward alcohol degradation in acute alcohol treated mice model. The oral administration of DTS20 showed decreased gastric mucous membrane damage produced in ethanol treated mice. In addition, intraperitoneal administration of DTS20 showed anti-inflammatory effects in inhibition tests of vascular permeability produced by acetic acid. DTS20 also reduced the concentration of nitric oxide (NO), tumor necrosis factor (TNF)-${\alpha}$ in macrophages that were activated by LPS. These results demonstrate that DTS20 possesses potential to stimulate the alcohol degradation and inhibit the inflammatory effects in mice.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.12C
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• pp.1660-1668
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• 2004

This paper proposes a Voice Activity Detection (VAD) algorithm based on Radial Basis Function (RBF) network using dual threshold. The k-means clustering and Least Mean Square (LMS) algorithm are used to upade the RBF network to the underlying speech condition. The inputs for RBF are the three parameters in a Code Exited Linear Prediction (CELP) coder, which works stably under various background noise levels. Dual hangover threshold applies in BRF-VAD for reducing error, because threshold value has trade off effect in VAD decision. The experimental result show that the proposed VAD algorithm achieves better performance than G.729 Annex B at any noise level.