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http://dx.doi.org/10.7841/ksbbj.2011.26.5.433

Effect of Herbal Composition, DTS20 on Alcohol Degradation and Anti-inflammatory Activity  

Yoon, Taek-Joon (Department of Food & Nutrition, Yuhan University)
Jo, Sun-Young (Department of Food Science and Biotechnology, Kyonggi University)
Lee, Sue-Jung (Department of Food & Nutrition, Yuhan University)
Kim, Eun-Young (Department of Food & Nutrition, Yuhan University)
Shin, Kwang-Soon (Department of Food Science and Biotechnology, Kyonggi University)
Suh, Hyung-Joo (Department of Food and Nutrition, Korea University)
Publication Information
KSBB Journal / v.26, no.5, 2011 , pp. 433-438 More about this Journal
Abstract
These studies were conducted to investigate the alcohol degradation effects of the extract of herbal composition (DTS20) containing Viscum album L., Lycium chinense L., Inonotus obliquus and Acanthopanax senticosus H., on the alcohol administered mice. To investigate anti-hangover effect, alcohol and alcohol dehydrogensae (ADH) concentration of blood were measured after oral administration of ethanol. The administration of DTS20 (200-500 mg/kg) had beneficial actions toward alcohol degradation in acute alcohol treated mice model. The oral administration of DTS20 showed decreased gastric mucous membrane damage produced in ethanol treated mice. In addition, intraperitoneal administration of DTS20 showed anti-inflammatory effects in inhibition tests of vascular permeability produced by acetic acid. DTS20 also reduced the concentration of nitric oxide (NO), tumor necrosis factor (TNF)-${\alpha}$ in macrophages that were activated by LPS. These results demonstrate that DTS20 possesses potential to stimulate the alcohol degradation and inhibit the inflammatory effects in mice.
Keywords
Herbal extracts; alcohol; inflammation; cytokine; NO;
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Times Cited By KSCI : 8  (Citation Analysis)
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1 Yang, D. S., S. G. Hong, S. M. Choi, B. N. Kim, H. J. Sung, and Y. Yoon (2004) Effect of oriental herbal composition, Jang Baek Union (JBU), on alcohol-induced hangover and CCl4-induced liver injury in rats. J. Korean Soc. Food Sci. Nutr. 33: 78-82.   DOI
2 Wang, X., C. X. Hai, X. Liang, S. X. Yu, W. Zhang, and Y. L. Li (2010) The protective effects of Acanthopanax senticosus Harms aqueous extracts against oxidative stress: role of Nrf2 and antioxidant enzymes. J. Ethnopharmacol. 127: 424-432.   DOI   ScienceOn
3 Day, C. P (2006) Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease. Liver Int. 26: 1021-1028.   DOI   ScienceOn
4 Mansouri, A., C. Demeilliers, S. Amsellem, D. Pessayre, and B. Fromenty (2001) Acute ethanol administration oxidatively damages and depletes mitochondrial DNA in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants. J. Pharmacol. Exp. Ther. 298: 737-743.
5 Thurman, R. G., B. Bradford, Y. Iimuro, K. Knecht, H. Connor, Y. Adachi, C. Wall, G. Arteel, J. Releigh, D. Forman, and R. P. Mason (1997) Role of kuffer cells, endotoxin and free radicals in hepatotoxicity due to prolonged alcohol consumption: studies in female and male rats. J. Nutr. 127: 903-906.
6 Albano, E. (2008) Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol. Aspects Med. 29: 9-16.   DOI   ScienceOn
7 Zamora, Z., R. Gonzalez, D. Guanche, N. Merino, S. Menendez, F. Hernandez, Y. Alonso, and S. Schulz (2008) Ozonized sunflower oil reduces oxidative damage induced by indomethacin in rat gastric mucosa. Inflamm. Res. 57: 39-43.
8 Lee, I. S., K. Kang, and R. W. Choue (2006) Beneficial effects of water extracts of Scutellariae Radix on immune function in mice fed alcohol. J. Korean Soc. Food Sci. Nutr. 35: 536-542.   DOI
9 Choi, J. S., T. J. Yoon, K. R. Kang, K. H. Lee, W. H. Kim, Y. H. Suh, J. Song, and M. H. Jung (2006) Glycoprotein isolated from Acanthopanax senticosus protects against hepatotoxicity induced by acute and chronic alcohol treatment. Biol. Pharm. Bull. 29: 306-314.   DOI   ScienceOn
10 Wheeler, M. D., M. Nakagami, B. U. Bradford, T. Uesugi, R. P. Mason, H. D. Connor, A. Dikalova, M. Kadiiska, and R. G. Thurman (2001) Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. J. Biol. Chem. 276: 36664-36672.   DOI
11 Zhao, W., F. Zhu, W. Shen, A. Fu, L. Zheng, Z. Yan, L. Zhao, and G. Fu (2009) Protective effects of DIDS against ethanolinduced gastric mucosal injury in rats. Acta. Biochim. Biophys. Sin. 41: 301-308.   DOI   ScienceOn
12 McClain, C. J., Z. Song, S. S. Barve, D. B. Hill, and I. Deaciuc (2004) Recent advance in alcoholic liver disease IV. dysregulated cytokine metabolism in alcohol liver disease. Am. J. Physiol. Gastrointest. Liver Physiol. 287: 497-502.   DOI
13 Chae, H. B. (2009) Alcoholic liver disease. Korean J. Gastroenterol. 53: 275-282.   DOI   ScienceOn
14 Mitsuyama, K., O. Tsuruta, Y. Matsui, K. Harada, N. Tomiyasu, A. Suzuki, K. Takaki, J. Masuda, K. Handa, Y. Satoh, B. L. Bennett, A. Toyonaga, and M. Sata (2006) Activation of c-Jun N-terminal kinase (JNK) signalling in experimentally induced gastric lesions in rats. Clin. Exp. Immunol. 143: 24-29.   DOI   ScienceOn
15 Olajide, O. A., S. O. Awe, J. M. Makinde, A. I. Ekhelar, A. Olusola, O. Morebise, and D. T. Okpako (2000) Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark. J. Ethnopharmacol. 71: 179-186.   DOI   ScienceOn
16 Lin, Q. Y., L. J. Jin, Z. H. Cao, Y. N. Lu, H. Y. Xue, and Y. P. Xu (2008) Acanthopanax senticosus suppresses reactive oxygen species production by mouse peritoneal macrophages in vitro and in vivo. Phytother. Res. 22: 740-745.   DOI   ScienceOn
17 Lee, H. J., J. R. DO, J. H. Kwon, and H. K. Kim (2010) Antioxidant effects of Viscum album L. extracts by extraction conditions. J. Korean Soc. Food Sci. Nutr. 39: 14-19.   DOI
18 Yoon, C. G., H. H. Kim, S. N. Chae, M. J. Oh, and G. H. Lee (2001) Hepatic oxygen free radical and alcohol metabolizing enzyme activities in rats fed diets supplemented with Lycium chinense ethanol extract. J. Korean Soc. Food Sci. Nutr. 30: 668-672.
19 Cui, Y., D. S. Kim, and K. C. Park (2005) Antioxidant effect of Inonotus obliquus. J. Ethnopharmacol. 96: 79-85.   DOI
20 Cha, W. S., J. H. Yoo, M. J. Min, H. G. Nam, Y. S. Kim, H. J. Shin, J. S. Kim, O. Y. Choi, R. Kim, and D. B. Choi (2010) Effect of complex extracts of mushroom and sharp toothed eel on the skin conditions with atopic dermatitis and acne symptoms. KSBB 25: 387-394.
21 Yoon, T. J. and S. Y. Jo (2010) Effect of Acanthopanax sentocosus extracts on alcohol degradation and anti-inflammatory activity in mice. Korean J. Food & Nutr. 23: 542-548.
22 Lee, S. J., A. Kim, J. H. Lee, M. H. Kim, B. S. Lee, Y. T. Jee, J. H. Bin, and J. M. Ha (2011) Effect of minerals added to medicinal plant extracts on alcohol-induced oxidative stress and alcihol metabolism in rats. J. Korean Soc. Food Sci. Nutr. 40: 393-400.   DOI
23 Liu, E. S. and C. H. Cho (2000) Relationship between ethanolinduced gastritis and gastric ulcer formation in rats. Digestion 62: 232-239.   DOI   ScienceOn
24 Piotrowski, J., E. Piotrowski, D. Skrodzka, A. Slomiany, and B. L. Slomiany (1997) Gastric mucosal apoptosis induced by ethanol: effect of antiulcer agents. Biochem. Mol. Biol. Int. 42: 247-254.
25 Jung, S. M., H. R. Schumacher, H. Kim, M. Kim, S. H. Lee, and F. Pessler (2007) Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. Arthritis Res. Ther. 9: R64.   DOI   ScienceOn
26 Wang, T., F. Fu, L. Zhang, B. Han, M. Zhu, and X. Zhang (2009) Effects of escin on acute inflammation and the immune system in mice. Pharmacol. Rep. 61: 697-704.   DOI
27 Santos, E. N., J. C. Lima, V. F. Noldin, V. Cechinel-Filho, V. S. Rao, E. F. Lima, G. Schmeda-Hirschmann, P. T. Jr. Sousa, and D. T. Martins (2011) Anti-inflammatory, antinociceptive, and antipyretic effects of methanol extract of Cariniana rubra stem bark in animal models. An. Acad. Bras. Cienc. 83: 557-566.   DOI   ScienceOn
28 Yang, H. M., S. S. Lim, Y. S. Kee, H. K. Shin, Y. S. Oh, and L. K. Kim (2007) Comparison of the anti-inflammatory effects of the extracts from Rubus coreanus and Rubus occidentalis. Korean J. Food Sci. Technol. 39: 342-347.