• 한국정보과학회논문지:소프트웨어및응용
• /
• 제31권2호
• /
• pp.137-152
• /
• 2004

모발분석(TMA: Tissue Mineral Analysis)은 머리카락 속에 있는 30여 가지의 미네랄과 8가지의 중금속의 양과 중요 미네랄 비율을 분석하여 체내에 과잉, 결핍 및 불균형 상태를 평가하고, 그 결과가 현재 인체에 미치는 영향을 예측하여, 건강을 유지하는 방향을 제시하는 임상 영양학 및 독성학 모발조직 검사방법을 말한다. 그러나 국내 TMA 분석방법은 몇 가지 문제점이 있다. 첫째, TMA 분석기기는 있으나 분석결과를 해석할 수 있는 한국형 의학 정보 데이타베이스가 없다. 둘째, 미국에서 보내오는 TMA 검사결과 자료가 영문이며 철저한 보안에 바탕을 둔 그래픽 파일 형태이므로 활용성이 적다. 셋째, TMA 관련 데이터베이스가 있어도 의료기관에서 사용하기 어려운 매우 낮은 수준이므로 TMA 분석 및 의료서비스를 위해 매번 미국에 의뢰해야 하므로 심각한 외화낭비를 초래한다. 넷째, TMA 결과가 서구식 생활패턴에서 비롯된 데이터 베이스로부터 구축된 것이므로 검사결과의 신뢰성 문제가 발생한다. 따라서 본 논문에서는 이러한 문제점을 해결하기 위해 국내 전문 기관으로부터 자료를 제공받아 TMA 관련 국내 최초 지능적 의학 전문가 시스템(IMES: Intelligent Medical Expert System)을 개발하였다. IMES는 TMA 자료를 다단계 통계분석 방법에 의한 결정 트리 분류기를 이용하여 분류하고 다중 퍼지 규칙베이스를 구축하여, 지능적 퍼지추론 방법에 의해 한글화된 데이터베이스로부터 복잡한 자료를 추론하도록 구축하였다. 본 IMES 시스템을 실제 적용한 결과 업무능률과 만족도가 각각 86%, 92% 증가함을 알 수 있었다.

• Journal of Nutrition and Health
• /
• 제51권4호
• /
• pp.295-306
• /
• 2018

본 연구는 스마트폰 중독청소년 80명을 대상으로 스마트폰 의존도에 따라 세군 (일반사용자군, 잠재적위험군, 고위험군)으로 분류하여 생활습관, 식행동, 모발 무기질 영양상태에 차이가 있는지 분석하였고 결과는 다음과 같다. 1. 본 연구대상자는 스마트폰 의존도가 높을수록 평균 주중 수면시간이 유의하게 적었고 첫 흡연연령은 늦었다. 전체 대상자의 우울감 존재율은 32.5%, 음주율 66.2%, 흡연율 55.0%로 매우 높고, 규칙적인 운동시 행률은 42.5%로 나타났다. 2. 식행동 항목에서는 스마트폰 의존도에 따라 군간 유의한 차이는 없었지만 잠재적위험군에서 식사속도가 빠르고 배부르게 먹는다는 비율이 높았으며 하루 간식을 2회 이상 섭취한다는 비율도 상대적으로 높았다. 그러나 스마트폰을 이용하면서 식사하는 경우 식사속도와 식사량에 큰 영향을 미치지는 않는 것으로 나타났다. 3. 개인의 식행동에 영향을 미치는 요인은 부모 (45.0%)와 모바일 (30.0%)의 비율이 우위를 차지하였다. 전반적으로 개선이 필요하다고 판단한 식습관은 불균형된 식사 (35.1%), 빠른 식사속도 (17.5%), 과식 (16.3%)이었으나 잠재적위험군은 불균형된 식사 (38.5%), 과식 (30.8%), 빠른 식사속도 (11.5%)로 세 군간 유의한 차이를 보였다. 4. 영양 및 건강정보 습득처는 핸드폰이 전체 37.5%를 차지하여 가장 높았고 전체 대상자의 32.5%만이 영양교육 및 상담을 받아본 경험이 있으며 교육요구도는 38.8%가 필요하다고 응답하였다. 5. 모발 무기질 총 17종을 분석한 결과 전체 대상자들은 정상범위보다 셀레늄의 농도는 낮고, 납의 농도는 높은 것으로 나타났다. 인과 황은 모두 정상범위에 있었지만 잠재적위험군에서 농도가 유의하게 높았고, 알루미늄의 경우는 고위험군이 정상범위보다 높고, 세 군중 가장 유의하게 높았다. 6. 세 군간 유의한 차이를 보인 인, 황, 알루미늄을 여러 변수별로 비교한 결과 인은 스트레스가 적은 군 (OR 1.18), 황은 여성 (OR 1.14), 고등학생 (OR 1.19), 수면시간 6.5시간 미만 (OR 1.88), 스트레스가 많은 군(OR 1.34), 우울감이 있는 군 (OR 1.20)에서 유의하게 높게 나타났다. 알루미늄은 여성 (OR 2.25)과 흡연군 (OR 1.32)에서 농도가 유의하게 높은 것으로 분석되었다. 이상의 결과를 종합하여, 스마트폰 의존도가 높은 청소년의 경우 수면, 음주, 흡연 등 건강에 유해한 생활습관과 높은 결식률, 불균형된 식사, 과식, 빠른 식사속도와 같은 식행동의 개선이 필요한 것으로 관찰되었다. 또한 과도한 인터넷 사용에 따라, 성장기 청소년에 요구되는 일부 무기질의 부족과 과잉에 대한 문제점도 있는 것을 알 수 있었다. 본 연구는 스마트폰 의존도 문제를 지닌 청소년을 대상으로 실시한 연구로 비의존 대조군이 존재하지 않아 청소년의 스마트폰 의존과 생활습관 및 식행동, 모발 무기질 영양상태와의 관련성을 직접적으로 설명하는 데는 제한점이 있다. 그러나 과의존 청소년의 경우 전반적인 생활습관과 식습관에 문제점이 많고, 의존 정도에 따라 식습관이나 모발 무기질 영양상태에 차이를 보인 연구 결과를 통하여 청소년 스마트폰 의존정도와 식습관, 무기질 영양과의 관련성이 있음이 제시되었다. 본 연구를 통해 미디어중독 청소년의 영양관리에 관한 기초자료를 마련할 수 있었고 나아가 청소년의 건강증진과 건전한 정보문화 정착을 기대하는 바이다.

• Journal of Nutrition and Health
• /
• 제37권3호
• /
• pp.193-201
• /
• 2004

The objective was to evaluate the factors influencing on the growth of children aged 3 - 6 years by mini dietary assessment and anthropometric indices in 556 children and by analyzing mineral contents of hair from 273 children by inductively coupled plasma mass spectrometry (ICP-MS). The mean concentration of zinc (Zn) in hair was 68.9 $\pm$ 31.1 ppm and the zinc level of 91 ％ children was less than 60％ of the reference value of 180 ppm. The mean content of lead (Pb) in hair was 1.76 $\pm$ 1.20 ppm, but only 67％ of 273 children was within the reference value of 2 ppm and the lead level of 33％ of children was 2 - 4 times higher than the reference value. The level of Zn was negatively correlated with Pb content (r = -0.305, p 〈 0.01). Hair Zn content, regardless of age, was significantly positively correlated with height (r = 0.214) and body weight (r = 0.159). The height of 95.3％ children was belonged to the normal range of 90 - 109.9％ of standard value and the body weight of 49.8％ children was in the range of 90 - 109.9％ of standard value. However, 8.1 ％ children was overweighted (110 - 119.9％ of standard) and 9.4％ children was obese (120 - 149.9％ of standard) and 0.9％ children was severe obese (〉 150％) which resulted in total 10.3％ obese. Contrary to our expectation, 32.8％ children was underweight (70 - 89.9％ of standard) and 36％ of the underweight children showed the low content of zinc (10 - 49 ppm) in hair. There was no significant correlation between dietary intake of Zn and hair Zn content. Hair Zn content was low even though children consumed greater than 75％ of their requirement for zinc. Regardless of dietary intake of Zn, hair Zn level was rather negatively correlated to the content of Pb in hair. 38.8％ children had an unbalanced diet which resulted in lower intake of calorie, Ca, Zn, vitamin B$_2$ compared with those consuming variety of foods. Therefore, it would be needed that new approach for nutrition education to improve eating habit having the unbalanced diet in preschool children. It might be also suggested to develop new food products to complement the nutrients of Zn, Ca, Fe as snacks or dietary supplement for Korean preschool children.

• 한국식품영양과학회지
• /
• 제29권1호
• /
• pp.99-105
• /
• 2000

The purpose of this study was to evaluat the Zn, Cu, Mn and Ni status and correlation of their concentrations in serum, urine, hair and fingernail in female college students. As the results are follows; The mean age of subjects was 22.5 years and height, weight and BMI were 160.1 cm, 51.0 kg and 20.0 respectively. The daily intake of energy 1769.5 kcal and the ratio of carbohydrate, fat and protein for energy is 60 : 20 : 15. The daily intake of energy (88.5%), vitamin B2 (86.1%), Ca (75.4%), Fe (58.3%) and Zn (63.0%) of subjects did not reach to Korean Recommended Dietary Allowance (RDA). The daily mean intake of Zn, Cu, Mn and Ni were 7.56 mg, 2.30 mg, 3.81 mg and 0.18 mg respectively. The concentrations of Zn in serum, urine, hair and nail were 85.6$\mu\textrm{g}$/dL, 391.2$\mu\textrm{g}$/day, 174.6$\mu\textrm{g}$/g and 102.4$\mu\textrm{g}$/g respectively and those Cu were 84.2$\mu\textrm{g}$/dL, 56.6 $\mu\textrm{g}$/day, 20.3$\mu\textrm{g}$/g and 4.3$\mu\textrm{g}$/g respectively. The concentrations of Mn in serum, urine, hari and nail were 0.2$\mu\textrm{g}$/dL, 1.1$\mu\textrm{g}$/day, 1.8$\mu\textrm{g}$/g and 1.6$\mu\textrm{g}$/g respectively and those of Ni were 0.6$\mu\textrm{g}$/dL, 24.5$\mu\textrm{g}$/day, 3.5$\mu\textrm{g}$/g and 3.1$\mu\textrm{g}$/g respectively. The daily intake of Mn showed the positive correlations with concentration of Mn in hair (p<0.05) and the daily intake of Ni was positively correlated with urinary exretion (p<0.05) and hair contents (p<0.001) of Ni. The more detailed studies about these trace mineral status should be required.

• 한방비만학회지
• /
• 제9권2호
• /
• pp.33-45
• /
• 2009

Objectives This study was performed to evaluate the relation between hair tissue mineral elements(HTME) and Heart rate variability(HRV) of the metabolic syndrome(MS). Methods 89 persons(41-69 ages) who visited Oriental hospital for medical examination were divided MS group(n=22) and control group(n=67). HTME and HRV were compared, and were analyzed correlation with five contents of the MS. Results (1) In total subjects, waist circumference had a positive correlation with Pb. Blood pressure had a negative correlation with Mg. High density lipoprotein cholesterol(HDL-chol) had a negative correlation with Pb, Sb and K, while positive correlation with Ca/K. Triglyceride(TG) had a negative correlation with Mg and Na/K, while positive correlation with K and Ca/Mg. (2) In total subjects, TG and fasting blood sugar(FBS) had negative correlation with high frequency(HF), while positive correlation with low frequency/high frequency ratio(LF/HF). (3) In MS group, most of the level of toxic minerals were higher, and the level of major nutritional minerals were lower, but there were no statistical signficance. In two groups, there is no contrast between the correlations of the MS contents and HTME. (4) In MS group, HF was significantly lower and LF/HF was higher than normal group. LF/HF had a negative correlation with waist circumference in MS group, while positive correlation in normal group. (5) In total subjects, TP had a positive correlation with Mg. In two groups, there is no contrast between the correlations of the MS contents and HRV. However LF/HF had a positive correlation with Na in MS group, TP and LF had negative correlation with Ca, while RMSSD and HF had negative correlation with Cu in normal group. Conclusion These results may suggest that HTME and HRV are useful in diagnosing and preventing the metabolic syndrome.

• 한국멀티미디어학회논문지
• /
• 제6권1호
• /
• pp.148-160
• /
• 2003

현재 세계 48개국의 의료기관에서 임상을 위해 널리 사용 중인 모발분석(TMA)은 중요 미네랄 비율을 분석하여 체내에 과잉, 결핍 및 불균형 상태를 평가하고 인체에 미치는 영향을 예측하여 건강유지 방향을 제시하는 임상 영양학 및 독성학 검사방법을 말한다. 그러나 국내 모발분석방법에는 몇 가지 문제점이 있다. 즉, 모발분석결과를 처리하고 해석할 수 있는 한국형 의료정보 데이터베이스가 없으므로 미국에 의뢰하고 있는데, 외화낭비는 물론 보내오는 모발분석 검사결과지가 영문이고 철저한 보안 위주파일이므로 국내의료 기관에서의 활용도가 매우 낮다. 또한 모발분석 결과가 서구식 데이터베이스로부터 분석된 것이므로 검사결과의 신뢰성 문제도 발생한다. 따라서 본 논문에서는 이러한 문제점을 해결하기 위해 국내 최초로 TMA 기반 한국형 의료정보시스템을 구축하였다. 이 시스템은 복잡한 모발분석 자료의 분류를 다단계 통계분석 방법에 의한 결정트리 분류기를 통해 수행하고, 다중 퍼지 규칙방식의 데이터베이스를 구축하여 지능형 퍼지추론 방법에 의해 모발분석 자료를 분석한다. 본 시스템의 성능을 실제 작업 환경에서 측정한 결과, 시스템을 사용하는 경우가 사용하지 않았을 경우보다 업무능률과 사용자 만족도가 각각 86%, 92% 증가하였다.

• Clinical and Experimental Pediatrics
• /
• 제58권10호
• /
• pp.363-368
• /
• 2015

Inflammatory bowel disease (IBD) is a chronic inflammatory disease mainly affecting the gastrointestinal tract. The incidence of the disease is rapidly increasing worldwide, and a number of patients are diagnosed during their childhood or adolescence. Aside from controlling the gastrointestinal symptoms, nutritional aspects such as growth, bone mineral density, anemia, micronutrient deficiency, hair loss, and diet should also be closely monitored and managed by the pediatric IBD team especially since the patients are in the development phase.

• 한국환경과학회지
• /
• 제17권7호
• /
• pp.809-816
• /
• 2008

The oriental ore minerals, which mainly consisted of talc, actinolite, sericite, and halloysite were developed, and then used to examine the healing effect on the skin wound in rats. Full-thickness square wounds were formed on the backs of rats after the hairs on the dorsal surface were shaved. The ore minerals were applied to examine the healing effect from day 0 to 15 after wounding. Notable wound healings in terms of congestion around the wound, wound contraction and epithelialization were found in ore mineral-treated groups. Moreover, microscopic results revealed the formation of epithelial layer, hair follicles and progressive angiogenesis in ore mineral-treated groups, while complete epithelial layer could not be found in the control. These results suggest that ore minerals from Korean indigenous ores may have wound healing effect on the skin injury in rats.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제25권1호
• /
• pp.28-36
• /
• 2014

Objectives : The goal of this study was to examine the association between zinc and lead level and symptoms of attention-deficit hyperactivity disorder (ADHD) among Korean children. Methods : A total of 89 clinic-referred children participated in the study (ADHD group=45, control group=44). The participants were 5-15 years old, and were mainly from urban areas of Seoul, Korea. ADHD was diagnosed using the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. We excluded children with a comorbid psychiatric disorder, medical illness requiring medication, or a prior history of taking ADHD medication. In order to evaluate the severity of ADHD symptoms, parents' Korean ADHD Rating Scale (K-ARS) was used. The ADHD diagnostic system (ADS) was used for evaluation of the severity of inattention and impulsivity. All participants completed the intelligence test and hair mineral analysis. Multiple regression analysis was used to examine the effect of hair zinc and lead levels on the K-ARS and ADS. We measured the predictive ability of the zinc and lead levels using logistic regression analysis. Results : The lead level explained the score for omission errors, commission errors, and response time SD in visual ADS in the ADHD group (adjusted $R^2$=.243, p<.01, adjusted $R^2$=.362, p<.01, and adjusted $R^2$=.275, p<.01), the score for omission errors of auditory ADS in ADHD group (adjusted $R^2$=.407, p<.01) and the entire group (adjusted $R^2$=.292, p<.01). Zinc was significantly explanatory for the K-ARS scores for the entire group (adjusted $R^2$=.248, p<.001) and the ADHD group (adjusted $R^2$=.247, p<.05). Conclusion : These findings suggest a possible role of zinc and lead in ADHD. Lead concentration in hair samples affected the ADS scores, and this was more prominent in children with ADHD. Children with ADHD had a lower zinc concentration in their hair, and the zinc concentration in hair showed negative correlation with the K-ARS score.

• 대한한방소아과학회지
• /
• 제21권2호
• /
• pp.51-67
• /
• 2007

Objectives The study was designed to find out the relationships between short stature and low weight among children and teenagers. Methods This research was performed in 21 children and teenagers from August 2006 to June 2007. We measured height, weight, body mass index, obesity rare, bone age, and HTMA. Moreover, we analyzed correlation with height, weight, mineral concentrations and ratios obtained from HTMA. Results There were significant correlations between HTMA and short stature and low weight. 1. Most subjects(76%) had slow metabolic types. 2. Ca, Mg, Zn, Ca/P, and Cr had significant differences between high bone age group and high chronological age group. 3. Fe/Cu had significant differences between a group that recent height is more smaller than inherited height and a group that recent height is more taller than inherited height. 4. Ca, Mg, Ca/P had significant differences between a low weight group and a normal weight group classified by obesity rate. Conclusions Children and teenagers with short stature and low weight have specific mineral characters.