• 제목/요약/키워드: hERG

검색결과 66건 처리시간 0.021초

The Limited Impact of AGN Outflows: IFU study of 20 local AGNs

  • Bae, Hyun-Jin;Woo, Jong-Hak;Karouzos, Marios;Gallo, Elena;Flohic, Helene;Shen, Yue;Yoon, Suk-Jin
    • 천문학회보
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    • 제42권1호
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    • pp.28.1-28.1
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    • 2017
  • To investigate AGN outflows as a tracer of AGN feedback on the host galaxies, we perform integral-field spectroscopy of 20 type 2 AGNs at z<0.1 using the Magellan/IMACS and the VLT/VIMOS. The observed objects are luminous AGNs with the [O III] luminosity >$10^{41.5}erg/s$, and exhibit strong outflow signatures in the [O III] kinematics. We obtain the maps of the narrow and broad components of [O III] and $H{\alpha}$ lines by decomposing the emission-line profile. The broad components in both [O III] and $H{\alpha}$ represent the non-gravitational kinematics, (i.e., gas outflows), while the narrow components represent the gravitational kinematics (i.e., rotational disks), especially in $H{\alpha}$. By using the spatially integrated spectra within the flux-weighted size of the narrow-line region, we estimate the outflow energetics. The ionized gas mass is $(1.0-38.5){\times}10^5M_{\odot}$, and the mean mass outflow rate is $4.6{\pm}4.3M_{\odot}/yr$, which is a factor of ~260 higher than the mean mass accretion rate $0.02{\pm}0.01M_{\odot}/yr$. The mean energy injection rate is $0.8{\pm}0.6%$ of the AGN bolometric luminosity Lbol, while the mean momentum flux is $(5.4{\pm}3.6){\times}L_{bol}/c$, except for two most kinematically energetic AGNs. The estimated energetics are consistent with the expectations for energy-conserving outflows from AGNs, yet we do not find any supporting evidence of instantaneous star-formation quenching due to the outflows.

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외국인 사전사용자의 관점에서 본 독일어 동사 결합가 사전의 문제점 - 통사 및 의미 정보를 중심으로 - (Probleme deutscher Verbvalenzlexika aus der Sicht $ausl\"{a}ndischer\;W\"{o}rterbuchbenutzer$ - unter besonderer $Ber\"{u}cksichtigung$ der syntaktischen u. semantischen Informationen -)

  • 김수남
    • 한국독어학회지:독어학
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    • 제5집
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    • pp.109-141
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    • 2002
  • Die neuere Entwicklung in der Valenzlexikographie $f\"{u}hrt$ hin zum didaktisch orientierten $W\"{o}rterbuch$, in dem die $Valenzeintr\"{a}ge$ neben anderen syntaktischen und semantischen Informationen stehen. Das $Valenzlexikon/-w\"{o}rterbuch$ wendet sich vorrangig an Lehrbuchautoren und Lehrer, die im Bereich Deutsch als Fremdsprache unterrichten, sowie $sekund\"{a}r$ an fortgeschrittene Deutschlemer. Das $Valenzw\"{o}rterbuch\;enth\"{a}lt$, neben den Informationen zur Valenz, genaue morphosyntaktische und semantische Erkl\"{a}rungen$ zu den Verben und ihrer spezifischen Umgebung, ferner Hinweise zur Morphologie, Wortbildung, Passiv- $f\"{a}higkeit$, Stil und Phraseologie. Die Strukturbeschreibungen sind durch zahlreiche Verwendungsbeispiele illustriert. In Helbig/Schenkel(1969, $^{8}1991$) sind die Verben nicht alphabetisch, sondern nach formaler und inhaltlicher $Zusammengeh\"{o}rigkeit$, nach Wortfamilien, Bedeutungsfeldern und Wortbildungsmitteln angeordnet, dagegen sind in Engel/Schumacher(1976, $^{2}1978$) und Bianco{I996) die Verben alphabetisch angeordnet In der vorliegenden Arbeit wurden lexikographische Probleme der Verbvalenz- lexika von Helbig/SchenkeJ(1969, $^{8}1991$), Engel/Schumacher(I976, $^{2}1978$) und Bianco(1996) aus der Sicht auslandischer $W\"{o}rterbuchbenutzer$ diskutiert. Hinsichtlich der Lexikoneintragungen (syntaktischer sowie semantischer Informationen) $f\"{u}r$ Verben kann man erkennen, dass zwischen einzelnen Valenzlexika viele Beschreibungsunterschiede $f\"{u}r$ ein bestimmtes Verb bestehen. Man kann feststellen, dass die Informationen zur Valenz, genaue morpho- syntaktische und semantische $Erkl\"{a}rungen$ zu den Verben und ihrer spezifischen Umgebung differieren. Problematisch $f\"{u}r$ nichtmuttersprachliche $W\"{o}rterbuch$benutzer sind die Unterschiede sowohl in Bezug auf Anzahl und Art der $Erg\"{a}nzungen$ als auch in Bezug auf Angabe der $Obligatheit/Fakultativit\"{a}t$ der Korrelate(d.h. der 'Praposi- tionaladverbien' oder der 'Pronominaladverbien'). Auch die $Beispiels\"{a}tze\;mit\;satzformigen\;Erg\"{a}nzungen$(dass-Satz, zu-Inf, ob-Satz, w-Satz) sollten systema- tisch angegeben werden. Das Valenzlexikon soil ein Nachschlagewerk und ein $Lernw\"{o}rterbuch$ zur weiteren Erforschung der syntaktish-semantischen Eigenschaften der deutschen Verben sein. Es ist zu hoffen, dass Valenzlexika als ein wichtiges Hilfsmittel $f\"{u}r$ das Fach Deutsch als Fremdsprache, das sich auf Theone und Praxis des Deutschunterrichts auswirken wird, noch an Bedeutung gewinnen $k\"{o}nnen$.

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Antitumor profiles and cardiac electrophysiological effects of aurora kinase inhibitor ZM447439

  • Lee, Hyang-Ae;Kwon, Miso;Kim, Hyeon-A;Kim, Ki-Suk
    • The Korean Journal of Physiology and Pharmacology
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    • 제23권5호
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    • pp.393-402
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    • 2019
  • Aurora kinases inhibitors, including ZM447439 (ZM), which suppress cell division, have attracted a great deal of attention as potential novel anti-cancer drugs. Several recent studies have confirmed the anti-cancer effects of ZM in various cancer cell lines. However, there have been no studies regarding the cardiac safety of this agent. We performed several cytotoxicity, invasion and migration assays to examine the anti-cancer effects of ZM. To evaluate the potential effects of ZM on cardiac repolarisation, whole-cell patch-clamp experiments were performed with human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and cells with heterogeneous cardiac ion channel expression. We also conducted a contractility assay with rat ventricular myocytes to determine the effects of ZM on myocardial contraction and/or relaxation. In tests to determine in vitro efficacy, ZM inhibited the proliferation of A549, H1299 (lung cancer), MCF-7 (breast cancer) and HepG2 (hepatoma) cell lines with $IC_{50}$ in the submicromolar range, and attenuated the invasive and metastatic capacity of A549 cells. In cardiac toxicity testing, ZM did not significantly affect $I_{Na}$, $I_{Ks}$ or $I_{K1}$, but decreased $I_{hERG}$ in a dose-dependent manner ($IC_{50}$: $6.53{\mu}M$). In action potential (AP) assay using hiPSC-CMs, ZM did not induce any changes in AP parameters up to $3{\mu}M$, but it at $10{\mu}M$ induced prolongation of AP duration. In summary, ZM showed potent broad-spectrum anti-tumor activity, but relatively low levels of cardiac side effects compared to the effective doses to tumor. Therefore, ZM has a potential to be a candidate as an anti-cancer with low cardiac toxicity.

MISCLASSIFIED TYPE 1 AGNS IN THE LOCAL UNIVERSE

  • Woo, Jong-Hak;Kim, Ji-Gang;Park, Daeseong;Bae, Hyun-Jin;Kim, Jae-Hyuk;Lee, Seung-Eon;Kim, Sang Chul;Kwon, Hong-Jin
    • 천문학회지
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    • 제47권5호
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    • pp.167-178
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    • 2014
  • We search for misclassified type 1 AGNs among type 2 AGNs identified with emission line flux ratios, and investigate the properties of the sample. Using 4 113 local type 2 AGNs at 0.02 < z < 0.05 selected from Sloan Digital Sky Survey Data Release 7, we detected a broad component of the $H{\alpha}$ line with a Full-Width at Half-Maximum (FWHM) ranging from 1 700 to $19090km\;s^{-1}$ for 142 objects, based on the spectral decomposition and visual inspection. The fraction of the misclassified type 1 AGNs among type 2 AGN sample is ~3.5%, implying that a large number of missing type 1 AGN population may exist. The misclassified type 1 AGNs have relatively low luminosity with a mean broad $H{\alpha}$ luminosity, log $L_{H\alpha}=40.50{\pm}0.35\;erg\;s^{-1}$, while black hole mass of the sample is comparable to that of the local black hole population, with a mean black hole mass, log $M_{BH}=6.94{\pm}0.51\;M_{\odot}$. The mean Eddington ratio of the sample is log $L_{bol}/L_{Edd}=-2.00{\pm}0.40$, indicating that black hole activity is relatively weak, hence, AGN continuum is too weak to change the host galaxy color. We find that the O III lines show significant velocity offsets, presumably due to outflows in the narrow-line region, while the velocity offset of the narrow component of the $H{\alpha}$ line is not prominent, consistent with the ionized gas kinematics of general type 1 AGN population.

Mn-Ir-Pt 새로운 반강자성체를 사용한 스핀밸브 거대자기저항에 관한 연구 (Study on the Spin Valve Giant Magnetoresistance With a New Mn-Ir-Pt Antife rromagnetic Material)

  • 서수정;윤성용;김장현;전동민;김윤식;이두현
    • 한국자기학회지
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    • 제11권4호
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    • pp.141-145
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    • 2001
  • Mn-Ir-Pt/Ni-Fe 교환이방성 이층박막은 계면에서 높은 교환결합자계(exchange bias field; $H_{ex}$)를 가질 뿐만 아니라 뛰어난 열적안정성과 Mn-Ir에 비하여 좋은 내식성을 나타내므로 스핀밸브형 다층막 소자의 고정층의 재료로 적합하다고 생각되어진다. 열적안정성에 관한 평가인 blocking 온도( $T_{b}$)는 Mn-Ir이 240 $^{\circ}C$로 Mn-Ir-Pt가 250 $^{\circ}C$로 Mn-Ir에 비하여 Mn-Ir-Pt의 $T_{b}$가 높은 것으로 평가되었으며, 내식성에 관한 평가인 부식전류밀도는 Mn-Ir-Pt 10배 정도의 낮은 값을 가지므로 내식성 또한 Mn-Ir에 비해 우수한 것으로 평가된다. Mn-Ir에 Pt를 약 1.9 at%정도 첨가하였을 때 $H_{ex}$가 가장 큰 값을 나타내었다. 본 연구에서 Ni-Fe/M $n_{78.3}$I $r_{19.8}$P $t_{1.9}$의 고정층을 사용한 스핀밸브 다층막의 자기적, 구조적 특성을 연구한 결과 약 5 %의 자기저항비를 얻을 수 있었다.다.다.다.다.다.다.

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FePd 인공격자박막의 나노구조 및 자기적 특성 (Nano-structure and Magnetic Properties of FePd Superlattice Thin Film)

  • 강준구;정인식;구정우;고중혁;구상모;남송민;하재근
    • 한국자기학회지
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    • 제18권5호
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    • pp.190-194
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    • 2008
  • FePd 합금박막을 스퍼터링법으로 초격자 박막의 형태로 제작하고 기판온도, 조성변화에 따른 미세구조 및 자기적 특성을 분석하였다. FePd 합금박막의 규칙화를 위한 열처리 온도를 FePt의 열처리 온도에 비해 $150^{\circ}C$ 낮추는데 성공하였다. 또한 FePd 규칙화 합금 박막은 화학양론적 조성일 때 장범위 규칙도는 가장 높은 값을 가졌으며(Fe조성 50 at.%, S = 0.79), 자기이방성 에너지는 Fe 조성이 약간 낮은 조성에서(Fe조성 48 at.%, $K_U=1.6{\times}10^7\;erg/cm^3$) 가장 높은 값을 나타내었다. 이것은 FePd 합금박막의 조성이 장범위 규칙도와 수직자기이방성에 직접적으로 영향을 미친다는 것을 나타낸다.

The Seoul National University AGN Monitoring Project (SAMP) : Photometric Light Curves

  • Son, Donghoon;Woo, Jong-Hak;Bae, Hyun-Jin;Jeon, Yiseul;Le, Huynh Anh;Park, Songyoun;Shin, Jaejin;Kim, Minjin;Park, Daeseong;Sung, Hyun-il;Gallo, Ellena;Hodges-Kluck, Edmund;Barth, Aaron;Treu, Tommaso;Malkan, Matt;Bennert, Vardha Nicola
    • 천문학회보
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    • 제42권1호
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    • pp.50.2-50.2
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    • 2017
  • We have been carrying out the long-term (3-5 years) AGN monitoring project since October 2015 to investigate the variability and measure the H beta line time lag of 69 nearby (0.06 < z < 0.47) AGNs based on the reverberation mapping method. Our targets have B band magnitudes of 14.4-18.6, luminosities of log L5100 = 45.6-48.1 erg/s, and the expected time lags of 28-597 light days. BVR band images are being taken with ~20-day cadence using MDM 1.3m, LOAO 1m and MDM 2.4m telescopes. Recently, Nickel 1m at Lick and DOAO 1m at Deokheung observatory are joined with photometric observations. Follow-up spectroscopic observations are on-going using the Lick 3m and MDM 2.4m telescopes. In this poster, we will describe our project including sample selection and the observational strategy, and present the preliminary results based on the 1st year photometry.

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NO EXCESS OF STAR FORMATION IN THE z = 1.4 STRUCTURE: Hα OBSERVATIONS OF THE RADIO-LOUD AGN 6CE1100+3505 FIELD

  • Shim, Hyunjin;Lee, Jong Chul;Hwang, Narae;Park, Byeong-Gon
    • 천문학회지
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    • 제52권6호
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    • pp.235-244
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    • 2019
  • We present the results of near-infrared imaging observations of the galaxy overdensity around the z = 1.44 radio-loud active galactic nucleus (AGN) 6CE1100+3505, which was carried out with the purpose of sampling the redshifted Hα emission from the actively star-forming galaxies that could constitute the overdensity. The existence of the structure around this AGN was spectroscopically confirmed by previous grism observations which are however limited to the central region. Using the CH4Off narrow/medium-band and H broad band filters in the Wide Infrared Camera (WIRCam) on the Canada-France-Hawaii Telescope (CFHT), we constructed a sample of objects that show a flux excess in the CH4Off band due to line emission. The emission line flux is ~ 4.9 × 10-16 erg s-1 cm-2, corresponding to a star formation rate (SFR) of ~ 50 M yr-1 for galaxies at redshifts z ~ 1.4. None of the galaxies with medium-band flux excess is located within 1 Mpc from the central AGN, and there is no evidence that the selected galaxies are associated with the proposed cluster. Along with the star formation quenching near the center that was found from the previous grism observations, the lack of extreme starbursts in the structure suggests that at z ~ 1.4, overdense regions are no longer favorable locations for vigorous star formation.

독일어 양상불변화사 doch의 우리말 번역 가능성 (Koreanische $\"{U}bersetzungsm\"{o}glichkeiten$ von Modalpartikel 'doch')

  • 김희자
    • 한국독어학회지:독어학
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    • 제5집
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    • pp.223-251
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    • 2002
  • Modalpartikeln, die auch $Abt\"{o}nungspartikeln,\;W\"{u}rzw\"{o}rter,\;F\"{a}rbew\"{o}rter$ usw. genannt werden, galten eine Zeitlang als $\"{U}berfl\"{u}ssiges$. Aber mit der 'kommunikativ­pragrnatischen Wende' hat die Partikelforschung einen enormen Aufschwung genommen. Auch im Femdsprachenunterricht waren Partikeln als etwas Unwichtiges oder in anderen Worten etwas schwer zu Behandelndes geblieben und wurden deshalb zur Seite geschoben. Mit Hilfe der Aufschwung der Partikelforschung in Deutschland untersuchte ich koreanische $\"{U}bersetzungsm\"{o}glichkeiten$ von Modalparikeln. Ich $\"{u}bernahm$ Diewaldische Methode. Sie $schl\"{a}gt$ ein Beschreibungsschema vor: Modalpartikeln haben verweisende und $verkn\"{u}fende$ Funktion. Sie weisen $n\"{a}hmlich$ auf den pragmatischen $Pr\"{a}text\;zur\"{u}ck$ und bringen ihn in relevanter Situation mit der Modalpartikel enthaltenden $\"{A}u{\ss}erung$ in Beziehung. Da braucht man also drei Ebenen: pragmatischer $Pr\"{a}text$, relevante Situation und partikelhaltige $Au{\ss}erung$. Die Schwierigkeit der $\"{U}bersetzungsm\"{o}glichkeiten$ von Modalkartikeln besteht darin, jeweiligen $Pr\"{a}text$ und jeweilige relevante Situation wiederherzustellen und auszudrticken. In diesem Aufsatz geht es nur um 'doch'. 'doch' ist eine der $h\"{a}ufigsten$ Modalpartikeln und tritt in vielen verschidenen Satzarten. 'doch' tritt in Aussage-, Imperativ-, Ausrufe­und Wunschsatzen auf. $Au{\ss}erdem$ tritt 'doch' in $Erg\"{a}nzungsfragen$ und Entscheidungsfragen mit Intonation auf und ist aber nur bei 'echten' Fragen ausgeschlossen. Aus der diachronischen Bedeutungsentwicklung und dem Bedeutungsvergleich zu ihren Homonymen stellten sich die semantischen Merkmale von 'doch' als $Adversativit\"{a}t\;und\;Konzessivit\"{a}t$. Aber diese semantischen Komponenten werden bei dem Modalpartikel $abgeschw\"{a}cht$ und pragmatische Faktoren werden in verschiedenen $Verwendungsm\"{o}glichkeiten$ verstarkt. Unter $Ber\"{u}cksichtigung\;jeweiligen\;Pr\"{a}textes$ und relevanter Situation schlug ich koreanische $\"{U}bersetzungsm\"{o}glichkeiten$ von 'doch' je nach der Satzart und nach der $Verwendungsm\"{o}glichkeit$ vor.

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섬유소 분해균 Aspergillus sp. HB 1의 세포융합에 관한 연구 (Cell Fusion of Cellulolytic Fungi, Aspergillus sp. HB1)

  • 김주호;장성열;최영길
    • 한국균학회지
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    • 제15권2호
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    • pp.80-86
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    • 1987
  • 자연계에서 섬유소분해능이 우수한 균을 분리하였고 섬유소분해능을 더욱 증진시키기 위한 기초단계로서 그 분리균주의 원형질체 생성과 융합의 최적조건을 조사하였다. 토양에서 채취한 시료로부터 섬유소분해능력이 우수한 Aspergillus sp., Penicillium sp., Trichoderma sp., 3균주를 분리 동정하였고 산업적으로 유용한 균주이며 cellulase activity가 있는 Aspergillus niger를 비교균주로 선택하여 각각의 효소활성도를 비교 조사한 결과, Aspergillus sp.가 가장 좋은 효소활성도를 보였으며 그 다음 Penicillium sp., Trichoderma sp., 그리고 Aspergillus niger 순이었다. 효소활성도가 가장 좋은 Aspergillus sp.에 자외선$(12erg/sec/mm^2)$을 4 분 30초 동안 조사하여 영양요구성 변이주를 유도, 분리하였다. 세포벽분해효소로는 pH6.0에서 ${\beta}-glucuronidase$가 효과적이었고 그 효소를 농도별로 처리해본 결과 5, 000unit/ml가 최적농도이었다. 재생률은 삼투안정제로 0.6M KCI을 사응하여 pH6.0에서보았을 때 야생형은 7.0%, met. 영양요구주는 7.5%, arg. 영양요구주는 5.2%이있다. 영양요구성변이주간의 원형질체융합에 필요한 PEG는 분자량이 6,000인 것이 좋았으며 최적농도는 $30^{\circ}C$ 이었다. 이때 융합율은 1.2%까지 획득하었다.

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