• Journal of Microbiology
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• 제45권6호
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• pp.572-577
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• 2007

To enhance therapeutic potential of murine monoclonal antibody, humanization by CDR grafting is usually used to reduce immunogenic mouse residues. Most humanized antibodies still have mouse residues critical for antigen binding, but the mouse residues may evoke immune responses in humans. Previously, we constructed a new humanized version (AKA) of mouse CC49 antibody specific for tumor-associated glycoprotein, TAG-72. In this study, to select a completely human antibody light chain against TAG-72, guided selection strategy using phage display was used. The heavy chain variable region (VH) of AKA was used to guide the selection of a human TAG-72-specific light chain variable region (VL) from a human VL repertoire constructed from human PBL. Most of the selected VLs were identified to be originated from the members of the human germline VK1 family, whereas the VL of AKA is more homologous to the VK4 family. Competition binding assay of the selected Fabs with mouse CC49 suggested that the epitopes of the Fabs overlap with that of CC49. In addition, they showed better antigen-binding affinity compared to parental AKA. The selected human VLs may be used to guide the selection of human VHs to get completely human anti-TAG72 antibody.

• 시스템엔지니어링학술지
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• 제5권1호
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• pp.67-72
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• 2009

User Requirements are analyzed and quantified by decision making models and system engineering methods to select alternative concepts which satisfy the various requirements. In this study, the design concepts for guided missile are derived using Quality Function Deployment(QFD) and Analytic Hierarchy Process(AHP). The design alternatives that satisfy the user requirements are extracted by QFD and Morphological Matrix, then the best design concept are obtained using AHP and Pugh concept Selection.

• 대한산업공학회지
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• 제21권1호
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• pp.85-101
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• 1995

Automated Guided Vehicles(AGVs) are widely used in computer integrated manufacturing(CIM) systems for material handling purposes. Although automated guided vehicles provide higher levels of flexibility and computer integrability, the installations are limited in number and one of the critical reasons lies in the complexity involved in the operation. The main objective of this research is to alleviate this problem by proposing efficient integrated operational control methods for AGV-based CIM systems. Particularly, this research is concerned with the mixed problem of dispatching automated guided vehicles and scheduling machines operation. The proposed dynamic heuristic algorithm uses various priority schemes and relevant information concerning the load of the system, the status of queues, and the position of AGVs in the scheduling process. The scheduling decision process is hierarchical in the sense that different decision criteria are applied sequentially to identify the most appropriate part to be served. This algorithm consists of two sections, the section of part selection by AGVs for the next service whenever an AGV completes the current assignment, and the section of part selection by machines for next service whenever a machine completes the current operation. The proposed algorithm has been compared with other scheduling schemes using the performance measure of mean flow-time and mean tardiness. Simulation results indicate that the proposed algorithm can reduce the mean flow-time and mean tardiness significantly.

• 비파괴검사학회지
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• 제25권1호
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• pp.20-26
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• 2005

유도초음파는 판, 봉 또는 관과 같은 구조물의 장거리 탐상에 사용되고 있다. 그러나, 유도초음파에는 그 모드가 많고 전파속도가 달라서, 원하는 모드를 선택적으로 발생시키고 수신하는 기법이 유도초음파를 응용하는데 핵심적인 기술 중 하나이다. 본 연구에서는 배열형 탐촉자의 위상을 조절하여 유도초음파를 발생시키는 방법에 대하여 연구하였다. 이를 위하여 8채널 초음파 펄서/리시버, 그리고 각각의 채널을 일정한 시간간격으로 구동할 수 있는 회로를 개발하였다. 8개의 탐촉자를 만들어서 배열형으로 사용하여 유도 초음파를 발생시켰다. 이웃한 요소 탐촉자 사이의 구동시간 간격을 제어하여 이에 맞는 위상속도를 지닌 유도초음파를 선택적으로 발생시켰고, 발생된 유도초음파의 군속도를 측정하였으며, 배열탐촉자에서 수신된 신호를 시간지연을 가지고 합성하여 유도초음파의 모드를 선택적으로 수신하였다. 그 결과, 이웃한 요소 탐촉자 사이의 구동시간 간격을 바꿈으로서 원하는 모드의 유도초음파를 선택적으로 발생시킬 수 있었다.

• 비파괴검사학회지
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• 제28권2호
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• pp.211-216
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• 2008

이 연구에서 다층구조물에서 각 모드에 대한 위상속도, 군속도, 감쇠 그리고 파형구조를 구하는 프로그램을 개발하였다. 판의 수와 재료 물성치를 변화시키면서 각 모드의 파형구조를 얻었다. 유체가 닿아 있는 구조물에서 유도파를 이용한 비파괴 검사의 성공여부는 에너지 손실을 최소화하는 모드선정의 최적화이다. 이 연구에서는 자유표면판재의 표면에서 정규화된 두께방향의 변위가 감쇠의 변화를 예측하기 위해서 사용되었으며 감쇠와 파형구조의 관계를 밝혔다. 이것은 유도파의 감쇠를 물이 닿아 있는 경우 복소수근을 찾는 수학적 어려움을 경감하면서 자유표면에서 두께방향 변위의 변화로부터 손쉽게 얻을 수 있다. 이 연구를 통하여 다층구조물에서 보다 민감하고 효율적인 비파괴 검사를 위한 유도파의 모드선정의 최적화 개념을 완성했다.

• Journal of Information Processing Systems
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• 제14권2호
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• pp.552-562
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• 2018

With the advent of the information society, image restoration technology has aroused considerable interest. Guided image filtering is more effective in suppressing noise in homogeneous regions, but its edge-preserving property is poor. As such, the critical part of guided filtering lies in the selection of the guided image. The result of the Expected Patch Log Likelihood (EPLL) method maintains a good structure, but it is easy to produce the ladder effect in homogeneous areas. According to the complementarity of EPLL with guided filtering, we propose a method of coupling EPLL and guided filtering for image de-noising. The EPLL model is adopted to construct the guided image for the guided filtering, which can provide better structural information for the guided filtering. Meanwhile, with the secondary smoothing of guided image filtering in image homogenization areas, we can improve the noise suppression effect in those areas while reducing the ladder effect brought about by the EPLL. The experimental results show that it not only retains the excellent performance of EPLL, but also produces better visual effects and a higher peak signal-to-noise ratio by adopting the proposed method.

• 비파괴검사학회지
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• 제21권4호
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• pp.391-397
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• 2001

비균질 적층 구조물에서의 유도초음파 전파는 이론적 분산성에 기초하여 실험적으로 규명된다. 이는 입사각도와 주파수의 적절한 선택은 적층 구조물에서의 유도초음파 발생에 중요하나는 깃을 드러낸다. 이론적 분산성은 접착층 두께와 층 두께, 물성치에 크게 의존한다. 실험적으로 분산성의 변화를 관찰하므로 비균질 적층 구조물의 접착층 두께를 측정하는 것이 가능하였다.

• 대한산업공학회지
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• 제13권1호
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• pp.11-24
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• 1987

Automatic Guided Vehicle Systems feature battery powered driverless vehicles with programming capabilities for path selection and positoning. Vehicles serve the machines in shop, following a guide path system installed on the shop floor. The basic problem in the system is to determine a fixed set of vehicle routes of minimal total distance(time) while keeping capacity and distance(time) constraints. In this paper, a heuristic algorithm is presented for scheduling the automatic guided vehicles. The algorithm routes the machines based on their distances and polor coordinate angles, taking into account the structural feature of the system. Computational experiments are performed on several test problems in order to evaluate the proposed algorithm. Finally, a framework for dealing with the case where supplies from the machines are probabilistic is described.

• Clinical Pain
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• 제20권2호
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• pp.59-69
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• 2021

Patients with pain, numbness, and weakness in their elbows, wrists, and hands often need proper rehabilitation treatments. Among them, musculoskeletal injection therapy should be performed after a full evaluation of the patient, taking into account history and physical examination leading to clinical diagnosis. General rules such as accurate diagnosis and injection materials selection are used to achieve maximum benefit with minimal side effects. During injection, patient location, aseptic care, penetration techniques, follow-up and follow-up care must be maintained. Specific techniques may vary depending on the type, lesion, and location of the injection therapy. For optimal effectiveness, physician should inject directly into the lesion and avoid the injection of surroundings as much as possible. Therefore, ultrasound-guided injections are needed to accurately inject. These conditions and other conditions of the hands, wrists, and elbows can be effectively diagnosed and treated with diagnostic ultrasound and ultrasound-guided injections.

• Tuberculosis and Respiratory Diseases
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• 제75권4호
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• pp.135-139
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• 2013

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is becoming a standard method for invasive mediastinal staging and for the diagnosis of paratracheal and peribronchial lesions. It is essential to understand the technical aspects of EBUS-TBNA to ensure safe and efficient procedures. In this review, we discuss the practical aspects to be considered during EBUS-TBNA, including anesthesia, manipulation of equipment, understanding mediastinal ultrasound images, target selection, number of aspirations needed per target, sample handling, and complications.