• Journal of Periodontal and Implant Science
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• v.53 no.4
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• pp.306-317
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• 2023

Purpose: Biphasic calcium phosphate (BCP), a widely used biomaterial for bone regeneration, contains synthetic hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), the ratio of which can be adjusted to modulate the rate of degradation. The aim of this study was to evaluate the clinical and radiographic benefits of reconstructing peri-implant bone defects with a newly developed BCP consisting of 60% β-TCP and 40% HA compared to demineralized bovine bone mineral (DBBM). Methods: This prospective, multicenter, parallel, single-blind randomized controlled trial was conducted at the periodontology departments of 3 different dental hospitals. Changes in clinical (defect width and height) and radiographic (augmented horizontal bone thickness) parameters were measured between implant surgery with guided bone regeneration (GBR) and re-entry surgery. Postoperative discomfort (severity and duration of pain and swelling) and early soft-tissue wound healing (dehiscence and inflammation) were also assessed. Data were compared between the BCP (test) and DBBM (control) groups using the independent t-test and the χ² test. Results: Of the 53 cases included, 27 were in the test group and 26 were in the control group. After a healing period of 18 weeks, the full and mean resolution of buccal dehiscence defects were 59.3% (n=16) and 71.3% in the test group and 42.3% (n=11) and 57.9% in the control group, respectively. There were no significant differences between the groups in terms of the change in mean horizontal bone augmentation (test group: -0.50±0.66 mm vs. control groups: -0.66±0.83 mm, P=0.133), postoperative discomfort, or early wound healing. No adverse or fatal complications occurred in either group. Conclusions: The GBR procedure with the newly developed BCP showed favorable clinical, radiographic, postoperative discomfort-related, and early wound healing outcomes for peri-implant dehiscence defects that were similar to those for DBBM.

• Korean Journal of Cognitive Science
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• v.34 no.2
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• pp.85-110
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• 2023

The gaze cueing effect appears as detecting a target rapidly and accurately when the direction of others' gaze corresponds with the location of the visual target. The gaze cue can be affected by the orientation of the face. The gaze cueing effect is strong when the face is presented upright, but the effect has only been observed in some studies when the face is presented inverted(e.g., Tipples, 2005). This study aimed to examine whether the gaze can operate as a cue to guide attention with upright faces, and to add variables that can affect the gaze cue, such as the orientation of the face, the orientation of the background, and a time interval between the gaze cue and the target(SOA). Furthermore, it systematically manipulated these variables to explore whether the gaze cueing effect can be observed under the various conditions. The results showed a significant gaze cueing effect even on the inverted face, contrasting with previous studies. These findings were consistently observed when the background stimulus was absent(Experiment 1) and present(Experiments 2 and 3). However, there was no significant interaction in the orientations between the face and the background. Moreover, in the short SOA(150 ms), we found a significant gaze cueing effect in conditions of every face and background orientation, whereas there was no significant gaze cueing effect in the long SOA(1000 ms). By presenting a consistent observation of the gaze cueing effect under the short SOA(150ms) even in the inverted faces, the results of this study pose questions about the reliability and repeatability of previous studies that did not report significant results of gaze cueing effects in that faces. Furthermore, our results are meaningful in providing additional evidence that attention can be guided toward the direction of the gaze even in various directions of the face and background.

• Nutrition Research and Practice
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• v.17 no.4
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• pp.682-697
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• 2023

BACKGROUND/OBJECTIVES: Tibetan tea is a kind of dark tea, due to the inherent complexity of natural products, the chemical composition and beneficial effects of Tibetan tea are not fully understood. The objective of this study was to unravel the composition of Tibetan tea using knowledge-guided multilayer network (KGMN) techniques and explore its potential antioxidant and hypolipidemic mechanisms in mice. MATERIALS/METHODS: The C57BL/6J mice were continuously gavaged with Tibetan tea extract (T group), green tea extract (G group) and ddH2O (H group) for 15 days. The activity of total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) in mice was detected. Transcriptome sequencing technology was used to investigate the molecular mechanisms underlying the antioxidant and lipid-lowering effects of Tibetan tea in mice. Furthermore, the expression levels of liver antioxidant and lipid metabolism related genes in various groups were detected by the real-time quantitative polymerase chain reaction (qPCR) method. RESULTS: The results showed that a total of 42 flavonoids are provisionally annotated in Tibetan tea using KGMN strategies. Tibetan tea significantly reduced body weight gain and increased T-AOC and SOD activities in mice compared with the H group. Based on the results of transcriptome and qPCR, it was confirmed that Tibetan tea could play a key role in antioxidant and lipid lowering by regulating oxidative stress and lipid metabolism related pathways such as insulin resistance, P53 signaling pathway, insulin signaling pathway, fatty acid elongation and fatty acid metabolism. CONCLUSIONS: This study was the first to use computational tools to deeply explore the composition of Tibetan tea and revealed its potential antioxidant and hypolipidemic mechanisms, and it provides new insights into the composition and bioactivity of Tibetan tea.

• The Journal of the Convergence on Culture Technology
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• v.9 no.3
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• pp.299-304
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• 2023

Recently, drones have been used as a major means of attack drones in major wars around the world, and it seems likely that they will evolve into game changers in the future. Recently, drones have been used as a major means of attack drones in major wars around the world, and it seems likely that they will evolve into game changers in the future. In the major wars of the 21century, attack drones are used for precision fire-guided or self-destruct attacks, For the purpose of cognitive warfare, its territory is expanding not only to land and air, but also to sea and water. These attack drones will perform multi-domain operations, and for this purpose, the level of autonomy will be improved and High-Low Mix We will continue to develop by strengthening concept-based scalability. North Korea has also been making considerable efforts to operate attack drones for a long time, and activities such as third-country-level self-explosive drones, artificial intelligence-based clustered self-explosive drones, and self-destructive stealth unmanned semi-submersible are expected. In addition to North Korea's provocations and attacks, it is hoped that there will be a need for active follow-up research on our military's countermeasures and utilization plans.

• 한국노년학
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• v.31 no.2
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• pp.223-241
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• 2011

The purpose of this research is to analyze the effect of an autobiography writing program as a method of education for older adults. The authors participated in the processes of all 10 sessions of the autobiography writing program as instructors or program assistants at a senior welfare center in Seoul, 2007. Data used for analysis were learners' narrations in class, written autobiographies by learners, and researchers' memo-notes. We analyzed their narrative flows using Haenninen(2000)'s theory of narrative flow and reconstructed their categories of activities as life histories. 'The innen narration' constructed by learners was a spiritual process in which they have imbued their life and living conditions with meaning. The learners reminisced their lives as 'unreflective narration' in the beginning of education. However, as the class went on, they gradually reminisced them as "reflective narration" and finally developed them as 'meta-reflective narration' through the intentional reflection. Likewise, we could interpret the transition of learners into meta-reflecter as the completion of ego-integration. As a conclusion, we found the effects of the autobiography writing education for older adults in educational, social, and psychological aspects.

• The Journal of Korean Academy of Prosthodontics
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• v.61 no.4
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• pp.367-378
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• 2023

With the recent development of computer-aided design-computer-aided manufacturing technology and 3D printing technology, and the introduction of various digital techniques, the accuracy and efficiency of top-down definitive prosthetic restoration are increasing. In this clinical case, stable occlusion support was obtained through the placement of a total of 9 maxillary and mandibular posterior implants in patient with anterior-posterior crossed occlusion. The edentulous area of the maxillary anterior teeth, which showed a tendency of high resorption of the residual alveolar bone, was restored with a Kennedy Class IV implant assisted removable partial denture to restore soft tissue esthetics. Computed tomography guided surgery was used to place implants in the planned position, double scan technique was used to reflect the stabilized occlusion in the interim restoration stage to the definitive prostheses, and metal 3D printing was used to manufacture the coping and framework. This clinical case reports that efficient and predictable top-down full mouth rehabilitation was achieved using various digital technologies and techniques.

• The Journal of Korean Academy of Prosthodontics
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• v.61 no.4
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• pp.284-292
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• 2023

Stable posterior occlusal support is crucial for adequate masticatory function and facial aesthetics. In elderly patients over the age of 65, masticatory ability has a significant impact on nutritional intake and overall health. This case report presents a prosthetic treatment of an elderly patient with edentulous maxilla and bilateral posterior edentulous mandible. The upper jaw was restored with a complete denture to establish an ideal occlusal plane, and the three-dimensional positions of the mandibular implants were determined accordingly. The implants were placed through computer-guided implant surgery and were immediately loaded with fixed provisional restorations. The implant-fixed zirconia final restorations were inserted in the lower posterior region, and the occlusal surface of posterior artificial teeth in the upper denture was substituted with cobalt-chrome alloy to resist occlusal wear. The patient's posterior occlusal support and masticatory function were promptly restored through this treatment process, and long-term stability against wear was also obtained.

• Economic and Environmental Geology
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• v.56 no.6
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• pp.887-897
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• 2023

Leading waste disposal countries, such as Sweden, Switzerland, and the United Kingdom, conduct safety assessments across all stages of High-Level Radioactive Waste Deep Geological Disposal Facilities-from planning and site selection to construction, operation, closure, and post-closure management. As safety assessments are repeatedly performed at each stage, generating vast amounts of diverse data over extended periods, it is essential to construct a database for safety assessment and establish a data management system. In this study, the safety assessment data management systems of leading countries, were analyzed, categorizing them into 1) input and reference data for safety assessments, 2) guidelines for data management, 3) organizational structures for data management, and 4) computer systems for data management. While each country exhibited differences in specific aspects, commonalities included the classification of safety assessment input data based on disposal system components, the establishment of organizations to supply, use, and manage this data, and the implementation of quality management systems guided by instructions and manuals. These cases highlight the importance of data management systems and document management systems for securing the safety and enhancing the reliability of High-Level Radioactive Waste Disposal Facilities. To achieve this, the classification of input data that can be flexibly and effectively utilized, ensuring the consistency and traceability of input data, and establishing a quality management system for input data and document management are necessary.

• Journal of Public Diplomacy
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• v.2 no.2
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• pp.53-80
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• 2022

Despite an astronomical budget for public diplomacy, China is experiencing successive failures in public diplomacy. The unfavorable feeling towards China is increasing every year in the world and China needs a new public diplomacy to resolve anti-Chinese sentiment. Here, we found that viewers of Korean-Chinese student YouTuber Deemd formed a friendly image towards China after watching Deemd's China vlog. Therefore, in this study, we tried to examine whether Deemd's vlogs affect the improvement of China's country image theoretically guided by the theory of mere exposure effect. In addition, we examined whether the improvement of a country image causes the 'Halo effect' that leads to an increase in the intention to visit China and purchase intention of Chinese products. It is expected that the results of this study can serve as a new digital media diplomacy solution for countries, including China, that want to capture the hearts of foreign public in the era of a new digital public diplomacy.

• Korean Journal of Radiology
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• v.21 no.4
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• pp.431-441
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• 2020

Objective: To compare the diagnostic performance and interobserver variability of strain ratio obtained from one or two regions of interest (ROI) on breast elastography. Materials and Methods: From April to May 2016, 140 breast masses in 140 patients who underwent conventional ultrasonography (US) with strain elastography followed by US-guided biopsy were evaluated. Three experienced breast radiologists reviewed recorded US and elastography images, measured strain ratios, and categorized them according to the American College of Radiology breast imaging reporting and data system lexicon. Strain ratio was obtained using the 1-ROI method (one ROI drawn on the target mass), and the 2-ROI method (one ROI in the target mass and another in reference fat tissue). The diagnostic performance of the three radiologists among datasets and optimal cut-off values for strain ratios were evaluated. Interobserver variability of strain ratio for each ROI method was assessed using intraclass correlation coefficient values, Bland-Altman plots, and coefficients of variation. Results: Compared to US alone, US combined with the strain ratio measured using either ROI method significantly improved specificity, positive predictive value, accuracy, and area under the receiver operating characteristic curve (AUC) (all p values < 0.05). Strain ratio obtained using the 1-ROI method showed higher interobserver agreement between the three radiologists without a significant difference in AUC for differentiating breast cancer when the optimal strain ratio cut-off value was used, compared with the 2-ROI method (AUC: 0.788 vs. 0.783, 0.693 vs. 0.715, and 0.691 vs. 0.686, respectively, all p values > 0.05). Conclusion: Strain ratios obtained using the 1-ROI method showed higher interobserver agreement without a significant difference in AUC, compared to those obtained using the 2-ROI method. Considering that the 1-ROI method can reduce performers' efforts, it could have an important role in improving the diagnostic performance of breast US by enabling consistent management of breast lesions.