• Asian-Australasian Journal of Animal Sciences
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• 제19권4호
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• pp.554-562
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• 2006

Two lines of mice, M16 selected for rapid growth and a randomly selected control ICR as well as their reciprocal crosses were used to study the effects of genotype on whole-body energetics and intestinal responses to monensin. Six mice, eight weeks of age, from each line or reciprocal cross were assigned to one of two treatments, 1) drinking water containing 20 mmol/L monensin dissolved in 0.5% V/V ethanol, and 2) drinking water containing 0.5% V/V ethanol (control) for two weeks. After 11 days (age of 9 weeks and 4 days), whole-body $O_2$ consumption was measured. At the end of two weeks, jejunal $O_2$ consumption, intestinal tissue composition and histomorphometrics as well as the rate and efficiency of glucose absorption were estimated. In comparison with the control, monensin administration in drinking water resulted in less daily water intake (13.4 vs. 15.5 ml/mouse, p<0.01), less protein to DNA ratio of jejunal mucosa (5.41 vs. 6.01 mg/mg, p<0.05), lower villus width (88 vs. $100{\mu}m$, p<0.05), and less jejunal tissue $O_2$ consumption enhancement by alcohol (7.2 vs. 10.5%, p<0.01) in mice. Other than those changes, monensin had little (p>0.05) effect on variables measured in either line of mice or their reciprocal cross. In contrast, the M16 line, selected for rapid growth, as compared to the ICR controls or the reciprocal crosses, had less initial (pre-monensin treatment) whole-body $O_2$ consumption per gram of body weight (1.68 vs. $2.11-2.34{\mu}mol/min{\cdot}g$ BW, p<0.01) as compared to the ICR and reciprocal crosses. In addition, the M16 mice exhibited greater growth (412 vs. 137-210 mg/d, p<0.05), better feed efficiency (41.7 vs. 19.9-29.3 mg gain/g feed, p<0.05), shorter small intestines adjusted for fasted body weight (1.00 vs. 1.22-1.44 cm/g FBW, p<0.05), wider villi (109 vs. $87-93{\mu}m$, p<0.05), more mature height of enterocytes (28.8 vs. $24.4-25.1{\mu}m$, p<0.05) and a lower rate (91 vs. $133-145{\eta}mol\;glucose/min{\cdot}g$ jejunum, p<0.05) and less energetic efficiency (95 vs. $59-72{\eta}mol$ ATP expended/${\eta}mol$ glucose uptake, p<0.05) of glucose absorption compared to the ICR line and the reciprocal cross. Monensin had little (p>0.05) effect on whole-body $O_2$ consumption and jejunal function, whilst selection for rapid growth resulted in an apparent down-regulation of intestinal function. These data suggest that genetic selection for increased growth does not result in concomitant changes in intestinal function. This asynchrony in the selection for production traits and intestinal function may hinder full phenotypic expression of genotypic growth potential.

• 한국미생물·생명공학회지
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• 제28권5호
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• pp.298-302
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• 2000

Fermentation parameters were estimated by use of a vent gas analyzer coupled to a computer data acquisition system in cultivation of Phellinus linteus WI-001, pro-ducer of polysaccharides known to have potent anticancer activities. Oxygen uptake rate(OUR), a critical indicator of the cells activities, was calculated by applying oxygen mass balance. In addition, by dividing the oxygen uptake rate hy the total oxygen consumed, on-line estimation of the cells specific growth rate was successfully done. It was also possible to estimate cell concentration directly bt use of oxygen-cell yield($Y_{x/o}$ ) which was obtained based on a correlation between cell growth and total oxygen consumed.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2001년도 International Meeting on Information Display
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• pp.9-12
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• 2001

With the explosive growth of Note-PC and Desktop monitor market, TFT LCD market confronted a entire supply shortage during 1999. Forecasting a more booming stage for the next several years, many TFT-LCD panel manufacturers continue to expand the capacity of their existing plants and also make an additional investment in building new plants. The new investment is concentrated on the $4^{th}$ generation TFT LCD line in order to improve investment efficiency. The set up of the Samsung's Gen 3.5 line progressed with satisfactorily performance using $600{\times}720mm$ glass size. We have continuously reviewed several issues regarding the glass size for our next Gen. 4 line, which leads to adopt $730{\times}920mm$. Due to the continuous enlargement of a substrate size and following difficulty in transferring cassettes, the next line is expected to be the last line that employs "cassette transfer". The layout of the next line will shift from conventional "concentration-type" to "separation-type" configuration for the purpose of reducing transfer distance as well as transfer time. The details will be discussed in this paper.

• Molecules and Cells
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• 제45권11호
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• pp.789-791
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• 2022

Targeting fibroblast growth factor receptors (FGFRs) has been slow compared to other targeted cancer therapies for receptor tyrosine kinases, such as epidermal growth factor receptors. The low efficacy and variable response have limited the growth of FGFR inhibitors in clinical use. Nevertheless, recent systematic and genomic approaches have identified the biological conditions for effectively targeting FGFRs and can accelerate the development of targeted drugs. Under clinical and preclinical trials, the inhibitors started fast growing furious races to target FGFRs. Finally, FGFRs will be more actionable and targetable with more precise and effective drugs at the end of the race, passing the finish line.

• 한국농림기상학회지
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• 제14권2호
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• pp.45-52
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• 2012

Enrichment planting은 라오스에서 산림복원 프로그램의 일환으로, 이차림에서 수종의 밀도를 증가시키는데 흔히 쓰인다. 본 연구는 다섯 종의 자생수종을 대상으로 임관층을 다양한 방법으로 소개하고 Enrichment planting을 실시하여 라오스에서 개벌 이후 적용할 수 있는 조림방법과 적합한 수종을 조사하였다. 본 연구결과, 수관층의 높이만 조사수종간 그리고 식재처리간 모두에서 통계적으로 유의한 차이가 나타났다. 묘목의 생존율과 수관층의 직경은 조사수종간에서는 유의한 차이가 나타났으나, 식재처리간에는 차이가 없었다. 반면 묘목의 근원경과 묘고는 식재처리간에서만 유의한 차이가 나타났다. 조사수종 중에는 Hopea odorata 와 Dalbergia cochinchinensis 가 다른 수종들에 비해 생존율과 수고생장 모두 양호한 것으로 나타났는데, 이는 이들 수종들이 향후 라오스 산림복원을 위한 Enrichment planting에 적용하기 적합할 것으로 판단된다. 또한 2m간격의 line planting은 묘목의 근원경 생장을 촉진시킬 수 있을 것으로 제안되지만 gap planting과 같이 넓은 간격의 line planting은 묘고생장을 촉진시킨 것으로 나타났다.

• 한국작물학회지
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• 제60권2호
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• pp.248-252
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• 2015

This study was conducted to compare the growth, inorganic components, and proximate components of Codonopsis lanceolata grown in 10 regions of Korea for selecting superior species and breeding by crossing. Among the all tested lines, the shortest plant height (217.12 cm) was observed from the Ulleungdo region line (No. 4) while the longest (273.9 cm) was observed from Hwasun region line (No. 9). In addition, the lines of central and northern region (No. 1~No. 7) tend to have shorter plant height than those of southern region (No. 8~No. 9) except Jejudo region line (No. 10). Flowering tends to be late towards southern region, and lines in central and northern regions were started flowering about 2 weeks earlier than those in southern regions. However, the heaviest root weight was 13.1 g, found in only Jejudo line (No. 10) whereas there was no significant difference found in the other regions which have a range of 8.3~11.0 g. The inorganic components were varied in each line, however, proportion of macroelements, such as K, Ca, and P, was the largest for every line. Especially for Heongseong region line (No. 2), had larger proportion of macroelements than the others. There was a difference of proximate compositions of Codonopsis lanceolata, except the moisture content, among all regions, however, it was generally shown that the content of crude protein (1.31~3.76%) and crude fiber (2.18~3.12%) was the highest.

• 한국약용작물학회지
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• 제23권2호
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• pp.132-137
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• 2015

This study was conducted to find out the variation in agronomic trait and chemical composition in the collected Perilla frutescens from China and Japan. From the results of growth investigation, the maximum number if branches was 26.7ea in Japan 134 line, followed by 25 nodes number in China 119 line. Among the different lines investigated, maximum number of panicle number (108.8) were observed in China 114 line. 1000 seed weight was maximum (4.12 g) in China 118 line. Flowering time of different collected lines varied significantly with average value of 175.5 days and the average line required for maturation of seedlings was 205.1 days. Plant height was the highest (248.9 cm) in China 107 line. Highest number of total picking leaves was 965ea, and the average picked period was 54 days. The major phenol compounds contained in Perilla frutescens showed wide variation for Syringic acid, Benzoic acid, Naringin, o-Coumaric acid, Myricetin, Naringenin and Hesperetin. Japan 139 line showed the highest level of total phenol contents ($8254.0{\mu}g/g$, dry weight).

• 대한기계학회논문집A
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• 제24권5호
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• pp.1331-1342
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• 2000

In power generation systems a variety of structural components typically operate at high temperature and pressure. Therefore a life assessment methodology accounting for gradual creep fracture is increasingly needed for these components. The most critical defects in such structure are generally found in the form of semi-elliptical surface cracks in the welded tubular joints. Therefore the analysis of a semi-elliptical surface crack in a plate or a shell is an important problem in engineering fracture mechanics. On this background, via shell/line-spring finite element analyses of such surface cracks in the welded T and L joints under various loadings, we investigate J-integral along the crack front We first develop T and L joints auto mesh generation program providing ABAQUS input file composed of shell/line-spring finite elements. We then further develop a T and L joints life assessment program based on the experimental creep crack growth law and auto mesh generation program in a graphical user interface format Finally the remaining life of T and L joints for various analytical parameters are assessed using the developed life assessment program.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 1999년도 제3회 압연심포지엄 논문집 압연기술의 미래개척 (Exploitation of Future Rolling Technologies)
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• pp.412-422
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• 1999

Scale defects generated on the strip surface in a tandem finishing mill line are collected from the strip trapped among the production mills by freezing the growing scale on the strip by the melt glass coating and shutting down the line simultaneously. The samples observed of its cross sectional figure showed the process of scale defect formation where the defects are formed at the base metal surface by thicker oxidized scale during each rolling passes. The properties of the oxidized layer growth both at rolling and inter-rolling are detected down sized rolling test simulating carefully the rolling condition of the production line. The thickness of the oxidized layer at each rolling pass are simulated numerically. The critical scale thickness to avoid the defect formation is determined through the expression of mutual relation between oxidized layer thickness and the lanks of the strip called quality for the scale defects. The scale growth of scale less than the critical thickness and also to keep the bulk temperature tuning the water flow rate and cooling time appropriately. Two units of Inerstand Cooler are designed and settled among the first three stands in the production line. Two units of scale defect is counted from the recoiled strip and the results showed distinct decrease of the defects comparing to the conventionaly rolled products.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제7권9호
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• pp.2232-2245
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• 2013

The present study proposes efficient procedural modeling methods for enabling the growth and creation of various trees with minimal user control. Growth volume algorithms are utilized in order to easily and effectively calculate many parameters that determine tree growth, including branch propagation. Procedural methods are designed so that users' interactive control structures can be applied to these algorithms to create unique tree models efficiently. First, through a two-line-based interactive growth volume control method, the growth information that determines the overall shape of the tree is intuitively adjusted. Thereafter, independent branch control methods designed to control individual branches are added to the growth deformation in order to enable the growth of unique trees. Whether the growth processes of desired trees can be easily and intuitively controlled by the proposed method is verified through experiments. Methods that can apply the proposed methods are also verified.